Includes: Type 1 von Willebrand Disease, Type 2A von Willebrand Disease, Type 2B von Willebrand Disease, Type 2M von Willebrand ... Von Willebrand Factor's primary function is binding to other proteins, in particular factor VIII, and it is important in ... June 2011). "Plasma von Willebrand factor levels are an independent risk factor for adverse events including mortality and ... Although von Willebrand did not identify the definite cause, he distinguished von Willebrand disease (vWD) from hemophilia and ...

Von Willebrand factor C and EGF domain-containing protein (VWCE) Von Willebrand factor (VWF) Chordin (CHRD) Chordin-like 1 ( ... Von Willebrand factor, type C (VWFC or VWC)is a protein domain is found in various blood plasma proteins: complement factors B ... "The secondary structure of the von Willebrand factor type A domain in factor B of human complement by Fourier transform ... For the von Willebrand factor the duplicated VWFC domain is thought to participate in oligomerization, but not in the initial ...

The von Willebrand factor type A (vWA) domain is a protein domain named after its occurrence in von Willebrand factor (vWF), a ... "The secondary structure of the von Willebrand factor type A domain in factor B of human complement by Fourier transform ... Perkins SJ, Edwards YJ (1995). "The protein fold of the von Willebrand factor type A domain is predicted to be similar to the ... Ruggeri ZM, Ware J (1993). "von Willebrand factor". FASEB J. 7 (2): 308-316. doi:10.1096/fasebj.7.2.8440408. PMID 8440408. ...

... (vWD) is an evolutionarily-conserved protein domain found in, among others, the von ... The vWD domain D'/D3 of the von Willebrand factor (vWF) serves as a carrier of clotting factor VIII (FVIII). The native ... domain of von Willebrand factor induced by CYS 25 and CYS 95 mutations lead to factor VIII binding defect and multimeric ... "The von Willebrand factor D'D3 assembly and structural principles for factor VIII binding and concatemer biogenesis". Blood. ...

See articles on Von Willebrand factor and on Von Willebrand factor type A domain. ENSG00000223757, ENSG00000227144, ... Von Willebrand factor A domain containing 7 is a protein that in humans is encoded by the VWA7 gene. ... "Entrez Gene: Von Willebrand factor A domain containing 7". Retrieved 2016-07-25. Valdes AM, Thomson G (2009). "Several loci in ...

Since this time, the factor causing the long bleeding time was called the "von Willebrand factor" in honor of Erik Adolf von ... Sadler JE (April 1994). "A revised classification of von Willebrand disease. For the Subcommittee on von Willebrand Factor of ... The von Willebrand factor is undetectable in the VWF antigen assay. Since the VWF protects coagulation factor VIII from ... "Canine von Willebrand Disease - Breed Summaries". ahdc.vet.cornell.edu. 2019-02-08. "Canine von Willebrand Disease". vetgen.com ...

... and is known as von Willebrand factor. Von Willebrand factor has two functions. Firstly, it is the carrier molecule for factor ... Von Willebrand disease and von Willebrand factor are named after him. He also researched metabolism, obesity and gout, and was ... now known as von Willebrand factor, that enables hemostasis. Von Willebrand was born on 1 February 1870 in Vaasa, then part of ... Von Willebrand, E. A. (1938). "Rasfrågor i modern belysning". Östnylandsk Ungdom (in Swedish): 5. Von Willebrand, E. A. (1939 ...

"Vonvendi (von willebrand factor- recombinant kit". DailyMed. 13 February 2019. Retrieved 27 March 2020. "Veyvondi-epar product ... against von Willebrand factor, causing the medicine to stop working and resulting in a loss of bleeding control. The most ... It is a recombinant von Willebrand factor. The most common adverse reactions are generalized itching, vomiting, nausea, ... Tran T, Arnall J, Moore DC, Ward L, Palkimas S, Man L (April 2020). "Vonicog alfa for the management of von Willebrand disease ...

1994 found CelVav and a von Willebrand factor A domain and with Wilson et al. 1998 provides the first credible evidence for an ... Sadler, J. Evan (1998). "Biochemistry and genetics of von Willebrand factor". Annual Review of Biochemistry. Annual Reviews. 67 ... C. elegans has been a model organism for research into ageing; for example, the inhibition of an insulin-like growth factor ... The tra-1 is a gene within the TRA-1 transcription factor sex determination pathway that is regulated post-transcriptionally ...

... such as Von Willebrand factor and vascular endothelial growth factor (VEGF). These substances could also have a role in PDP ... 1992). "Von Willebrand factor antigen in hypertrophic osteoarthropathy". J Rheumatol. 19 (5): 765-767. PMID 1613707. Silveria ... Von Willebrand factor is a marker of platelet and endothelial activation. This suggests that the activation of endothelial ... platelet-derived growth factor (PDGF) and epidermal growth factor (EGF). It has not been described yet what role these ...

... also known as von Willebrand factor-cleaving protease (VWFCP)-is a zinc-containing metalloprotease enzyme that cleaves von ... Fujimura Y, Matsumoto M, Yagi H, Yoshioka A, Matsui T, Titani K (January 2002). "Von Willebrand factor-cleaving protease and ... Kremer Hovinga JA, Studt JD, Lämmle B (2005). "The von Willebrand factor-cleaving protease (ADAMTS-13) and the diagnosis of ... Sonneveld MA, de Maat MP, Leebeek FW (July 2014). "Von Willebrand factor and ADAMTS13 in arterial thrombosis: a systematic ...

Moake JL (2004). "von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura". Seminars in Hematology. 41 (1): 4 ... "Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic ... 173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis". Arthritis ...

"Entrez Gene: von Willebrand factor A domain containing 2". Sengle G, Kobbe B, Morgelin M, Paulsson M, Wagener R (December 2003 ... von Willebrand factor A domain-containing protein 2, also known as A domain-containing protein similar to matrilin and collagen ... AMACO is a member of the von Willebrand factor A-like (VWA) domain containing protein superfamily and consists of three VWA- ... a new member of the von Willebrand factor A-like domain protein superfamily with a regulated expression in the kidney". The ...

This gene encodes a member of the von Willebrand factor A domain containing protein family. This family of proteins is thought ... This protein contains five von Willebrand factor A domains. The specific function of this gene has not yet been determined. Two ... the closest relative of cartilage matrix protein within the von Willebrand factor type A-like module superfamily". J Biol Chem ...

Moake, JL (2004). "von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura". Semin Hematol. 41 (1): 4-14. doi ... factor H, factor HR1 or HR3, membrane cofactor protein, factor I, factor B, complement C3, and thrombomodulin). This results in ... an enzyme that cleaves von Willebrand factor (vWf), a large protein involved in blood clotting, into smaller pieces. (TTP also ... The complement system activation may be due to mutations in the complement regulatory proteins (factor H, factor I, or membrane ...

It is an anti-von Willebrand factor humanized immunoglobulin. It acts by blocking platelet aggregation to reduce organ injury ...

This results in decreased break down of large multimers of von Willebrand factor (vWF) into smaller units. Less commonly TTP is ... In 1982, the disease had been linked with abnormally large von Willebrand factor multimers. The identification of a deficient ... ADAMTS13 is a metalloproteinase responsible for the breakdown of von Willebrand factor (vWF), a protein that links platelets, ... Moake JL (January 2004). "Von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura". Seminars in Hematology. ...

"Entrez Gene: Von Willebrand factor A domain containing 5A". Retrieved 2017-06-06. Zhou YQ, Chen SL, Ju JY, Shen L, Liu Y, Zhen ... Von Willebrand factor A domain containing 5A is a protein that in humans is encoded by the VWA5A gene. GRCh38: Ensembl release ...

It cleaves fibrin, fibronectin, thrombospondin, laminin, and von Willebrand factor. Plasmin, like trypsin, belongs to the ... and factor XII (Hageman factor). Fibrin is a cofactor for plasminogen activation by tissue plasminogen activator. Urokinase ... "Hepatic to pancreatic switch defines a role for hemostatic factors in cellular plasticity in mice". Proceedings of the National ... "Plasminogen binds the heparin-binding domain of insulin-like growth factor-binding protein-3". The American Journal of ...

The von Willebrand factor (VWF) serves as an essential accessory molecule. In general terms, platelet activation initiated by ... FGF (Fibroblast Growth Factor) ligands bind to receptors tyrosine kinase, FGFR (Fibroblast Growth Factor Receptors), and form a ... "Nuclear factor erythroid 2-related factor 2 facilitates neuronal glutathione synthesis by upregulating neuronal excitatory ... They are involved in regulation of kinases and phosphatases, G protein associated factors and transcriptional factors. Gaseous ...

More recently, he has described an allosteric disulfide that controls platelet capture via von Willebrand factor at sites of ... "Autoregulation of von Willebrand factor function by a disulfide bond switch". Science Advances. 4 (2): eaaq1477. Bibcode: ... Specifically, he found that an allosteric disulfide bond in tissue factor plays a crucial role in the coagulation process. ... His early research explored the molecular process that transitions tissue factor from a cryptic to active form. ...

An example a protein with calcium coordination is von Willebrand factor (vWF) which has an essential role in blood clot ... Calcium modulates force sensing by the von Willebrand factor A2 domain. Nature Communications 2011 Jul 12;2:385. [1] Dougherty ... Many enzymes require calcium ions as a cofactor, including several of the coagulation factors. Extracellular calcium is also ...

Healthy volunteers displayed an increase in von-Willebrand-factor (vWf) activity. Isolated molecules formed under Oprelvekin ... IL-11 is a member of a family of human growth factors and is being produced in the bone marrow of healthy adults. Synonyms are ... These increases in coagulation factors may contribute to the development of stroke (see under side-effects), but a precise ... Oprelvekin is recombinant interleukin eleven (IL-11), a thrombopoietic growth factor that directly stimulates the proliferation ...

One is von Willebrand factor (vWF), a multimeric protein that plays a major role in blood coagulation. Storage of long polymers ... They manufacture, store and release two principal molecules, von Willebrand factor and P-selectin, and thus play a dual role in ... Lenting PJ, Christophe OD, Denis CV (26 March 2015). "von Willebrand factor biosynthesis, secretion, and clearance: connecting ... Type III von Willebrand Disease is a severe bleeding disorder, like severe hemophilia type A or B. VWF acts in primary ...

Handa, M; Titani, K; Holland, L Z; Roberts, J R; Ruggeri, Z M (1986). "The von Willebrand factor-binding domain of platelet ... Von Willebrand factor. She went on to examine reproduction in sea urchins, salps, and amphioxus, known as lancelet. Holland ...

Titani K, Takio K, Handa M, Ruggeri ZM (August 1987). "Amino acid sequence of the von Willebrand factor-binding domain of ... The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent ... Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib- ... June 2002). "Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein ...

... s also reduce factor VIII-Ag Von Willebrand factor, thereby decreasing platelet function. Clots formed after ... and in certain intravenous fluids to solubilize other factors, such as iron (in a solution known as Iron Dextran). Intravenous ...

March 2005). "The prevalence of the cysteine1584 variant of von Willebrand factor is increased in type 1 von Willebrand disease ... von Willebrand factor is modified by ABO blood group genotype and is a major determinant of plasma von Willebrand factor ... O'Donnell J, Laffan MA (August 2001). "The relationship between ABO histo-blood group, factor VIII and von Willebrand factor". ... November 2006). "High von Willebrand factor levels increase the risk of first ischemic stroke: influence of ADAMTS13, ...

Marchant, R. E.; Lea, A. S.; Andrade, J. D.; Bockenstedt, P. (1992). "Interactions of von Willebrand factor on mica studied by ...

Alternatively, cryoprecipitate contains other coagulation factors, factors VIII, XIII, and von Willebrand factor. There are no ... The only risk factor is if both parents of a child carry the recessive allele linked to the disorder.[citation needed] ... Factor I Deficiency Neerman-Arbez, Marguerite; De Moerloose, Philippe (2007). "Mutations in the fibrinogen gene cluster ... doi:10.2147/vhrm.s5305 "Factor I deficiency (Fibrinogen deficiency) - Canadian Hemophilia Society". www.hemophilia.ca. ...