Inactivation or deletion of the tumor suppressor p53, which is a key regulator of cancer, significantly increases reprogramming ... "Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells". Cell Stem Cell. 7 (2 ... endothelial stem cells (to form lining of blood vessels) from umbilical cord blood; and mesenchymal stem cells (to form ... "Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors". Cell. 126 (4): 663- ...

... induces PPAR-gamma expression which in turn induces p53, a tumor suppressor gene involved in cell cycle regulation and ... to chromosome 17p13.1 and expression in cultured human retinoblastoma cells". Genomics. 19 (2): 266-72. doi:10.1006/geno. ... "PEDF induces p53-mediated apoptosis through PPAR gamma signaling in human umbilical vein endothelial cells". Cardiovascular ... Soon thereafter, the same laboratory sequenced the PEDF protein and compared it to a human fetal eye library. They found that ...

"Interleukin 1beta induces functional prostaglandin E synthase in cultured human umbilical vein endothelial cells". J. Physiol. ... Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53-induced apoptosis. Knockout ... The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been ... Alfaidy N, Sun M, Challis JR, Gibb W (2003). "Expression of membrane prostaglandin E synthase in human placenta and fetal ...

The goal was to cure malignant brain tumors by using recombinant DNA to transfer a gene making the tumor cells sensitive to a ... Gendicine is a cancer gene therapy that delivers the tumor suppressor gene p53 using an engineered adenovirus. In 2003, it was ... "Collection and Storage of Umbilical Cord Stem Cells for Treatment of Sickle Cell Disease" at ClinicalTrials.gov "Ten things you ... She did this by incubating the patient's cells in tissue culture with DNA extracted from a donor with normal hemoglobin. In ...

Receptor CD44 participates in cell adhesion interactions required by tumor cells. Although hyaluronan binds to receptor CD44, ... During fetal development, the migration path through which neural crest cells migrate is rich in HA. HA is closely associated ... In humans, there are at least seven types of hyaluronidase-like enzymes, several of which are tumor suppressors. The ... The average molecular weight in human synovial fluid is 3-4 million Da, and hyaluronic acid purified from human umbilical cord ...