Thyrotropic cellFollicular cellTRH stimulation test: Prior to the availability of sensitive TSH assays, thyrotropin releasing hormone (TRH)HypothyroidismHyperthyroidismSymptoms and signs of Graves' disease: Virtually all the symptoms and signs of Graves' disease result from the direct and indirect effects of hyperthyroidism, with exceptions being Graves' ophthalmopathy, goitre and pretibial myxedema (which are caused by the autoimmune processes of Graves' disease). These clinical manifestations are dramatic and involve virtually every system in the body.Reverse triiodothyronineCongenital hypothyroidismThyroid hormone: The thyroid hormones, triiodothyronine (T3) and its prohormone, thyroxine (T4), are tyrosine-based hormones produced by the thyroid gland that are primarily responsible for regulation of metabolism. T3 and T4 are partially composed of iodine (see molecular model).Thyroglobulin: Thyroglobulin (Tg) is a 660 kDa, dimeric protein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Thyroglobulin protein accounts for approximately half of the protein content of the thyroid gland.Iodine deficiencyIodothyronine deiodinase: Iodothyronine deiodinases ( and ) are a subfamily of deiodinase enzymes important in the activation and deactivation of thyroid hormones. Thyroxine (T4), the precursor of 3,5,3’-triiodothyronine (T3) is transformed into T3 by deiodinase activity.TriiodideCrosstalk (biology): Biological crosstalk refers to instances in which one or more components of one signal transduction pathway affects another. This can be achieved through a number of ways with the most common form being crosstalk between proteins of signalling cascades.ExophthalmosGoitreAnterior pituitary: A major organ of the endocrine system, the anterior pituitary (also called the adenohypophysis or pars anterior), is the glandular, anterior lobe that together with the posterior lobe (posterior pituitary, or the neurohypophysis) makes up the pituitary gland (hypophysis). The anterior pituitary regulates several physiological processes including stress, growth, reproduction and lactation.Bioline Reagents: Bioline Reagents is a primary manufacturer and developerBioline: The PCR Company | Company Profile of a wide range of specialised molecular biology products for the life science industry and research markets. It manufactures reagents including ultra-pure nucleotides, DNA polymerases and mixes, DNA markers, competent cells, products for RNA analysis and other general reagents for molecular biology.PropylthiouracilImmunoassay: An immunoassay is a biochemical test that measures the presence or concentration of a macromolecule in a solution through the use of an antibody or immunoglobulin. The macromolecule detected by the immunoassay is often referred to as an "analyte" and is in many cases a protein.Infiltrative ophthalmopathy: Infiltrative ophthalmopathy is found in Graves disease and resembles exophthalmos, except that the blurry or double vision is acquired because of weakness in the ocular muscles of the eye. In addition, there is no known correlation with the patient's thyroid levels.Prolactin cellHarderian gland: The Harderian gland is a gland found within the eye's orbit which occurs in tetrapods (reptiles, amphibians, birds and mammals) that possess a nictitating membrane.Thyroid cancerAutoimmune thyroiditisHigh anion gap metabolic acidosisAutoantibody: An autoantibody is an antibody (a type of protein) produced by the immune system that is directed against one or more of the individual's own proteins. Many autoimmune diseases, (notably lupus erythematosus), are caused by such autoantibodies.MyxedemaPituitary adenomaToxic nodular goiterLeRoy ApkerThyroidectomySomatotropic cellRiedel's thyroiditisCyclase-associated protein family: In molecular biology, the cyclase-associated protein family (CAP) is a family of highly conserved actin-binding proteins present in a wide range of organisms including yeast, flies, plants, and mammals. CAPs are multifunctional proteins that contain several structural domains.Euthyroid sick syndromeBeef cattle: Beef cattle are cattle raised for meat production (as distinguished from dairy cattle, used for milk production). The meat of adult cattle is known as beef.Superior orbital fissure: The superior orbital fissure is a foramen in the skull, although strictly it is more of a cleft, lying between the lesser and greater wings of the sphenoid bone.Iopanoic acidSuperabsorbent polymer: Superabsorbent polymers (SAPs) (also called slush powder) are polymers that can absorb and retain extremely large amounts of a liquid relative to their own mass. Horie, K, et.Sheehan's syndromeBucladesineSubacute thyroiditisCell membraneBurst kinetics: Burst kinetics is a form of enzyme kinetics that refers to an initial high velocity of enzymatic turnover when adding enzyme to substrate. This initial period of high velocity product formation is referred to as the "Burst Phase".Equine chorionic gonadotropin: Equine chorionic gonadotropin (eCG) is a gonadotropic hormone produced in the chorion of pregnant mares. Most commonly called pregnant mare's serum gonadotropin (PMSG) in the past, the hormone is commonly used in concert with progestogen to induce ovulation in livestock prior to artificial insemination.Cell ablation: Cell ablation (also known as tissue ablation) is a biotechnological tool for studying cell lineage and/or function and is a form of ablation. The process consists of selectively destroying one or multiple cells in a given organism by any chosen means.Kennel clubGs alpha subunit: The Gs alpha subunit (Gαs, Gsα, or Gs protein) is a heterotrimeric G protein subunit that activates the cAMP-dependent pathway by activating adenylyl cyclase. A mnemonic for remembering this subunit is to look at the first letters in each word (Gαs = Adenylate Syclase).Coles PhillipsFamilial dysalbuminemic hyperthyroxinemia: Familial dysalbuminemic hyperthyroxinemia is a type of hyperthyroxinemia associated with mutations in the human serum albumin gene.
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