Thalidomide
However, thalidomide is a teratogenic substance, and a proportion of children born during the 1960s had thalidomide embryopathy ... A clinical trial studying the use of thalidomide in leprosy soon followed. Thalidomide has been used by Brazilian physicians as ... Folkman persuaded the patient's doctor to try thalidomide, and that doctor conducted a clinical trial of thalidomide for people ... The precise mechanism of action for thalidomide is not known, although efforts to identify thalidomide's teratogenic action ...
Thalidomide scandal
"Thalidomide Monograph for Professionals". Drugs.com. Retrieved 14 November 2019. "Thalidomide: The Fifty Year Fight (no longer ... Anon (7 June 2002). "Thalidomide:40 years on". BBC News. BBC. Retrieved 1 May 2009. "Report of Thalidomide at University of New ... The Spanish advocacy group for victims of thalidomide estimates that in 2015, there were 250-300 living victims of thalidomide ... Despite its severe side effects, thalidomide was sold in pharmacies in Canada until 1962. The effects of thalidomide increased ...
Thalidomide!! A Musical
... is a British musical written and composed by Mat Fraser, who was born with phocomelia as a result of ... The production tells the story of a love affair between Glyn, a thalidomide survivor (Fraser) and a non-disabled woman, Katie ... a 2009 documentary film Mat Fraser on why he felt compelled to write Thalidomide!! A Musical , , Guardian Unlimited Arts Sharp ... the drug thalidomide being taken during his mother's pregnancy. Fraser and Anna Winslet play all the roles in the show. The ...
List of thalidomide side effects
... exposure to thalidomide. "US Label: Thalomid (thalidomide) capsule [Celgene Corporation]". DailyMed. Celgene Corporation. ... "UK Label: Thalidomide Celgene 50 mg Hard Capsules". electronic Medicines Compendium. Celgene Ltd. 1 August 2013. Retrieved 17 ... For information regarding birth defects, see thalidomide. Somnolence (drowsiness; ~40%) Edema (~60%) Hypotension (low blood ...
Wonder Drug: The Secret History of Thalidomide in America and its Hidden Victims
Olszynko-Gryn, Jesse (30 June 2023). "Thalidomide in AmericaWonder Drug: The Secret History of Thalidomide in America and Its ... Wonder Drug: The Secret History of Thalidomide in America and its Hidden Victims is a non-fiction book authored by Jennifer ... It tells the story of how Frances Oldham Kelsey of the Food and Drug Administration (FDA) found flaws in thalidomide research. ... Thomas, Katie (23 March 2020). "The Unseen Survivors of Thalidomide Want to Be Heard". The New York Times. Archived from the ...
NoBody's Perfect
Thalidomide!! A Musical "SHAKING AND STIRRING: A portrait of Niko von Glasow" (PDF). German Films Quarterly: 6-7. 2009. ... NoBody's Perfect explores the specific problems which the twelve thalidomide victims faced during their lives, as well as their ... who produced the drug Thalidomide. Following the release and German Film Award in 2009, Niko went on to meet with various ... resulting in a powerful campaign for the victims of thalidomide. ...
Pyoderma gangrenosum
... thalidomide; infliximab; or plasmapheresis. Superficial granulomatous pyoderma Brown recluse spider bite Jackson JM, Callen JP ...
Philip Venables
"Thalidomide". British Music Collection. 21 April 2009. "Time Stands Still by Philip Venables , University of York Music Press ... va and Thalidomide for the BBC Singers. His artistic collaborations have included Bound to Hurt, with Turner Prize winner ...
Theresia Degener
"Thalidomide". www.sciencemuseum.org.uk. Retrieved 7 April 2017. "Membership of the Committee". www.ohchr.org. Retrieved 7 April ... Degener is well known for being an outspoken victim of the Contergan Skandal, also known as the thalidomide disaster/tragedy, ... which makes reference to the drug thalidomide first marketed in 1957 in West Germany under the trade-name Contergan. The drug, ...
Erythema nodosum
Thalidomide has been used successfully in the treatment of Erythema nodosum leprosum, and it was approved by the U.S. FDA for ... According to a 2009 meta-analysis, there is some evidence of benefit for both thalidomide and clofazimine in the treatment of ... Rouhi, Maureen (2005). "Thalidomide". Chemical & Engineering News Archive. 83 (25): 122. doi:10.1021/cen-v083n025.p122. Van ...
2005 in British music
October - Thalidomide!! A Musical, by Mat Fraser, is premièred at Battersea Arts Centre, London. Patrick Doyle - Nanny McPhee ... Archived 8 October 2011 at the Wayback Machine Mat Fraser on why he felt compelled to write Thalidomide!! A Musical , , ...
Chiral drugs
Thalidomide is a classical example highlighting the alleged role of chirality in drug toxicity. Thalidomide was a racemic ... thalidomide, evil partner and vice versa. It is a bidirectional chiral inversion. Hence the argument that the thalidomide ... Besides the thalidomide tragedy, another event that raised the importance of issues of stereochemistry in drug research and ... The tragedy of thalidomide illustrates the potential for extreme consequences resulting from the administration of a racemate ...
Developmental toxicity
The effects of thalidomide led to important discoveries in the biochemical pathways of limb development. Many thalidomide ... "JSONpedia - Thalidomide". jsonpedia.org. Retrieved 2016-04-14. Kim JH, Scialli AR (July 2011). "Thalidomide: the tragedy of ... "Thalidomide Societies , US Thalidomide Survivors". 2019-12-29. Retrieved 2023-04-19. Gilbert, Scott (2014). Developmental ... Thalidomide was used as treatment for cancers, leprosy and HIV, however, the drug was extensively used for the treatment of ...
Michaelina Argy
"For services to Thalidomide Survivors". "The National Advisory Council (NAC)". The Thalidomide Trust. Archived from the ... "Thalidomide campaigner from Sussex awarded MBE". ITV News. 12 June 2015. Retrieved 2 July 2020. v t e (Use dmy dates from April ... Michaelina "Mikey" Argy MBE (born 1962) is an English thalidomide survivor and activist. She is a past chair of the National ... "Media Enquiries". Thalidomide Trust. Retrieved 2 July 2020. "With courage and determination..." (PDF). Michael Hall News. ...
Rosaleen Moriarty-Simmonds
Ruth (1 July 2016). "To Remember is to Care - Thalidomide Memorial". Thalidomide Society. Retrieved 1 October 2017. "No. 61092 ... She was born without arms or legs after her mother was prescribed thalidomide in pregnancy. She attended Ysgol Erw'r Delyn, a ... She was one of the leading campaigners for the creation of the Thalidomide Memorial in Cathays Park, Cardiff, to commemorate ... Mears, Tyler (24 January 2016). "What's it like being the son of TWO victims of thalidomide? James Moriarty-Simmonds tells his ...
Cereblon
As they report in the current issue of Science, a protein known as cereblon latched on tightly to the thalidomide. "Thalidomide ... "Thalidomide - A Second Chance? - programme summary". BBC. Retrieved 2009-05-01. Anon. "Born Freak". Happy Birthday Thalidomide ... Thalidomide was used as a treatment for morning sickness from 1957 until 1961 but was withdrawn from the market after it was ... The drug thalidomide binds to cereblon and changes which substrates can be degraded by it, which leads to an antiproliferative ...
List of public art in Cardiff
"Thalidomide Memorial, Cardiff". historypoints.org. Retrieved 5 September 2021. "Statue in memory of Mark Jervis". Entomologia ...
1957 in science
2008). "Thalidomide" (PDF). Bombay Hospital Journal. 50 (3): 446. Archived from the original (PDF) on 2011-07-22. Retrieved ... October 1 - The drug Thalidomide is launched as a sedative by Grünenthal GmbH. October 11 - An article by Fred Kummerow ...
Kefauver-Harris Amendment
Before the Thalidomide scandal in Europe, and Canada, U.S. drug companies only had to show their new products were safe. After ... The amendment was a response to the thalidomide tragedy, in which thousands of children were born with birth defects as a ... The majority of the tragic birth defects that occurred were in other countries because Thalidomide had not been approved for ... Frances Oldham Kelsey was the FDA reviewer who refused to approve Thalidomide for use. It introduced a "proof-of-efficacy" ...
Ama Sumani
It was thalidomide. Allafrica.com Ghana News Today Medicalnewstoday.com Guardian report No Borders South Wales (Articles ... Despite the kidney dialysis treatments, she was not able to access a supply of thalidomide, a drug that might have prolonged ... Murphy, Clare (3 April 2008). "Thalidomide: a curse and a blessing?". BBC News. news.bbc.co.uk. Retrieved 2 February 2011. ... Deported Ghanaian Ama Sumani needed thalidomide to prolong her life...Last month, a woman who was controversially deported back ...
Jacob Sheskin
Brynner, R. (April 03, 2006). Thalidomide and Cancer. 3 Quarks Daily. Raza, A. (February, 2002). The third coming: Thalidomide ... Penna, G. O., Martelli, C. M. T., Stefani, M. M. A., Macedo, V. O., Maroja, M. d. F., & Chaul, A. (2005). Thalidomide in the ... "Thalidomide chronology". Grünenthal. Retrieved 2009-07-27. "מקבלי התואר יקיר ירושלים בשנים עברו". unknown. Archived from the ... Stevens, T., & Brynner, R. (2001), Dark remedy: The impact of thalidomide and its revival as a vital medicine. Cambridge, MA: ...
William McBride (doctor)
Thalidomide apology insulting, campaigners say BBC News 1 September 2012. Accessed 31 March 2017 "William McBride got the ... The thalidomide story. Sydney Publishing (University of Sydney), 17 January 2016 "Dr William McBride: The flawed character ... Working with P H Huang, he proposed that thalidomide caused malformations by interacting with the DNA of the dividing embryonic ... He published a letter on the teratogenicity of thalidomide following the findings of a midwife named Pat Sparrow, which ...
Health crisis
Rouhi, Maureen (June 20, 2005). "Top Pharmaceuticals: Thalidomide". Chemical & Engineering News. 83 (25). doi:10.1021/cen- ... Birth defects by thalidomide 1981: Toxic oil syndrome or simply toxic syndrome HIV/AIDS 1996: Bovine spongiform encephalopathy ... Health care Health policy Health law Medicalization Primary health care Routine health outcomes measurement Thalidomide ...
VigiBase
1957- Thalidomide tragedy. 1968- WHO Programme established with 10 member states. International ADR terminology and drug ...
Racemization
Thalidomide can be used to treat multiple myeloma. Another commonly used drug is ibuprofen which is only anti-inflammatory as ... Thalidomide as the (R) enantiomer is effective against morning sickness, while the (S) enantiomer is teratogenic, causing birth ... "Use of thalidomide in leprosy". WHO:leprosy elimination. World Health Organization. Archived from the original on November 10, ... Stolberg SG (17 July 1998). "Thalidomide Approved to Treat Leprosy, With Other Uses Seen". The New York Times. Retrieved 8 ...
Enantioselective synthesis
However, following the thalidomide disaster the development and licensing of drugs changed dramatically. First synthesized in ... doi:10.1016/S0140-6736(61)90927-8. Ito, Takumi; Ando, Hideki; Handa, Hiroshi (May 2011). "Teratogenic effects of thalidomide: ... McBride, W. G. (1961). "Thalidomide and Congenital Abnormalities". The Lancet. 278 (7216): 1358. ... suggested that one enantiomer of thalidomide was teratogenic while the other possessed all the therapeutic activity. This ...
Stereochemistry
An often cited example of the importance of stereochemistry relates to the thalidomide disaster. Thalidomide is a ... thalidomide enantiomers. In the human body however, thalidomide undergoes racemization: even if only one of the two enantiomers ... Thalidomide is currently used for the treatment of other diseases, notably cancer and leprosy. Strict regulations and controls ... Stephens TD, Bunde CJ, Fillmore BJ (June 2000). "Mechanism of action in thalidomide teratogenesis". Biochemical Pharmacology. ...
Regulation of therapeutic goods
Emanuel, Michael (2012). "Thalidomide and its sequelae". The Lancet. 380 (9844): 781-783. doi:10.1016/s0140-6736(12)60468-1. ... One other major catastrophe occurred in the late 1950s when Thalidomide, which was originally sold in Germany (introduced into ... the pharmaceutical industry later complied due to the thalidomide situation. The European Economic Commission also passed a ...
Lesley Florence
Florence, A. Leslie (31 December 1960). "Is Thalidomide to Blame?". British Medical Journal. 2 (5217): 1954. ISSN 0007-1447. ... known for his letter on his observations of neurological side effects of thalidomide, published on 31 December 1960 in the ...
Chiral inversion
Ibuprofen Dexibuprofen Ketoprofen Thalidomide Fenoprofen Chiral drugs Chiral switch Aboul-Enein HY, Wainer IW (1997). The ... Eriksson T, Björkman S, Höglund P (August 2001). "Clinical pharmacology of thalidomide". European Journal of Clinical ... thalidomide, and tiaprofenic acid. A brief list of select pharmaceutical drugs that go through chiral inversion are presented ...