Vielmetter J, Kayyem JF, Roman JM, Dreyer WJ (1995). "Neogenin, an avian cell surface protein expressed during terminal ... Neogenin is a protein that in humans is encoded by the NEO1 gene. NEO1 has been shown to interact with PTK2. Also Neogenin ... v t e (Articles with short description, Short description matches Wikidata, Genes on human chromosome 15, Human proteins, All ... a DCC-related protein, and the mapping of its gene (NEO1) to chromosomal position 15q22.3-q23". Genomics. 41 (3): 414-21. doi: ...
"Dimerization of the N-terminal amphipathic alpha-helix domain of the fungal immunomodulatory protein from Ganoderma tsugae (Fip ... Avian Pathology. 42 (3): 235-247. doi:10.1080/03079457.2013.780121. PMID 23627727. S2CID 24714876. Lin WH, Hung CH, Hsu CI, Lin ... Protein Data Bank Accession number 3KCW_A) from G. microsporum FIP-tve (NCBI DNA Accession number XM_008037967; Protein ... Hsu HC, Hsu CI, Lin RH, Kao CL, Lin JY (April 1997). "Fip-vvo, a new fungal immunomodulatory protein isolated from Volvariella ...
This region gets its name from a viral protein called Myb derived from the avian myeloblastosis virus. Specifically, the ... The basic domain sits at the N-terminal, and has two main functions: the prevention of t-loop excision by XRCC3, and the ... There are 4 domain categories on the TERF2 protein that allow it to bind to both other proteins in the shelterin protein ... TERF2 is also known to recruit certain client proteins, also known as accessory factors. These client proteins are often ...
The viral protein interacts with CIDE-B, a liver-specific pro-apoptotic protein whose carboxy-terminal killing domain induces ... Suarez, David L. (2009). "Influenza A Virus". In David E. Swayne (ed.). Avian Influenza. John Wiley & Sons. p. 3. ISBN ... NS2 possesses a hydrophobic amino-terminal subdomain as well as a carboxy-terminal cytoplasmic domain, with the amino-terminal ... NS1 influenza protein Erdtmann L, Franck N, Lerat H, et al. (May 2003). "The hepatitis C virus NS2 protein is an inhibitor of ...
The NS1 protein can be divided into an N terminal (RNA binding) domain and C terminal (effector domain). The RNA binding domain ... The NS1 protein of the highly pathogenic avian H5N1 viruses circulating in poultry and waterfowl in Southeast Asia is currently ... The NS1 influenza protein (NS1) is a viral nonstructural protein encoded by the NS gene segments of type A, B and C influenza ... As a consequence of its binding to dsRNA, the NS1 protein blocks the activation of the dsRNA-activated protein kinase (PKR) in ...
The function of the UBX domain is not known although the fragment of avian FAF-1 containing the UBX domain causes apoptosis of ... Additionally, the absence of a carboxy-terminal di-glycine motif, however, indicates that UBX domains are not covalently ... In molecular biology, the UBX protein domain is found in ubiquitin-regulatory proteins, which are members of the ubiquitination ... the human Rep-8 reproduction protein and several hypothetical proteins from yeast. ...
In many cases they are synthesised as part of a larger precursor protein, either as a prepropeptide or as an N-terminal domain ... avian ovomucoid; acrosin inhibitor; and elastase inhibitor. These proteins contain between 1 and 7 Kazal-type inhibitor repeats ... Peptide proteinase inhibitors can be found as single domain proteins or as single or multiple domains within proteins; these ... The amino terminal segment of this domain binds to the active site of its target proteases, thus inhibiting their function. ...
The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain ... The name Crk is from "CT10 Regulator of Kinase" where CT10 is the avian virus from which was isolated a protein, lacking kinase ... v-Crk, a transforming oncoprotein from avian sarcoma viruses, is a fusion of viral "gag" protein with the SH2 and SH3 domains ... Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene. The CRK protein ...
Matrix proteins are produced as N-terminal domains of Gag precursor polyproteins. The Gag polyprotein directs the assembly and ... It includes Gag polyproteins from several avian endogenous retroviruses. Matrix proteins are also components of beta- ... Gag-derived proteins govern the entire assembly and release of the virus particles, with matrix proteins playing key roles in ... Typical matrix proteins of retroviruses form an alpha helical bundle structure . One family of these proteins represents matrix ...
The nascent protein contains a N-terminal signal peptide sequence, a conserved "ZP domain" module, a consensus furin cleavage ... as well as its full-length avian homolog (PDB: 3NK3, 3NK4​) revealed that the protein's ZP module consists of two ... The protein encoded by this gene is a major structural component of the ZP and functions in primary binding and stimulation of ... ZP3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ...
... heat shock proteins (sHsps), particularly in their C-terminal halves. The relationship between these families is one of classic ... Simpson A, Bateman O, Driessen H, Lindley P, Moss D, Mylvaganam S, Narebor E, Slingsby C (1994). "The structure of avian eye ... More proteins containing βγ-crystallin domains have now been characterized as calcium binding proteins with Greek key motif as ... RCSB Protein Data Bank (Protein pages needing a picture, Articles needing cleanup from March 2021, All pages needing cleanup, ...
In 1980, synemin was first identified in avian smooth muscle and was initially described as an IF-associated protein due to its ... Both isoforms have a very short N-terminal domain of 10 amino acids and a long C-terminal domain consisting of 1243 amino acids ... IF proteins are cytoskeletal proteins that confer resistance to mechanical stress and are encoded by a dispersed multigene ... the low degree of conservation between these two proteins compared to other cloned IF proteins suggested that synemin was not ...
GARTfase is located on the C-terminal end of the protein. Human GARTfase has been crystallized by vapor-diffusion sitting drop ... Many residues in the active site are conserved across bacterial, yeast, avian and human enzymes. In humans, GARTfase is part of ... the purN enzyme is a 23 kDa protein but in humans it is part of a trifunctional protein of 110 kDa which includes AIRS and GARS ... Protein Engineering. 13 (5): 323-7. doi:10.1093/protein/13.5.323. PMID 10835105. Tong X, Zhao F, Thompson CB (February 2009). " ...
Like other proteins in this complex, RELA contains a N-terminal REL-homology domain (RHD), and also a C-terminal ... RELA, or v-rel avian reticuloendotheliosis viral oncogene homolog A, is also known as p65 or NFKB3. It is located on chromosome ... "Interaction of the COOH-terminal transactivation domain of p65 NF-kappa B with TATA-binding protein, transcription factor IIB, ... "The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation". Oncogene ...
Although an α8 subunit/gene is present in avian species such as the chicken, it is not present in human or mammalian species. ... nAChR function can be modulated by phosphorylation by the activation of second messenger-dependent protein kinases. PKA and PKC ... In contrast, paracrine transmission (volume transmission) involves neurotransmitters released by axon terminals, which then ... The nAChR subunits have been divided into 4 subfamilies (I-IV) based on similarities in protein sequence. In addition, ...
Smith DF, Albers MW, Schreiber SL, Leach KL, Deibel MR (November 1993). "FKBP54, a novel FK506-binding protein in avian ... Young JC, Obermann WM, Hartl FU (July 1998). "Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa ... FK506 binding protein 5, also known as FKBP5, is a protein which in humans is encoded by the FKBP5 gene. The protein encoded by ... March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human ...
"Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase". Proceedings of the National ... Maki Y, Bos TJ, Davis C, Starbuck M, Vogt PK (May 1987). "Avian sarcoma virus 17 carries the jun oncogene". Proceedings of the ... Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, ... The human JUN encodes a protein that is highly similar to the viral protein, which interacts directly with specific target DNA ...
... of the RT protein C-terminal. The DNA polymerase domain occupies ~55% of the RT protein N-terminal. The RNase H domains of MMLV ... Although the RT structures from human, murine and avian retroviruses display different subunits, the relative sizes, ... A notable difference between the various RNase H proteins is the presence or absence of the C-helix (present in E. coli, MLV ... "Structure of ribonuclease H phased at 2 A resolution by MAD analysis of the selenomethionyl protein". Science. 249 (4975): 1398 ...
85% of these predicted proteins contained start and stop codon, and 12% contained an N-terminal secretion signal sequence, ... On the other hand, by performing whole-genome synteny comparison between the Indian cobra and other reptilian and avian genomes ... Using protein homology information and expression data from different tissues of the cobra, 23,248 protein-coding genes, 31,447 ... These 19 venom specific toxins (VSTs) encode the core effector toxin proteins and include 9 three-finger toxins (out of which ...
"Subcellular localization of proteins encoded by oncogenes of avian myeloblastosis virus and avian leukemia virus E26 and by ... The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C- ... MYB factors represent a family of proteins that include the conserved MYB DNA-binding domain. Plants contain a MYB-protein ... "Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role ...
... cleaves terminal sialic acid residues from glycan structures on the surface of the infected cell. This ... In growing fears of a global avian flu pandemic, scientists began to look for a cause of resistance to the Tamiflu medication. ... The cause was determined to be a histidine-to-tyrosine (amino acid) substitution at position 274 in its neuraminidase protein.[ ... Neuraminidases cleave the terminal sialic acid residues from carbohydrate chains in glycoproteins. Sialic acid is a negatively ...
Avian Tnnt3 gene has evolved with additional alternatively spliced exons, w, P1-7(x) and y, encoding the N-terminal variable ... Two variable regions of the fsTnT protein are generated by alternative splicing (Fig. 3). In the N-terminal region of fsTnT, ... Jin JP, Samanez RA (Feb 2001). "Evolution of a metal-binding cluster in the NH(2)-terminal variable region of avian fast ... presumably serves as a calcium reservoir in avian fast pectoral muscles. Together with more N-terminal negative charges, this ...
... it also contains motifs for rolling circle replication in the C-terminal region. VP2 is a 23kd nonstructural protein with ... A second virus in this genus-Avian gyrovirus 2-has been described. The viral genome shares ~40% of its sequence with Chicken ... These proteins share 38.8%, 40.3%, and 32.2% amino acid identities between their homologs in the CAV. Two species have been ... The unique, single protein, trumpet-shaped capsomeres of Gyrovirus are arranged into 12 pentomers yielding a capsid 60 units in ...
Cohen, PA; Mani, JC; Lane, DP (1998). "Characterization of a new intrabody directed against the N-terminal region of human p53 ... avian influenza, prion diseases, inflammation, Parkinson's disease, and Huntington's disease. Optimizations required for ... or expression as a fusion protein with maltose binding protein or other stable intracellular proteins. Such optimizations have ... Since the 1990s ER intrabodies have been used in various research areas to knock down membrane proteins and secreted proteins. ...
... each Maf family protein possesses an extended homology region (EHR), which contributes to stable DNA binding. The C-terminal ... HUGO Gene Nomenclature Committee (HGNC)-approved gene names of MAFF, MAFG and MAFK are "v-maf avian musculoaponeurotic ... and Bach proteins (Bach1 and Bach2). Because these proteins cannot bind DNA by themselves, sMaf proteins are indispensable ... phosphorylation through an ERK phosphorylation site in the C-terminal region. sMaf proteins form homodimers by themselves and ...
C-terminal-binding protein 2 also known as CtBP2 is a protein that in humans is encoded by the CTBP2 gene. The CtBPs - CtBP1 ... The multi use functionality of the CtBP2 locus appears to be conserved between avian and primate retinae with production of the ... "C-Terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins ... "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2". ...
These proteins are named Rep 78, Rep68, Rep 52, and Rep 40 based on their molecular weight. Due to inverted terminal repeats ( ... Adeno-associated dependoparvovirus A Adeno-associated dependoparvovirus B Anseriform dependoparvovirus 1 Avian ... The 3' open reading frame is the structural capsid protein, cap, which can be spliced to form two RNAs, one for virion protein ... Three proteins (VP1, VP2 and VP3) are present in each capsomere. Each capsid is made from 5 VP1, 5 VP2, and 50 VP3 proteins. ...
The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs in the N-terminal domain which are ... Similar trends have also been observed in rhinovirus (HRV), enterovirus 71 (EV-71), and avian reovirus (ARV) infections. In the ... hnRNP A1 inhibits the binding of Rex protein to its response element in 3' long terminal repeat (LTR) of all viral RNAs. ... The protein also has a glycine rich arginine-glycine-glycine (RGG) region called the RGG box which enables protein and RNA ...
Modeling of this protein reveals that it is likely made up of 3 α-helices with N- and C-terminal loops. It has a small stretch ... Apoptin: Apoptin, a protein produced from avian viruses, causes p53-deficient tumor-specific apoptosis manner. After attaching ... This protein binds to anti-apoptotic proteins resulting in these proteins' inhibition. As a p53 inducible gene, NOXA is ... NS1 is considered a regulatory protein due to its activity in transcription, translation, and protein-protein interactions, ...
Many of these stimuli activate the c-Jun N-terminal kinases (JNKs) leading to the phosphorylation of Jun proteins and enhanced ... The AP-1 subunit Jun was identified as a novel oncoprotein of avian sarcoma virus, and Fos-associated p39 protein was ... Masuda A, Yoshikai Y, Kume H, Matsuguchi T (November 2004). "The interaction between GATA proteins and activator protein-1 ... the c-jun protein contains three short regions, which consist of clusters of negatively charged amino acids in its N-terminal ...