... telomerase activity Human telomerase reverse transcriptase (TERT) gene on genecards.org The Telomerase Database - A Web-based ... Telomerase is a good biomarker for cancer detection because most human cancers cells express high levels of it. Telomerase ... Telomerase activation has been observed in ~90% of all human tumors, suggesting that the immortality conferred by telomerase ... Telomerase reverses telomere shortening. Telomerase restores short bits of DNA known as telomeres, which are otherwise ...

Telomerase RNA component, also known as TR, TER or TERC, is an ncRNA found in eukaryotes that is a component of telomerase, the ... "Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase ... Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mice suggest that telomerase ... Chang JT, Chen YL, Yang HT, Chen CY, Cheng AJ (July 2002). "Differential regulation of telomerase activity by six telomerase ...

... (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase, ... "Entrez Gene: TERT telomerase reverse transcriptase". Cong YS, Wen J, Bacchetti S (January 1999). "The human telomerase ... This method does not eliminate telomerase activity, but it does lower telomerase activity and levels of hTERT mRNA seen in the ... Lung cancer is the most well characterized type of cancer associated with telomerase. There is a lack of substantial telomerase ...

... fold named TEL patch that interacts with the catalytic subunit of telomerase, hTERT, has been proven essential for telomerase ... Wang F, Podell ER, Zaug AJ, Yang Y, Baciu P, Cech TR, Lei M (2007). "The POT1-TPP1 telomere complex is a telomerase ... Wang F, Podell ER, Zaug AJ, Yang Y, Baciu P, Cech TR, Lei M (2007). "The POT1-TPP1 telomere complex is a telomerase ... TPP1 has also been demonstrated as the only pathway required for recruitment of telomerase to chromosome ends, and it also ...

Retrotransposons also spread by copying DNA and RNA from one another, and telomerase contains an RNA that is used as template ... Podlevsky JD, Bley CJ, Omana RV, Qi X, Chen JJ (January 2008). "The telomerase database". Nucleic Acids Research. 36 (Database ...

This event can be counteracted by telomerase, an enzyme that extends the ends of the chromosomes by copying the telomeres and ... Chan SR, Blackburn EH (2004). "Telomeres and telomerase". Philos. Trans. R. Soc. Lond. B Biol. Sci. 359 (1441): 109-21. doi: ...

Telomerase and telomeres were first discovered in this species as well by Elizabeth Blackburn and Carol Greider. The first ... Chadwick, Derek J.; Cardew, Gail (2008-04-30). Telomeres and Telomerase. John Wiley & Sons. p. 20. ISBN 978-0-470-51544-0. ... ISBN 978-981-4635-01-1. Corey, David R. (2009-12-24). "Telomeres and Telomerase: From Discovery to Clinical Trials". Chemistry ...

Hela cells and human fibroblast-derived iPS cells showed high telomerase activity while Muse was at nearly the same level as ... Low telomerase activity. Selectively accumulate into damaged tissue by intravenous or local injections by sphingosine-1- ... This can be explained in part by their intrinsically low telomerase activity, eradicating the risk of tumorigenesis through ... Muse cells are characterized by low telomerase activity, not a strong indicator of tumorigenicity. ...

Telomerase gene therapy utilizing an adeno-associated virus at the Spanish National Cancer Research Centre (CNIO), has ... "Telomeres and Telomerase Group". Spanish National Cancer Research Centre. 19 May 2008. Archived from the original on 3 December ... This might make us suspect that positive results from telomerase gene therapies in mice, where life span is extended and health ... The research and development community will find out in the years ahead by trying telomerase gene therapies in primates and ...

"Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies". Genome Medicine. 8 (1): 69. doi: ... Such phenomena is brought about by the presence of telomerase, which would catalyse the reaction of adding nucleotide sequences ... It replenishes the telomeres that are lost during DNA replication, compensating for enough telomerase sequence so that the ... Studies have discovered the linkage between the abnormal replenishing of telomere, overactivity of telomerase, and cancer ...

"Nucleolin interacts with telomerase". The Journal of Biological Chemistry. 279 (49): 51508-15. doi:10.1074/jbc.M407643200. PMID ... and Telomerase reverse transcriptase. GRCh38: Ensembl release 89: ENSG00000115053 - Ensembl, May 2017 GRCm38: Ensembl release ...

Geron has granted a license to Telomerase Activation Sciences to sell TA-65, the telomerase activator agent also derived from ... Geron's progress with telomerase vaccines attracted a modest monetary investment in 2005 from Merck. GRN1005, an LRP-directed ... Geron originally investigated telomerase as a means of understanding and modifying human aging. However, Geron has ceased aging ... The company is in the early stages of developing a telomerase based treatment for HIV called TAT0002, which is the saponin ...

... s use telomerase, a protein that restores telomeres, to protect their DNA and extend their cell division limit (the ... Cong YS, Wright WE, Shay JW (September 2002). "Human telomerase and its regulation". Microbiology and Molecular Biology Reviews ...

Telomerase is expressed by most vertebrates during embryonic stages but is generally absent from adult stages of life. However ... Telomerase is especially present in green spotted lobsters - whose markings are thought to be produced by the enzyme ... This longevity may be due to telomerase, an enzyme that repairs long repetitive sections of DNA sequences at the ends of ... Cong YS, Wright WE, Shay JW (September 1, 2002). "Human Telomerase and Its Regulation". Microbiology and Molecular Biology ...

Studies have shown that 90 percent of cancer cells contain large amounts of an enzyme called telomerase. Telomerase is an ... This is because they contain raised amounts of telomerase. The idea that the human body can be repaired in old age to a more ... A cancer cell has in essence turned on the telomerase gene, and this allows them to have an unlimited amount of divisions ... Peter J. Hornsby (2007). "Telomerase and the aging process". Experimental Gerontology. 42 (7): 575-81. doi:10.1016/j.exger. ...

Bernardes De Jesus, B.; Schneeberger, K.; Vera, E.; Tejera, A.; Harley, C. B.; Blasco, M. A. (2011). "The Telomerase Activator ... Salvador, L.; Singaravelu, G.; Harley, C. B.; Flom, P.; Suram, A.; Raffaele, J. M. (2016). "A Natural Product Telomerase ... Located in Madrid, it provides telomere diagnostics as well as telomerase measurement. It was founded by American entrepreneur ... The Dutch famine birth cohort study Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes The Telomerase ...

Jiang, J; Wang, Y; Sušac, L; Chan, H; Basu, R; Zhou, ZH; Feigon, J (17 May 2018). "Structure of Telomerase with Telomeric DNA ... Zhang, Q; Kim, NK; Feigon, J (20 December 2011). "Architecture of human telomerase RNA". Proceedings of the National Academy of ... Theimer, CA; Blois, CA; Feigon, J (4 March 2005). "Structure of the human telomerase RNA pseudoknot reveals conserved tertiary ... Her research group has invested significant effort in determining the structure of telomerase, using NMR, X-ray crystallography ...

"What are telomeres and telomerase?". The University of Texas Southwestern Medical Center at Dallas. Archived from the original ... which may be prone to error Activation of telomerase Prevention of apoptosis Several genes are commonly mutated in mesothelioma ...

Telomerase is expressed by most vertebrates during embryonic stages but is generally absent from adult stages of life. However ... Homeostatic telomerase activity observed in both asexual and sexual animals is not sufficient to maintain telomere length, ... The term "immortalization" was first applied to cancer cells that expressed the telomere-lengthening enzyme telomerase, and ... Cong YS (2002). "Human Telomerase and Its Regulation". Microbiology and Molecular Biology Reviews. 66 (3): 407-425. doi:10.1128 ...

... by reactivating telomerase, the enzyme responsible for telomere length maintenance. However, telomerase is virtually ... Ahmed A, Tollefsbol T (August 2001). "Telomeres and telomerase: basic science implications for aging". Journal of the American ... Blackburn EH (September 2005). "Telomerase and Cancer: Kirk A. Landon--AACR prize for basic cancer research lecture". Molecular ... Guterres, Adam N.; Villanueva, Jessie (September 2020). "Targeting telomerase for cancer therapy". Oncogene. 39 (36): 5811-5824 ...

In their telomerase research, West and colleagues at Geron cloned the RNA component of telomerase and collaborated with Thomas ... Geron published evidence of the role of telomerase in cancer and cell immortalization in collaboration with Woodring Wright and ... cellular aging and telomerase. He is the founder and CEO of AgeX Therapeutics, a startup focused on the field of experimental ... "The RNA Component of Human Telomerase". Science. 269 (5228): 1236-1241. Bibcode:1995Sci...269.1236F. doi:10.1126/science. ...

... telomerase activity, and advanced clinical grade. Transl On- col. 2012; 5: 56-65. Armanios M. Telomerase and idiopathic ... thus promoting telomerase-mediated elongation. The true nature of TERRA's interaction with telomerase remains incompletely ... At the same time, telomerase activity is known to be at its greatest when telomeres are short and at its lowest activity when ... Ng L. J., Cropley J. E., Pickett H. A., Reddel R. R., Suter C. M. (2009). Telomerase activity is associated with an increase in ...

These include Telomerase, P53, and HINT1. Telomerase is a protein complex with telomerase reverse transcriptase (TERT), an RNA ... and both reptin and pontin have been shown to be key factors in telomerase assembly and activity. Telomerase is an important ... "Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly". Cell. 132 (6): 945-957 ...

"Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies". Genome Medicine. 8 (1): 69. doi: ... This occurs through telomerase activation or the activation of a telomere-recombination pathway (i.e., the ALT pathway). Thus, ... For example, the telomerase inhibitor imetelstat, first proposed in 2003, has been held up in clinical trials due to ... Although telomerase activation does not occur during the cell cycle of normal somatic human cells, the association between ...

Since normal telomerase activity in most human cells is low, targeting parasitic telomerase function might be a successful ... Telomerase "replenishes" the telomere "cap" and requires no ATP In most multicellular eukaryotic organisms, telomerase is ... The cloning of the catalytic component of telomerase enabled experiments to test whether the expression of telomerase at levels ... Telomeres and Telomerase: The Means to the End Nobel Lecture by Elizabeth Blackburn, which includes a reference to the impact ...

Lustig AJ (1999). "Crisis intervention: The role of telomerase". Proc Natl Acad Sci USA. 96 (7): 3339-41. Bibcode:1999PNAS... ...

Embryonic stem cells express telomerase, which allows them to divide repeatedly and form the individual. In adults, telomerase ... Telomerase is an enzyme which rebuilds the telomeres in stem cells and cancer cells, allowing them to replicate an infinite ... With the presence of telomerase, each dividing cell can replace the lost bit of DNA, and any single cell can then divide ... No definitive work has yet demonstrated that telomerase can be used in human somatic cells to prevent healthy tissues from ...

Telomerase activity is found in childhood ependymoma. In addition, telomerase reactivation and maintenance of telomeres appears ... Use of telomerase inhibitors such as Imetelstat seem to have very low toxicity compared to other chemotherapy. The only known ... Rushing, EJ; Yashima, K; Brown, DF; White Cl, 3rd; Shay, JW; Risser, RC; Gazdar, AF (1997). "Expression of telomerase RNA ... Low expression of nucleolin, an interacting protein of telomerase, was found to be the single most important biological ...

Telomerase is an unusual polymerase because it contains its own RNA template as part of its structure. It synthesizes telomeres ... The main function of these regions is to allow the cell to replicate chromosome ends using the enzyme telomerase, as the ... Nugent CI, Lundblad V (April 1998). "The telomerase reverse transcriptase: components and regulation". Genes & Development. 12 ... and telomerase, which is required for the replication of telomeres. For example, HIV reverse transcriptase is an enzyme for ...

Shay JW, Wright WE (2011). "Role of telomeres and telomerase in cancer". Semin Cancer Biol. 21 (6): 349-353. doi:10.1016/j. ...