Targeting of gastric cancer cells with Shiga toxin B-subunit". Molecular Cancer Therapeutics. 15 (5): 1008-1017. doi:10.1158/ ... Shiga toxin can be used for targeted therapy of certain gastrointestinal cancers that express the receptor of the Shiga toxin. ... 2009). "Shiga toxin receptor Gb3Cer/CD77: Tumor-association and promising therapeutic target in pancreas and colon cancers". ... Globotriaosylceramide is also one of the targets of Shiga toxin, which is responsible for pathogenicity of enterohemorrhagic ...

"Functional analysis of the Shiga toxin and Shiga-like toxin type II variant binding subunits by using site-directed mutagenesis ...

The Shiga-toxin inhibits the binding of eEF-1-dependent binding of aminoacyl tRNA to the 60S subunit of the ribosome, thus ... HUS can be divided into two main categories: Shiga-toxin-associated HUS (STx-HUS), which normally presents with diarrhea, and ... Generally, renal complications are particularly predominant with Shiga-toxin-associated hemolytic uremic syndrome (STx-HUS) and ... bacterial Shiga toxins or endotoxins, antibodies, and drugs; and congenital predisposing conditions, including decreased levels ...

Cholera toxin, pertussis toxin, and shiga toxin all have their targets in the cytosol of the cell. After their B subunit binds ... Cholera toxin, shiga toxin, and SubAB toxin all have B subunits that are made up of five identical protein components, meaning ... AB5 Toxins Biochemistry Cholera toxin Pertussis toxin Shiga toxin Subtilase Le Nours, J.; Paton, A. W.; Byres, E.; Troy, S.; ... The A subunit of an AB5 toxin is the portion responsible for catalysis of specific targets. For Shiga toxin family, the A ...

His team has validated the B-subunit of Shiga toxin (STxB) as a "pilot" for the delivery of therapeutic compounds to precise ... Shiga toxin induces tubular membrane invaginations for its uptake into cells. Nature 450: 670-675. Comments: Nat Rev Mol Cell ... Mechanism of Shiga toxin clustering on membranes. ACS Nano 11: 314-324 (& co-first authors, # authors from Johannes group, * ... Shiga toxin induces lipid compression: a mechanism for generating membrane curvature. Nano Lett 19: 7365-7369 Johannes L, ...

Food poisoning with Shiga toxin often also has effects on the lungs and the nervous system. The B subunits of the toxin bind to ... The term Shiga-like toxins is another antiquated term which arose prior to the understanding that Shiga and Shiga-like toxins ... 2017), "Chapter 3: Structure of Shiga toxins and other AB5 toxins", Shiga toxins: A Review of Structure, Mechanism, and ... Shiga toxin type 1 and type 2 (Stx-1 and 2) are the Shiga toxins produced by some E. coli strains. Stx-1 is identical to Stx of ...

This group excludes bacterial AB5 toxins such as Shiga toxin, as the carbohydrate-binding ability evolved separately and these ... They inactivate 60S ribosomal subunits by an N-glycosidic cleavage, which releases a specific adenine base from the sugar- ... Examples include: Abrin Beetin Ricin Saporin Shiga toxin A Spiroplasma toxin Trichosanthin Viscumin (European mistletoe) ... H7 and of Shiga toxin on eukaryotic ribosomes. RNA N-glycosidase activity of the toxins". European Journal of Biochemistry. 171 ...

... subunit according to the AB toxin model. This confusing nomenclature is due to the naming of the toxin's subunits before their ... "Production of Shiga toxin and a cytolethal distending toxin (CLDT) by serogroups of Shigella spp." in Microbiology Letters. The ... Cytolethal distending toxins are classified as AB toxins, with an active ("A") subunit that directly damages DNA and a binding ... In terms of function, it is an AB toxin. In this context, the CdtB subunit is actually the catalytically active "A" subunit, ...

The B subunits assist in adherence and entry of the toxin into host intestinal cells, while the A subunit is cleaved and ... Tests for toxin production can use mammalian cells in tissue culture, which are rapidly killed by shiga toxin. Although ... Shiga toxin-producing E. coli (STEC), specifically serotype O157:H7, have also been transmitted by flies, as well as direct ... ISBN 0-8138-0430-2, p. 270 Paton JC, Paton AW (1 July 1998). "Pathogenesis and diagnosis of Shiga toxin-producing Escherichia ...

Toxins of this type include cholera toxin, pertussis toxin, Shiga toxin and heat-labile enterotoxin from E. coli. Once in the ... Another group of intracellular toxins is the AB toxins. The 'B'-subunit (binding) attaches to target regions on cell membranes ... An example is Shiga toxin. Other toxins act at elongation factor-2. In the case of the diphtheria toxin, EF2 is ADP-ribosylated ... AB5 toxin) By domain architecture of the toxin (for example, polymorphic toxins) By the ability of the toxin to endure in ...

Some strains of E. coli, for example O157:H7, can produce Shiga toxin (classified as a bioterrorism agent). The Shiga toxin ... Oral inactivated vaccines consisting of toxin antigen and whole cells, i.e. the licensed recombinant cholera B subunit (rCTB)- ... the Shiga toxin-producing strain of E. coli. E. coli encompasses an enormous population of bacteria that exhibit a very high ... is where the spread of the gene encoding for the Shiga toxin from the Shigella bacteria to E. coli helped produce E. coli O157: ...

Alpha toxin Anthrax toxin Dinotoxin Cyanotoxin Diphtheria toxin Exotoxin Pertussis toxin Shiga toxin Shiga-like toxin K R ... and the RNA polymerase β subunit gene. PCR is effective when the gene of a known enzyme for producing the microbial toxin or ... Shiga toxins (Stxs), responsible for foodborne illnesses, are a classification of toxins produced by Shiga toxin-producing ... Toxin A and toxin B are two toxins produced by Clostridium difficile. Toxin A and toxin B are glycosyltransferases that cause ...

"Hemolytic uremic syndrome-associated Shiga toxins promote endothelial-cell secretion and impair ADAMTS13 cleavage of unusually ... C-jun has been shown to be essential for fibroblast proliferation, and levels of both AP-1 subunits have been shown to be ... AP-1 functions are heavily dependent on the specific Fos and Jun subunits contributing to AP-1 dimers. The outcome of AP-1 ... c-Jun, which is one of the AP-1 subunits, regulates the growth of breast cancer cells. Activated c-Jun is predominantly ...

... shiga toxins MeSH D23.946.123.794.100 - shiga-like toxin i MeSH D23.946.123.794.124 - shiga-like toxin ii MeSH D23.946.123.794. ... beta subunit, human MeSH D23.101.840.375 - hormones, ectopic MeSH D23.101.840.400 - ki-67 antigen MeSH D23.101.840.500 - ... shiga toxins MeSH D23.946.330.575.120 - shiga-like toxin i MeSH D23.946.330.575.124 - shiga-like toxin ii MeSH D23.946.330.575. ... 500 - shiga toxin MeSH D23.946.123.868 - streptolysins MeSH D23.946.123.893 - tetanus toxin MeSH D23.946.123.946 - virulence ...

In addition to chemical agents, the properties of many different toxins were also investigated by the Unit. To name a few, ... sub-Units and their branches. The Unit 731 complex covered six square kilometers (2.3 sq mi) and consisted of more than 150 ... a professor at Shiga University of Medical Science. Nishiyama reportedly intended to publish the list online to encourage ... in response to a request by Professor Katsuo Nishiyama of the Shiga University of Medical Science. After World War II, the ...