Ethyl groupTherapeutic Targets Database: Therapeutic Target Database (TTD) is a database provided by Bioinformatics and Drug Design Group in National University of Singapore, which provides information about the known and explored therapeutic protein and nucleic acid targets, the targeted disease, pathway information and the corresponding drugs directed at each of these targets. Also included in this database are links to relevant databases containing information about target function, sequence, 3D structure, ligand binding properties, enzyme nomenclature and drug structure, therapeutic class, clinical development status.Sharpless asymmetric dihydroxylation: Sharpless asymmetric dihydroxylation (also called the Sharpless bishydroxylation) is the chemical reaction of an alkene with osmium tetroxide in the presence of a chiral quinine ligand to form a vicinal diol.Reaction coordinateSpin–lattice relaxation in the rotating frame: Spin–lattice relaxation in the rotating frame is the mechanism by which Mxy, the transverse component of the magnetization vector, exponentially decays towards its equilibrium value of zero, under the influence of a radio frequency (RF) field in nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI). It is characterized by the spin–lattice relaxation time constant in the rotating frame, T1ρ.DNA-encoded chemical library: DNA-encoded chemical libraries (DEL) is a technology for the synthesis and screening of collections of small molecule compounds of unprecedented size. DEL is used in medicinal chemistry to bridge the fields of combinatorial chemistry and molecular biology.Ligand (biochemistry): In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. In protein-ligand binding, the ligand is usually a signal-triggering molecule binding to a site on a target protein.Noncovalent solid-phase organic synthesis: Noncovalent solid-phase organic synthesis or NC-SPOS is a form of Solid-phase synthesis whereby the organic substrate is bonded to the solid phase not by a covalent bond but by other chemical interactions. This bond may consist of an induced dipole interaction between a hydrophobic matrix and a hydrophobic anchor.SalicylanilideDNA binding site: DNA binding sites are a type of binding site found in DNA where other molecules may bind. DNA binding sites are distinct from other binding sites in that (1) they are part of a DNA sequence (e.KavainConvergent synthesis: In chemistry a convergent synthesis is a strategy that aims to improve the efficiency of multistep synthesis, most often in organic synthesis. In this type of synthesis several individual pieces of a complex molecule are synthesised in stage one and then in stage two these pieces are combined to form the final product Organic Synthesis, 3th Ed.MethanofuranHexene: Hexene is an alkene with a molecular formula C6H12. The prefix "hex" is derived from the fact that there are 6 carbon atoms in the molecule, while the "-ene" suffix denotes that there is an alkene present—two carbon atoms are connected via a double bond.Phase problem: In physics the phase problem is the name given to the problem of loss of information concerning the phase that can occur when making a physical measurement. The name itself comes from the field of x-ray crystallography, where the phase problem has to be solved for the determination of a structure from diffraction data.Antileukemic drug: Antileukemic drugs, anticancer drugs that are used to treat one or more types of leukemia, include:Benzopyrone: Benzopyrone may refer to either of two ketone derivatives of benzopyran which constitute the core skeleton of many flavonoid compounds:Discovery and development of cephalosporins: Cephalosporins are a broad class of bactericidal antibiotics that include the β-lactam ring and share a structural similarity and mechanism of action with other β-lactam antibiotics (e.g.Proximity ligation assay: Proximity ligation assay (in situ PLA) is a technology that extends the capabilities of traditional immunoassays to include direct detection of proteins, protein interactions and modifications with high specificity and sensitivity. Protein targets can be readily detected and localized with single molecule resolution and objectively quantified in unmodified cells and tissues.Concentration effect: In the study of inhaled anesthetics, the concentration effect is the increase in the rate that the Fa(alveolar concentration)/Fi(inspired concentration) ratio rises as the alveolar concentration of that gas is increased. In simple terms, the higher the concentration of gas administered, the faster the alveolar concentration of that gas approaches the inspired concentration.Fast atom bombardment: Fast atom bombardment (FAB) is an ionization technique used in mass spectrometry in which a beam of high energy atoms strikes a surface to create ions. It was developed by Michael Barber at the University of Manchester.BacitracinFood physical chemistry: Food physical chemistry is considered to be a branch of Food chemistryJohn M. de Man.IsobutyramideLactone: Lactones are cyclic esters of hydroxycarboxylic acids, containing a 1-oxacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.Fragment-based lead discovery: Fragment-based lead discovery (FBLD) also known as fragment-based drug discovery (FBDD) is a method used for finding lead compounds as part of the drug discovery process. It is based on identifying small chemical fragments, which may bind only weakly to the biological target, and then growing them or combining them to produce a lead with a higher affinity.Protein primary structure: The primary structure of a peptide or protein is the linear sequence of its amino acid structural units, and partly comprises its overall biomolecular structure. By convention, the primary structure of a protein is reported starting from the amino-terminal (N) end to the carboxyl-terminal (C) end.ThiazolineMesoionic: Mesoionic compounds are dipolar five membered heterocyclic compounds in which both the negative and the positive charges are delocalized. A completely uncharged structure cannot be written and mesoionic compounds cannot be represented satisfactorily by any one mesomeric structure.PyranWIN 56,098: WIN 56,098 is a chemical that is considered to be an aminoalkylindole derivative. It is a tricyclic aryl derivative that acts as a competitive antagonist at the CB2 cannabinoid receptor.ForskolinColes PhillipsOrganic base: An organic base is an organic compound which acts as a base. Organic bases are usually, but not always, proton acceptors.Burst kinetics: Burst kinetics is a form of enzyme kinetics that refers to an initial high velocity of enzymatic turnover when adding enzyme to substrate. This initial period of high velocity product formation is referred to as the "Burst Phase".Acetone thiosemicarbazoneTransition metal benzyne complex: Transition metal benzyne complexes are organometallic complexes that contain benzyne ligands (C6H4). Unlike benzyne itself, these complexes are less reactive although they undergo a number of insertion reactions.Combes quinoline synthesis: The Combes quinoline synthesis is a chemical reaction, which was first reported by Combes in 1888. It involves the condensation of unsubstituted anilines (1) with β-diketones (2) to form substituted quinolines (4) after an acid-catalyzed ring closure of an intermediate Schiff base (3).C4H7N3O3Database of protein conformational diversity: The Database of protein conformational diversity (PCDB) is a database of diversity of protein tertiary structures within protein domains as determined by X-ray crystallography. Proteins are inherently flexible and this database collects information on this subject for use in molecular research.AcacetinMedian toxic dose: ==Introduction==CyclazocineBenzo(c)thiopheneSEA Native Peptide LigationTriterpenoid saponin: Triterpenoid saponins are triterpenes which belong to the group of saponin compounds. Triterpenes are a type of terpene containing 30 carbon atoms.ATC code S01: ==S01A Anti-infectives==ImideSoyasapogenol B glucuronide galactosyltransferase: Soyasapogenol B glucuronide galactosyltransferase (, UDP-galactose:SBMG-galactosyltransferase, UGT73P2, GmSGT2 (gene), UDP-galactose:soyasapogenol B 3-O-glucuronide beta-D-galactosyltransferase) is an enzyme with system name UDP-alpha-D-galactose:soyasapogenol B 3-O-glucuronide beta-D-galactosyltransferase. This enzyme catalyses the following chemical reactionTwo-dimensional infrared spectroscopyHigh throughput biologyRainer Ludwig ClaisenFlavonols: Flavonols are a class of flavonoids that have the 3-hydroxyflavone backbone (IUPAC name : 3-hydroxy-2-phenylchromen-4-one). Their diversity stems from the different positions the phenolic -OH groups.PyrazoleExogenous bacteria: Exogenous bacteria are microorganisms introduced to closed biological systems from the external world. They exist in aquatic and terrestrial environments, as well as the atmosphere.FamprofazoneAnaerobacter: Anaerobacter are a genus of Gram-positive bacteria related to Clostridium. They are anaerobic chemotrophs and are unusual spore-formers as they produce more than one spore per bacterial cell (up to five spores).Hopanoids: Hopanoids are natural pentacyclic compounds (containing five rings) based on the chemical structure of hopane. The first known triterpenoid of the class, hydroxyhopanone, was isolated by two chemists at The National Gallery, London working on the chemistry of dammar gum, a natural resin used as a varnish for paintings.Taccalonolide: Taccalonolides are a class of microtubule-stabilizing agents isolated from Tacca chantrieri that has been shown to have selective cancer-fighting properties. Other examples of microtubule-stabilizing agents include taxanes and epothilones, both of which prevent cancer cells from dividing by interfering with tubulin.Baby hamster kidney cell: Baby Hamster Kidney fibroblasts (aka BHK cells) are an adherent cell line used in molecular biology.TerpyridineMultidrug-resistant gram-negative bacteria: MDRGN bacteria is an abbreviation for multidrug resistant gram-negative bacteria. For hospitalized patients, and especially patients in intensive care units, these bacterial infections pose a serious and (as of 2010) rapidly emerging threat.AdamantaneM-Cumenyl methylcarbamateStanley SpiroRGD motifDibenzoylmethaneThroat irritation: Throat irritation can refer to a dry cough, a scratchy feeling at the back of the throat, or a sensation of a lumpy feeling or something stuck at the back of the throat.Journal of Medical Toxicology: The Journal of Medical Toxicology is a peer-reviewed medical journal on medical toxicology and the official journal of the American College of Medical Toxicology. It publishes original articles, illustrative cases, review articles, and other special features that are related to the clinical diagnosis and management of patients with exposure to various poisons.Fischer oxazole synthesis: The Fischer oxazole synthesis is a chemical synthesis of an oxazole from a cyanohydrin and an aldehyde in the presence of anhydrous hydrochloric acid.Wiley, R.
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