"Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways". The ... Husain M, D'Agati VD, He JC, Klotman ME, Klotman PE (Nov 2005). "HIV-1 Nef induces dedifferentiation of podocytes in vivo: a ... an actin-associated protein in telencephalic dendrites and renal podocytes". The Journal of Cell Biology. 139 (1): 193-204. doi ... synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes ...
"The chloride intracellular channel 5A stimulates podocyte Rac1, protecting against hypertension-induced glomerular injury". ... In these mice, podocyte foot processes were also more sparse and disperse than in wild-type mice. Chloride channel GRCh38: ... CLIC5A is expressed chiefly in the renal glomerulus, specifically in podocytes. Within the cell, CLIC5A is localized to the ... which could represent a mechanism by which podocyte foot processes form to enable renal filtration. Two human families with ...
ER stress also stimulates transmembrane protein IRE1α activity. Upon activation, IRE1α splices the XBP-1 mRNA introns to ... and is a suppressor of podocyte MCP-1". American Journal of Physiology. Renal Physiology. 299 (5): F965-72. doi:10.1152/ ... March 2002). "Activation of peroxisome proliferator-activated receptor-gamma stimulates the growth arrest and DNA-damage ... November 2010). "TRB3 is stimulated in diabetic kidneys, regulated by the ER stress marker CHOP, ...
Studies have shown that in the setting of diabetes, various factors stimulate the RAAS, which is one of the most important ... a widening of the slit membranes of the podocytes, an increase in the number of mesangial cells, and an increase in mesangial ... Bindings of AGEs to RAGE receptors enhances production of cytosolic Reactive Oxygen Species (ROS) as well as stimulates ... lead to podocyte injury, oxidative stress, inflammation and fibrosis. As injury worsens, kidney function decreases and ...
SPMs also stimulate anti-inflammatory and tissue reparative types of responses in epithelium cells, endothelium cells, ... fibroblasts, smooth muscle cells, osteoclasts, osteoblasts, goblet cells, and kidney podocytes as well as activate the heme ... This negates KEAP1's ability to bind NFE2L2; in consequence, NFE2L2 becomes free to translocate to the nuclease and stimulate ... Macrophages: inhibit their infiltration into inflamed tissues and release of pro-inflammatory cytokines; stimulate their ...
... hypertrophy of the podocytes, vacuolized podocytes, thickened basement membranes, and diminished patency of the capillary lumen ... "A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase ... "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase ...
In the kidney, CYR61 is expressed in podocytes in normal adult and embryonic glomeruli, but expression is decreased in IgA ... CYR61 is able to support cell adhesion, stimulate cell migration, promote growth factor-induced cell proliferation and ... CYR61 also accelerates and promotes the chondrogenic differentiation of mouse limb bud mesenchymal cells, and stimulates ... "Simvastatin inhibits cytokine-stimulated Cyr61 expression in osteoblastic cells: a therapeutic benefit for arthritis". ...
For instance, researchers have built an array of PDMS microchambers, aligned with sensors and stimulating electrodes as a tool ... basement membrane and the epithelial podocytes. The fluid that is filtered from the capillary blood into Bowman's space is ... Cheng W, Klauke N, Sedgwick H, Smith GL, Cooper JM (November 2006). "Metabolic monitoring of the electrically stimulated single ... For instance, cardiac hypertrophy and fibrosis are studied via the respective biomarker level of the mechanically stimulated ...
Hell SW, Wichmann J (June 1994). "Breaking the diffraction resolution limit by stimulated emission: stimulated-emission- ... Pullman JM, Nylk J, Campbell EC, Gunn-Moore FJ, Prystowsky MB, Dholakia K (February 2016). "Visualization of podocyte ... A readout laser stimulates fluorescence and bleaches or photoswitches the fluorophores back to a dark state, typically within ... Stimulated emission depletion microscopy (STED) uses two laser pulses, the excitation pulse for excitation of the fluorophores ...
It stimulates erythropoiesis (production of red blood cells) in the bone marrow. Calcitriol, the activated form of vitamin D, ... Distinct cell types include: Kidney glomerulus parietal cell Kidney glomerulus podocyte Kidney proximal tubule brush border ... The intercalated A cells are stimulated when the body is experiencing acidic conditions. Under acidic conditions, the high ...
Suppression of granulocyte-colony-stimulating factor (G-CSF) by RNAi abolished the beneficial effects of Muse cells, leading to ... preferentially integrate into the damaged glomeruli and spontaneously differentiate into cells expressing markers of podocytes ...
Further studies suggested that the activation of HCA2 on microglial cells stimulated their change from a pro-inflammatory to ... kidney podocytes; and 9) cells in the nervous system, e.g., microglia cells in the brain's cerebral cortex and hippocampus, ... Plaisance EP, Lukasova M, Offermanns S, Zhang Y, Cao G, Judd RL (March 2009). "Niacin stimulates adiponectin secretion through ... Excessive activation of these neurons caused by inflammation stimulates the production of pro-inflammatory cytokines (e.g., ...
Active ROCK in these cells seems to stimulate the disruption of E-Cadherin-mediated cell-cell contacts by activating actomyosin ... "Rho-ROCK signal pathway regulates microtubule-based process formation of cultured podocytes--inhibition of ROCK promoted ... 2. Other functions and targets RhoA-GTP stimulates the phospholipid phosphatase activity of PTEN (phosphatase and tensin ... in turn stimulate a myosin light chain kinase, forcing a contraction. Rho-associated protein kinase are serine or threonine ...
Fibrin stimulates the proliferation of endothelial cells of Bowman capsule, and an influx of monocytes. Rapid growing and ... Inflammation that affects the cells surrounding the glomerulus, podocytes, increases the permeability to proteins, resulting in ... changes on electron microscopy within the glomeruli may show a fusion of the foot processes of the podocytes (cells lining the ...
... is highly expressed in the adult podocyte, with transcripts showing an approximate tenfold enrichment compared to total ... "DACH1 stimulates shear stress-guided endothelial cell migration and coronary artery growth through the CXCL12-CXCR4 signaling ... It is also more widely expressed in the earlier developing kidney, but again including definite podocyte expression. Hepatocyte ...
On the contrary, podocytes do not proliferate under normal conditions. If minor damage to the nephron tubules occurs, the lost ... as a result of which the secretion of vasopressin by the posterior pituitary gland is stimulated, and thirst also arises. The ... Renal corpuscles are composed of 4 cell types: fenestrated endothelium, mesangial cells, podocytes and parietal epithelial ...
This induces widening of inter-podocyte radii and lowers the number of podocytes which increases the amount of albumin that is ... Erythropoietin stimulating agents (ESAs): During normal kidney function in those with SCD, in response to anemia and hypoxia, ...
This circulating factor damages the podocyte which changes its structure. The podocytes are now less able to restrict urinary ... Hyperlipidaemia is caused by two factors: Hypoproteinemia stimulates protein synthesis in the liver, resulting in the ... There is also evidence that the circulating factor could be signalling via the PAR-1 receptro on the podocytes. The kidney ... "Podocyte protease activated receptor 1 stimulation in mice produces focal segmental glomerulosclerosis mirroring human disease ...
CARP has also been identified as a transcriptional co-activator of tumor suppressor protein p53 for stimulating gene expression ... "Upregulated expression of cardiac ankyrin-repeated protein in renal podocytes is associated with proteinuria severity in lupus ... "Upregulated expression of cardiac ankyrin-repeated protein in renal podocytes is associated with proteinuria severity in lupus ...
It was shown to stimulate EMT in some systems by promoting/maintaining stemness of cancer cells, as is the case in pancreatic ... "Renin-angiotensin blockade resets podocyte epigenome through Kruppel-like Factor 4 and attenuates proteinuria". Kidney ... Klf4 was required for accumulation of β-catenin at the Tert promoter but was unable to stimulate Tert expression in the absence ...