Stem-cell niche
... called the cancer stem cell niche. The CSC niche is very similar to normal stem cells niche (embryonic stem cell (ESC), Adult ... The GSC niche consists of necessary somatic cells-terminal filament cells, cap cells, escort cells, and other stem cells which ... Several factors are important to regulate stem-cell characteristics within the niche: cell-cell interactions between stem cells ... These ECM factors are equally important when stem cells are grown in vitro. Given a choice between niche cell-stem cell ...
Hematopoietic stem cell niche
2010). "The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche". Cell Stem Cell ... Cell Stem Cell. 7 (3): 391-402. doi:10.1016/j.stem.2010.06.020. PMID 20804974. Adams GB; et al. (2006). "Stem cell engraftment ... immune cells, and even platelets all originate from the same progenitor cell, the hematopoietic stem cell (HSC). As these cells ... 2003). "Osteoblastic cells regulate the haematopoietic stem cell niche". Nature. 425 (6960): 841-846. Bibcode:2003Natur.425.. ...
Injury-induced stem-cell niche
... where transplanted neural stem cells persisted undifferentiated in perivascular areas, also called atypical stem cell niches, ... An injury-induced stem-cell niche is a cellular microenvironments generated during tissue injury. These environments are ... Wikipedia articles that are too technical from January 2014, All articles that are too technical, Stem cells, Induced stem ... "Remodelling the injured CNS through the establishment of atypical ectopic perivascular neural stem cell niches". Archives ...
Daniela Drummond-Barbosa
"Stem cells find their niche". Nature. 414 (6859): 98-104. doi:10.1038/35102160. ISSN 1476-4687. PMID 11689954. S2CID 2904709. ... Her research considers stem cell regulation. Drummond-Barbosa grew up in Belo Horizonte in Brazil. She earned her undergraduate ... She has focused on the ovarian stem cells of Drosophila and how they respond to diet, concentrating on hormones, insulin and ... She focused on how germline stem cells are regulated by diet and the control of meiotic maturation in Drosophila. In 2009 ...
Rostral migratory stream
Conover, Joanne; Notti, Ryan (2007). "The neural stem cell niche". Cell and Tissue Research. 331 (1): 211-224. doi:10.1007/ ... "neurogenic niche", a zone in which stem cells are retained after embryonic development for the production of new cells of the ... In the RMS, vascular cells are arranged parallel to the route of the migrating cells and provide a scaffolding. Glial cells are ... "Aging of the subventricular zone neural stem cell niche: evidence for quiescence-associated changes between early and mid- ...
Allan C. Spradling
Spradling, A.; Drummond-Barbosa, D.; Kai, T. (2001). "Stem cells find their niche". Nature. 414 (6859): 98-104. Bibcode: ... egg development and stem cells. He was elected to the American Philosophical Society in 2016. Orr-Weaver, T. (2003). "The 2003 ... Spradling obtained an A.B. in physics from the University of Chicago and a Ph.D. in cell biology from the Massachusetts ...
Spermatogonial stem cell
"Testicular niche required for human spermatogonial stem cell expansion". Stem Cells Translational Medicine. 3 (9): 1043-1054. ... The stem cells are capable of dividing into more SSCs which is vital for maintaining the stem cell pool. Alternatively, they go ... Various other somatic cells in the interstitial tissue support Sertoli cells such as Leydig cells and peritubular myoid cells ... Cell Stem Cell. 11 (5): 715-726. doi:10.1016/j.stem.2012.07.017. ISSN 1934-5909. PMC 3580057. PMID 23122294. Roe, Mandi; ...
Neural stem cell
... or stem cell niche. Some neural cells are migrated from the SVZ along the rostral migratory stream which contains a marrow-like ... In symmetric cell division, both daughter cells are also stem cells. In asymmetric division, a stem cell produces one stem cell ... "FoxO3 regulates neural stem cell homeostasis". Cell Stem Cell. 5 (5): 527-539. doi:10.1016/j.stem.2009.09.014. PMC 2775802. ... have been reported to contain neural stem cells. There are two basic types of stem cell: adult stem cells, which are limited in ...
Angiopoietin
"Quiescent stem cells in the niche". Stembook. Cambridge, MA: Harvard Stem Cell Institute. doi:10.3824/stembook.1.6.1. PMID ... Tie-2/Ang-1 signaling activates β1-integrin and N-cadherin in LSK-Tie2+ cells and promotes hematopoietic stem cell (HSC) ... Endothelial cells secrete angiopoietin-2 for autocrine signaling while parenchymal cells of the extravascular tissue secrete ... Ang-2 works with VEGF to facilitate cell proliferation and migration of endothelial cells. Changes in expression of Ang-1, Ang- ...
Renal stem cell
"The renal papilla is a niche for adult kidney stem cells". Journal of Clinical Investigation. 114 (6): 795-804. doi:10.1172/ ... Renal stem cells are self-renewing, multipotent stem cells which are able to give rise to all the cell types of the kidney. It ... "Intrinsic Epithelial Cells Repair the Kidney after Injury". Cell Stem Cell. 2 (3): 284-91. doi:10.1016/j.stem.2008.01.014. PMID ... Thus, Lgr5+ cells can potentially be a marker for renal stem and/or progenitor cells. There is much debate regarding the cells ...
Plant stem cell
... cambium also serves as a niche for plant stem cells: "Procambium cells fulfill the criteria for being stem cells since they ... Plant stem cells are innately undifferentiated cells located in the meristems of plants. Plant stem cells serve as the origin ... dedifferentiated cells were generally regarded as stem cells of plant: "…we propose to extend the concept of stem cells to ... cell biology) Stem cell Weigel D, Jürgens G (February 2002). "Stem cells that make stems". Nature. 415 (6873): 751-4. Bibcode: ...
Canals of Hering
... so-called oval cells. Liver stem cells are theorized to originate in the niches of the canals. They are named for Ewald Hering ... Kordes, Claus; Häussinger, Dieter (2013-05-01). "Hepatic stem cell niches". Journal of Clinical Investigation. American Society ... Liver stem cells are hypothesized to inhabit the canals. They are found between the bile canaliculi and interlobular bile ducts ... Oliva, Joan; French, Barbara A.; Qing, X.; French, Samuel W. (2010). "The identification of stem cells in human liver diseases ...
Striated muscle tissue
Yin, Hang; Price, Feodor; Rudnicki, Michael A. (January 1, 2013). "Satellite Cells and the Muscle Stem Cell Niche". ... The satellite cells re-enter the cell cycle to multiply. They then leave the cell cycle to self-renew or differentiate as ... Both smooth muscle cells and cardiac muscle cells have a single nucleus, and skeletal muscle cells have many nuclei. The main ... These cells respond to signals from the autonomic nervous system to either increase or decrease the heart rate. Pacemaker cells ...
Granulopoiesis
... begins from a haematopoietic stem cells. These are multipotent cells that reside in the bone marrow niche and have the ability ... Cell Stem Cell. 10 (2): 120-36. doi:10.1016/j.stem.2012.01.006. PMID 22305562. Wahed A, Dasgupta A (2015-01-01). "Chapter 2 - ... Morrison SJ, Scadden DT (January 2014). "The bone marrow niche for haematopoietic stem cells". Nature. 505 (7483): 327-34. ... Ng, Ashley P.; Alexander, Warren S. (2017-02-06). "Haematopoietic stem cells: past, present and future". Cell Death Discovery. ...
Siddhartha Mukherjee
He has been investigating the microenvironment ("niche") of stem cells, particularly on blood-forming (haematopoietic) stem ... Kassem, Moustapha; Bianco, Paolo (2015). "Skeletal Stem Cells in Space and Time". Cell. 160 (1-2): 17-19. doi:10.1016/j.cell. ... Morrison, Sean J.; Scadden, David T. (2014). "The bone marrow niche for haematopoietic stem cells". Nature. 505 (7483): 327-334 ... doi:10.1016/j.cell.2014.11.042. PMC 4436082. PMID 25594183. McGonagle, Dennis; Jones, Elena A. (2015). "A new in vivo stem cell ...
Henry Kronenberg
Osteoblastic cells regulate the haematopoietic stem cell niche. Calvi LM, Adams GB, Weibrecht KW, Weber JM, Olson DP, Knight MC ... and studies that identified a role for parathyroid hormone in the regulation of the bone marrow stem cell niche. He has served ...
Amy Wagers
Mayack, S. R.; Wagers, A. J. (2 May 2008). "Osteolineage niche cells initiate hematopoietic stem cell mobilization". Blood. 112 ... She has also identified novel regulators (such as EGR1) of stem cell trafficking and stem cell number in bone marrow and during ... Wagers researches intrinsic and extrinsic regulators of stem cell function and how stem cells impact tissue regeneration and ... and principal faculty of the Harvard Stem Cell Institute. She is co-chair of the Department of Stem Cells and Regenerative ...
Perivascular space
Morrison, S. J; Scadden, D. T (2014). "The bone marrow niche for haematopoietic stem cells". Nature. 505 (7483): 327-334. ... Often, cell debris and foreign particles, which are impermeable to the BBB will get through the endothelial cells, only to be ... The production of cAMP aids in the modulation of auto-reactive T cells by regulatory T cells. . The perivascular space is ... This holds true for many T and B cells, as well as monocytes, giving this small fluid filled space an important immunological ...
Multiphoton lithography
Vazin, Tandis; Schaffer, David V. (March 2010). "Engineering strategies to emulate the stem cell niche". Trends in ... "Three-dimensional structural niches engineered via two-photon laser polymerization promote stem cell homing". Acta ... Their final application range from stemness maintenance in adult mesenchymal stem cells, such as into the NICHOID scaffold ... Considering filters, they can be used to separate the plasma from the red blood cells, to separate cell populations (in ...
Myosatellite cell
These cells represent the oldest known adult stem cell niche, and are involved in the normal growth of muscle, as well as ... Myosatellite cells, also known as satellite cells, muscle stem cells or MuSCs, are small multipotent cells with very little ... Yin, Hang; Price, Feodor; Rudnicki, Michael A. (January 2013). "Satellite Cells and the Muscle Stem Cell Niche". Physiological ... However, other cells in the body such as pericytes and hematopoietic stem cells have all been shown to be able to contribute to ...
Timeline of aging research
"Dedifferentiation maintains melanocyte stem cells in a dynamic niche". Nature. 616 (7958): 774-782. Bibcode:2023Natur.616..774S ... "Old human cells rejuvenated with stem cell technology". News Center (in Samoan). Retrieved 26 July 2021. Ocampo A, Reddy P, ... A study shows the clonal diversity of stem cells that produce blood cells gets drastically reduced around age 70 to a faster- ... Irving M (25 March 2020). "Stem cell technique winds back aging in human cells". New Atlas. Retrieved 26 July 2021. Wade N (24 ...
Alison Woollard
Appleford, P. J.; Woollard, A. (2009). "RUNX genes find a niche in stem cell biology". Journal of Cellular Biochemistry. 108 (1 ... subscription required) Woollard, Alison (1995). Cell cycle control in fission yeast (DPhil thesis). University of Oxford. " ... Cell. 78 (5): 813-822. doi:10.1016/S0092-8674(94)90542-8. PMID 8087848. S2CID 7449103. Chang, F.; Woollard, A.; Nurse, P. (1996 ... Journal of Cell Science. 109 (1): 131-142. doi:10.1242/jcs.109.1.131. PMID 8834798. ...
Elaine Fuchs
Fuchs E., Tumber T., Guasch G. (2004). Socializing with the neighbors: stem cells and their niche. The Cell. Vol. 116, 769-778 ... Slow-Cycling Cells in the Stem Cell Race". Cell. 137 (5): 811-819. doi:10.1016/j.cell.2009.05.002. PMC 2716122. PMID 19490891. ... 2015). From Skin Cells to Stem Cells, Pioneer Researcher Elaine Fuchs Wins Cell Biologists' Highest Honor. ASCB. Retrieved ... cite book}}: ,journal= ignored (help) Fuchs, Elaine (May 8, 2018). "Skin Stem Cells in Silence, Action, and Cancer". Stem Cell ...
Cell therapy
Wilson A, Trumpp A (February 2006). "Bone-marrow haematopoietic-stem-cell niches". Nature Reviews. Immunology. 6 (2): 93-106. ... Stem cell Stem cell therapy Allotransplantation Autotransplantation Xenotransplantation Regenerative medicine Mesenchymal stem ... cell Hematopoietic stem cell transplantation Stem cell therapy for macular degeneration "Cell Therapy". American Cancer Society ... "The impact of market volatility on the cell therapy industry". Cell Stem Cell. 9 (5): 397-401. doi:10.1016/j.stem.2011.10.010. ...
INPP5D
"SHIP is required for a functional hematopoietic stem cell niche". Blood. 113 (13): 2924-33. doi:10.1182/blood-2008-02-138008. ... "Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells". ... SHIP1 is expressed predominantly by hematopoietic cells but also, for example, by osteoblasts and endothelial cells. This ... for example T cell receptor (TCR) and CD79a/b. SHIP1 does not bind only to intracellular chains of cell surface receptor. Its ...
High-grade serous carcinoma
"Ovary and fimbrial stem cells: biology, niche and cancer origins". Nature Reviews Molecular Cell Biology. 16 (10): 625-638. doi ... "Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche". Nature. 495 (7440): 241-245. Bibcode: ... However, as HGSC tends to have the same clinical behaviour, regardless of its primary cell origin, determining cell origin is ... A 2007 paper describes the process of determining cell of origin as "Tumour origin is typically assigned to the organ ...
Melanocortin 2 receptor accessory protein
Walczak EM, Hammer GD (January 2015). "Regulation of the adrenocortical stem cell niche: implications for disease". Nature ... and also on the cell membrane, which indicates that MC2 needs MRAP to reach the cell membrane. In addition to cell trafficking ... MRAP mutations were found to disable the movement of MC2 to the cell surface of adrenal gland cells; this would make MC2 ... where there is a small population of adrenal stem cells The use of MRAP knockout transgenic mice revealed under-developed ...
Breast cancer stem cell
Li, L; Neaves, WB (2006). "Normal stem cells and cancer stem cells: the niche matters". Cancer Research. 66 (9): 4553-4557. doi ... Balicki, D (2007). "Moving forward in human mammary stem cell biology and breast cancer progression using ALDH". Cell Stem Cell ... Breast cancer stem cells establish their cell identity by expressing unique pattern of proteins and surface markers as ... while there are also studies which concluded that these cells come from the misplacement of somatic stem cells de novo. The ...
Crocodile
Specialized stem cell niche enables repetitive renewal of alligator teeth Archived 4 November 2013 at the Wayback Machine ... "Specialized stem cell niche enables repetitive renewal of alligator teeth". PNAS. 110 (22): E2009-E2018. Bibcode:2013PNAS.. ... Next to each full-grown tooth, there is a small replacement tooth and an odontogenic stem cell in the dental lamina in standby ... Hansen, A (2007). "Olfactory and solitary chemosensory cells: two different chemosensory systems in the nasal cavity of the ...
Crocodilia
"Specialized stem cell niche enables repetitive renewal of alligator teeth". Proceedings of the National Academy of Sciences of ... Next to each full-grown tooth there is a small replacement tooth and an odontogenic stem cell in the dental lamina in standby, ... crocodiles raised in crocodile farms is also used in research to 3D-print new cartilage for humans by mixing human stem cells ... Under its current definition as a crown group (as opposed to a stem-based group), Crocodylia is now restricted to only the last ...