Palvimo JJ (December 2007). "PIAS proteins as regulators of small ubiquitin-related modifier (SUMO) modifications and ... PIAS protein entry at the Protein Information Resource (PIR) PIAS+Proteins at the U.S. National Library of Medicine Medical ... Protein inhibitor of activated STAT (PIAS), also known as E3 SUMO-protein ligase PIAS, is a protein that regulates ... Attachment of a SUMO protein to the target allows for protein-protein interaction between PIAS and the transcription factor. ...

SAE2 has been shown to interact with SAE1, Small ubiquitin-related modifier 1, and UBE2I. GRCh38: Ensembl release 89: ... Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1), or sumoylation, regulates ... "Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design". ... "Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1". J. Biol. Chem. 274 (15): ...

This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' ... Small ubiquitin-related modifier 4 is a protein that in humans is encoded by the SUMO4 gene. This gene is a member of the SUMO ... "Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese ... "Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese population". The ...

Small ubiquitin-related modifier 1 is a protein that in humans is encoded by the SUMO1 gene. This gene encodes a protein that ... small ubiquitin-like modifier) protein family. It is a ubiquitin-like protein and functions in a manner similar to ubiquitin in ... "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related ... Small ubiquitin-related modifier 1 has been shown to interact with: C22orf25, DAXX, DNMT3B, P53, PIAS1, PML, SAE2, SP1, TDG, ...

Small ubiquitin-related modifier 3 is a protein that in humans is encoded by the SUMO3 gene. SUMO proteins, such as SUMO3, and ... Saitoh H, Hinchey J (March 2000). "Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3 ... Eaton EM, Sealy L (August 2003). "Modification of CCAAT/enhancer-binding protein-beta by the small ubiquitin-like modifier ( ... Su HL, Li SS (August 2002). "Molecular features of human ubiquitin-like SUMO genes and their encoded proteins". Gene. 296 (1-2 ...

Small ubiquitin-related modifier 2 is a protein that in humans is encoded by the SUMO2 gene. This gene encodes a protein that ... small ubiquitin-like modifier) protein family. It is a ubiquitin-like protein and functions in a manner similar to ubiquitin in ... Saitoh H, Hinchey J (Mar 2000). "Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3 ... "In vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: definitive ...

Saitoh H, Hinchey J (March 2000). "Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3 ... In molecular biology, SUMO (Small Ubiquitin-like Modifier) proteins are a family of small proteins that are covalently attached ... SUMO proteins are similar to ubiquitin and are considered members of the ubiquitin-like protein family. SUMOylation is directed ... "A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2". Cell. 88 (1): 97- ...

"Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related ... chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a ... "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi:10.1016/j.cell ... Chromodomain-helicase-DNA-binding protein 3 is an enzyme that in humans is encoded by the CHD3 gene. This gene encodes a member ...

Small ubiquitin-related modifier needs to be associated with it before it can be localized at the nuclear pore. RANGAP1 has ... "A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2". Cell. 88 (1): 97- ... The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Rangap1 (Fug1), ... "Entrez Gene: RANGAP1 Ran GTPase activating protein 1". Hochstrasser M (2000). "Biochemistry. All in the ubiquitin family". ...

"Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related ... PIAS1 has been shown to interact with: DNMT3A, P53, STAT1, Small ubiquitin-related modifier 1, Sp3 transcription factor, and ... implication of small ubiquitin-related modifier 1 modification". Mol. Endocrinol. 17 (12): 2529-2542. doi:10.1210/me.2003-0299 ... and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of ...

"Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related ... Sumoylation is a process in which a Small Ubiquitin-like MOdifier (SUMO) is covalently attached to other proteins in order to ... It is also sometimes referred to as "ubiquitin conjugating enzyme E2I" or "ubiquitin carrier protein 9", even though these ... For example, sumoylation may affect a protein's localization in the cell, its ability to interact with other proteins or DNA. ...

"Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related ... "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related ... androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability ... Tussie-Luna MI, Michel B, Hakre S, Roy AL (2003). "The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta / ...

... catalyzes maturation SUMO protein (small ubiquitin-related modifier), which causes hydrolysis peptide bond of SUMO is in ... Mikolajczyk J, Drag M, Békés M, Cao JT, Ronai Z, Salvesen GS (Sep 2007). "Small ubiquitin-related modifier (SUMO)-specific ... The important nucleophile is cysteine located at the N-terminal alpha helix of the protein core, the other two amino acids, ... Kim YH, Sung KS, Lee SJ, Kim YO, Choi CY, Kim Y (Nov 2005). "Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) ...

The sumoylation of BMAL1 by small ubiquitin-related modifier 3 signals its ubiquitination in the nucleus, leading to ... One of BMAL1 protein's earliest discovered functions in circadian regulation was related to the CLOCK-BMAL1 (CLOCK-ARNTL) ... The protein encoded by the BMAL1 gene in mammals binds with a second bHLH-PAS protein via the PAS domain, CLOCK (or its paralog ... The CRY protein is also signaled for degradation by poly-ubiquitination from the FBXL3 protein resulting in the disinhibition ...

Known UBLs include: small ubiquitin-like modifier (SUMO), ubiquitin cross-reactive protein (UCRP, also known as interferon- ... It is also believed that the Saccharomyces cerevisiae protein Urm1, a ubiquitin-related modifier, is a "molecular fossil" that ... Few ubiquitin-like protein (FUB1), MUB (membrane-anchored UBL), ubiquitin fold-modifier-1 (UFM1) and ubiquitin-like protein-5 ( ... DUBs cleave these proteins to produce active ubiquitin. They also recycle ubiquitin that has been bound to small nucleophilic ...

Promyelocytic leukemia protein, SUMO3, and Small ubiquitin-related modifier 1. Click on genes, proteins and metabolites below ... Several bacterial proteins have strong sequence homology with this protein. The protein encoded by this gene belongs to the TDG ... "Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover". EMBO J. 21 (6): ... "Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover". EMBO J. 21 (6): ...

... and Small ubiquitin-related modifier 1. GRCh38: Ensembl release 89: ENSG00000026103 - Ensembl, May 2017 GRCm38: Ensembl release ... The mature Fas protein has 319 amino acids, has a predicted molecular weight of 48 kiloDaltons and is divided into three ... Similar sequences related by evolution (orthologs) are found in most mammals. Previous reports have identified as many as eight ... In most cell types, caspase-8 catalyzes the cleavage of the pro-apoptotic BH3-only protein Bid into its truncated form, tBid. ...

In archaea, the small archaeal modifier proteins (SAMPs) share the beta-grasp fold and have been shown to play a ubiquitin-like ... Saitoh, Hisato; Pu, Robert T.; Dasso, Mary (October 1997). "SUMO-1: wrestling with a new ubiquitin-related modifier". Trends in ... Ubiquitin-like proteins (UBLs) are a family of small proteins involved in post-translational modification of other proteins in ... "The dual role of ubiquitin-like protein Urm1 as a protein modifier and sulfur carrier". Protein & Cell. 2 (8): 612-9. doi: ...

A small ubiquitin-related modifier protein modification of BMAL1 has also been proposed as another level of post-translational ... also employed a genome-wide small interfering RNA screen in U2OS cell line to identify additional clock genes and modifiers ... Methylation of a protein structure adds a methyl group and regulates the protein function or gene expression and in histone ... CCA1/LHY and TOC1 proteins repress the expression of each other's genes. The result is that as CCA1/LHY protein levels start to ...

"Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related ... "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related ... "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ...

... prior to their conjugation to target proteins small ubiquitin-related modifier 1 GRCh38: Ensembl release 89: ENSG00000112701 - ... Ubiquitin-like molecules (UBLs), such as SUMO1, are structurally related to ubiquitin and can be ligated to target proteins in ... "Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs". The ... "Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its ...

Dasso published key findings on the small ubiquitin-related modifier (SUMO) pathway that then contributed to the discovery of ... a process in which proteins are tagged by SUMO proteins, thereby modifying the tagged protein's function. In 2010, her team ... Dasso then expanded her work, looking for proteins involved in the replication checkpoint, which led her to a collaboration ... Years earlier, Nishimoto had shown that cells without the RCC1 protein attempted to divide before completing DNA replication, ...

SUMOylation, the covalent linkage to the SUMO protein (Small Ubiquitin-related MOdifier) neddylation, the covalent linkage to ... Proteins are created by ribosomes translating mRNA into polypeptide chains, which may then change to form the mature protein ... Attachment of lipid molecules, known as lipidation, often targets a protein or part of a protein attached to the cell membrane ... List of software for visualization of proteins and their PTMs PyMOL - introduce a set of common PTM's into protein models ...

... transfer of SUMO protein to other proteins). The Small Ubiquitin-related Modifier, SUMO-1, is a ubiquitin-like family member ... Broad spectrum identification of cellular small ubiquitin-related modifier (SUMO) substrate proteins, J. Biol. Chem. 279 (2004 ... Modification of proteins by ubiquitin and ubiquitin-like proteins, Annu. Rev. Cell Dev. Biol. (2006) Jun 5, Electronic ... Protein modification by SUMO. Annu. Rev. Biochem. 73, 355-382 (2004) Melchior, F. SUMO-nonclassical ubiquitin. Annu. Rev. Cell ...

SKI protein, STAT3, Serum response factor and Small ubiquitin-related modifier 1, Sp1 transcription factor, TOPBP1, Thymine-DNA ... is the protein product of the PML gene. PML protein is a tumor suppressor protein required for the assembly of a number of ... The proteins held by PML-NBs are then sumoylated, inactivating the virions permanently. Promyelocytic leukemia protein has been ... These microstructures contain PML protein but not the many interacting proteins normally associated with PML-NBs. PML-NBs are ...

... post-translational modification at lysine 210 with a small ubiquitin-related modifier (SUMO), or sumoylation, is required. SUMO ... DNA repair protein XRCC4 also known as X-ray repair cross-complementing protein 4 or XRCC4 is a protein that in humans is ... Two XRCC4 proteins are post-translationally modified for recognition and localization to Ku70/80 (5). The two XRCC4 proteins ... The X-ray repair cross-complementing protein 4 is one of several core proteins involved in the non-homologous end joining (NHEJ ...

Small ubiquitin-related modifier 1), TBX22, TCOF (Treacle protein), TFAP2A, VAX1, TP63, ARHGAP29, NOG, NTN1, WNT genes, and ...

Small ubiquitin-related modifier 1 (SUMO-1) is a protein produced by human cells that is involved in the modification of many ... Kroetz MB (2005). "SUMO: a ubiquitin-like protein modifier". Yale J Biol Med. 78 (4): 197-201. PMC 2259148. PMID 16720014. ... Müller S, Matunis MJ, Dejean A (January 1998). "Conjugation with the ubiquitin-related modifier SUMO-1 regulates the ... The ICP0 gene and protein from HSV-1 have orthologs in related viruses from the herpes virus family. HSV-2 ICP0 is predicted to ...

May 2011). "Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library ... slightly concave surface that is suitable for targeting surfaces typically involved in protein-protein interactions. Single- ... May 2011). "Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library ... The native FN3 scaffold consists of 94 amino acids and has a molecular mass of about 10 kDa, fifteen times smaller than an IgG ...

"Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs". J. Biol ... "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347-55. doi: ... Gong L, Millas S, Maul GG, Yeh ET (2000). "Differential regulation of sentrinized proteins by a novel sentrin-specific protease ...