... (Maolate, Musil) is a centrally acting muscle relaxant used to treat muscle pain and spasms. ... Other central effects include sedation, anxiolysis, and dizziness. A related chemical, chlorphenesin (C9H11ClO3) without the ... Kurachi M, Aihara H (September 1984). "Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats". ... Muscle relaxants, Carbamates, Secondary alcohols, Phenol ethers, Chloroarenes, Drugs with unknown mechanisms of action, ...

... is a centrally acting muscle relaxant. Cyclobenzaprine is a 5-HT2 receptor antagonist; it relieves muscle spasm ... through action on the central nervous system at the brain stem, rather than targeting the peripheral nervous system or muscles ... Cyclobenzaprine may affect the medications used in surgical sedation and some surgeons request that patients temporarily ... van Tulder MW, Touray T, Furlan AD, Solway S, Bouter LM (2003). Van Tulder MW (ed.). "Muscle relaxants for non-specific low ...

... may interact with other medications such as anti-depressants, sleeping pills, muscle relaxants and other ... "Benadryl - Ohio History Central". ohiohistorycentral.org. Retrieved November 2, 2020. "Johnson & Johnson Acquisition of Pfizer ... Mixing diphenhydramine with alcohol can also increase the chances of losing consciousness due to sedation. This combination can ... where he was conducting research into muscle relaxants. In 1946, Benadryl was approved by the Food and Drug Administration (FDA ...

Patients most commonly report sedation as the main adverse effect of muscle relaxants. Usually, people become less alert when ... "The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system". ... A muscle relaxant is a drug that affects skeletal muscle function and decreases the muscle tone. It may be used to alleviate ... A muscle relaxant is chosen based on its adverse-effect profile, tolerability, and cost. Muscle relaxants (according to one ...

... (Quiactin) is an anxiolytic and muscle relaxant which can produce sedative and hypnotic effects in sufficiently high ... Kuhn WL, Ketteler HJ, Van Maanen EF (January 1960). "Effects of oxanamide on the central nervous system". Proceedings of the ... with minimal sedation or other side effects. ...

It has sedative, hypnotic, muscle relaxant and central nervous system depressant properties. It was highly abused, and had high ... When depressants are used, effects often include ataxia, anxiolysis, pain relief, sedation or somnolence, cognitive or memory ... muscle relaxant and tranquilizer) Lorbamate (muscle relaxant and tranquilizer) Nisobamate (tranquilizer) Pentabamate ( ... Their muscle relaxant effects are useful for strains, sprains, and muscle injuries combined with rest, physical therapy, and ...

Modern anesthetists have at their disposal a variety of muscle relaxants for use in anesthesia. The ability to produce muscle ... Used as a paralyzing agent by indigenous peoples in Central and South America for hunting and for therapeutic purposes, curare ... relaxation irrespective of sedation has permitted anesthetists to adjust the two effects independently and on the fly to ensure ... effectively paralyzing the muscles of the body. Curare is an example of a non-depolarizing muscle relaxant that blocks the ...

In addition to the hypnotic properties, triazolam's amnesic, anxiolytic, sedative, anticonvulsant, and muscle relaxant ... Triazolam, sold under the brand name Halcion among others, is a central nervous system (CNS) depressant tranquilizer of the ... This practice is known as sedation dentistry. Adverse drug reactions associated with the use of triazolam include: Relatively ...

The muscle relaxant properties of nitrazepam are produced via inhibition of polysynaptic pathways in the spinal cord of ... Excess sedation, hypersalivation, swallowing difficulty, and high incidence of aspiration pneumonia, as well as several deaths ... Sato K, Hong YL, Yang MS, Shibuya T, Kawamoto H, Kitagawa H (April 1985). "Pharmacologic studies of central actions of ... Date SK, Hemavathi KG, Gulati OD (November 1984). "Investigation of the muscle relaxant activity of nitrazepam". Archives ...

... is a centrally acting skeletal muscle relaxant that has significant adverse effects, especially on the central ... sedation, increased risk of fractures," noting that "effectiveness dosages tolerated by older adults is questionable." ... Methocarbamol is a centrally acting muscle relaxant. How it works is unclear, but it does not appear to affect muscles directly ... One trial of methocarbamol versus cyclobenzaprine, a well-studied muscle relaxant, in those with localized muscle spasm found ...

... is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. It achieves this by inhibiting ... Central nervous system side effects are quite frequently noted and encompass speech and visual disturbances, mental depression ... Dantrolene often causes sedation severe enough to incapacitate the patient to drive or operate machinery.[medical citation ... A new class of muscle relaxants". Journal of Medicinal Chemistry. 10 (5): 807-810. doi:10.1021/jm00317a011. PMID 6048486. Ellis ...

It is also a component of the combination drug Equagesic (discontinued in the UK in 2002), acting as a muscle relaxant. ... Berger, clinical director of Wallace Laboratories, described it as a relaxant of the central nervous system, whereas other ... causing sedation and altered perception of pain. Meprobamate has the ability to activate currents even in the absence of GABA. ... Muscle relaxants, Anxiolytics, Carbamates, GABAA receptor positive allosteric modulators, NMDA receptor antagonists). ...

It has sedative, muscle relaxant, anticonvulsant, and anxiolytic effects similar to those produced by other benzodiazepine ... Effect of hydrolyzate of flutazolam on the central nervous system]". Yakugaku Zasshi: Journal of the Pharmaceutical Society of ... derivatives, and though it is around the same potency as diazepam, it produces a more marked sedation and impaired coordination ...

... amnestic and muscle relaxant properties. Benzodiazepines act as a central nervous system depressant. The relative strength of ... from mild sedation to anesthesia. The following are classified as anticonvulsants: Phenobarbital (1912). See also the related ... Barbiturates are drugs that act as central nervous system (CNS) depressants, and by virtue of this they produce a wide spectrum ... which had the distinct advantage of treating epileptic seizures with less sedation. By the 1970s, a National Institutes of ...

Although muscle relaxants may have the major side effect of sedation, thiocolchicoside is free from sedation effects, likely ... "The muscle relaxant thiocolchicoside is an agonist of GABAA receptor function in the central nervous system". Neuropharmacology ... Thiocolchicoside (Muscoril, Myoril, Neoflax) is a muscle relaxant with anti-inflammatory and analgesic effects. Its mechanism ... a GABA-mimetic muscle relaxant drug, in normal volunteers". European Journal of Drug Metabolism and Pharmacokinetics. 20 (4): ...

However, benzodiazepines such as diazepam can be used for their muscle-relaxant properties to alleviate pain caused by muscle ... Diazepam increases the central depressive effects of alcohol, other hypnotics/sedatives (e.g., barbiturates), other muscle ... It is also used as a premedication for inducing sedation, anxiolysis, or amnesia before certain medical procedures (e.g., ... The muscle relaxant properties of diazepam are produced via inhibition of polysynaptic pathways in the spinal cord. Diazepam ...

Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects. ... Hester JB, Rudzik AD, Kamdar BV (November 1971). "6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines which have central nervous ... due to their ability to produce strong sedation and amnesia at oral doses of as little as 0.5 mg. Life-threatening adverse ...

Simultaneous use of hydromorphone with other opioids, muscle relaxants, tranquilizers, sedatives, and general anesthetics may ... Hydromorphone and related opioids produce their major effects on the central nervous system and gastrointestinal tract. These ... More common side effects include lightheadedness, dizziness, sedation, itching, constipation, nausea, vomiting, headache, ... It may be used by mouth or by injection into a vein, muscle, or under the skin. Effects generally begin within half an hour and ...

It may also be prescribed as an anticonvulsant or muscle relaxant. It is also used as a premedication. Clorazepate is ... Floppy infant syndrome and sedation in the newborn may also occur. Symptoms of floppy infant syndrome and the neonatal ... 1969). "Sur des nouvelles benzodiazepines hydrosolubles douées d'une puissante activité sur le système nerveux central" [On new ... It possesses anxiolytic, anticonvulsant, sedative, hypnotic, and skeletal muscle relaxant properties. Clorazepate is an ...

... a close relative of diphenhydramine used mainly as a skeletal muscle relaxant and anti-Parkinsons agent) Periciazine (low- ... Sedation is a common side effect of H1-antihistamines that readily cross the blood-brain barrier; some of these drugs, such as ... However, upon high doses second-generation antihistamines will begin to act on the central nervous system and thus can induce ... H1-antihistamines work by binding to histamine H1 receptors in mast cells, smooth muscle, and endothelium in the body as well ...

It possesses anxiolytic, anticonvulsant, sedative, hypnotic, and skeletal muscle relaxant properties. It is typically taken by ... The central nervous system depressing effects of the drug can be intensified by alcohol consumption, so alcohol should be ... Sedation Euphoria Motor impairment Confusion Irritability and aggression Psychomotor agitation Lack of motivation Loss of ... skeletal muscle relaxant, and anxiolytic effects. It acts by binding to the benzodiazepine site of the GABA receptors, which ...

Myasthenia gravis - This condition is characterized by muscle weakness, so a muscle relaxant such as lorazepam may exacerbate ... Sedation is the side effect people taking lorazepam most frequently report. In a group of around 3,500 people treated for ... Sleep apnea - Sleep apnea may be worsened by lorazepam's central nervous system depressant effects. It may further reduce the ... Many beneficial effects of lorazepam (e.g., sedative, muscle relaxant, anti-anxiety, and amnesic effects) may become adverse ...

... and muscle relaxant effects. There are three receptors of the gamma-aminobutyric acid. The two receptors GABA-α and GABA-ρ are ... "The Role of GABA Receptor Agonists in Anesthesia and Sedation". CNS Drugs. 31 (10): 845-856. doi:10.1007/s40263-017-0463-7. ... "The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central ...

... 's muscle relaxant effect inhibits the transmission of neural impulses in the central nervous system. In scientific ... Xylazine is a drug used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle, and other ... In the United States, xylazine was approved by the FDA only for veterinary use as a sedative, analgesic, and muscle relaxant in ... Xylazine is widely used in veterinary medicine as a sedative, muscle relaxant, and analgesic. It is frequently used in the ...

... and skeletal muscle relaxant properties compared to other benzodiazepines. It was patented in 1962 and approved for medical use ... Floppy infant syndrome and sedation in the newborn may also occur. Symptoms of floppy infant syndrome and the neonatal ... Symptoms of an oxazepam overdose include: Respiratory depression Excessive somnolence Altered consciousness Central nervous ... Concomitant use of oxazepam and alcohol can lead to increased sedation and memory impairment, severe problems with coordination ...

It also stimulates synthesis and release of various vascular smooth muscle cell relaxants, such as nitric oxide, endothelium- ... In the central nervous system, histamine released into the synapses is primarily broken down by histamine-N-methyltransferase, ... second-generation H1 antihistamines do not readily permeate the blood-brain barrier and thus are less likely to cause sedation ... Histamine is involved in the inflammatory response and has a central role as a mediator of itching. As part of an immune ...

... muscle relaxant, antidepressant and anticonvulsant activity. The activity of alprazolam in the central nervous system is dose ... Some of the sedation and tiredness may improve within a few days. Alprazolam withdrawal may occur if use is suddenly decreased ... muscle relaxant, hypnotic and amnesic; however, it is used mainly as an anxiolytic.[medical citation needed] Giving alprazolam ... Like all central nervous system depressants, alprazolam in larger-than-normal doses can cause significant deterioration in ...

Normal treatment is to maintain sedation and ventilate the patient on an intensive care unit until muscle function has returned ... Suxamethonium is also commonly used as the sole muscle relaxant during electroconvulsive therapy, favoured for its short ... It can also be viewed as a central moiety of succinic acid with two choline moieties, one on each end. Suxamethonium was first ... Calcium is removed from the muscle cell cytoplasm independent of repolarization (depolarization signaling and muscle ...

It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It produces a metabolite ... Flurazepam could be therefore unsuitable as a sleeping medication for some individuals due to next-day sedation; however, this ... rebound insomnia and central nervous system (CNS) related adverse effects. Flurazepam is best used for a short time period and ... daytime sedation, motor incoordination, and increased risk of motor vehicle accidents and falls. In addition, the effectiveness ...

Because of their muscle relaxant action, benzodiazepines may cause respiratory depression in susceptible individuals. For that ... Combined with other central nervous system (CNS) depressants such as alcohol and opioids, the potential for toxicity and fatal ... This often results in increased sedation, impaired motor coordination, suppressed breathing, and other adverse effects that ... It has been suggested that some of their anticonvulsant, anxiolytic, and muscle relaxant effects may be in part mediated by ...