SC-17599Opioid receptor: Opioid receptors are a group of inhibitory G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin.Opioid: Opioids are substances that act on the nervous system in a similar way to opiates such as morphine and codeine. In a medical context the term usually indicates medications that are artificially made rather than extracted from opium.TAN-67: TAN-67 (SB-205,607) is a opioid drug used in scientific research that acts as a potent and selective δ-opioid agonist,Fujii H, Kawai K, Kawamura K, Mizusuna A, Onoda Y, Murachi M, Tanaka T, Endoh T, Nagase H. Synthesis of optically active TAN-67, a highly selective delta opioid receptor agonist, and investigation of its pharmacological properties.SpiradolineNociceptin receptor: The nociceptin receptor or NOP also known as the orphanin FQ receptor or kappa-type 3 opioid receptor is a protein that in humans is encoded by the OPRL1 (opioid receptor-like 1) gene. The nociceptin receptor is a G protein-coupled receptor whose natural ligand is known as nociceptin or orphanin FQ, a 17 amino acid neuropeptide.Low-dose naltrexone: Low-dose naltrexone (LDN) describes the off-label use of the medication naltrexone at low doses for diseases such as multiple sclerosis. Naltrexone is typically prescribed for opioid dependence or alcohol dependence, as it is a strong opioid antagonist.Proenkephalin: Proenkephalin (PENK), formerly known as proenkephalin A (since proenkephalin B was renamed prodynorphin), is an endogenous opioid polypeptide hormone which, via proteolyic cleavage, produces the enkephalin peptides [Met]enkephalin, and to a lesser extent, [Leu]enkephalin. Upon cleavage, each proenkephalin peptide results in the generation of four copies of [Met]enkephalin, two extended copies of [Met]enkephalin, and one copy of [Leu]enkephalin.Morphia (disambiguation): Morphia, also called morphine, is a highly potent opiate analgesic drug.Uniform State Narcotic Drug Act: The National Conference of Commissioners on Uniform State Laws developed the Uniform State Narcotic Drug Act in 1934 due to the lack of restrictions in the Harrison Act of 1914. The act was a revenue-producing act and, while it provided penalties for violations, it did not give authority to the states to exercise police power regarding either seizure of drugs used in illicit trade or punishment of those responsible.MorphiceptinDynorphin: Dynorphins (Dyn) are a class of opioid peptides that arise from the precursor protein prodynorphin. When prodynorphin is cleaved during processing by proprotein convertase 2 (PC2), multiple active peptides are released: dynorphin A, dynorphin B, and α/β-neo-endorphin.Agonist–antagonistTynorphin: Tynorphin is a synthetic opioid peptide which is a potent and competitive inhibitor of the enkephalinase class of enzymes which break down the endogenous enkephalin peptides. It specifically inactivates dipeptidyl aminopeptidase III (DPP3) with very high efficacy, but also inhibits neutral endopeptidase (NEP), aminopeptidase N (APN), and angiotensin-converting enzyme (ACE) to a lesser extent.DiprenorphineCancer pain: Pain in cancer may arise from a tumor compressing or infiltrating nearby body parts; from treatments and diagnostic procedures; or from skin, nerve and other changes caused by a hormone imbalance or immune response. Most chronic (long-lasting) pain is caused by the illness and most acute (short-term) pain is caused by treatment or diagnostic procedures.EpanololCompound analgesic: Compound analgesics are those with multiple active ingredients; they include many of the stronger prescription analgesics.Cyclorphan: Cyclorphan is an opioid compound that is a δ-opioid receptor agonist, a κ-opioid receptor agonist, and a μ-opioid receptor antagonist. Chemically, it is a morphinan and is related to levorphanol.OhmefentanylAlcohol tolerance: Alcohol tolerance refers to the bodily responses to the functional effects of ethanol in alcoholic beverages. This includes direct tolerance, speed of recovery from insobriety and resistance to the development of alcoholism.Methadone clinic: A methadone clinic is a clinic which has been established for the dispensing of methadone (Dolophine), a schedule II opioid analgesic, to those who abuse heroin and other opioids. The focus of these clinics is the elimination or reduction of opioid usage by putting the patient on methadone.Pain scale: A pain scale measures a patient's pain intensity or other features. Pain scales are based on self-report, observational (behavioral), or physiological data.HydromorphoneBenzomorphanPyrrolidinePreventive analgesia: Preventive analgesia is a practice aimed at reducing short- and long-term post-surgery pain. Activity in the body's pain signalling system during surgery produces "sensitization"; that is, it increases the intensity of post-operative pain.Benzodiazepine withdrawal syndromeConcentration effect: In the study of inhaled anesthetics, the concentration effect is the increase in the rate that the Fa(alveolar concentration)/Fi(inspired concentration) ratio rises as the alveolar concentration of that gas is increased. In simple terms, the higher the concentration of gas administered, the faster the alveolar concentration of that gas approaches the inspired concentration.Chronic painPolysubstance dependence: A person with polysubstance dependence is psychologically addicted to being in an intoxicated state without a preference for one particular substance. Although any combination of three drugs can be used, studies have shown that alcohol is commonly used with another substance.Casomorphin: Casomorphins are peptides, i.e.Salvinorin B methoxymethyl etherComfort Food (novel): Comfort Food: A Novel by Noah Ashenhurst contains a cast of characters: a romantic academic, a self-assured young writer, an enigmatic musician, a slacker, a wealthy mountaineer, and a former heroin addict—characters whose lives intersect in the unique, award-winning debut novel.OxymorphoneRGD motifGTS-21Hypoalgesia: Hypoalgesia or hypalgesia denotes a decreased sensitivity to painful stimuli.Another Grey Area: Another Grey Area is a 1982 album by Graham Parker and was released on the Arista Records label. It was produced by Jack Douglas and Graham Parker.Opioid overdose: .0, -CyclazocineNalbuphineArt Van DammeOpioid-induced hyperalgesia: Opioid-induced hyperalgesia or opioid-induced abnormal pain sensitivity, also called paradoxical hyperalgesia is a phenomenon associated with the long term use of opioids such as morphine, hydrocodone, oxycodone, and methadone. Over time, individuals taking opioids can develop an increasing sensitivity to noxious stimuli, even evolving a painful response to previously non-noxious stimuli (allodynia).Hydrocodone/ibuprofenSufentanilLoperamideDrug interaction: A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own.QuadazocineNociceptor: A nociceptor is a sensory neuron (nerve cell) that responds to potentially damaging stimuli by sending signals to the spinal cord and brain. This process, called nociception, usually causes the perception of pain.Neuromere: Neuromeres are morphologically or molecularly defined transient segments of the early developing brain. Rhombomeres are such segments that make up the rhombencephalon or hindbrain.Ligand (biochemistry): In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. In protein-ligand binding, the ligand is usually a signal-triggering molecule binding to a site on a target protein.Somatostatin family: A:99-116Phenylpiperidine: Phenylpiperidine is a chemical compound with a phenyl moiety directly attached to piperidine. There are a variety of pharmacological effects associated some phenylpiperidines including morphine-like activity or other central nervous system effects.NoracymethadolCodeinePentazocineA. N. Hartley: Annie Norah Hartley (1902 – 1994), usually known simply as Norah Hartley, was a dog breeder and the first female board member of the Kennel Club.Temporal analysis of products: Temporal Analysis of Products (TAP), (TAP-2), (TAP-3) is an experimental technique for studyingColes PhillipsWIN 56,098: WIN 56,098 is a chemical that is considered to be an aminoalkylindole derivative. It is a tricyclic aryl derivative that acts as a competitive antagonist at the CB2 cannabinoid receptor.Artery to the ductus deferens: The artery to the ductus deferens (deferential artery) is an artery in males that provides blood to the ductus deferens.Substance-related disorderStanley Spiro