Endothelin receptor antagonist: A endothelin receptor antagonist (ERA) is a drug that blocks endothelin receptors.Laboratoire Plasma et Conversion d'Energie: The Laboratoire Plasma et Conversion d'Energie (LAPLACE), Toulouse is a Centre National de la Recherche Scientifique (CNRS) laboratory, operated jointly by the CNRS, the University of Toulouse and the Institut National Polytechnique of Toulouse.Ecarin clotting timeDarusentanSulfonamide (medicine): Sulfonamide or sulphonamide is the basis of several groups of drugs. The original antibacterial sulfonamides (sometimes called sulfa drugs or sulpha drugs) are synthetic antimicrobial agents that contain the sulfonamide group.PyrrolidineRetroviral aspartyl protease: Retroviral aspartyl proteases are single domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses). These proteases are generally part of a larger pol or gag polyprotein.Diazepine: Diazepine is a seven-membered heterocyclic compound with two nitrogen atoms (e.g.DonepezilRGD motifPhenylpiperidine: Phenylpiperidine is a chemical compound with a phenyl moiety directly attached to piperidine. There are a variety of pharmacological effects associated some phenylpiperidines including morphine-like activity or other central nervous system effects.Astacin: In molecular biology, astacin is a family of metallopeptidases. These metallopeptidases belong to the MEROPS peptidase family M12, subfamily M12A (astacin family, clan MA(M)).Aortic pressure: Central aortic blood pressure (CAP or CASP) is the blood pressure at the root of aorta. Studies have shown the importance of central aortic pressure and its implications in assessing the efficacy of antihypertensive treatment with respect to cardiovascular risk factors.Lidanserin: Lidanserin (INN; ZK-33,839) is a drug which acts as a combined 5-HT2A and α1-adrenergic receptor antagonist. It was developed as an antihypertensive agent but was never marketed.Endothelial activation: Endothelial activation is a proinflammatory and procoagulant state of the endothelial cells lining the lumen of blood vessels. It is most characterized by an increase in interactions with white blood cells (leukocytes), and it is associated with the early states of atherosclerosis and sepsis, among others.Vascular smooth musclePulmonary Hypertension Association: The Pulmonary Hypertension Association (PHA) is a 501(c) organization non-profit support, education, advocacy and awareness association for pulmonary hypertension (PH). It provides information to the public about the illness and acts as a support group for those with the disease, providing medical provider location services and emotional support for those suffering from the illness.SEA Native Peptide LigationMature messenger RNA: Mature messenger RNA, often abbreviated as mature mRNA is a eukaryotic RNA transcript that has been spliced and processed and is ready for translation in the course of protein synthesis. Unlike the eukaryotic RNA immediately after transcription known as precursor messenger RNA, it consists exclusively of exons, with all introns removed.Blood vessel: The blood vessels are the part of the circulatory system that transports blood throughout the human body. There are three major types of blood vessels: the arteries, which carry the blood away from the heart; the capillaries, which enable the actual exchange of water and chemicals between the blood and the tissues; and the veins, which carry blood from the capillaries back toward the heart.Kidney: The kidneys are bean-shaped organs that serve several essential regulatory roles in vertebrates. They remove excess organic molecules from the blood, and it is by this action that their best-known function is performed: the removal of waste products of metabolism.Concentration effect: In the study of inhaled anesthetics, the concentration effect is the increase in the rate that the Fa(alveolar concentration)/Fi(inspired concentration) ratio rises as the alveolar concentration of that gas is increased. In simple terms, the higher the concentration of gas administered, the faster the alveolar concentration of that gas approaches the inspired concentration.HypertensionEcteinascidia turbinata: Ecteinascidia turbinata, the mangrove tunicate, is a sea squirt species in the genus Ecteinascidia, which was described to science in 1880 by William Abbott Herdman. The cancer drug trabectedin is isolated from E.SulfonylPulmonary artery banding: Pulmonary Artery Banding (PAB) was introduced by Muller and Danimann in 1951 as a surgical technique to reduce excessive pulmonary blood flow in infants suffering from congenital heart defects.Muller WH, Dammann JF.Muscle contraction: Muscle contraction is the activation of tension-generating sites within muscle fibers. In physiology, muscle contraction does not mean muscle shortening because muscle tension can be produced without changes in muscle length such as holding a heavy book or a dumbbell at the same position.PyrazolopyrimidineAngiotensin receptor: The angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II.IndoleMyocytolysis: Myocytolysis refers to a degenerative change (often reversible) that occurs to myocytes upon myocardial strain. This phenomenon tends to occur when neighboring cardiac muscle loses its ability to contract (i.Anterior interventricular branch of left coronary artery: The left anterior descending artery (also LAD, anterior interventricular branch of the left coronary artery, or anterior descending branch), also known as the "widow maker", is an artery of the heart.ClevidipineCalcium signaling: Calcium ions are important for cellular signalling, as once they enter the cytosol of the cytoplasm they exert allosteric regulatory effects on many enzymes and proteins. Calcium can act in signal transduction resulting from activation of ion channels or as a second messenger caused by indirect signal transduction pathways such as G protein-coupled receptors.Macula densaNeprilysin: Neprilysin ( also known as membrane metallo-endopeptidase (MME), neutral endopeptidase (NEP), cluster of differentiation 10 (CD10), and common acute lymphoblastic leukemia antigen (CALLA) is an enzyme] that in humans is encoded by the MME gene. Neprilysin is a [[zinc-dependent metalloprotease that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.IsoxazoleVasodilation: Vasodilation (or vasodilatation) refers to the widening of blood vessels. It results from relaxation of smooth muscle cells within the vessel walls, in particular in the large veins, large arteries, and smaller arterioles.TetrazoleNitric-oxide synthase (NAD(P)H-dependent): Nitric-oxide synthase (NAD(P)H-dependent) (, nitric oxide synthetase, NO synthase) is an enzyme with system name L-arginine,NAD(P)H:oxygen oxidoreductase (nitric-oxide-forming). This enzyme catalyses the following chemical reactionWIN 56,098: WIN 56,098 is a chemical that is considered to be an aminoalkylindole derivative. It is a tricyclic aryl derivative that acts as a competitive antagonist at the CB2 cannabinoid receptor.MelanocyteEthernet flow control: Ethernet flow control is a mechanism for temporarily stopping the transmission of data on Ethernet family computer networks. The first flow control mechanism, the PAUSE frame, was defined by the IEEE 802.EndralazineTetrahydrodeoxycorticosteroneSubtherapeutic antibiotic use in swine: Antibiotics are commonly used in commercial swine production in the United States and around the world. They are used for disease treatment, disease prevention and control, and growth promotion.Hirschsprung's diseaseTemporal analysis of products: Temporal Analysis of Products (TAP), (TAP-2), (TAP-3) is an experimental technique for studyingGross pathology: Gross pathology refers to macroscopic manifestations of disease in organs, tissues, and body cavities. The term is commonly used by anatomical pathologists to refer to diagnostically useful findings made during the gross examination portion of surgical specimen processing or an autopsy.Renal medullaColes PhillipsDistributing artery: A distributing artery (or muscular artery) is a medium-sized artery that draw blood from an elastic artery and branch into "resistance vessels" including small arteries and arterioles. In contrast to the mechanism elastic arteries use to store energy generated by the heart's contraction, distributing arteries contain layers of smooth muscle.New Zealand rabbitLentiginosis: Lentiginosis refers to the presence of lentigines in large numbers or in a distinctive configuration.http://cancerweb.Retrograde perfusion: Retrograde perfusion is an artificial method of providing blood supply to an organ by delivering oxygenated blood through the veins. It may be performed during surgery that interrupts the normal arterial supply of blood to that organ.Vasopressin analogue: Vasopressin analogues are chemicals similar in function but not necessarily similar in structure to vasopressin (ADH), such as desmopressin.PHLPP: The PHLPP isoforms (PH domain and Leucine rich repeat Protein Phosphatases) are a pair of protein phosphatases, PHLPP1 and PHLPP2, that are important regulators of Akt serine-threonine kinases (Akt1, Akt2, Akt3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP may act as a tumor suppressor in several types of cancer due to its ability to block growth factor-induced signaling in cancer cells.Kennel clubHypoxic hypoxia: Hypoxic hypoxia is a result of insufficient oxygen available to the lungs. A blocked airway, a drowning or a reduction in partial pressure (high altitude above 10,000 feet) are examples of how lungs can be deprived of oxygen.
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