Proteoglycans are proteins that are heavily glycosylated. The basic proteoglycan unit consists of a "core protein" with one or ... Proteoglycans occur in connective tissue. Proteoglycans are categorized by their relative size (large and small) and the nature ... Iozzo, RV; Schaefer, L (March 2015). "Proteoglycan form and function: A comprehensive nomenclature of proteoglycans". Matrix ... Individual functions of proteoglycans can be attributed to either the protein core or the attached GAG chain. They can also ...

PMID 14501214 Levine JM, Nishiyama A. "The NG2 chondroitin sulfate proteoglycan: a multifunctional proteoglycan associated with ... Neural/glial antigen 2, or NG2, is a rat integral membrane proteoglycan found in the plasma membrane of many diverse cell types ... "NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesis." Dev. Dyn. (2001 Oct) 222(2):218 - 227 ... "Chondroitin sulphate proteoglycans: inhibitory components of the glial scar." Prog Brain Res. 2001;132:611-9. PMID 11545024. ...

... or lubricin is a proteoglycan that in humans is encoded by the PRG4 gene. It acts as a joint/boundary lubricant ... "Immunolocalisation and expression of proteoglycan 4 (cartilage superficial zone proteoglycan) in tendon". Matrix Biology. 21 (7 ... "Entrez Gene: PRG4 proteoglycan 4". Schumacher BL, Block JA, Schmid TM, Aydelotte MB, Kuettner KE (May 1994). "A novel ... Schmidt TA, Plaas AH, Sandy JD (May 2009). "Disulfide-bonded multimers of proteoglycan 4 PRG4 are present in normal synovial ...

Chondroitin sulfate proteoglycans (CSPGs) are proteoglycans consisting of a protein core and a chondroitin sulfate side chain. ... Chondroitin sulfate proteoglycans are composed of a core protein and a sugar side chain. The core protein is generally a ... Chondroitin sulfate proteoglycans have been implicated in Alzheimer's disease, stroke, and epilepsy. The two primary markers of ... Galtrey, C. M.; Fawcett, J. W. (2007). "The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the ...

In enzymology, a N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase (EC 2.4.1.226) is an enzyme that catalyzes ... beta-D-glucuronosyl-proteoglycan The 3 substrates of this enzyme are UDP-alpha-D-glucuronate, [[N-acetyl-beta-D-galactosaminyl ... 1->4)-beta-D-glucuronosyl-]], and proteoglycan, whereas its 3 products are UDP, [[beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D- ... galactosaminyl-(1->4)-]], and beta-D-glucuronosyl-proteoglycan. This enzyme belongs to the family of glycosyltransferases, ...

In enzymology, a N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase (EC 2.4.1.225) is an enzyme that catalyzes ... beta-D-glucuronosyl-proteoglycan The 3 substrates of this enzyme are UDP-alpha-D-glucuronate, [[N-acetyl-alpha-D-glucosaminyl-( ... 1->4)-beta-D-glucuronosyl-]], and proteoglycan, whereas its 3 products are UDP, [[beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D- ... glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase. Other names in common use include N-acetylglucosaminylproteoglycan ...

Glucuronyl-galactosyl-proteoglycan+4-alpha-N-acetylglucosaminyltransferase at the U.S. National Library of Medicine Medical ... Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase (EC 2.4.1.223, alpha-N-acetylglucosaminyltransferase ... beta-D-xylosyl-proteoglycan This enzyme is involved in the initiation of heparin and heparan sulfate synthesis. Kitagawa H, ... beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase. This enzyme catalyses the following chemical reaction ...

Glucuronosyl-N-acetylgalactosaminyl-proteoglycan+4-beta-N-acetylgalactosaminyltransferase at the U.S. National Library of ... Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase (EC 2.4.1.175, N- ... N-acetyl-beta-D-galactosaminyl-proteoglycan This enzyme is involved in the biosynthesis of chondroitin sulfate. Rohrmann K, ... N-acetyl-beta-D-galactosaminyl-proteoglycan ⇌ {\displaystyle \rightleftharpoons } UDP + N-acetyl-beta-D-galactosaminyl-(1->4)- ...

Glucuronosyl-N-acetylglucosaminyl-proteoglycan+4-alpha-N-acetylglucosaminyltransferase at the U.S. National Library of Medicine ... Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase (EC 2.4.1.224, alpha-N- ... N-acetyl-alpha-D-glucosaminyl-proteoglycan This enzyme is involved in the biosynthesis of heparin and heparan sulfate. Kim BT, ... N-acetyl-alpha-D-glucosaminyl-proteoglycan ⇌ {\displaystyle \rightleftharpoons } UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)- ...

... -2 (GPC2) is a cell surface heparan sulfate proteoglycan that is important for neuronal cell adhesion and neurite ... Glypicans constitute one of the two major families of heparan sulfate proteoglycans, with the other major family being ... Filmus J, Selleck SB (August 2001). "Glypicans: proteoglycans with a surprise" (PDF). The Journal of Clinical Investigation. ...

FACIT collagen (Fibril Associated Collagens with Interrupted Triple helices) is a type of collagen and also a proteoglycan that ... Proteoglycans and Glycosaminoglycans. Archived from the original on 2006-10-10. Retrieved 2007-03-08. Olsen BR (2014). "Matrix ...

Different types of proteoglycans exist, depending on the sugar that is linked to the oxygen atom of the residue in the protein ... Proteoglycans are usually found on the cell surface and in the extracellular matrix (ECM), and are important for the strength ... Proteoglycans consist of a protein with one or more sugar side chains, known as glycosaminoglycans (GAGs), attached to the ... Absence of proteoglycans is associated with heart and respiratory failure, defects in skeletal development and increased tumor ...

The protein is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The ... Zhang X, Wu C, Song J, Götte M, Sorokin L (November 2013). "Syndecan-1, a cell surface proteoglycan, negatively regulates ... Piperigkou Z, Mohr B, Karamanos N, Götte M (September 2016). "Shed proteoglycans in tumor stroma". Cell and Tissue Research. ... Zhang L, David G, Esko JD (November 1995). "Repetitive Ser-Gly sequences enhance heparan sulfate assembly in proteoglycans". ...

Kim, CW; Goldberger, OA; Gallo, RL; Bernfield, M (1994). "Members of the syndecan family of heparan sulfate proteoglycans are ... Klaus Elenius & Markku Jalkanen (1994). "Function of the syndecans - a family of cell surface proteoglycans". Journal of Cell ... 1992). "Biology of syndecans: a family of transmembrane heparan sulfate proteoglycans". Annu. Rev. Cell Biol. 8: 365-393. doi: ... David, G. (1 August 1993). "Integral membrane heparan sulfate proteoglycans". FASEB J. 7 (11): 1023-1030. doi:10.1096/fasebj. ...

Another important function of the Golgi apparatus is in the formation of proteoglycans. Enzymes in the Golgi append proteins to ... Prydz K, Dalen KT (January 2000). "Synthesis and sorting of proteoglycans". Journal of Cell Science. 113. 113 Pt 2 (2): 193-205 ... glycosaminoglycans, thus creating proteoglycans. Glycosaminoglycans are long unbranched polysaccharide molecules present in the ...

"Entrez Gene: SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1". Périn JP, Alliel PM, Jollès P, ... Kohfeldt E, Maurer P, Vannahme C, Timpl R (1997). "Properties of the extracellular calcium binding module of the proteoglycan ... This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The ... Alliel PM, Perin JP, Jollès P, Bonnet FJ (1993). "Testican, a multidomain testicular proteoglycan resembling modulators of cell ...

The Biochemistry of Glycoproteins and Proteoglycans. Boston, MA: Springer US. ISBN 978-1-4684-1006-8. OCLC 840287599. Kornfeld ...

It occurs as a proteoglycan (HSPG, i.e. Heparan Sulfate ProteoGlycan) in which two or three HS chains are attached in close ... Jackson DG, Bell JI, Dickinson R, Timans J, Shields J, Whittle N (February 1995). "Proteoglycan forms of the lymphocyte homing ... Iozzo RV (1998). "Matrix proteoglycans: from molecular design to cellular function". Annual Review of Biochemistry. 67: 609-52 ... Proteoglycans: structure, biology and molecular interactions. New York, New York: Marcel Dekker Inc. pp. 27-59. ...

Proteoglycans: structure, biology and molecular interactions. Marcel Dekker Inc. New York, New York. pp. 27-59.{{cite book}}: ... of human mammary myoepithelial-like cells by hepatocyte growth factor/scatter factor depends on heparan sulfate proteoglycans ...

Halper J (2014). "Proteoglycans and Diseases of Soft Tissues". Progress in Heritable Soft Connective Tissue Diseases. Advances ... Fibromodulin is a 42kDa protein of a family of small interstitial leucine-rich repeat proteoglycans (SLRPs). It can have up to ... Schaefer L, Gröne HJ, Raslik I, Robenek H, Ugorcakova J, Budny S, Schaefer RM, Kresse H (Oct 2000). "Small proteoglycans of ... Smith MM, Melrose J (2015). "Proteoglycans in normal and healing skin". Adv Wound Care. 4 (3): 152-73. doi:10.1089/wound. ...

Proteoglycans may also help to trap and store growth factors within the ECM. Described below are the different types of ... It occurs as a proteoglycan (PG) in which two or three HS chains are attached in close proximity to cell surface or ECM ... Iozzo RV (1998). "Matrix proteoglycans: from molecular design to cellular function". Annual Review of Biochemistry. 67 (1): 609 ... Proteoglycans have a net negative charge that attracts positively charged sodium ions (Na+), which attracts water molecules via ...

"Entrez Gene: PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)". PDB: ... Eosinophil major basic protein, often shortened to major basic protein (MBP; also called Proteoglycan 2 (PRG2)) is encoded in ... Instead, MBP recognises heparan sulfate proteoglycans. Two crystallographic structures of MBP have been determined. Major basic ... Bone marrow proteoglycan) at the PDBe-KB. (Genes on human chromosome 11, Human proteins). ...

... embedded in hyaluronan and proteoglycans. Skin proteoglycans are varied and have very specific locations. For example, ... Smith, Margaret Mary; Melrose, James (March 2015). "Proteoglycans in Normal and Healing Skin". Advances in Wound Care. 4 (3): ... Iozzo, Renato V. (August 2005). "Basement membrane proteoglycans: from cellar to ceiling". Nature Reviews Molecular Cell ...

Lennarz WJ (1980). The Biochemistry of Glycoproteins and Proteoglycans. Boston, MA: Springer US. p. 227. ISBN 9781468410068. ...

Bland CE, Ginsburg H, Silbert JE, Metcalfe DD (August 1982). "Mouse heparin proteoglycan. Synthesis by mast cell-fibroblast ...

... is a proteoglycan that is on average 90 - 140 kilodaltons (kDa) in molecular weight. It belongs to the small leucine- ... Krumdieck R, Höök M, Rosenberg LC, Volanakis JE (December 1992). "The proteoglycan decorin binds C1q and inhibits the activity ... Fisher LW, Termine JD, Young MF (March 1989). "Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology ... Yamaguchi Y, Mann DM, Ruoslahti E (July 1990). "Negative regulation of transforming growth factor-beta by the proteoglycan ...

Heparanase Bame KJ (June 2001). "Heparanases: endoglycosidases that degrade heparan sulfate proteoglycans". Glycobiology. 11 (6 ... beta-D-glycosidic bonds of heparan sulfate chains in heparan sulfate proteoglycan Heparanase cleaves the linkage between a ...

These structures contain proteins, proteoglycans, and lipids. Enamel lamellae should not be confused with two similar entities ...

Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many ... Rosenberg, RD.; Shworak, NW.; Liu, J.; Schwartz, JJ.; Zhang, L. (May 1997). "Heparan sulfate proteoglycans of the ...

Pawlak AS, Hammond T, Hammond E, Gray SD (January 1996). "Immunocytochemical study of proteoglycans in vocal folds". Ann. Otol ... proteoglycan like fibromodulin, decorin and versican. All these extracellular matrix components together regulate the water ...

Keratan sulfate which may modify core proteins through N-linked glycosylation or O-linked glycosylation of the proteoglycan ... Additionally, for three other keratan sulfated proteoglycans, lumican, keratocan, and mimecan (OGN), the consensus sequence NX( ... Proteoglycans: structure, biology and molecular interactions. New York: Marcel Dekker Inc. pp. 27-59. ISBN 978-0-8247-0334-9.{{ ... HSGAG and CSGAG modified proteoglycans first begin with a consensus Ser-Gly/Ala-X-Gly motif in the core protein. Construction ...