Hunter T (1991). "Protein kinase classification". Protein Phosphorylation Part A: Protein Kinases: Assays, Purification, ... One very important group of protein kinases are the MAP kinases (acronym from: "mitogen-activated protein kinases"). Important ... Hanks SK, Hunter T (May 1995). "Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain ... Protein kinases are also found in bacteria and plants. Up to 30% of all human proteins may be modified by kinase activity, and ...
... (MT-PK) also known as myotonic dystrophy protein kinase (MDPK) or dystrophia myotonica protein kinase ( ... Myotonin-protein kinase is a serine-threonine kinase that is closely related to other kinases that interact with members of the ... Dystrophia myotonica protein kinase (DMPK) is a serine/threonine kinase composed of a kinase domain and a coiled-coil domain ... The dmpk gene product is a Ser/Thr protein kinase homologous to the MRCK p21-activated kinases and Rho kinase family. Data ...
... may refer to: Histidine kinase, an enzyme Protein-histidine tele-kinase, an enzyme Protein-histidine ... pros-kinase, an enzyme This disambiguation page lists articles associated with the title Protein histidine kinase. If an ... Look up protein kinase in Wiktionary, the free dictionary. ...
The protein kinase domain is a structurally conserved protein domain containing the catalytic function of protein kinases. ... Hanks SK, Hunter T (May 1995). "Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain ... Protein kinase function has been evolutionarily conserved from Escherichia coli to Homo sapiens. Protein kinases play a role in ... Protein kinases are a group of enzymes that move a phosphate group onto proteins, in a process called phosphorylation. This ...
It should not be confused with 5'-AMP-activated protein kinase (AMP-activated protein kinase). Protein kinase A, more precisely ... Protein kinase Signal transduction G protein-coupled receptor Serine/threonine-specific protein kinase Myosin light-chain ... out of 540 different protein kinase genes that make up the human kinome, only one other protein kinase, casein kinase 2, is ... Protein kinase A acts to phosphorylate many enzymes important in metabolism. For example, protein kinase A phosphorylates ...
A protein kinase inhibitor (PKI) is a type of enzyme inhibitor that blocks the action of one or more protein kinases. Protein ... the tyrosine kinases act on tyrosine, and a number (dual-specificity kinases) act on all three. There are also protein kinases ... and protein kinase inhibitors can be used to treat diseases due to hyperactive protein kinases (including mutant or ... PMID 34354255 A list of US FDA-approved small molecule protein kinase inhibitors, their protein kinase targets, therapeutic ...
... including integrin-linked kinase (ILK) and mitogen-activated protein kinase-activated protein kinase-2 (MAPKAPK2) can also ... Protein kinase B (PKB), also known as Akt, is the collective name of a set of three serine/threonine-specific protein kinases ... For example, PI 3-kinases may be activated by a G protein coupled receptor or receptor tyrosine kinase such as the insulin ... There are three different genes that encode isoforms of Protein kinase B. These three genes are referred to as AKT1, AKT2, and ...
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G ... "A novel protein kinase with leucine zipper-like sequences: its catalytic domain is highly homologous to that of protein kinase ... "A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta ... This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 ( ...
... protein tau kinase, STK31, tau kinase, [tau-protein] kinase, tau-protein kinase I, tau-protein kinase II, tau-tubulin kinase, ... Human genes encoding proteins with Tau-protein kinase activity include: BRSK1 BRSK2 GSK3A GSK3B Ishiguro K, Ihara Y, Uchida T, ... In enzymology, a tau-protein kinase (EC 2.7.11.26) is an enzyme that catalyzes the chemical reaction ATP + tau protein ⇌ {\ ... Other names in common use include ATP:tau-protein O-hosphotransferase, brain protein kinase PK40erk, cdk5/p20, CDK5/p23, ...
Serine/threonine-protein kinase D1 is an enzyme that in humans is encoded by the PRKD1 gene. Members of the protein kinase D ( ... "The pleckstrin homology domain of protein kinase D interacts preferentially with the eta isoform of protein kinase C". J. Biol ... Holmes AM (1996). "In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence ... "Bruton's tyrosine kinase (Btk) associates with protein kinase C mu". FEBS Lett. 461 (1-2): 68-72. doi:10.1016/s0014-5793(99) ...
... membrane-bound receptor for activated protein kinase C proteins). The protein kinase C enzymes are known for their long-term ... In cell biology, Protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are ... The consensus sequence of protein kinase C enzymes is similar to that of protein kinase A, since it contains basic amino acids ... Aug 2016 Wikimedia Commons has media related to Protein kinase C and PKC activators. protein+kinase+c at the U.S. National ...
... NA-activated also known as protein kinase R (PKR), interferon-induced, double-stranded RNA-activated protein ... Patel RC, Sen GC (August 1998). "PACT, a protein activator of the interferon-induced protein kinase, PKR". The EMBO Journal. 17 ... July 1999). "DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase ... September 2012). "Induction of dsRNA-activated protein kinase links mitochondrial unfolded protein response to the pathogenesis ...
... histidine kinase, histidine protein kinase, protein histidine kinase, protein kinase (histidine), and HK3. Fujitaki JM, Fung G ... In enzymology, a protein-histidine tele-kinase (EC 2.7.13.2) is an enzyme that catalyzes the chemical reaction ATP + protein L- ... protein-histidine kinases). The systematic name of this enzyme class is ATP:protein-L-histidine Ntau-phosphotransferase. Other ... the two substrates of this enzyme are ATP and protein L-histidine, whereas its two products are ADP and protein Ntau-phospho-L- ...
... , also known as B lymphocyte kinase, is a non-receptor tyrosine kinase that in humans is encoded by ... microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase". Mol. Cell. Biol. 13 (9): ... It is of the Src family of tyrosine kinases. The tyrosine-protein kinase BLK has been shown to interact with UBE3A. ... 1993). "Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector ...
The Raf kinase inhibitor protein (RKIP) is a kinase inhibitor protein, that regulates many signaling pathways within the cell. ... RKIP has also been shown to inhibit G protein coupled receptor kinases (GRK) when phosphorylated by protein kinase C. Via this ... Lorenz, Kristina; Lohse, Martin J.; Quitterer, Ursula (4 December 2003). "Protein kinase C switches the Raf kinase inhibitor ... "Raf-1 Kinase Inhibitor Protein: Structure, Function, Regulation of Cell Signaling, and Pivotal Role in Apoptosis". In Vande ...
... ketosamine 3-kinase 2, fructosamine-3-kinase-related protein, ribulosamine/erythrulosamine 3-kinase, ribulosamine 3-kinase) is ... Protein-ribulosamine 3-kinase (EC 2.7.1.172, FN3KRP, FN3K-related protein, FN3K-RP, ... "A mammalian protein homologous to fructosamine-3-kinase is a ketosamine-3-kinase acting on psicosamines and ribulosamines but ... Protein-ribulosamine+3-kinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 2.7. ...
... or protein kinase G (PKG) is a serine/threonine-specific protein kinase that is activated by cGMP ... EC 2.7.11.12 Cyclic GMP-Dependent Protein Kinases and the Cardiovascular System cGMP-Dependent+Protein+Kinases at the U.S. ... suppression of the kinase activity in the absence of cGMP, and interactions with other proteins including protein substrates (2 ... Protein pages needing a picture, Genes on human chromosome 4, Protein kinases, EC 2.7.11). ...
Protein kinase C and Rho-associated protein kinase are involved in regulating calcium ion intake; these calcium ions, in turn ... DMPK-related cell division control protein 42 (Cdc42)-binding kinases (MRCK) and citron kinase. All of these kinases are ... Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine specific ... Rho-associated protein kinase are serine or threonine kinases that determine the calcium sensitivity in smooth muscle cells. ...
... , also known as spleen tyrosine kinase, is an enzyme which in humans is encoded by the SYK gene. SYK ... "Entrez Gene: SYK Spleen tyrosine kinase". Chan AC, Iwashima M, Turck CW, Weiss A (November 1992). "ZAP-70: a 70 kd protein- ... Sada K, Minami Y, Yamamura H (September 1997). "Relocation of Syk protein-tyrosine kinase to the actin filament network and ... Roskoski R (2016). "Ibrutinib inhibition of Bruton protein-tyrosine kinase (BTK) in the treatment of B cell neoplasms". ...
... histidine kinase, histidine protein kinase, protein histidine kinase, protein kinase (histidine), and HK2. Fujitaki JM, Fung G ... In enzymology, a protein-histidine pros-kinase (EC 2.7.13.1) is an enzyme that catalyzes the chemical reaction ATP + protein L- ... protein-histidine kinases). The systematic name of this enzyme class is ATP:protein-L-histidine Npi-phosphotransferase. Other ... the two substrates of this enzyme are ATP and protein L-histidine, whereas its two products are ADP and protein Npi-phospho-L- ...
The A-kinase anchoring proteins or A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have ... AKAPs act as scaffold proteins wherein they bind PKA and other signaling proteins and physically tether these multi-protein ... Marin, Wenwen (January 2020). "A-kinase anchoring protein 1 (AKAP1) and its role in some cardiovascular diseases". Journal of ... Articles with short description, Short description matches Wikidata, A-kinase-anchoring proteins). ...
It should not be confused with cyclic AMP-activated protein kinase (protein kinase A). AMPK is a heterotrimeric protein complex ... "AMP-activated protein kinase kinase activity and phosphorylation of AMP-activated protein kinase in contracting muscle of ... 5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme (EC 2.7.11.31) that ... liver kinase B1 (LKB1), which works in a complex with STRAD and MO25, Calcium/calmodulin-dependent protein kinase kinase II-( ...
This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This ... Wee1-like protein kinase has been shown to interact with YWHAB and PIN1. GRCh38: Ensembl release 89: ENSG00000166483 - Ensembl ... WEE1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology v t e (Articles ... protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition ...
Signal transduction MAP kinase kinase MAP kinase kinase kinase MAP kinase kinase kinase kinase MAPK1 (ERK2) MAPK3 (ERK1) MAPK7 ... A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine ... MAP Kinase Resource . Table of names for mitogen-activated kinases. MAPK cascade picture Mitogen-Activated+Protein+Kinases at ... Extracellular signal-regulated kinases (ERKs) c-Jun N-terminal kinases (JNKs) p38 mitogen-activated protein kinases (p38s) ...
... (EC 2.7.1.171, FN3K, fructosamine 3-kinase) is an enzyme with systematic name ATP:(protein)-N6-D- ... Protein-fructosamine+3-kinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 2.7. ... This enzyme catalyses the following chemical reaction ATP + [protein]-N6-D-fructosyl-L-lysine ⇌ {\displaystyle \ ... Szwergold BS, Howell S, Beisswenger PJ (September 2001). "Human fructosamine-3-kinase: purification, sequencing, substrate ...
... also known as C-terminal Src kinase is an enzyme that, in humans, is encoded by the CSK gene. This ... Universal protein resource accession number P41240 for "Tyrosine-protein kinase CSK" at UniProt. Bräuninger A, Holtrich U, ... and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases". Growth Factors. 23 (3): 233-44 ... "Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell ...
In molecular biology, the kinase binding protein CGI-121 family of proteins includes the kinase binding protein CGI-121 and its ... CGI-121 has been shown to bind to the p53-related protein kinase (PRPK). CGI-121 is part of a conserved protein complex, KEOPS ... p53-related protein kinase)-binding protein". Biochem. Biophys. Res. Commun. 303 (2): 399-405. doi:10.1016/S0006-291X(03)00333- ... This family of proteins also include archaeal homologues. Miyoshi A, Kito K, Aramoto T, Abe Y, Kobayashi N, Ueda N (April 2003 ...
... is a protein that in humans is encoded by the CDC42BPB gene. This gene encodes a member of ... The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this ... "Entrez Gene: CDC42 binding protein kinase beta". Retrieved 2017-05-31. Choi SH, Czifra G, Kedei N, Lewin NE, Lazar J, Pu Y, ... myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta". J. Biol. Chem. 283 (16): 10543-9. doi:10.1074/jbc. ...
Other names in common use include GPBPK, GPBP kinase, STK11, and Goodpasture antigen-binding protein kinase. This enzyme ... protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[Goodpasture antigen-binding protein] ... In enzymology, a Goodpasture-antigen-binding protein kinase (EC 2.7.11.9) is an enzyme that catalyzes the chemical reaction ATP ... Vieites B, Granero F, Forteza J, Saus J (2000). "Goodpasture antigen-binding protein, the kinase that phosphorylates the ...
... are a family of protein kinases within the AGC (protein kinase A, protein kinase G, protein kinase C) group of kinases. Like ... GRK2 activity can be modulated by its phosphorylation by protein kinase A or protein kinase C, and by post-translational ... In the folded proteins, the kinase domain forms a typical bi-lobe kinase structure with a central ATP-binding active site. The ... In particular, G protein-coupled receptor kinase 2 is known to interact with a diverse repertoire of non-GPCR partner proteins ...