The term prostate-specific antigen is a misnomer: it is an antigen but is not specific to the prostate. Although present in ... Prostate-specific antigen has been shown to interact with protein C inhibitor. Prostate-specific antigen interacts with and ... and that prostate was the source. In 1979, Wang purified a tissue-specific antigen from the prostate ('prostate antigen'). PSA ... "The Prostate-Specific Antigen (PSA) Test: Questions and Answers". National Cancer Institute. 21 March 2022. Prostate-Specific+ ...
Prostate-specific antigen (PSA; hk3, human kallikrein gene 3) and human glandular kallikrein (hK2) are used as tumor markers ... KLK2, KLK3, KLK4, KLK5 and KLK14 are expressed in the prostate and are thought to be responsible for regulating semen ... for prostate cancer. Ecallantide, lanadelumab, and berotralstat are FDA-approved drugs that inhibit kallikrein and can be used ... kallikrein 5 is a member of a proteolytic cascade pathway involved in seminal clot liquefaction and potentially in prostate ...
... that binds the prostate protein prostate-specific membrane antigen is used to detect metastases distant from the prostate. CT ... typically blood tests for levels of prostate-specific antigen (PSA) - indicate unusual growth of prostate tissue due to ... This is typically done through blood tests for levels of the protein prostate-specific antigen (PSA), which are elevated in ... A diagnosis of prostate cancer requires a biopsy of the prostate. Prostate biopsies are typically taken by a needle passing ...
Prostate specific antigen (PSA): for prostate cancer. estrogens and progesterone receptor (ER & PR) staining are used both ... A great amount of non-specific binding causes high background staining which will mask the detection of the target antigen. To ... including deparaffinization and antigen retrieval. For formalin-fixed paraffin-embedded tissues, antigen-retrieval is often ... "IHC Tip 1: Antigen retrieval - should I do PIER or HIER?". AbD Serotec. Archived from the original on 2016-04-23. Retrieved ...
... prostate-specific antigen (PSA) ≤ 10 ng/mL; three positive cancer cores with a maximum cancer core length of 5 mm in any one ... Stage T1-T2a and prostate specific antigen less than or equal to 10 ng/mL and Gleason Grade Group 1 based on transrectal ... Padeliporfin, sold under the brand name Tookad, is a medication used to treat men with prostate cancer. The most common side ... Moore CM, Pendse D, Emberton M (January 2009). "Photodynamic therapy for prostate cancer--a review of current status and future ...
"The female prostate and prostate-specific antigen. Immunohistochemical localization, implications of this prostate marker in ... They are homologues of the male prostate gland and are also referred to as the female prostate. Pelvic floor muscles help to ... Through hundreds of photographs, she demonstrates that the image of a female displaying her vulva is not specific to European ... Rimoin, Lauren P.; Kwatra, Shawn G.; Yosipovitch, Gil (2013). "Female-specific pruritus from childhood to postmenopause: ...
"Screening for Prostate Cancer With Prostate-Specific Antigen Testing: American Society of Clinical Oncology Provisional ... "Prostate specific antigen best practice statement: 2009 update". The Journal of Urology. 189 (1 Suppl): S2-S11. doi:10.1016/j. ... Harris, Gardner (6 October 2011). "U.S. Panel Says No to Prostate Screening for Healthy Men". New York Times. Retrieved 2011-10 ... American Cancer Society Prostate Cancer Advisory, Committee (Mar-Apr 2010). "American Cancer Society guideline for the early ...
Prostate-specific antigen (PSA) is secreted by the epithelial cells of the prostate gland and can be detected in a sample of ... Carroll PR, Whitson JM, Cooperberg MR (February 2011). "Serum prostate-specific antigen for the early detection of prostate ... 4 November 2014). "Recommendations on screening for prostate cancer with the prostate-specific antigen test". Canadian Medical ... Bouchelouche, Kirsten; Choyke, Peter L. (2018). "Advances in prostate-specific membrane antigen PET of prostate cancer". ...
Lippi G, Plebani M, Franchini M, Guidi GC, Favaloro EJ (October 2009). "Prostate-specific antigen, prostate cancer, and ... PAP levels have been reported to be elevated in men with prostate cancer. Gebbink MF (July 2011). "Tissue-type plasminogen ...
"Bioassay of prostate-specific antigen (PSA) using microcantilevers" (PDF). Nature Biotechnology. 19 (9): 856-860. doi:10.1038/ ...
Jun T, Oh WK (July 2022). ""Does Circulating Tumor DNA Measure Up to Prostate-Specific Antigen?"". JAMA Oncol. 8 (7): 972-974. ... Oh is Chief Medical Officer for the Prostate Cancer Foundation, the world's leading philanthropy for prostate cancer. He ... prostate cancer and for three trials of neoadjuvant chemotherapy in high-risk localized prostate cancer patients. At the Dana- ... William Oh, MD". Mount Sinai Hospital homepage Icahn School of Medicine at Mount Sinai homepage Prostate Cancer Foundation ...
Jeong S, Han SR, Lee YJ, Lee SW (March 2010). "Selection of RNA aptamers specific to active prostate-specific antigen". ... Savory N, Abe K, Sode K, Ikebukuro K (December 2010). "Selection of DNA aptamer against prostate specific antigen using a ... prostate specific antigen (PSA), dopamine, and the non-classical oncogene, heat shock factor 1 (HSF1). Aptamers have been ... Aptamers are short sequences of artificial DNA, RNA, XNA, or peptide that bind a specific target molecule, or family of target ...
2003). "ELAC2/HPC2 polymorphisms, prostate-specific antigen levels, and prostate cancer". J. Natl. Cancer Inst. 95 (11): 818-24 ... a putative prostate cancer susceptibility gene product, potentiates TGF-beta/Smad-induced growth arrest of prostate cells". ... 2002). "ELAC2 and prostate cancer risk in Afro-Caribbeans of Tobago". Hum. Genet. 111 (4-5): 398-400. doi:10.1007/s00439-002- ... 2001). "A candidate prostate cancer susceptibility gene at chromosome 17p". Nat. Genet. 27 (2): 172-80. doi:10.1038/84808. PMID ...
Akiyama K, Nakamura T, Iwanaga S, Hara M (December 1987). "The chymotrypsin-like activity of human prostate-specific antigen, ...
... prostate-specific antigen, alpha-seminoprotein, seminin, P-30 antigen, antigen (human clone HPSA-1 prostate-specific protein ... Prostate-specific antigen Digby M, Zhang XY, Richards RI (March 1989). "Human prostate specific antigen (PSA) gene: structure ... Christensson A, Laurell CB, Lilja H (December 1990). "Enzymatic activity of prostate-specific antigen and its reactions with ... human prostate-specific), human glandular kallikrein, antigen PSA (human clone 5P1 protein moiety reduced)) is an enzyme. This ...
"Mutations in the prostate specific antigen (PSA/KLK3) correlate with male infertility". Scientific Reports. 7 (1): 11225. ... "Mutations in the prostate specific antigen (PSA/KLK3) correlate with male infertility". Scientific Reports. 7 (1): 11225. ...
Prostate-specific antigen (PSA) may be detected within a 48-hour period. The seminal fluid of vasectomized men also contains a ...
Amanitin-based antibody-drug conjugates targeting the prostate-specific membrane antigen PSMA. Poster #664. AACR Annual Meeting ... α-Amanitin has an unusually strong and specific attraction to the enzyme RNA polymerase II. Upon ingestion and uptake by liver ...
September 2018). "Prostate cancer screening with prostate-specific antigen (PSA) test: a systematic review and meta-analysis". ... November 2014). "Recommendations on screening for prostate cancer with the prostate-specific antigen test". CMAJ. 186 (16): ... Prostate biopsy is a procedure in which small hollow needle-core samples are removed from a man's prostate gland to be examined ... MRI-guided prostate biopsy appears to be superior to standard TRUS-biopsy in prostate cancer detection. Several groups in the U ...
2004). "Regulation of the expression of the prostate-specific antigen by claudin-7". J. Membr. Biol. 194 (3): 187-97. doi: ... Peacock RE, Keen TJ, Inglehearn CF (1998). "Analysis of a human gene homologous to rat ventral prostate.1 protein". Genomics. ...
... are not hormone-sensitive and do not express prostate-specific antigen (PSA). DU145 cells have moderate metastatic ... Castration-resistant prostate cancer (CRPC) is prostate cancer that progresses despite extremely low testosterone in the body ... DU145 (DU-145) is a human prostate cancer cell line. DU145, PC3, and LNCaP are considered to be the standard prostate cancer ... Although specific pathways remain unclear, deactivating the NEK6 gene is able to decrease clonogenic capacity, proliferation, ...
... diagnosis by prostate-specific antigen". Gastrointestinal Endoscopy. 33 (6): 467-468. doi:10.1016/s0016-5107(87)71703-9. PMID ... Complications are uncommon, but include massive rectal bleeding, ulceration into the prostate gland or formation of a stricture ... Gilrane TB, Orchard JL, Al-Assaad ZA (December 1987). "A benign rectal ulcer penetrating into the prostate-- ...
Some screening protocols are currently not accurate (such as prostate-specific antigen testing). Others such as a colonoscopy ... Some specific foods are linked to specific cancers. There is strong evidence that processed meat and red meat intake increases ... Epigenetic mechanisms are necessary to maintain normal sequences of tissue specific gene expression and are crucial for normal ... is a prostate cancer vaccine Inactivated tumor cells are investigated as potential bifunctional cancer vaccines Newer forms of ...
Noguchi K, Uemura H, Takeda M, Sekiguchi Y, Ogawa K, Hosaka M (September 2000). "[Rebound of prostate specific antigen after ... Allylestrenol therapy for BPH is associated with a significant decrease in prostate-specific antigen levels, which may mask the ... July 2006). "Recovery of serum prostate specific antigen value after interruption of antiandrogen therapy with allylestrenol ... Allylestrenol has also been studied in the treatment of prostate cancer in Japan. The medication has been studied as a puberty ...
Proteolysis by prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The ... Semenogelin along with prostate-specific antigen, are commonly tested for during crime scene investigation. de Lamirande E, ...
After immobilizing single-domain antibodies on sensor surfaces sensing human prostate-specific antigen (hPSA) were tested. The ... December 2005). "Engineering camel single-domain antibodies and immobilization chemistry for human prostate-specific antigen ... Like a whole antibody, it is able to bind selectively to a specific antigen. With a molecular weight of only 12-15 kDa, single- ... Nanobody conjugates recognizing antigen presenting cells have been successfully used for tumor detection or targeted antigen ...
Prostate-Specific Antigen) and has been contributing to prostate cancer. There are a lot of biomarkers are considering as being ... The specific alkali metal(s) and gases are also chosen based on the desired applications. Once the cell is complete, a surface ... One specific example of biomarker is blood cholesterol that is commonly acquainted with us reliable for coronary heart disease ... Generally, the NMR coils are hand made for the specific purpose, either by turning copper wire by hand in the desired shape, or ...
18 (CK18) and prostate specific antigen (PSA). This would help in the further characterization of disseminated individual ... Prostate specific antigen, placental alkaline phosphatase, human chorionic gonadotrophin, α-fetoprotein and others are organ- ... In the flow cytometry-based screening, a mixture of antigen-negative cells and antigen-positive cells is used as the antigen to ... "Immunocytochemical double staining of cytokeratin and prostate specific antigen in individual prostatic tumour cells". ...
The median maximum decrease in levels of prostate-specific antigen (PSA) levels was 99.6%. Enzalutamide has approximately 8- ... nonmetastatic castration-resistant prostate cancer, and metastatic castration-sensitive prostate cancer (mCSPC). It is taken by ... The drug has only 2-fold lower affinity for the AR than DHT, the endogenous ligand of the AR in the prostate gland. When LNCaP ... In doing so, it prevents the effects of these hormones in the prostate gland and elsewhere in the body. Enzalutamide was first ...
"Prostate specific antigen: a prognostic marker of survival in good prognosis metastatic prostate cancer? (EORTC 30892)". ... January 2003). "Tissue polypeptide-specific antigen (TPS) determinations before and during intermittent maximal androgen ... Smith PH, Robinson M, Richards B, Suciu S, De Pauw M, Sylvester R, Denis L (June 1984). "Estramustine phosphate in prostate ... April 2004). "Metastatic prostate cancer treated by flutamide versus cyproterone acetate. Final analysis of the "European ...