SLP-76 is triggered when the TCR binds its ligand by the phosphorylation of tyrosines on the N-terminus by ZAP-70, a tyrosine ... "SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells". ... activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine ... activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine ...
Tyrosine-protein kinase TXK is an enzyme that in humans is encoded by the TXK gene. GRCh38: Ensembl release 89: ENSG00000074966 ... 1996). "Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function". J. Biol. ... "A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment ... a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12". Hum Mol ...
... protein kinase Lck is recruited and phosphorylates the ITAMs of the CD3 cytoplasmic tail. ZAP70 is then recruited to the ... "Tyrosine phosphorylation-dependent activation of NF-kappa B. Requirement for p56 LCK and ZAP-70 protein tyrosine kinases". ... "DNA binding of repressor nuclear factor-kappaB p50/p50 depends on phosphorylation of Ser337 by the protein kinase A catalytic ... Through a cascade of phosphorylation events, the kinase complex is activated and NF-κB is able to enter the nucleus to ...
... mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C ... Gotoh N, Toyoda M, Shibuya M (Apr 1997). "Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in ... Walk SF, March ME, Ravichandran KS (Aug 1998). "Roles of Lck, Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation ... receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase". The ...
... spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70 ... Katzav S, Sutherland M, Packham G, Yi T, Weiss A (December 1994). "The protein tyrosine kinase ZAP-70 can associate with the ... Huby RD, Carlile GW, Ley SC (December 1995). "Interactions between the protein-tyrosine kinase ZAP-70, the proto-oncoprotein ... and it is a member of the protein-tyrosine kinase family and is a close homolog of SYK. SYK and ZAP70 share a common ...
Phosphorylated ITAMs in the cytoplasmic tails of CD3 recruit protein tyrosine kinase Zap70 that can bind to the phosphorylated ... Tyrosine kinase Fyn might be involved in ITAM phosphorylation but is not essential for TCR signalling. ... Zap70 is able to phosphorylate multiple tyrosine residues of the transmembrane protein LAT. LAT is a scaffold protein ... These pathway use a phosphorylation cascade of three successive acting protein kinases to transmit a signal. The three MAPK ...
... a Syk family protein tyrosine kinase, to bind, become activated, and phosphorylate LAT. ZAP-70 phosphorylates tyrosines on LAT ... Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular ... and are members of the Grb2 protein family, such as Gads. Moreover, phosphorylation of LAT tyrosine 132 allows for PLCγ1-LAT ... "SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells". ...
Huby RD, Carlile GW, Ley SC (Dec 1995). "Interactions between the protein-tyrosine kinase ZAP-70, the proto-oncoprotein Vav, ... induces tyrosine phosphorylation of alpha-tubulin and its association with the SH2 domain of the p59fyn protein tyrosine kinase ... Tubulin alpha-4A chain is a protein that in humans is encoded by the TUBA4A gene. Microtubules of the eukaryotic cytoskeleton ... Kirsch J, Langosch D, Prior P, Littauer UZ, Schmitt B, Betz H (Nov 1991). "The 93-kDa glycine receptor-associated protein binds ...
"Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway". The Journal of Biological ... Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE (Jan 1998). "LAT: the ZAP-70 tyrosine kinase substrate that links ... "Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav". Biochemistry. 41 (34): 10732-40. ... GRB2-related adapter protein is a protein that in humans is encoded by the GRAP gene. This gene encodes a member of the GRB2/ ...
Dephosphorylation of kinases LCK and ZAP70 by a PTPN22 is specific concerning the phosphorylated tyrosine in those proteins - ... and by a phosphorylation of its activation tyrosine (Y394). LCK then phosphorylate tyrosines in the CD3 complex creating a ... Cloutier JF, Veillette A (September 1996). "Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine ... is a cytoplasmatic protein encoded by gene PTPN22 and a member of PEST family of protein tyrosine phosphatases. This protein is ...
"Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases". The Journal ... Lck tyrosine phosphorylates a number of proteins, the most important of which are the CD3 receptor, CEACAM1, ZAP-70, SLP-76, ... "Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase". The ... Lck (or lymphocyte-specific protein tyrosine kinase) is a 56 kDa protein that is found inside specialized cells of the immune ...
However, activation of SYK relies less on phosphorylation by Src family kinases than ZAP70. SYK and ZAP70 share a common ... Tyrosine-protein kinase SYK, also known as spleen tyrosine kinase, is an enzyme which in humans is encoded by the SYK gene. SYK ... along with ZAP70, is a member of the Syk family of tyrosine kinases. These cytoplasmic non-receptor tyrosine kinases share a ... "Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases". The Journal of Biological ...
... which activates Protein kinase A. PKA leads to protein tyrosine phosphorylation.Phospholipase C (PLC) is involved in acrosome ... Syk kinase is specific of lymphocytes B and Zap-70 is present in T cells. After activation of these enzymes, some adaptor ... These proteins activate protein tyrosine kinase (PTK) that phosphorylates various proteins important for capacitation and ... Phosphatidylinositol 3-Kinase) results in activation of AKT/PKB (Protein Kinase B). This kinase is involved in cell survival ...
Such prolonged phosphorylation of ITAMs by Lck kinase allows time for ZAP-70 recruitment, its activation by phosphorylation and ... The tyrosine kinase Lck functions either in conjunction with a co-receptor molecule (CD4 or CD8) or as a free Lck kinase. The ... On plasma membrane of a T cell there is the T-cell receptor (consists of α,β chains and multiple CD3 adaptor proteins), as well ... tyrosine kinase Lck phosphorylates ITAMs in CD3 complex) and factors that inhibit signalling (tyrosine phosphatases CD45 and ...
Kinase activity of Zap70 can be increased by phosphorylation of Tyr-493 in the activation loop by Src family member Lck. ... to tyrosine residues in proteins. Non-receptor tyrosine kinases are a subgroup of protein family tyrosine kinases, enzymes that ... Unlike the receptor tyrosine kinases (RTKs), the second subgroup of tyrosine kinases, the non-receptor tyrosine kinases are ... Non-receptor tyrosine kinases do not contain only a tyrosine kinase domain, nRTKs also possess domains that mediate protein- ...
"Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in ... is a binding partner for c-Src family protein-tyrosine kinases". Curr. Biol. 6 (8): 981-8. doi:10.1016/s0960-9822(02)00642-5. ... Paz PE, Wang S, Clarke H, Lu X, Stokoe D, Abo A (2001). "Mapping the Zap-70 phosphorylation sites on LAT (linker for activation ... "Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor". ...
... activated tyrosine kinase. The receptor protein tyrosine phosphatase PTPmu (PTPRM) is capable of dephosphorylating PLCG1. Two ... "Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in ... Paz PE, Wang S, Clarke H, Lu X, Stokoe D, Abo A (June 2001). "Mapping the Zap-70 phosphorylation sites on LAT (linker for ... PLCG1 can be activated by receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases. For example, when activated, ...
1999). "A direct interaction between the adaptor protein Cbl-b and the kinase zap-70 induces a positive signal in T cells". ... 1999). "Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation". Oncogene. 18 (5): 1147-56. ... 1997). "Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation". Oncogene ... Elly C, Witte S, Zhang Z, Rosnet O, Lipkowitz S, Altman A, Liu YC (February 1999). "Tyrosine phosphorylation and complex ...
Raab M, Yamamoto M, Rudd CE (1994). "The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase ... Gary-Gouy H, Lang V, Sarun S, Boumsell L, Bismuth G (1997). "In vivo association of CD5 with tyrosine-phosphorylated ZAP-70 and ... "Human CD5 signaling and constitutive phosphorylation of C-terminal serine residues by casein kinase II". J. Immunol. 161 (11): ... "Residues Y429 and Y463 of the human CD5 are targeted by protein tyrosine kinases". Eur. J. Immunol. 31 (4): 1191-8. doi:10.1002 ...
"T Cell Receptor Signalling Results in Rapid Tyrosine Phosphorylation of the Linker Protein LAT Present in Detergent-Resistant ... then recruit doubly acylated non-receptor Src-like tyrosine kinases to phosphorylate ITAM tyrosine residues. In addition to ... Following this procedure, ZAP-70 (which is also different with IgE signalling) binds to phosphorylated ITAMs, which leads to ... Csk may then suppress the Src-family kinases through phosphorylation. B cell antigen receptor (BCR) is a complex between a ...
"Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS". Molecular and ... Paz PE, Wang S, Clarke H, Lu X, Stokoe D, Abo A (June 2001). "Mapping the Zap-70 phosphorylation sites on LAT (linker for ... "SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1". The Journal of Biological ... "Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein ...
"Synergistic activation of a family of phosphoinositide 3-kinase via G-protein coupled and tyrosine kinase-related receptors". ... Ibarrola I, Vossebeld PJ, Homburg CH, Thelen M, Roos D, Verhoeven AJ (1997). "Influence of tyrosine phosphorylation on protein ... Paz PE, Wang S, Clarke H, Lu X, Stokoe D, Abo A (2001). "Mapping the Zap-70 phosphorylation sites on LAT (linker for activation ... "Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity". J. Biol. Chem. 269 ( ...
Katzav S, Sutherland M, Packham G, Yi T, Weiss A (1995). "The protein tyrosine kinase ZAP-70 can associate with the SH2 domain ... activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine ... Hehner SP, Li-Weber M, Giaisi M, Dröge W, Krammer PH, Schmitz ML (April 2000). "Vav synergizes with protein kinase C theta to ... Matsuguchi T, Inhorn RC, Carlesso N, Xu G, Druker B, Griffin JD (1995). "Tyrosine phosphorylation of p95Vav in myeloid cells is ...
... intracellular protein kinases interact with surface receptors to generate an intracellular protein-tyrosine phosphorylation ... leading to the recruitment of a second tyrosine kinase ZAP-70 that control the ability of T-cells to respond to foreign ... 1989) The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. Proc. ... CD4, CD8 and the TcR/CD3 Complex: a novel class of protein tyrosine kinase receptor (1990) Immunology Today, 11, 400-406 ...
"The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src ... "Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases". J. Biol. Chem. 273 (15): 8867- ... Lin H, Martelli MP, Bierer BE (January 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T ... Howlett CJ, Robbins SM (March 2002). "Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular ...
2003). "Tyrosine phosphorylation of VHR phosphatase by ZAP-70". Nat. Immunol. 4 (1): 44-8. doi:10.1038/ni856. PMID 12447358. ... They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are ... Dual specificity protein phosphatase 3 is an enzyme that in humans is encoded by the DUSP3 gene. The protein encoded by this ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ...
... is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been ... Tyrosine phosphorylation of target proteins by Fyn serves to either regulate target protein activity, and/or to generate a ... Tau protein, TrkB, TYK2, TUBA3C, WAS, and ZAP-70, The Src family of kinases is commonly associated with its role in "invasion ... Fyn is a tyrosine-specific phospho-transferase that is a member of the Src family of non-receptor tyrosine protein kinases. ( ...
"Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity". The Journal of ... "Binding of HIV-1 to its receptor induces tyrosine phosphorylation of several CD4-associated proteins, including the ... Lin H, Martelli MP, Bierer BE (January 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T ... Fukazawa T, Miyake S, Band V, Band H (June 1996). "Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) ...
It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein ... May 2002). "Tyrosine phosphorylation regulates alpha II spectrin cleavage by calpain". Molecular and Cellular Biology. 22 (10 ... "Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation". The Journal of ... July 2002). "Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight ...
... tyrosine kinase receptors and Src homology 3 domain proteins". Oncogene. 10 (8): 1475-83. PMID 7537362. Lindholm CK, Gylfe E, ... "The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in ... Lymphocyte cytosolic protein 2, PIK3R1, Src, VAV1, and ZAP-70. GRCh38: Ensembl release 89: ENSG00000107338 - Ensembl, May 2017 ... tyrosine kinase receptors and Src homology 3 domain proteins". Oncogene. 10 (8): 1475-83. PMID 7537362. Welsh M, Mares J, ...