Phosphatidylinositol phosphate
... may refer to: Phosphatidylinositol 3-phosphate, also known as PI(3)P Phosphatidylinositol 4- ... phosphate, also known as PI(4)P Phosphatidylinositol 5-phosphate, also known as PI(5)P This disambiguation page lists articles ... associated with the title Phosphatidylinositol phosphate. If an internal link led you here, you may wish to change the link to ...
Phosphatidylinositol 5-phosphate
Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and ... Phosphatidylinositol 4-phosphate and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate). Notably, steady-state PtdIns5P ... Phosphatidylinositol 5-phosphate is one of the 7 known cellular phosphoinositides with less understood functions. It is ... Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells. J ...
Phosphatidylinositol-4-phosphate 5-kinase
Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A) Phosphatidylinositol-5-phosphate 4-kinase type-2 beta (PIP4K2B ... Phosphatidylinositol-4-phosphate 5-kinases (PIP5Ks, or PI4P5Ks) are a class of enzymes that phosphorylate phosphatidylinositol ... September 2010). "Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain ... Type I phosphatidylinositol-4-phosphate 5-kinase (PIP5KI) are further classified as PIP5Kα, PIP5Kβ and PIP5Kγ on the basis of ...
Phosphatidylinositol 3-phosphate
... (PtdIns3P) is a phospholipid found in cell membranes that helps to recruit a range of proteins ... Phosphatidylinositol 3-phosphate-binding protein 2 Gillooly DJ, Simonsen A, Stenmark H (April 2001). "Cellular functions of ... Stenmark H, Aasland R, Driscoll PC (February 2002). "The phosphatidylinositol 3-phosphate-binding FYVE finger". FEBS Letters. ... phosphatidylinositol 3-phosphate and FYVE domain proteins". The Biochemical Journal. 355 (Pt 2): 249-58. doi:10.1042/0264-6021: ...
Phosphatidylinositol 4-phosphate
Phosphatidylinositol 3-phosphate Phosphatidylinositol 5-phosphate Phosphatidylinositol (3,4,5)-trisphosphate Godi A et al., ... Phosphatidylinositol-4-phosphate (PtdIns4P, PI-4-P, PI4P, or PIP) is a precursor of phosphatidylinositol (4,5)-bisphosphate. ... "Lipid Membrane Curvature Induced by Distearoyl Phosphatidylinositol 4-Phosphate". Soft Matter. 8 (11): 3090-3093. doi:10.1039/ ... "Pressure-dependent inverse bicontinuous cubic phase formation in a phosphatidylinositol 4-phosphate/phosphatidylcholine system ...
Phosphatidylinositol phosphate kinases
Phosphatidylinositol-4-phosphate 3-kinase Phosphatidylinositol-4,5-bisphosphate 3-kinase Phosphatidylinositol-4-phosphate 5- ... Phosphatidylinositol phosphate kinases (PIPK) are kinases that phosphorylate the phosphoinositides PtdInsP and PtdInsP2 that ... The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity. Mol Cell 2000 5:1-11 v t e ( ... Phosphatidylinositol phosphate kinases, a multifaceted family of signalling enzymes. J Biol Chem 1999; 274:9907-9910 Kunz J, ...
Phosphatidylinositol-4-phosphate 3-kinase
In enzymology, a phosphatidylinositol-4-phosphate 3-kinase (EC 2.7.1.154) is an enzyme that catalyzes the chemical reaction ATP ... The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase. Other names in ... This enzyme participates in phosphatidylinositol signaling system. As of late 2007, 3 structures have been solved for this ... the two substrates of this enzyme are ATP and 1-phosphatidyl-1D-myo-inositol 4-phosphate, whereas its two products are ADP and ...
1-phosphatidylinositol-4-phosphate 5-kinase
... phosphatidylinositol 4-phosphate kinase, phosphatidylinositol-4-phosphate 5-kinase, and type I PIP kinase. This enzyme ... In enzymology, 1-phosphatidylinositol-4-phosphate 5-kinase (EC 2.7.1.68) is an enzyme that catalyzes the chemical reaction ATP ... The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase. Other names in ... participates in 3 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, and regulation of ...
1-phosphatidylinositol-3-phosphate 5-kinase
... and phosphatidylinositol 3-phosphate 5-kinase. This enzyme participates in phosphatidylinositol signaling system and regulation ... In enzymology, a 1-phosphatidylinositol-3-phosphate 5-kinase (EC 2.7.1.150) is an enzyme that catalyzes the chemical reaction ... "The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae". ... The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase. Other names in ...
1-phosphatidylinositol-5-phosphate 4-kinase
In enzymology, a 1-phosphatidylinositol-5-phosphate 4-kinase (EC 2.7.1.149) is an enzyme that catalyzes the chemical reaction ... This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, and ... The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase. This enzyme is ... Rameh LE, Tolias KF, Duckworth BC, Cantley LC (1997). "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". ...
PIP5K1C
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma is an enzyme that in humans is encoded by the PIP5K1C gene. This gene ... Ishihara H, Shibasaki Y, Kizuki N, Wada T, Yazaki Y, Asano T, Oka Y (May 1998). "Type I phosphatidylinositol-4-phosphate 5- ... 2007). "Type Igamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct ... "Entrez Gene: PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma". "Salmonella infection data for Pip5k1c". ...
Metabolic regulation of hematopoiesis
Targets of PTPMT-1 include phosphatidylinositol phosphates (PIPs). When PIPs are acted upon by PTPMT-1, the mitochondrial ... Upregulation of glycolysis in proliferative HSCs may drive the pentose phosphate pathway (PPP) to maintain redox balance upon ... The PPP generates nicotinamide adenine dinucleotide phosphate (NADPH), which is a powerful cellular reducing agent. Production ...
Phytase
Conway SJ, Miller GJ (2007). "Biology-enabling inositol phosphates, phosphatidylinositol phosphates and derivatives". Nat Prod ... The organic phosphate found in phytic acid is largely unavailable to the animals that consume it, but the inorganic phosphate ... phenyl phosphate, fructose 1,6-bisphosphate, glucose 6-phosphate, glycerophosphate and 3-phosphoglycerate. Only a few phytases ... Phytases hydrolyze phosphates from phytic acid in a stepwise manner, yielding products that again become substrates for further ...
Andrew Bruce Holmes
"Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes". Organic & Biomolecular Chemistry. 8 (1 ...
Phosphatidylinositol diacylglycerol-lyase
Michell RH, Allan D (1975). "Inositol cyclis phosphate as a product of phosphatidylinositol breakdown by phospholipase C ( ... 2-cyclic-phosphate-forming). Other names in common use include monophosphatidylinositol phosphodiesterase, phosphatidylinositol ... 2-cyclic-phosphate-forming). It participates in inositol phosphate metabolism. As of late 2007, two structures have been solved ... The enzyme phosphatidylinositol diacylglycerol-lyase (EC 4.6.1.13) catalyzes the following reaction: 1-phosphatidyl-1D-myo- ...
MTMR2
Phosphatidylinositol-3-phosphate phosphatase". Retrieved March 7, 2020. Laporte J, Hu LJ, Kretz C, Mandel JL, Kioschis P, Coy ... Myotubularin-related protein 2 also known as phosphatidylinositol-3,5-bisphosphate 3-phosphatase or phosphatidylinositol-3- ... "RecName: Full=Myotubularin-related protein 2; AltName: Full=Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; AltName: Full= ... phosphate phosphatase is a protein that in humans is encoded by the MTMR2 gene. This gene is a member of the myotubularin ...
PIK3C2A
Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide is an enzyme that in humans is encoded by the ... A source of phosphatidylinositol 3-phosphate". J. Biol. Chem. 273 (23): 14081-14084. doi:10.1074/jbc.273.23.14081. PMID 9603905 ... Cook JA, August A, Henderson AJ (2002). "Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a ... 1998). "Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat ...
Omegasome
... is a cell organelle consisting of lipid bilayer membranes enriched for phosphatidylinositol 3-phosphate (abbreviated ... Nascimbeni, Anna Chiara; Codogno, Patrice; Morel, Etienne (2017). "Phosphatidylinositol-3-phosphate in the regulation of ... 2008). "Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically ...
HGS (gene)
"Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells". EMBO J. 19 (17): 4577-88. doi:10.1093/emboj/ ...
PIP4K2C
Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma is an enzyme in humans that is encoded by the PIP4K2C gene. It is one ... "Entrez Gene: Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma". PDBe-KB provides an overview of all the structure ... of the phosphatidylinositol 4-phosphate 5-kinases. GRCh38: Ensembl release 89: ENSG00000166908 - Ensembl, May 2017 GRCm38: ... information available in the PDB for Human Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP4K2C) Portal: Biology v t ...
PIKFYVE
September 2006). "Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed ... PIKfyve activity is responsible for the production of both PtdIns(3,5)P2 and phosphatidylinositol 5-phosphate (PtdIns5P). ... Sbrissa D, Ikonomov OC, Deeb R, Shisheva A (December 2002). "Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve ... Sbrissa D, Ikonomov OC, Deeb R, Shisheva A (December 2002). "Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve ...
Phosphatidylinositol 4,5-bisphosphate
PIP2 is formed primarily by the type I phosphatidylinositol 4-phosphate 5-kinases from PI(4)P. In metazoans, PIP2 can also be ... 2005). "Phosphatidylinositol phosphate kinase type Iγ regulates dynamics of large dense-core vesicle fusion". PNAS. 102 (14): ... Bulley SJ, Clarke JH, Droubi A, Giudici ML, Irvine RF (2015). "Exploring phosphatidylinositol 5-phosphate 4-kinase function". ... Phosphatidylinositol 4,5-bisphosphate or PtdIns(4,5)P2, also known simply as PIP2 or PI(4,5)P2, is a minor phospholipid ...
PIP4K2A
"Entrez Gene: PIP5K2A phosphatidylinositol-4-phosphate 5-kinase, type II, alpha". Xu H, Yang W, Perez-Andreu V, Devidas M, Fan Y ... Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha is an enzyme that in humans is encoded by the PIP4K2A gene. ... This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family. Through genome wide association studies (GWAS), ... Overview of all the structural information available in the PDB for UniProt: P48426 (Phosphatidylinositol 5-phosphate 4-kinase ...
Phosphatidylinositol-3,4-bisphosphate 4-phosphatase
This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system. Howell S, Barnaby RJ, Rowe ... 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate This enzyme belongs to the family of hydrolases, specifically those ... The enzyme phosphatidylinositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) that catalyzes the reaction 1-phosphatidyl-myo- ...
1-phosphatidylinositol 4-kinase
This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system. As of late 2007, the ... phosphatidylinositol 4-kinase, phosphatidylinositol kinase, type II phosphatidylinositol kinase, PI kinase, and PI 4-kinase. ... phosphatidylinositol-3-phosphate". Nature. 332 (6165): 644-6. Bibcode:1988Natur.332..644W. doi:10.1038/332644a0. PMID 2833705. ... In enzymology, a 1-phosphatidylinositol 4-kinase (EC 2.7.1.67) is an enzyme that catalyzes the chemical reaction ATP + 1- ...
TLN1
Ling K, Doughman RL, Firestone AJ, Bunce MW, Anderson RA (Nov 2002). "Type I gamma phosphatidylinositol phosphate kinase ... "Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin". Nature. 420 ( ...
Inositol-tetrakisphosphate 1-kinase
This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system. As of late 2007, 3 ...
PIP5K1A
Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha is an enzyme that in humans is encoded by the PIP5K1A gene. GRCh38: ... "Entrez Gene: PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha". Honda A, Nogami M, Yokozeki T, et al. (1999). " ... 2000). "Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible ... Xie Y, Zhu L, Zhao G (Jun 2000). "Assignment of type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K1A) to human chromosome ...
PIP4K2B
Phosphatidylinositol-5-phosphate 4-kinase type-2 beta is an enzyme that in humans is encoded by the PIP4K2B gene. The protein ... "Entrez Gene: PIP5K2B phosphatidylinositol-4-phosphate 5-kinase, type II, beta". Bultsma, Yvette; Keune, Willem-Jan; Divecha, ... This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family. The encoded protein sequence does not show ... 2007). "Genomic tagging of endogenous type IIbeta phosphatidylinositol 5-phosphate 4-kinase in DT40 cells reveals a nuclear ...
Lewis C. Cantley
... phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae". J. Biol. Chem. 264 (34): 20181-4. doi:10.1016/S0021 ... phosphatidylinositol-3-phosphate". Nature. 332 (6165): 644-6. Bibcode:1988Natur.332..644W. doi:10.1038/332644a0. PMID 2833705. ... Whitman M, Downes CP, Keeler M, Keller T, Cantley L (April 1988). "Type I phosphatidylinositol kinase makes a novel inositol ... Yoakim M, Hou W, Songyang Z, Liu Y, Cantley L, Schaffhausen B (September 1994). "Genetic analysis of a phosphatidylinositol 3- ...