European Association for Clinical Pharmacology and TherapeuticsFragment-based lead discovery: Fragment-based lead discovery (FBLD) also known as fragment-based drug discovery (FBDD) is a method used for finding lead compounds as part of the drug discovery process. It is based on identifying small chemical fragments, which may bind only weakly to the biological target, and then growing them or combining them to produce a lead with a higher affinity.Timeline of the nuclear program of Iran: This is the timeline of the nuclear program of Iran.Drug action: The action of drugs on the human body is called pharmacodynamics, and what the body does with the drug is called pharmacokinetics. The drugs that enter the human tend to stimulate certain receptors, ion channels, act on enzymes or transporter proteins.List of pharmaceutical compound number prefixes: This list of pharmaceutical compound number prefixes details a pharmaceutical drug labeling standard. Pharmaceutical companies produce a large number of compounds, which cannot all be given names.Concentration effect: In the study of inhaled anesthetics, the concentration effect is the increase in the rate that the Fa(alveolar concentration)/Fi(inspired concentration) ratio rises as the alveolar concentration of that gas is increased. In simple terms, the higher the concentration of gas administered, the faster the alveolar concentration of that gas approaches the inspired concentration.Proton-sensing G protein-coupled receptorsInternational Committee on Aeronautical Fatigue and Structural IntegrityLigand (biochemistry): In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. In protein-ligand binding, the ligand is usually a signal-triggering molecule binding to a site on a target protein.International Society for Traumatic Stress Studies: International Society for Traumatic Stress Studies (ISTSS) was established on March 2, 1985 in Washington, D.C.John Killaly: John Killaly (1776–1832) was the most significant Irish canal engineer working originally for the Grand Canal company and later, as an engineer, under the Directors-General of Inland Navigation.List of podcasting companies: This is a list of notable podcast production and distribution companies. This includes both audio and video podcasts.The Flash ChroniclesInternational Psychopharmacology Algorithm Project: The International Psychopharmacology Algorithm Project (IPAP) is a non-profit corporation whose purpose is to "enable, enhance, and propagate" use of algorithms for the treatment of some Axis I psychiatric disorders.Idiosyncratic drug reactionPharmacogenetics: Pharmacogenetics is the study of inherited genetic differences in drug metabolic pathways which can affect individual responses to drugs, both in terms of therapeutic effect as well as adverse effects. The term pharmacogenetics is often used interchangeably with the term pharmacogenomics which also investigates the role of acquired and inherited genetic differences in relation to drug response and drug behavior through a systematic examination of genes, gene products, and inter- and intra-individual variation in gene expression and function.Loftus, North YorkshireGABAA-rho receptor: The GABAA-rho receptor (previously known as the GABAC receptor) is a subclass of GABAA receptors composed entirely of rho (ρ) subunits. GABAA receptors including those of the ρ-subclass are ligand-gated ion channels responsible for mediating the effects of gamma-amino butyric acid (GABA), the major inhibitory neurotransmitter in the brain.Neuropharmacology: Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular.Org 20599WIN 56,098: WIN 56,098 is a chemical that is considered to be an aminoalkylindole derivative. It is a tricyclic aryl derivative that acts as a competitive antagonist at the CB2 cannabinoid receptor.Acetylcholine receptorBRL-15,572Community-based clinical trial: Community-based clinical trials are clinical trials conducted directly through doctors and clinics rather than academic research facilities. They are designed to be administered through primary care physicians, community health centers and local outpatient facilities.Benzodiazepine misuse: The non-medical use of Benzodiazepine drugs (called misuse or abuse in public health journals) is the use of benzodiazepines without a prescription, often for recreational purposes, which poses risks of dependence, withdrawal and other long-term effects. Benzodiazepines are one of the more common prescription drugs used recreationally.Ethyl groupGraphic facilitation: Graphic Facilitation is the use of large scale imagery to lead groups and individuals towards a goal. The method is used in various processes such as meetings, seminars, workshops and conferences.Baby hamster kidney cell: Baby Hamster Kidney fibroblasts (aka BHK cells) are an adherent cell line used in molecular biology.Syllabus: A syllabus (pl. syllabi) is an outline and summary of topics to be covered in an education or training course.Phenylpiperidine: Phenylpiperidine is a chemical compound with a phenyl moiety directly attached to piperidine. There are a variety of pharmacological effects associated some phenylpiperidines including morphine-like activity or other central nervous system effects.BentazepamDavid Steinman: You may also be looking for David B. Steinman, builder of bridges.JWH-196: JWH-196 is a synthetic cannabinoid receptor ligand from the naphthoylindole family. It is the indole 2-methyl derivative of related compound JWH-175, and the carbonyl reduced analog of JWH-007.Drug interaction: A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own.Patch clamp: The patch clamp technique is a laboratory technique in electrophysiology that allows the study of single or multiple ion channels in cells. The technique can be applied to a wide variety of cells, but is especially useful in the study of excitable cells such as neurons, cardiomyocytes, muscle fibers, and pancreatic beta cells.BioSimMolecular modificationAllosteric regulationPiperoxanOpioid: Opioids are substances that act on the nervous system in a similar way to opiates such as morphine and codeine. In a medical context the term usually indicates medications that are artificially made rather than extracted from opium.PivagabineAntileukemic drug: Antileukemic drugs, anticancer drugs that are used to treat one or more types of leukemia, include:A. N. Hartley: Annie Norah Hartley (1902 – 1994), usually known simply as Norah Hartley, was a dog breeder and the first female board member of the Kennel Club.Journal of Medical Toxicology: The Journal of Medical Toxicology is a peer-reviewed medical journal on medical toxicology and the official journal of the American College of Medical Toxicology. It publishes original articles, illustrative cases, review articles, and other special features that are related to the clinical diagnosis and management of patients with exposure to various poisons.Reversal potential: In a biological membrane, the reversal potential (also known as the Nernst potential) of an ion is the membrane potential at which there is no net (overall) flow of that particular ion from one side of the membrane to the other. In the case of post-synaptic neurons, the reversal potential is the membrane potential at which a given neurotransmitter causes no net current flow of ions through that neurotransmitter receptor's ion channel.TerpyridineHSD2 neurons: HSD2 neurons are a small group of neurons in the brainstem which are uniquely sensitive to the mineralocorticosteroid hormone aldosterone, through expression of HSD11B2. They are located within the caudal medulla oblongata, in the nucleus of the solitary tract (NTS).Rosalyn Sussman YalowMitragyna: Mitragyna is a genus of trees in the Rubiaceae family. Members of this genus contain antimalarial and analgesic indole alkaloids.Burst kinetics: Burst kinetics is a form of enzyme kinetics that refers to an initial high velocity of enzymatic turnover when adding enzyme to substrate. This initial period of high velocity product formation is referred to as the "Burst Phase".Osmotic controlled-release oral delivery system: OROS (Osmotic [Controlled] Release Oral [Delivery] System) is a controlled release oral drug delivery system in the form of a tablet. The tablet has a rigid water-permeable jacket with one or more laser drilled small holes.Periodic current reversalCiproxifanNewington Green Unitarian ChurchNeural drug delivery systems: Neural drug delivery is the next step beyond the basic addition of growth factors to nerve guidance conduits. Drug delivery systems allow the rate of growth factor release to be regulated over time, which is critical for creating an environment more closely representative of in vivo development environments.Bath salts (drug): Bath salts is a term used in North America to describe a number of recreational designer drugs. The name derives from instances in which the drugs were sold disguised as true bath salts.Enlightenment Intensive: An Enlightenment Intensive is a group retreat designed to enable a spiritual enlightenment experience within a relatively short time. Devised by Americans Charles (1929–2007) and Ava Berner in the 1960s,http://www.Temporal analysis of products: Temporal Analysis of Products (TAP), (TAP-2), (TAP-3) is an experimental technique for studyingNonbenzodiazepine: Nonbenzodiazepines (sometimes referred to colloquially as "Z-drugs") are a class of psychoactive drugs that are very benzodiazepine-like in nature. Nonbenzodiazepines pharmacodynamics are almost entirely the same as benzodiazepine drugs and therefore employ similar benefits, side-effects, and risks.Calcium signaling: Calcium ions are important for cellular signalling, as once they enter the cytosol of the cytoplasm they exert allosteric regulatory effects on many enzymes and proteins. Calcium can act in signal transduction resulting from activation of ion channels or as a second messenger caused by indirect signal transduction pathways such as G protein-coupled receptors.Nicotine replacement therapyNihon UniversityCyclophane: 300px|right|Scheme 1. CyclophanesA cyclophane is a hydrocarbon consisting of an aromatic unit (typically a benzene ring) and an aliphatic chain that forms a bridge between two non-adjacent positions of the aromatic ring.CariprazinePharmaceutical manufacturing: Drug manufacturing is the process of industrial-scale synthesis of pharmaceutical drugs by pharmaceutical companies. The process of drug manufacturing can be broken down into a series of unit operations, such as milling, granulation, coating, tablet pressing, and others.Cannabinoid receptor antagonist: The discovery of the endogenous cannabinoid system led to the development of CB1 receptor antagonists. The first cannabinoid receptor antagonist, rimonabant, was described in 1994.Strychnine poisoning