OST4: In molecular biology, OST4 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4) is a subunit of the oligosaccharyltransferase complex.Extended-spectrum penicillin: The extended-spectrum penicillins are a group of antibiotics that have the widest antibacterial spectrum of all penicillins.Comprehensive Pharmacy Review, Leon Shargel, 6th edition, p917 Some sources identify them with antipseudomonal penicillins,Elsevier's Integrated Review Pharmacology, By Mark Kester, Kelly Dowhower Karpa, Kent E.BenzylpenicillinFerric uptake regulator family: In molecular biology, the ferric uptake regulator (FUR) family of proteins includes metal ion uptake regulator proteins. These are responsible for controlling the intracellular concentration of iron in many bacteria.MecillinamCarboxypeptidase A inhibitor: In molecular biology, the carboxypeptidase A inhibitor family is a family of proteins which is represented by the well-characterised metallocarboxypeptidase A inhibitor (MCPI) from potatoes, which belongs to the MEROPS inhibitor family I37, clan IE. It inhibits metallopeptidases belonging to MEROPS peptidase family M14, carboxypeptidase A.Peptidoglycan binding domainLactamSortaseList of strains of Escherichia coli: Escherichia coli is a well studied bacterium that was first identified by Theodor Escherich, after whom it was later named.BacitracinDiscovery and development of cephalosporins: Cephalosporins are a broad class of bactericidal antibiotics that include the β-lactam ring and share a structural similarity and mechanism of action with other β-lactam antibiotics (e.g.PropicillinQuellung reaction: The Quellung reaction is a biochemical reaction in which antibodies bind to the bacterial capsule of Streptococcus pneumoniae, Klebsiella pneumoniae, Neisseria meningitidis, Haemophilus influenzae, Page 340 Escherichia coli, and Salmonella. The antibody reaction allows these species to be visualized under a microscope.SaPI: SaPIs (Staphylococcus aureus or superantigen pathogenicity islands) are a family of mobile genetic elements resident in the genome of some strains of Staphylococcus aureus. Much like bacteriophages, SaPIs can be transferred to uninfected cells and integrate into the host chromosome.CefiximeBeta-lactamaseCefotaximeAcylation: In chemistry, acylation (rarely, but more formally: alkanoylation) is the process of adding an acyl group to a compound. The compound providing the acyl group is called the acylating agent.CefoxitinCefalexinAmpicillinSCCmec: SCCmec, or staphylococcal cassette chromosome mec, is a mobile genetic element of Staphylococcus bacterial species. This genetic sequence includes the mecA gene coding for resistance to the antibiotic methicillin and is the only known way for Staphylococcus strains to spread the gene in the wild by horizontal gene transfer.Cell envelope: The cell envelope comprises the inner cell membrane and the cell wall of a bacterium, if present, plus a bacterial outer membrane, if one is present (i.e.Coles PhillipsSporulation in Bacillus subtilis: Bacillus subtilis is a rod-shaped, Gram-positive bacteria that is naturally found in soil and vegetation, and is known for its ability to form a small, tough, protective and metabolically dormant endospore. B.Protein primary structure: The primary structure of a peptide or protein is the linear sequence of its amino acid structural units, and partly comprises its overall biomolecular structure. By convention, the primary structure of a protein is reported starting from the amino-terminal (N) end to the carboxyl-terminal (C) end.Silent mutation: Silent mutations are mutations in DNA that do not significantly alter the phenotype of the organism in which they occur. Silent mutations can occur in non-coding regions (outside of genes or within introns), or they may occur within exons.Escherichia coli (molecular biology): Escherichia coli (; commonly abbreviated E. coli) is a gammaproteobacterium commonly found in the lower intestine of warm-blooded organisms (endotherms).AztreonamAvery–MacLeod–McCarty experimentCloxacillinXyloglucan endotransglucosylase: Xyloglucan endotransglucosylase (XET) is an apoplastic enzyme found across the plant kingdom. The enzyme catalyzes the endotransglucosylation of two xyloglucan polysaccharides, effectively 'stitching' them together.TigemonamPGLO: The pGLO plasmid is an engineered plasmid used in biotechnology as a vector for creating genetically modified organisms. The plasmid contains several reporter genes, most notably for the green fluorescent protein (GFP) and the ampicillin resistance gene.Carbapenem: Carbapenems are antibiotics used for the treatment of infections known or suspected to be caused by multidrug-resistant (MDR) bacteria. Their use is primarily in people who are hospitalized.Bacterial spore: A bacterial spore is a spore or spore-like structure produced by bacteria. These include endospores, Akinetes, and spores produced by Actinobacteria and Azotobacter.CeftriaxoneStreptococcus dysgalactiae: Streptococcus dysgalactiae is a species of Streptococcus.Plectasin: Plectasin is an antibiotic found by Novozymes in the Pezizalean fungus Pseudoplectania nigrella. Plectasin belongs to the antimicrobial peptide class called Defensins, which is also present in invertebrates such as flies and mussels.PanipenemMolar mass distribution: In linear polymers the individual polymer chains rarely have exactly the same degree of polymerization and molar mass, and there is always a distribution around an average value. The molar mass distribution (or molecular weight distribution) in a polymer describes the relationship between the number of moles of each polymer species (Ni) and the molar mass (Mi) of that species.Proximity ligation assay: Proximity ligation assay (in situ PLA) is a technology that extends the capabilities of traditional immunoassays to include direct detection of proteins, protein interactions and modifications with high specificity and sensitivity. Protein targets can be readily detected and localized with single molecule resolution and objectively quantified in unmodified cells and tissues.Neisseria gonorrhoeae: Neisseria gonorrhoeae, also known as gonococci (plural), or gonococcus (singular), is a species of Gram-negative coffee bean-shaped diplococci bacteria responsible for the sexually transmitted infection gonorrhea.CodinaeopsinSymmetry element: A symmetry element is a point of reference about which symmetry operations can take place. In particular, symmetry elements can be centers of inversion, axes of rotation and mirror planes.Enterococcus faecium: Enterococcus faecium is a Gram-positive, alpha-hemolytic or nonhemolytic bacterium in the genus Enterococcus. It can be commensal (innocuous, coexisting organism) in the human intestine, but it may also be pathogenic, causing diseases such as neonatal meningitis or endocarditis.GyrA RNA motif: The gyrA RNA motif is a conserved RNA structure identified by bioinformatics. The RNAs are present in multiple species of bacteria within the order Pseudomonadales.Cephamycin: Cephamycins are a group of beta-lactam antibiotics. They are very similar to cephalosporins, and the cephamycins are sometimes classified as cephalosporins.NafcillinPiperacillinLigation-independent cloning: Ligation-independent cloning (LIC) is a form of molecular cloning that is able to be performed without the use of restriction endonucleases or DNA ligase. This allows genes that have restriction sites to be cloned without worry of chopping up the insert.Burst kinetics: Burst kinetics is a form of enzyme kinetics that refers to an initial high velocity of enzymatic turnover when adding enzyme to substrate. This initial period of high velocity product formation is referred to as the "Burst Phase".Streptomyces peucetius: Streptomyces peucetius ATCC 27952WIN 56,098: WIN 56,098 is a chemical that is considered to be an aminoalkylindole derivative. It is a tricyclic aryl derivative that acts as a competitive antagonist at the CB2 cannabinoid receptor.CefaclorEnterococcus faecalis: Enterococcus faecalis – formerly classified as part of the group D Streptococcus system – is a Gram-positive, commensal bacterium inhabiting the gastrointestinal tracts of humans and other mammals. Like other species in the genus Enterococcus, E.Margaret Jope: Margaret Jope (1913–2004) was a Scottish biochemist, born as Henrietta Margaret Halliday in Peterhead, Scotland.ATC code J07: ==J07A Bacterial vaccines==Cell membraneSorbinilEnterococcus avium: Enterococcus avium, a species of Enterococcus, is most commonly found in birds. Rarely, it is also a cause of infection in humans, and in such cases, may be vancomycin-reistant, and is referred to as VREA.Autolysis (biology): In biology, autolysis, more commonly known as self-digestion, refers to the destruction of a cell through the action of its own enzymes. It may also refer to the digestion of an enzyme by another molecule of the same enzyme.VanY protein domain: In molecular biology, VanY are protein domains found in enzymes named metallopeptidases. They are vital to bacterial cell wall synthesis and antibiotic resistance.Neisseria subflava: Neisseria subflava is a common inhabitant found in the human upper respiratory tract. It is considered non-pathogenic, although in rare case it can be the causative agent of postoperative meningitis (after a neurological surgery), which is called surgical site infection (SSI).Staphylococcus cohnii: Staphylococcus cohnii is a Gram positive, coagulase-negative member of the bacterial genus Staphylococcus consisting of clustered cocci. The species commonly lives on human skin; clinical isolates have shown high levels of antibiotic resistance.Mercurial diureticTriparental mating: Triparental mating is a form of Bacterial conjugation where a conjugative plasmid present in one bacterial strain assists the transfer of a mobilizable plasmid present in a second bacterial strain into a third bacterial strain. Plasmids are introduced into bacteria for such purposes as transformation, cloning, or transposon mutagenesis.Resistome: The resistome is a proposed expression by Gerard D. Wright for the collection of all the antibiotic resistance genes and their precursors in both pathogenic and non-pathogenic bacteria.
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