Claudin and occludin are proteins that are essential for the formation of the tight junctions between the cells of the blood- ... Neutrophils carry MMP-9., which has also been shown to degrade occludin. This leads to further disruption of the BBB and BSCB ... The study showed that MMP-3 accomplishes this damage by degrading claudin-5, occludin, and ZO-1 (another tight junction protein ... Furuse M, Fujita K, Hiiragi T, Fujimoto K, Tsukita S (Jun 1998). "Claudin-1 and -2: novel integral membrane proteins localizing ...

"Entrez Gene: CLDN1 claudin 1". Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG (Nov 2003). "Role of claudin ... novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin". J. Cell Biol. 141 (7 ... Claudin-1 is a protein that in humans is encoded by the CLDN1 gene. It belongs to the group of claudins. Tight junctions ... The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight ...

... have increased blood-brain barrier permeability due to decreased expression of tight junction proteins occludin and claudin-5 ... 25 (5): 378-387. doi:10.1016/j.smim.2013.09.003. PMID 24209708. Palm, Noah W.; de Zoete, Marcel R.; Flavell, Richard A. (August ... 13 (5): 321-335. doi:10.1038/nri3430. PMID 23618829. S2CID 205491968. Hooper Lora V., Bry Lynn, Falk Per G., Gordon Jeffrey I ... 9 (5): 313-323. doi:10.1038/nri2515. PMC 4095778. PMID 19343057. Mazmanian, Sarkis K.; Round, June L.; Kasper, Dennis L. (2008 ...

Occludin cooperates with members of the claudin family directly or indirectly and together they form the long strands of tight ... But occludin has a structure with two similar extracellular loops compared to claudin and tetraspanin, which have one ... Occludin play a role in selective regulation by an incorporating itself into the claudin-based strands. The different ... JAMs in epithelial cells can aggregate with TJ strands, that are made of polymers of claudin and occludin. JAM-A maintains ...

Furuse, M. (December 15, 1993). "Occludin: a novel integral membrane protein localizing at tight junctions". The Journal of ... Furuse, Mikio; Fujita, Kohji; Hiiragi, Takashi; Fujimoto, Kazushi; Tsukita, Shoichiro (June 29, 1998). "Claudin-1 and −2: Novel ... including occludins and claudins), adherens junctions, and cadherins. January 25, 1955: Publication of the first issue of The ... 4 (5): 557-566. doi:10.1083/jcb.4.5.557. PMC 2224556. PMID 13587549. Siekevitz, Philip; Palade, George E. (July 1, 1960). "A ...

2004). "Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium". Am. J. ... Claudin-12 is a protein that in humans is encoded by the CLDN12 gene. It belongs to the group of claudins. GRCh38: Ensembl ... "Entrez Gene: CLDN12 claudin 12". Human CLDN12 genome location and CLDN12 gene details page in the UCSC Genome Browser. Kniesel ... 2001). "claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and ...

... claudin-2, claudin-6, claudin-7 and occludin) and transcription factors (including GATA4). Changes in the expression of claudin ... Paschoud S, Bongiovanni M, Pache JC, Citi S (September 2007). "Claudin-1 and claudin-5 expression patterns differentiate lung ... Cordenonsi M, Turco F, D'atri F, Hammar E, Martinucci G, Meggio F, Citi S (September 1999). "Xenopus laevis occludin. ... Guillemot L, Citi S (August 2006). "Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase ...

Transmembrane proteins - including junctional adhesion molecule, occludin, and claudin. It is believed that claudin is the ... 33 (5): 535-48. doi:10.1016/j.devcel.2015.03.023. PMID 25982676. Bosveld F, Markova O, Guirao B, Martin C, Wang Z, Pierre A, ... 5 (1): 53-61. doi:10.1530/revreprod/5.1.53. PMID 10711736. Brembeck FH, Rosário M, Birchmeier W (February 2006). "Balancing ... August 5-9, 2007. Elsinore, Denmark". Cell Communication & Adhesion. 14 (6): 275-346. 2007. doi:10.1080/15419060801891042. PMID ...

Claudin-1, and Occludin. The envelope of HCV is similar to very low-density lipoproteins (VLDL) and low-density lipoproteins ( ... Claudin 1, which is a tight-junction protein, and CD81 link to create a complex, priming them for later HCV infection processes ... This triggers the migration of occludin, which is another tight-junction complex, to the basolateral membrane. The HCV particle ... The 5′ UTR has a ribosome binding site or internal ribosome entry site (IRES) that initiates the translation of a very long ...

... is a consequence of mast cell degranulation releasing a serine protease mast cell protease II that digests occludin and claudin ... 29 (5): 777-780. doi:10.1016/s0020-7519(99)00019-3. ISSN 0020-7519. PMID 10404275. Nieuwhof, G. J.; Bishop, S. C. (2005). " ... 110 (5): 420-429. doi:10.1038/hdy.2012.90. ISSN 0018-067X. PMC 3630823. PMID 23512009. Benavides, Magda Vieira; Sonstegard, Tad ... 122 (5): 571-582. doi:10.1017/s0031182001007570. ISSN 0031-1820. PMID 11393831. S2CID 9280474. Hutchings, M.R; Knowler, K.J; ...

... and occludin". The Journal of Biological Chemistry. 275 (27): 20520-6. doi:10.1074/jbc.M905251199. PMID 10877843. Gupta SK, ... is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule". The ... 15 (5): 525-30. doi:10.1016/S0955-0674(03)00104-2. PMID 14519386. Naik UP, Eckfeld K (2004). "Junctional adhesion molecule 1 ( ...

The increase in claudin-4 prevents the movement of Na+ ions between the cells, and the appearance of ENaC in the apical ... Ovarian hormones control the changing expression of claudins and occludin in rat uterine epithelial cells during early ... For example, it has been shown that it is the claudin component of tight junctions regulates the charge selectivity of the ... Studies have found an increase in claudin-4 within the tight junctions of uterine epithelial cells at the time of implantation ...

Compared to normal endothelial cells, the cells lining the BBB are connected by occludin and claudin which form tight junctions ... 90 (5): 948-954. doi:10.1016/j.neuron.2016.04.039. PMC 5092154. PMID 27253448. Abdelhak A, Weber MS, Tumani H (2017). "Primary ... 181 (5): 3567-74. doi:10.4049/jimmunol.181.5.3567. PMID 18714030. Malik M, Chen YY, Kienzle MF, Tomkowicz BE, Collman RG, ... 28 (3): 230-5. doi:10.1179/016164106X98080. PMID 16687046. S2CID 16896871. Washington R, Burton J, Todd RF 3rd, Newman W, ...

Patients with ALS have been found to have decreased expression of certain proteins, like ZO-1 or claudin-5, that weaken the ... largely due to the relatively low expression of tight junction proteins like ZO-1 and occludin. For example, mannitol, an ... "Involvement of Claudin-11 in Disruption of Blood-Brain, -Spinal Cord, and -Arachnoid Barriers in Multiple Sclerosis." Molecular ... Only 5-10% of ALS cases have an identifiable cause, most often is a mutation in the gene SOD1. Regardless of whether the cause ...

Beeman N, Webb PG, Baumgartner HK (February 2012). "Occludin is required for apoptosis when claudin-claudin interactions are ... Occludin also plays an important role in the apoptosis. The C-terminus of occludin is important in receiving and transmitting ... Occludin plays a critical role in maintaining the barrier properties of a tight junction. Thus, mutation or absence of occludin ... Disruption of occludin regulation is an important aspect of a number of diseases. Strategies to prevent and/or reverse occludin ...

... such as occludin, claudins (such as Claudin-5), junctional adhesion molecule (such as JAM-A). Each of these tight junction ... In mice, Claudin-5 loss during development is lethal and results in size-selective loosening of the BBB. The blood-brain ... February 2018). "claudin 5". Biology Open. 7 (2): bio030494. doi:10.1242/bio.030494. PMC 5861362. PMID 29437557. Abbott NJ, ... May 2003). "Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice". The Journal of Cell Biology. 161 ...

Claudin-2 is a protein that in humans is encoded by the CLDN2 gene. It belongs to the group of claudins. Members of the claudin ... Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin". J. Cell Biol. 141 (7 ... Claudin-2 is expressed in cation-leaky epithelia such as that of the kidney proximal tubule. Mice that are deficient in claudin ... "Entrez Gene: CLDN2 claudin 2". Muto, S.; Hata, M.; Taniguchi, J.; Tsuruoka, S.; Moriwaki, K.; Saitou, M.; Furuse, K.; Sasaki, H ...

Claudins are a family of proteins which, along with occludin, are the most important components of the tight junctions (zonulae ... The name claudin comes from Latin word claudere ("to close"), suggesting the barrier role of these proteins. A recent review ... A chimeric claudin was synthesized to help enhance the understanding of both the structure and function of the tight junction. ... All human claudins (with the exception of Claudin 12) have domains that let them bind to PDZ domains of scaffold proteins. The ...

These complexes, formed primarily of members of the claudin and the occludin families, consist of about 35 different proteins, ... Epithelial cells are continuously renewed every 4-5 days through a process of cell division, maturation, and migration. Renewal ...

For example, claudin 11 has been shown to be a necessary component of these tight junctions as mice lacking this gene have a ... addition the blood testis barrier provides architectural support and is composed of tight junction components such as occludins ... A characteristic of EMT is loss of the epithelial markers (E-cadherin, cytokeratins, claudin, occluding, desmoglein, desmocolin ... 5 (5): 429-441. doi:10.1016/s1535-6108(04)00115-1. PMID 15144951. Olbryt M, Habryka A, Tyszkiewicz T, Rusin A, Cichoń T, Jarząb ...