... are derivatives of the nucleosides. They contain - in contrast to most nucleosides - instead of the β-D- ... v t e (Nucleosides, Arabinosides, All stub articles, Organic chemistry stubs). ... "Rational design of arabinosyl nucleosides as antitumor and antiviral agents", Jpn J Antibiot. 1977 Dec;30 Suppl:104-120; PMID ...

Heating the blocked nucleoside in Eq. (6) in the presence of a protected sugar chloride provides the nucleoside in 59% yield. ... 4)). Glycosylation of thymine with protected 1-acetoxy ribose produced 60% of the N1 nucleoside and 23% of the N3 nucleoside. ... yielding the desired β-nucleoside 2. A second reaction of this nucleoside with 1 generates bis(riboside) 3. Depending on the ... is the most common method for forming nucleosides in this manner. Nucleosides are typically synthesized through the coupling of ...

Nucleosides, Nucleotides & Nucleic Acids is a monthly academic journal published by Taylor & Francis since 2000, continuing the ... earlier Nucleosides and Nucleotides in series. It discusses topics relating to the biochemistry of molecules in these classes. ...

Nucleosides are glycosylamines that can be thought of as nucleotides without a phosphate group. A nucleoside consists simply of ... Arabinosyl nucleosides Nucleobase Salvage enzyme Synthesis of nucleosides Ramesh, Deepthi; Vijayakumar, Balaji Gowrivel; Kannan ... into nucleosides (such as thymidine) and phosphate. The nucleosides, in turn, are subsequently broken down in the lumen of the ... In a nucleoside, the anomeric carbon is linked through a glycosidic bond to the N9 of a purine or the N1 of a pyrimidine. ...

Nucleoside analogues are nucleosides that are structurally similar (analogous) to the nucleosides used in DNA and RNA synthesis ... A nucleoside triphosphate is a nucleoside containing a nitrogenous base bound to a 5-carbon sugar (either ribose or deoxyribose ... Nucleoside analogues may also be used to treat viral infections. For example, azidothymidine (AZT) is a nucleoside analogue ... Nucleoside triphosphates cannot be absorbed well, so all nucleoside triphosphates are typically made de novo. The synthesis of ...

... s (NTs) are a group of membrane transport proteins which transport nucleoside substrates like adenosine ... There are two known types of nucleoside transporters, concentrative nucleoside transporters (CNTs; SLC28) and equilibrative ... "Physiological and pharmacological roles of nucleoside transporter proteins". Nucleosides, Nucleotides & Nucleic Acids. 27 (6): ... Baldwin SA, Beal PR, Yao SY, King AE, Cass CE, Young JD (February 2004). "The equilibrative nucleoside transporter family, ...

Carbocyclic nucleosides were originally limited to a five-membered ring system, matching the ring-size of the nucleosides; ... Carbocyclic nucleosides (also referred to as carbanucleosides) are nucleoside analogues in which a methylene group has replaced ... There are two approaches used in the synthesis of carbocyclic nucleosides. Linear approaches to chiral carbocyclic nucleosides ... Zhu XF (March 2000). "The latest progress in the synthesis of carbocyclic nucleosides". Nucleosides, Nucleotides & Nucleic ...

This enzyme is also called nucleoside N-ribosyltransferase. Koch AL (November 1956). "Some enzymes of nucleoside metabolism of ... In enzymology, a nucleoside ribosyltransferase (EC 2.4.2.5) is an enzyme that catalyzes the chemical reaction D-ribosyl-base1 ... The systematic name of this enzyme class is nucleoside:purine(pyrimidine) D-ribosyltransferase. ...

Lysidine is an uncommon nucleoside, rarely seen outside of tRNA. It is a derivative of cytidine in which the carbonyl is ... Sonawane, Kailas D.; Tewari, Ravindra (19 September 2008). "Conformational Preferences of Hypermodified Nucleoside Lysidine ( ... k2C) Occurring at 'Wobble' Position in Anticodon Loop of tRNAIle". Nucleosides, Nucleotides & Nucleic Acids. 27 (10-11): 1158- ...

... (EC 1.1.3.28) is an enzyme with systematic name nucleoside:oxygen 5'-oxidoreductase. This enzyme catalyses ... Nucleoside+oxidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 1.1.3). ... Isono Y, Sudo T, Hoshino M (1989). "Purification and reaction of a new enzyme, nucleoside oxidase". Agric. Biol. Chem. 53: 1663 ... Isono Y, Sudo T, Hoshino M (1989). "Properties of a new enzyme, nucleoside oxidase, from Pseudomonas maltophilia LB-86". Agric ...

Other names in common use include nucleoside triphosphate phosphohydrolase, nucleoside-5-triphosphate phosphohydrolase, and ... In enzymology, a nucleoside-triphosphatase (NTPase) (EC 3.6.1.15) is an enzyme that catalyzes the chemical reaction NTP + H2O ... LEWIS M, WEISSMAN S (1965). "Properties of a soluble nucleoside triphosphatase activity in mammalian liver". Arch. Biochem. ... Matsushita S, Raacke ID (1968). "Purification of nucleoside triphosphatases from pea seedling ribosomes". Biochim. Biophys. ...

In enzymology, a nucleoside phosphotransferase (EC 2.7.1.77) is an enzyme that catalyzes the chemical reaction a nucleotide + a ... The systematic name of this enzyme class is nucleotide:nucleoside 5'-phosphotransferase. Other names in common use include ... Prasher DC, Carr MC, Ives DH, Tsai TC, Frey PA (1982). "Nucleoside phosphotransferase from barley. Characterization and ... Brunngraber EF, Chargaff E (1967). "Purification and properties of a nucleoside phosphotransferase from carrot". J. Biol. Chem ...

... s are structural analogues of a nucleoside, which normally contain a nucleobase and a sugar. Nucleotide ... so it is possible to design nucleoside analogues that are preferentially incorporated by the former. Some nucleoside analogues ... Since nucleoside analogues require two phosphorylations to be activated, one carried out by a viral enzyme and the other by ... Nucleoside and nucleotide analogues can be used in therapeutic drugs, including a range of antiviral products used to prevent ...

... type B nucleoside diphosphatase, GDPase, CDPase, nucleoside 5'-diphosphatase, type L nucleoside diphosphatase, NDPase, and ... In enzymology, a nucleoside-diphosphatase (EC 3.6.1.6) is an enzyme that catalyzes the chemical reaction a nucleoside ... The systematic name of this enzyme class is nucleoside-diphosphate phosphohydrolase. Other names in common use include thiamine ... GIBSON DM, AYENGAR P, SANADI DR (1955). "A phosphatase specific for nucleoside diphosphates". Biochim. Biophys. Acta. 16 (4): ...

In enzymology, a nucleoside phosphoacylhydrolase (EC 3.6.1.24) is an enzyme that catalyzes the chemical reaction Hydrolyses ... Spahr PF, Gesteland RF (1970). "Purification and properties of a new enzyme from Escherichia coli: nucleoside phosphocyl ... The systematic name of this enzyme class is nucleoside-5'-phosphoacylate acylhydrolase. ...

... s are derivatives of natural or synthetic nucleosides. They are used to synthesize oligonucleotides, ... nucleosides modified at the 2'-position (OMe, protected NH2, F), nucleosides containing non-canonical bases (hypoxanthine and ... derivatives of nucleosides (nucleoside phosphoramidites) that serve as building blocks in phosphite triester methodology. To ... RO)2P-N(R1)2 + R2-N3 + H2O ---- (RO)2P(=O)-N(R1)2 + R2-NH2 + N2; The naturally occurring nucleotides (nucleoside-3'- or 5'- ...

... nucleoside trans-N-deoxyribosylase, trans-deoxyribosylase, trans-N-deoxyribosylase, trans-N-glycosidase, nucleoside ... nucleoside deoxyribosyltransferase II [purine(pyrimidine), and nucleoside:purine(pyrimidine) deoxyribosyltransferase]. This ... In enzymology, a nucleoside deoxyribosyltransferase (EC 2.4.2.6) is an enzyme that catalyzes the chemical reaction 2-deoxy-D- ... The systematic name of this enzyme class is nucleoside:purine(pyrimidine) deoxy-D-ribosyltransferase. Other names in common use ...

"Purification and characterization of purine nucleoside phosphorylase and pyrimidine nucleoside phosphorylase from Bacillus ... In enzymology, a pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) is an enzyme that catalyzes the chemical reaction a ... The systematic name of this enzyme class is pyrimidine-nucleoside:phosphate alpha-D-ribosyltransferase. This enzyme is also ... Saunders PP, Wilson BA, Saunders GF (1969). "Purification and comparative properties of a pyrimidine nucleoside phosphorylase ...

The systematic name of this enzyme class is nucleoside-triphosphate diphosphohydrolase. This enzyme is also called nucleoside- ... In enzymology, a nucleoside-triphosphate diphosphatase (EC 3.6.1.19) is an enzyme that catalyzes the chemical reaction a ... Chern CJ, MacDonald AB, Morris AJ (1969). "Purification and properties of a nucleoside triphosphate pyrophosphohydrolase from ... the two substrates of this enzyme are nucleoside triphosphate and H2O, whereas its two products are nucleotide and diphosphate ...

... and functions as a substrate-specific channel for nucleosides and deoxy-nucleosides. The protein contains 294 amino acids, the ... Nucleoside-specific porin (the tsx gene of Escherichia coli) is an outer membrane protein, Tsx, which constitutes the receptor ... Bremer E, Martinussen J, Middendorf A, Valentin-Hansen P (1990). "Analysis of the tsx gene, which encodes a nucleoside-specific ...

In enzymology, a nucleoside-phosphate kinase (EC 2.7.4.4) is an enzyme that catalyzes the chemical reaction ATP + nucleoside ... the two substrates of this enzyme are ATP and nucleoside monophosphate, whereas its two products are ADP and nucleoside ... This enzyme is also called NMP-kinase, or nucleoside-monophosphate kinase. A number of crystal structures have been solved for ... Nucleoside monophosphate binding induces further changes that render the enzyme catalytically capable of facilitating a ...

SLC28A1 is a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine. It also transports the ... Human concentrative nucleoside transporters include SLC28A1, SLC28A2 and SLC28A3 proteins. SLC28A2 is a purine-specific Na+- ... nucleoside cotransporter". The Journal of Biological Chemistry. 270 (23): 13596-9. doi:10.1074/jbc.270.23.13596. PMID 7775409. ... "Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein". The Journal of ...

Nucleoside phosphorylase is an enzyme which cleaves a nucleoside by phosphorylating the ribose to produce a nucleobase and ... Purine nucleoside phosphorylase, PNP, PNPase or inosine phosphorylase (EC 2.4.2.1) is an enzyme that in humans is encoded by ... Purine nucleoside phosphorylase deficiency Canduri F, dos Santos DM, Silva RG, Mendes MA, Basso LA, Palma MS, de Azevedo WF, ... Borgers M, Verhaegen H, De Brabander M, De Cree J, De Cock W, Thoné F, Geuens G (Nov 1978). "Purine nucleoside phosphorylase in ...

Nucleoside diphosphate kinase activity involves the transfer of the γ-phosphate of nucleoside triphosphate (NTP) to nucleoside ... Nucleoside Nucleotide Nucleoside monophosphate Nucleoside triphosphate Thymidine kinase Thymidylate kinase Thymidine kinase in ... Nucleoside-diphosphate kinases (NDPKs, also NDP kinase, (poly)nucleotide kinases and nucleoside diphosphokinases) are enzymes ... Nucleoside-Diphosphate+Kinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) EC 2.7.4.6 Portal: ...

Solute carrier family Equilibrative nucleoside transporters Nucleoside transporters Augustine blood group system GRCh38: ... Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are ... "A single glycine mutation in the equilibrative nucleoside transporter gene, hENT1, alters nucleoside transport activity and ... Equilibrative nucleoside transporter 1 (ENT1) is a protein that in humans is encoded by the SLC29A1 gene. Multiple ...

Mangravite LM, Badagnani I, Giacomini KM (2004). "Nucleoside transporters in the disposition and targeting of nucleoside ... Solute carrier family Equilibrative nucleoside transporters Nucleoside transporters GRCh38: Ensembl release 89: ENSG00000174669 ... Equilibrative nucleoside transporter 2 (ENT2) is a protein that in humans is encoded by the SLC29A2 gene. ... 2004). "The equilibrative nucleoside transporter family, SLC29". Pflügers Arch. 447 (5): 735-43. doi:10.1007/s00424-003-1103-2 ...

In enzymology, a diphosphate-purine nucleoside kinase (EC 2.7.1.143) is an enzyme that catalyzes the chemical reaction ... The systematic name of this enzyme class is diphosphate:purine nucleoside phosphotransferase. This enzyme is also called ... Tryon VV, Pollack D (1984). "Purine metabolism in Acholeplasma laidlawii B: novel PPi-dependent nucleoside kinase activity". J ... Tryon VV, Pollack JD (1985). "Distinctions in Mollicutes purine metabolism: pyrophosphate-dependent nucleoside kinase and ...

Concentrative nucleoside transporters Nucleoside transporters Solute carrier family GRCh38: Ensembl release 89: ENSG00000156222 ... 2004). "Transport of physiological nucleosides and anti-viral and anti-neoplastic nucleoside drugs by recombinant Escherichia ... Concentrative nucleoside transporter 1 (CNT1) is a protein that in humans is encoded by the SLC28A1 gene. ... 2004). "Nucleoside transporter profiles in human pancreatic cancer cells: role of hCNT1 in 2',2'-difluorodeoxycytidine- induced ...

Concentrative nucleoside transporters Nucleoside transporters Solute carrier family GRCh38: Ensembl release 89: ENSG00000137860 ... "Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter, CNT2". J. ... Concentrative nucleoside transporter 2 (CNT2) is a protein that in humans is encoded by the SLC28A2 gene. ... Wang J, Su SF, Dresser MJ, Schaner ME, Washington CB, Giacomini KM (Feb 1998). "Na(+)-dependent purine nucleoside transporter ...

... (EC 1.1.3.39) is an enzyme with systematic name nucleoside:oxygen 5'-oxidoreductase (H2O2- ... Nucleoside+oxidase+(H2O2-forming) at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC ... Koga S, Ogawa J, Cheng L, Choi Y, Yamada H, Shimizu S (November 1997). "Nucleoside Oxidase, a Hydrogen Peroxide-Forming Oxidase ...