Nociceptor: A nociceptor is a sensory neuron (nerve cell) that responds to potentially damaging stimuli by sending signals to the spinal cord and brain. This process, called nociception, usually causes the perception of pain.Mechanosensation: Mechanosensation is a response mechanism to mechanical stimuli. The physiological foundation for the senses of touch, hearing and balance, and pain is the conversion of mechanical stimuli into neuronal signals: mechanosensation.DihydrocapsaicinOpioid-induced hyperalgesia: Opioid-induced hyperalgesia or opioid-induced abnormal pain sensitivity, also called paradoxical hyperalgesia is a phenomenon associated with the long term use of opioids such as morphine, hydrocodone, oxycodone, and methadone. Over time, individuals taking opioids can develop an increasing sensitivity to noxious stimuli, even evolving a painful response to previously non-noxious stimuli (allodynia).Cancer pain: Pain in cancer may arise from a tumor compressing or infiltrating nearby body parts; from treatments and diagnostic procedures; or from skin, nerve and other changes caused by a hormone imbalance or immune response. Most chronic (long-lasting) pain is caused by the illness and most acute (short-term) pain is caused by treatment or diagnostic procedures.Thermoreceptor: A thermoreceptor is a sensory receptor, or more accurately the receptive portion of a sensory neuron, that codes absolute and relative changes in temperature, primarily within the innocuous range. In the mammalian peripheral nervous system, warmth receptors are thought to be unmyelinated C-fibres (low conduction velocity), while those responding to cold have both C-fibers and thinly myelinated A delta fibers (faster conduction velocity).Fishpaper: Fish paper or fishpaper is a strong, flexible, fibrous dielectric paper. It resists moderate heat and mechanical injury, and is often used for wrapping coils and insulating stove-top parts.Dermal equivalent: The dermal equivalent is an in vitro model of the dermal layer of skin. It is constructed by seeding dermal fibroblasts into a collagen gel.TRPV1: The transient receptor potential cation channel subfamily V member 1 (TrpV1), also known as the capsaicin receptor and the vanilloid receptor 1, is a protein that, in humans, is encoded by the TRPV1 gene. It was the first isolated member of the transient receptor potential vanilloid receptor proteins that in turn are a sub-family of the transient receptor potential protein group.Nerve fiber layer: The retinal nerve fiber layer (nerve fiber layer, stratum opticum, RNFL) is formed by the expansion of the fibers of the optic nerve; it is thickest near the porus opticus, gradually diminishing toward the ora serrata.Nav1.5: NaV1.5 is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit.Interoceptor: An interoceptor is a sensory receptor that detects stimulus within the body. Examples of stimuli that would be detected by interoceptors include blood pressureCampbell, Neil A.Hypoalgesia: Hypoalgesia or hypalgesia denotes a decreased sensitivity to painful stimuli.Inferior longitudinal fasciculus: The inferior longitudinal fasciculus connects the temporal lobe and occipital lobe, running along the lateral walls of the inferior and posterior cornua of the lateral ventricle.Compound muscle action potential: The compound muscle action potential (CMAP) or compound motor action potential is an electromyography investigation (electrical study of muscle function).Brassica nigra: Brassica nigra (black mustard) ( Sanskrit : राजक्षवक, rajakshavak ; Marathi :काळी मोहरी, Kali Mohari ) is an annual weedy plant cultivated for its seeds, which are commonly used as a spice.Pain scale: A pain scale measures a patient's pain intensity or other features. Pain scales are based on self-report, observational (behavioral), or physiological data.Neuropharmacology: Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular.Neuropathic painVentricular action potentialPercolation threshold: Percolation threshold is a mathematical concept related to percolation theory, which is the formation of long-range connectivity in random systems. Below the threshold a giant connected component does not exist; while above it, there exists a giant component of the order of system size.TRPML: TRPML (transient receptor potential cation channel, mucolipin subfamily) comprises a group of three evolutionarily related proteins that belongs to the large family of transient receptor potential ion channels. The three proteins TRPML1, TRPML2 and TRPML3 are encoded by the mucolipin-1 (MCOLN1), mucolipin-2 (MCOLN2) and mucolipin-3 (MCOLN3) genes, respectively.Sodium channel: Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.Acid-sensing ion channel: Acid-Sensing Ion Channels (ASICs) are neuronal voltage-insensitive cationic channels activated by extracellular protons. ASIC proteins are a subfamily of the ENaC/Deg superfamily of ion channels.House DividedCold shock response: Cold shock response is the physiological response of organisms to sudden cold, especially cold water.Menthol cigarette: A menthol cigarette is a cigarette flavored with the compound menthol, a substance which triggers the cold-sensitive nerves in the skin without actually providing a drop in temperature.Triangular interval: The triangular interval (also known as the lateral triangular space,Photo at tufts.edu lower triangular space, and triceps hiatus) is a space found in the axilla.PulpitisMechanobiology: Mechanobiology is an emerging field of science at the interface of biology and engineering. It focuses on the way that physical forces and changes in cell or tissue mechanics contribute to development, physiology, and disease.BradykininAntipruritic: Antipruritics, also known as anti-itch drugs, are medications that inhibit the itching (Latin: pruritus) often associated with sunburns, allergic reactions, eczema, psoriasis, chickenpox, fungal infections, insect bites and stings like those from mosquitoes, fleas, and mites, and contact dermatitis and urticaria caused by plants such as poison ivy (urushiol-induced contact dermatitis) or stinging nettle.Trigeminovascular system: The trigeminovascular system consists of neurons in the trigeminal nerve that innervate cerebral blood vessels. It has been hypothesized that the trigeminovascular system may be involved in some types of headaches.Freund: __NOTOC__Periodic current reversalSuperior cluneal nerves: The superior cluneal nerves innervate the skin of the upper part of the buttocks. They are the terminal ends of lateral rami of the posterior rami of lumbar spinal nerves (L1, 2, 3).Endoneurium: The endoneurium (also called endoneurial channel, endoneurial sheath, endoneurial tube, or Henle's sheath) is a layer of delicate connective tissue around the myelin sheath of each myelinated nerve fiber. Its component cells are called endoneurial cells.Patch clamp: The patch clamp technique is a laboratory technique in electrophysiology that allows the study of single or multiple ion channels in cells. The technique can be applied to a wide variety of cells, but is especially useful in the study of excitable cells such as neurons, cardiomyocytes, muscle fibers, and pancreatic beta cells.Neuromere: Neuromeres are morphologically or molecularly defined transient segments of the early developing brain. Rhombomeres are such segments that make up the rhombencephalon or hindbrain.GDNF family of ligands: The GDNF family of ligands (GFL) consists of four neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF), neurturin (NRTN), artemin (ARTN), and persephin (PSPN). GFLs have been shown to play a role in a number of biological processes including cell survival, neurite outgrowth, cell differentiation and cell migration.Cortical stimulation mapping: Cortical stimulation mapping (often shortened to CSM) is a type of electrocorticography that involves a physically invasive procedure and aims to localize the function of specific brain regions through direct electrical stimulation of the cerebral cortex. It remains one of the earliest methods of analyzing the brain and has allowed researchers to study the relationship between cortical structure and systemic function.Microneurography: Microneurography is a neurophysiological method employed by scientists to visualize and record the normal traffic of nerve impulses that are conducted in peripheral nerves of waking human subjects. The method has been successfully employed to reveal functional properties of a number of neural systems, e.Falx cerebri: The falx cerebri is also known as the cerebral falx, named from its sickle-like form. It is a large, crescent-shaped fold of meningeal layer of dura mater that descends vertically in the longitudinal fissure between the cerebral hemispheres.Inflammation: Inflammation (Latin, [is part of the complex biological response of body tissues to harmful stimuli, such as pathogen]s, damaged cells, or irritants.Uremic pruritus: Uremic pruritus (also known as uraemic pruritus or renal pruritus) is caused by chronic kidney failure and is the most common internal systemic cause of itching.James, William; Berger, Timothy; Elston, Dirk (2005).Leguminous lectin family: In molecular biology, the leguminous lectin family is a family of lectin proteins.Compound analgesic: Compound analgesics are those with multiple active ingredients; they include many of the stronger prescription analgesics.Pulp (tooth): The dental pulp is the part in the center of a tooth made up of living connective tissue and cells called odontoblasts. The dental pulp is a part of the dentin–pulp complex (endodontium).TRPM: TRPM is a family of transient receptor potential ion channels (the "M" stands for "melastatin"). Functional TRPM channels are believed to form tetramers.Thermal grill illusion: The thermal grill illusion is a sensory illusion originally demonstrated in 1896 by the Swedish physician Torsten Thunberg. The illusion is created by an interlaced grill of warm (e.VincristineCinnamaldehydeMigraine Disability Assessment Test: The MIDAS or Migraine Disability Assessment Test is a test used by doctors to determine how severely migraines affect a patient's life. Patients are asked questions about the frequency and duration of their headaches, as well as how often these headaches limited their ability to participate in activities at work, at school, or at home.TRPC: TRPC is a family of transient receptor potential cation channels in animals.HSD2 neurons: HSD2 neurons are a small group of neurons in the brainstem which are uniquely sensitive to the mineralocorticosteroid hormone aldosterone, through expression of HSD11B2. They are located within the caudal medulla oblongata, in the nucleus of the solitary tract (NTS).FormicationConcentration effect: In the study of inhaled anesthetics, the concentration effect is the increase in the rate that the Fa(alveolar concentration)/Fi(inspired concentration) ratio rises as the alveolar concentration of that gas is increased. In simple terms, the higher the concentration of gas administered, the faster the alveolar concentration of that gas approaches the inspired concentration.
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