Neprilysin: Neprilysin ( also known as membrane metallo-endopeptidase (MME), neutral endopeptidase (NEP), cluster of differentiation 10 (CD10), and common acute lymphoblastic leukemia antigen (CALLA) is an enzyme] that in humans is encoded by the MME gene. Neprilysin is a [[zinc-dependent metalloprotease that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.Enkephalinase inhibitor: An enkephalinase inhibitor is a type of enzyme inhibitor which inhibits one or more members of the enkephalinase class of enzymes that break down the endogenous enkephalin opioid peptides. Examples include racecadotril, ubenimex (bestatin), RB-101, and D-phenylalanine, as well as the endogenous opioid peptides opiorphin and spinorphin.Senile plaquesInsulin-degrading enzyme: Insulin-degrading enzyme, also known as IDE is a human enzyme.Tynorphin: Tynorphin is a synthetic opioid peptide which is a potent and competitive inhibitor of the enkephalinase class of enzymes which break down the endogenous enkephalin peptides. It specifically inactivates dipeptidyl aminopeptidase III (DPP3) with very high efficacy, but also inhibits neutral endopeptidase (NEP), aminopeptidase N (APN), and angiotensin-converting enzyme (ACE) to a lesser extent.Amyloid precursor proteinAlzheimer's Disease Neuroimaging Initiative: Alzheimer’s Disease Neuroimaging Initiative (ADNI) is a worldwide project that provides reliable clinical data for the research of pathology principle, prevention and treatment of Alzheimer’s disease (AD). Multiple research groups contribute their findings of the biological markers to the understanding of the progression of Alzheimer’s disease in the human brain.Retroviral aspartyl protease: Retroviral aspartyl proteases are single domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses). These proteases are generally part of a larger pol or gag polyprotein.ThermolysinAstacin: In molecular biology, astacin is a family of metallopeptidases. These metallopeptidases belong to the MEROPS peptidase family M12, subfamily M12A (astacin family, clan MA(M)).QuinuclidineLearning Plan: A Learning Plan is a document (possibly an interactive or on-line document) that is used to plan learning, usually over an extended period of time.Amyloid: Amyloids are insoluble fibrous protein [species|aggregates] sharing specific structural traits. They are insoluble and arise from at least 18 inappropriately folded versions of proteins and polypeptides present naturally in the body.MethanofuranAmyloid precursor protein secretase: Secretases are enzymes that "snip" pieces off a longer protein that is embedded in the cell membrane.[of the amyloid precursor protein] Among other roles in the cell, secretases act on the amyloid precursor protein (APP) to cleave the protein into three fragments.