N-Acetylneuraminic acid
Neuraminic acid N-Glycolylneuraminic acid Sialic acid Severi E, Hood DW, Thomas GH (2007). "Sialic acid utilization by ... N-Acetylneuraminic acid (Neu5Ac or NANA) is the predominant sialic acid found in human cells, and many mammalian cells. Other ... Severi E, Randle G, Kivlin P, Whitfield K, Young R, Moxon R, Kelly D, Hood D, Thomas GH (2005). "Sialic acid transport in ... Post DM, Mungur R, Gibson BW, Munson RS Jr (2005). "Identification of a novel sialic acid transporter in Haemophilus ducreyi". ...
N-acylneuraminate-9-phosphatase
Jourdian GW, Swanson A, Watson D, Roseman S (1966). "N-Acetylneuraminic (sialic) acid 9-phosphatase". Methods Enzymol. 8: 205- ... Other names in common use include acylneuraminate 9-phosphatase, N-acylneuraminic acid 9-phosphate phosphatase, and N- ... acylneuraminic (sialic) acid 9-phosphatase. This enzyme participates in aminosugars metabolism. ...
N-acetylneuraminate 7-O(or 9-O)-acetyltransferase
Schauer R (May 1970). "[Biosynthesis of N-acetyl-O-acetylneuraminic acids. I. Incorporation of (14C) acetate into sections of ... Schauer R (June 1970). "[Biosynthesis of N-acetyl-O-acetylneuraminic acids. II. Substrate and intracellular localization of ...
N-acetylneuraminate 4-O-acetyltransferase
Schauer R (May 1970). "[Biosynthesis of N-acetyl-O-acetylneuraminic acids. I. Incorporation of (14C) acetate into sections of ... Schauer R (June 1970). "[Biosynthesis of N-acetyl-O-acetylneuraminic acids. II. Substrate and intracellular localization of ...
Bimal Kumar Bachhawat
... with the discovery of CMP-N-acetylneuraminic acid which led to the understanding of the occurrence of N-acetylneuraminic acid ... Minor J. Coon Gaucher's disease Tay-Sachs disease CMP-N-acetylneuraminic acid India portal Science portal Medicine portal " ... Shoyab, Bachhawat B. K. (1967). "Enzymic degradation of cytidine 5'-monophosphate-N-acetylneuraminic acid". Biochem. J. 102 (2 ... On his return to India, he focused his studies on amino acids and inorganic sulphate metabolism, as well as glycosaminoglycan. ...
CMAS (gene)
The enzyme encoded by this gene catalyzes the activation of Neu5Ac to Cytidine 5-prime-monophosphate N-acetylneuraminic acid ( ... "Entrez Gene: CMAS cytidine monophosphate N-acetylneuraminic acid synthetase". Human CMAS genome location and CMAS gene details ... monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs". ... CMP-Neu5Ac), which provides the substrate required for the addition of sialic acid. Sialic acids of cell surface glycoproteins ...
Ganglioside
N-acetylneuraminic acid, NANA) linked on the sugar chain. NeuNAc, an acetylated derivative of the carbohydrate sialic acid, ... N-acetyl-alpha-neuraminic acid aNeu5Ac9Ac = N-acetyl-9-O-acetylneuraminic acid bDGalp = beta-D-galactopyranose bDGalpNAc = N- ... A ganglioside is a molecule composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (e.g. ...
Neuraminic acid
Sialic acid N-Acetylneuraminic acid N-Glycolylneuraminic acid Blanco, Antonio; Blanco, Gustavo (2017-01-01), Blanco, Antonio; ... As a family, these residues are known as sialic acids. For example, N-acetylneuraminic acid, Neu5Ac, is typical in human ... Neuraminic acid (5-amino-3,5-dideoxy-D-glycero-D-galacto-non-2-ulosonic acid) is an acidic (in particular ulosonic) amino sugar ... The N- or O-substituted derivatives of neuraminic acid are collectively known as sialic acids, the predominant form in ...
CMP-N-acetylneuraminate monooxygenase
N-acetylneuraminic monooxygenase, and cytidine-5'-monophosphate-N-acetylneuraminic acid hydroxylase. This enzyme participates ... "The biosynthesis of N-glycoloylneuraminic acid occurs by hydroxylation of the CMP-glycoside of N-acetylneuraminic acid". Biol. ... Kozutsumi Y, Kawano T, Yamakawa T, Suzuki A (November 1990). "Participation of cytochrome b5 in CMP-N-acetylneuraminic acid ... Lottspeich F, Schauer R (1996). "CMP-N-acetylneuraminic acid hydroxylase: the first cytosolic Rieske iron-sulphur protein to be ...
N-Acetylmannosamine
ManNAc is the first committed biological precursor of N-acetylneuraminic acid (Neu5Ac, sialic acid) (Figure 1). Sialic acids ... Sialic acid becomes "activated" by CMP-sialic acid synthetase in the nucleus. CMP-sialic acid acts as a sialic acid donor to ... Comb, D. G.; Roseman, S (1960). "The sialic acids. I. The structure and enzymatic synthesis of N-acetylneuraminic acid". ... By aldolase treatment of sialic acid. to produce ManNAc and pyruvic acid. By base catalysed epimerization of N-acetyl ...
N-acetylneuraminate lyase
N-acetylneuraminic acid aldolase, neuraminate aldolase, N-acetylneuraminic lyase, N-acetylneuraminic acid lyase, NPL, NALase, ... COMB DG, ROSEMAN S (1960). "The sialic acids. I. The structure and enzymatic synthesis of N-acetylneuraminic acid". J. Biol. ... Other names in common use include N-acetylneuraminic acid aldolase, acetylneuraminate lyase, sialic aldolase, sialic acid ... aldolase, sialate lyase, N-acetylneuraminic aldolase, neuraminic aldolase, N-acetylneuraminate aldolase, neuraminic acid ...
NANS
"Entrez Gene: NANS N-acetylneuraminic acid synthase (sialic acid synthase)". Lolas F (1978). "Event-related slow brain ... 2000). "Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which does not have ... This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity ... "Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero- D-galacto- ...
Beta-galactoside alpha-2,6-sialyltransferase
8. Preparation of N-acetylneuraminic acid-1-14C-labeled ceruloplasmin". J. Biol. Chem. 245 (4): 759-66. PMID 4313609. Paulson ... "The sialic acids. XV. Transfer of sialic acid to glycoproteins by a sialyltransferase from colostrum". J. Biol. Chem. 248 (16 ...
N-Glycolylneuraminic acid
N-Acetylneuraminic acid Neuraminic acid Sialic acid Chou, Hsun-Hua; Takematsu, Hiromu; Diaz, Sandra; Iber, Jane; Nickerson, ... The gene CMAH encodes for CMP-N-acetylneuraminic acid hydroxylase, which is the enzyme responsible for CMP-Neu5Gc from CMP-N- ... Neu5Gc is closely related to the commonly known N-acetylneuraminic acid (Neu5Ac). Neu5Ac differs by a single oxygen atom that ... N-Glycolylneuraminic acid (Neu5Gc) is a sialic acid molecule found in most non-human mammals. Humans cannot synthesize Neu5Gc ...
CMAH
In most mammals, the enzyme hydroxylates N-acetylneuraminic acid (Neu5Ac), producing N-glycolylneuraminic acid (Neu5Gc). Neu5Ac ... "The biosynthesis of N-glycoloylneuraminic acid occurs by hydroxylation of the CMP-glycoside of N-acetylneuraminic acid". ... Cytidine monophospho-N-acetylneuraminic acid hydroxylase (Cmah) is an enzyme that is encoded by the CMAH gene. ... Hayakawa T, Aki I, Varki A, Satta Y, Takahata N (2005). "Fixation of the Human-Specific CMP-N-Acetylneuraminic Acid Hydroxylase ...
Multiregional origin of modern humans
The CMP-N-acetylneuraminic acid hydroxylase CMAH pseudogene shows 2.9 Mya coalescence time. Hayakawa, T; Aki, I; Varki, A; ... Satta, Y; Takahata, N (February 2006). "Fixation of the Human-Specific CMP-N-Acetylneuraminic Acid Hydroxylase Pseudogene and ...
Human coronavirus OC43
Instead, it recognizes 5-N-acetyl-9-O-acetylneuraminic acid (Neu5,9Ac2) (30, 43). The same sugar receptor is also recognized by ... single-stranded RNA virus that enters its host cell by binding to the N-acetyl-9-O-acetylneuraminic acid receptor. OC43 is one ...
Anhydrosialidase
Elimination of α-sialyl groups in N-acetylneuraminic acid glycosides, releasing 2,7-anhydro-α-N-acetylneuraminate This enzyme ... 7-anhydro-α-N-acetylneuraminic acid from sialoglycoconjugates". J. Biol. Chem. 265 (35): 21629-33. PMID 2254319. Portal: ...
Zanamivir
It was also known, as far back as 1974, that 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA), a sialic acid analogue, is ... 3-dehydro-N-acetylneuraminic acid". Virology. 58 (2): 457-463. doi:10.1016/0042-6822(74)90080-4. PMID 4362431. Laver G (1 March ... owing to the formation of a salt bridge with a conserved glutamic acid (119) in the active site. Glu 119 was also noticed to be ... in an attempt to design derivatives of DANA that would bind tightly to the amino acid residues of the catalytic site, so would ...
UDP-N-acetylglucosamine 2-epimerase
"A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and ...
Blood type (non-human)
June 2007). "Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domestic cat AB ...
GNE (gene)
... regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. UDP-GlcNAc 2-epimerase ... "A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and ... "A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Purification and ... Modification of cell surface molecules with sialic acid is crucial for their function in many biologic processes, including ...
UDP-N-acetylglucosamine 2-epimerase (hydrolysing)
"A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and ... Chou WK, Hinderlich S, Reutter W, Tanner ME (March 2003). "Sialic acid biosynthesis: stereochemistry and mechanism of the ...
Discovery and development of neuraminidase inhibitors
3-didehydro-N-acetylneuraminic acid (Neu5Ac2en or DANA) which is an analogue of N-acetylneuraminic acid (Neu5Ac), inhibits the ... N-acetylneuraminic acid (Neu5Ac) is one of the two most common sialic acid in mammals. It is a monosaccharide with a backbone ... The Neu5Ac-derived 2-deoxy-α-D-N-acetylneuraminic acid (2-deoxy- α-Neu5Ac) was the first template used and also the first ... 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (Neu5Ac2en) is a pan-selective inhibitor for neuraminidase. Neu5Ac2en is a ...
RENBP
1997). "A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular ... Luchansky SJ, Yarema KJ, Takahashi S, Bertozzi CR (2003). "GlcNAc 2-epimerase can serve a catabolic role in sialic acid ...
Monosialoganglioside sialyltransferase
Yip MC (1973). "The enzymic synthesis of disialoganglioside: rat brain cytidine-5'-monophospho-N-acetylneuraminic acid: ...
Ernst Klenk
Klenk discovered that N-acetylneuraminic acid is a characteristic of glycoproteins that are cell receptors for some ( ... He succeeded in classifying many polyenoic acids as 4 basic acid types: palmitoleic, oleic, linoleic,or α-linolenic. His ... In the mid-1950s, Klenk resumed the work he had begun two decades earlier on the structure of highly unsaturated fatty acids. ... Blix, F. G.; Gottschalk, A.; Klenk, E. (1957). "Proposed Nomenclature in the Field of Neuraminic and Sialic Acids". Nature. 179 ...
CMP-sialic acid transporter
Misaki R, Fujiyama K, Seki T (2006). "Expression of human CMP-N-acetylneuraminic acid synthetase and CMP-sialic acid ... "Inhibition of CMP-sialic acid transport in human liver and colorectal cancer cell lines by a sialic acid nucleoside conjugate ( ... CMP-sialic acid transporter is a protein that in humans is encoded by the SLC35A1 gene. Solute carrier family GRCh38: Ensembl ... Zhao W, Chen TL, Vertel BM, Colley KJ (2006). "The CMP-sialic acid transporter is localized in the medial-trans Golgi and ...
Pneumococcal pneumonia
Neuraminidase also increases instances of epithelial binding through its cleavage of N-acetylneuraminic acid, glycolipids, ...
Hemagglutinin esterase
The receptor binding activity involve the attachment of HEs to N-acetyl-9-O-acetylneuraminic acid (9-O-Ac- Neu5Ac) of ... The fatty acid, stearic acid, was detected to be the prevailing fatty acid attached to HEF, whereas the fatty acid palmitic ... of a serine amino acid, with the help of two other amino acids (histidine and aspartic acid), on the carbonyl group of the ... Glycolipids and glycoproteins contain N-acetyl-9-O-acetylneuraminic acid (9-O-Ac- Neu5Ac) that serve as viral receptor in which ...