Exercise therapy for idiopathic inflammatory myopathies: Although they vary in particulars, polymyositis, dermatomyositis and inclusion body myositis are idiopathic inflammatory myopathies (IIM)primarily characterized by chronic inflammation] of human [[skeletal muscle tissueLundberg I. and Y-L Chung, 2000.Inclusion body myositisPolymyositisDermatomyositis: - (ILDS M33.910)Gcn2: GCN2 (general control nonderepressible 2) is a serine/threonine-protein kinase that senses amino acid deﬁciency through binding to uncharged transfer RNA (tRNA). It plays a key role in modulating amino acid metabolism as a response to nutrient deprivation.Myokine: A myokine is one of several hundred cytokines or other small proteins (~5–20 kDa) and proteoglycan peptides that are produced and released by muscle cells (myocytes) in response to muscular contractions.Bente Klarlund Pedersen , Thorbjörn C.Acquired non-inflammatory myopathy: Acquired non-inflammatory myopathy (ANIM) is a neurological disorder primarily affecting skeletal muscle, most commonly in the limbs of humans, resulting in a weakness or dysfunction in the muscle. A myopathy refers to a problem or abnormality with the myofibrils, which compose muscle tissue.Autoantibody: An autoantibody is an antibody (a type of protein) produced by the immune system that is directed against one or more of the individual's own proteins. Many autoimmune diseases, (notably lupus erythematosus), are caused by such autoantibodies.Thigh: In humans, the thigh is the area between the pelvis and the knee. Anatomically, it is part of the lower limb.