Cardiac muscle cells also called cardiomyocytes are the contractile myocytes of the cardiac muscle. The cells are surrounded by ... The individual myocytes that make up the myocardium also differ between cardiac chambers. Ventricular cardiomyocytes are longer ... "Cardiovascular Physiology= Cardiac muscle Concept". "Cells Alive: Pumping Myocytes". Bergmann O, Bhardwaj RD, Bernard S, et al ... The ease of ion movement along cardiac muscle fibers axes is such that action potentials are able to travel from one cardiac ...
Cardiac myocytes also possess V1R. Additionally V1R are located in brain, testis, superior cervical ganglion, liver, blood ...
Within the lumen of the cardiac myocyte, the sarcoplasmic reticulum serves as the area of controlling the amount of calcium ... This fluctuation within the myocyte contributes to the rhythmic "pacemaking" of the cardiac tissue. There are two classes of ... Myocytes are incredibly specialized cells with only a select number of different organelle types. A myocyte is composed of ... Cardiomyocytes are a particular form of myocyte, only present in heart tissue. Along with the basic myocyte elements, these ...
1998). "Termination of Ca2+ release by a local inactivation of ryanodine receptors in cardiac myocytes". Proc. Natl. Acad. Sci ... 1998). "Termination of Ca2+ release by a local inactivation of ryanodine receptors in cardiac myocytes". Proc. Natl. Acad. Sci ... "Fractional SR Ca release is regulated by trigger Ca and SR Ca content in cardiac myocytes". American Journal of Physiology. ... "T-tubule function in mammalian cardiac myocytes". Circulation Research. 92 (11): 1182-92. doi:10.1161/01.res.0000074908.17214. ...
Gap junctions are critical for cardiac myocytes; mice and humans deficient in a particular gap junction protein have severe ... It has a critical role in development, particularly of cardiac and neural function. Other types of cell signaling include ...
May 2014). "Genetically encoded Ca2+ indicators in cardiac myocytes". Circulation Research. 114 (10): 1623-39. doi:10.1161/ ... 2008) used a transgenic cardiac-specific GCaMP zebrafish line to image cardiomyocyte activation throughout the cardiac cycle; ... As a result, experiments using cardiac tissue should carefully control the level of GCaMP expression. Since Ca2+ is a common ... March 2006). "Imaging cellular signals in the heart in vivo: Cardiac expression of the high-signal Ca2+ indicator GCaMP2". ...
Kanter HL, Saffitz JE, Beyer EC (1992). "Cardiac myocytes express multiple gap junction proteins". Circ. Res. 70 (2): 438-44. ... Kanter HL, Saffitz JE, Beyer EC (1994). "Molecular cloning of two human cardiac gap junction proteins, connexin40 and ...
"Expression of MEF2 genes during human cardiac development". Tohoku J. Exp. Med. 187 (1): 15-23. doi:10.1620/tjem.187.15. PMID ... Myocyte-specific enhancer factor 2A is a protein that in humans is encoded by the MEF2A gene. MEF2A is a transcription factor ... Yu YT, Breitbart RE, Smoot LB, Lee Y, Mahdavi V, Nadal-Ginard B (October 1992). "Human myocyte-specific enhancer factor 2 ... Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA (1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen- ...
They are expressed in skeletal and cardiac myocytes. Troponin T binds to tropomyosin and helps position it on actin, and ... The cardiac subtype of troponin T is especially useful in the laboratory diagnosis of heart attack because it is released into ... Slow skeletal troponin T1, TNNT1 (19q13.4, 191041) Cardiac troponin T2, TNNT2 (1q32, 191045) Fast skeletal troponin T3, TNNT3 ( ... Review Date 10/6/2015 "Development of the Cardiac Troponin T Immunoassay". American Association for Clinical Chemistry, Inc. ...
Ito1 is Ca2+-independent and has been clearly demonstrated in myocytes from different cardiac regions and species. There are ... The cardiac transient outward potassium current (referred to as Ito1 or Ito ) is one of the ion currents across the cell ... It is the main contributing current during the repolarizing phase 1 of the cardiac action potential. It is a result of the ... It is activated after the fast increase of the membrane potential following the phase 0 of the cardiac action potential. Once ...
Ikeda K, Tojo K, Oki Y, Nakao K (September 2002). "Urocortin has cell-proliferative effects on cardiac non-myocytes". Life ... These effects are likely mediated through the CRF type 2 receptor, as this receptor is found in the cardiac atria and ...
2007). "Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes". J. Biol. Chem. 282 (45): 32749-57. doi:10.1074/ ...
Huang X, Walker JW (Apr 2004). "Myofilament anchoring of protein kinase C-epsilon in cardiac myocytes". Journal of Cell Science ... Disatnik MH, Buraggi G, Mochly-Rosen D (Feb 1994). "Localization of protein kinase C isozymes in cardiac myocytes". ... PKCε binds and phosphorylates cardiac troponin I (cTnI) and cardiac troponin T (cTnT) in complex with troponin C (cTnC); ... "A selective epsilon-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death". The ...
... (Ccna2) is a key protein involved in the direction of mammalian cardiac myocytes to grow and divide, and has been ... Normally, Ccna2 is silenced postnatally in mammalian cardiac myocytes. Because of this gene silencing, adult heart muscle cells ... Delivery of Ccna2 into cardiac tissue invokes a regenerative response and markedly enhances cardiac function. Increased ... Ccna2 mediated cardiac repair showed both a decrease in fibrosis in the peri-infarct tissue and a greater number of ...
Cardiac myocyte renewal has been found to occur in normal adult humans, and at a higher rate in adults following acute heart ... "Evidence that human cardiac myocytes divide after myocardial infarction". The New England Journal of Medicine. 344 (23): 1750-7 ... MRL mice show the same amount of cardiac injury and scar formation as normal mice after a heart attack. However, recent studies ... Even in adult myocardium following infarction, proliferation is only found in around 1% of myocytes around the area of injury, ...
Cohen-Barak O, Yi Z, Hagiwara N, Monzen K, Komuro I, Brilliant MH (2003). "Sox6 regulation of cardiac myocyte development". ...
Cohen-Barak O, Yi Z, Hagiwara N, Monzen K, Komuro I, Brilliant MH (October 2003). "Sox6 regulation of cardiac myocyte ...
"Enhancing Macroautophagy Protects against Ischemia/Reperfusion Injury in Cardiac Myocytes". "Gottlieb Lab". Delbridge, Lea M. D ... Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes. Journal of Biological Chemistry, 281 ... These concepts, tools, and approaches have extended beyond the cardiac field and have led to novel findings in the fields of ... Gottlieb has been at the leading edge of research on mitochondria in cardiac homeostasis, which led her into the study of ...
"Stretch-activated whole cell currents in adult rat cardiac myocytes". American Journal of Physiology. Heart and Circulatory ...
... reversibly binds to β-adrenergic receptors on cardiac myocytes. Inhibition of these receptors prevents a response to ... Reis Filho JR, Cardoso JN, Cardoso CM, Pereira-Barretto AC (June 2015). "Reverse Cardiac Remodeling: A Marker of Better ...
"Three-dimensional engineered heart tissue from neonatal rat cardiac myocytes". Biotechnology and Bioengineering. 68 (1): 106-14 ... Human engineered cardiac tissues (hECTs) are derived by experimental manipulation of pluripotent stem cells, such as human ... hECTs also express key cardiac genes (α-MHC, SERCA2a and ACTC1) nearing the levels seen in the adult heart. Analogous to the ... Zhang D, Shadrin IY, Lam J, Xian HQ, Snodgrass HR, Bursac N (Jul 2013). "Tissue-engineered cardiac patch for advanced ...
... is expressed at very low levels in cardiac myocytes. Although its presence has been noted in cardiomyocytes of both ... Pathological states that increase cardiac stress and promote heart failure can induce a rise in both cardiac myostatin mRNA and ... Therefore, minimizing cardiac myostatin may improve cardiac output. Muscular dystrophy Muscle hypertrophy Myostatin-related ... in which cardiac myostatin induces whole-body muscular atrophy. Physiologically, minimal amounts of cardiac myostatin are ...
Extensive cardiac necrosis can occur by day three after infection as incubated viruses lyse myocytes, resulting in severe and ... T-cells not only lyse and destroy infected myocytes, but due to molecular mimicry, they also destroy normal, healthy cardiac ... Essentially, sCAR-Fc mimics CAR receptors on cardiac cells, competitively inhibiting viral attachment and entry into myocytes. ... "Coxsackievirus B3 infection leads to cell death of cardiac myocytes". J. Mol. Cell. Cardiol. 26 (7): 907-13. doi:10.1006/jmcc. ...
"Phosphoregulation of the titin-cap protein telethonin in cardiac myocytes". The Journal of Biological Chemistry. 289 (3): 1282- ... Telethonin has a unique β-sheet structure, which enables antiparallel association with the Titin Z1-Z2 domains in cardiac and ... Telethonin is expressed in cardiac and skeletal muscle at Z-discs and functions to regulate sarcomere assembly, T-tubule ... Telethonin expression is developmentally regulated in both cardiac and skeletal muscle and is thought to be critical to ...
Shaw RM, Colecraft HM (May 2013). "L-type calcium channel targeting and local signalling in cardiac myocytes". Cardiovascular ... Powers PA, Gregg RG, Hogan K (Sep 1992). "Linkage mapping of the human gene for the alpha 1 subunit of the cardiac DHP- ... It depolarizes at -30mV and helps define the shape of the action potential in cardiac and smooth muscle. The protein encoded by ... "Assignment of the human gene for the alpha 1 subunit of the cardiac DHP-sensitive Ca2+ channel (CCHL1A1) to chromosome 12p12- ...
"The use of magnetic targeting for drug delivery into cardiac myocytes". Journal of Magnetism and Magnetic Materials. 473: 21-25 ... a composite of mono-disperse Fe3O4 and polystyrene nanoparticles were utilized for cardiac myocyte treatment via magnetic ...
Wu F, Yan W, Pan J, Morser J, Wu Q (May 2002). "Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes". The ... Wang W, Cui Y, Shen J, Jiang J, Chen S, Peng J, Wu Q (Nov 2012). "Salt-sensitive hypertension and cardiac hypertrophy in ... Yan W, Wu F, Morser J, Wu Q (Jul 2000). "Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic ... Yan W, Wu F, Morser J, Wu Q (Jul 2000). "Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic ...
Nitroxyl has also been shown to increase the sensitivity to cardiac myocytes to Ca2+, which in turn enhances the force of ... Therefore, stimulation of SERCA leads to accelerated uptake of Ca2+ from the cytosol of the cardiac myocyte. Secondly, the ... Sarcoplasmic reticulum CaATPase (SERCA) is an energy-dependent ion pump found the sarcoplasmic reticulum of cardiac myocytes ... "Nitroxyl Activates SERCA in Cardiac Myocytes via Glutathiolation of Cysteine 674". Circulation Research. 104 (6): 720-723. doi: ...
... efficacy as a cardiac differentiation factor because it promotes the transdifferentiation of cardiac cells to skeletal myocytes ... "5-azacytidine promotes the transdifferentiation of cardiac cells to skeletal myocytes". Cellular Reprogramming. 16 (5): 324-30 ...
Cannell MB, Berlin JR, Lederer WJ (1987-01-01). "Intracellular calcium in cardiac myocytes: calcium transients measured using ... The first real time (video rate) Ca2+ imaging was carried out in 1986 in cardiac cells using intensified video cameras. Later ...