These included lists and maps of mouse genes and mutants, information on inbred strains, and brief reports of useful results ... 1997). A Life Story of Mouse News Letter and Mouse Genome. Mouse Genome 95:818-820. Searle AG. (1974). "The origins of Mouse ... This replaced Inbred Strains of Mice. The journal was run by a company Mouse News Letter Ltd, limited by guarantee and with ... 1996). "Chapter 4: Mouse Chromosome Atlas" in Genetic Variants and Strains of the Laboratory Mouse 3rd Edition Eds MF Lyon, S. ...

Wounds on mice were inoculated with the two strains. The pigmented strains created lingering abscesses. Wounds with the ... Colonies of the two strains were also exposed to human neutrophils. The mutant colonies quickly succumbed while many of the ... When comparing a normal strain of S. aureus with a strain modified to lack staphyloxanthin, the wildtype pigmented strain was ... more likely to survive incubation with an oxidizing chemical such as hydrogen peroxide than the mutant strain was. ...

He began developing large, mutant strain, colonies of mice. Under the charge of Dr. William Castle, Little helped to expand the ... Making Mice, pp. 30-35 Rader, Making Mice Rader, Making Mice, pp. 190-195 Rader, Making Mice, p. 252 Allen, Garland E. Thomas ... in mice was one that may have created a negative response to the fertility of the mice thus discontinuing the strain. Little ... This necessity for funds all but stopped the continuation of these strains of mice. The transition for these laboratories to ...

Various mutant strains of mice have been created by a number of methods. A small selection from the many available strains ... "000646 - AJ Strain Details". "002105 - New Zealand Obese Strain Details". "000928 - CAST Strain Details". "003715 - Strain ... "000658 - C3HFe Strain Details". "001976 - NOD Strain Details". "000670 - DBA1 Strain Details". "001026 - Strain Details". " ... inbred mouse strain and initiated the systematic generation of inbred strains. The mouse has since been used extensively as a ...

Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects". Nature Genetics. 26 (1): 109-113. doi:10.1038 ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Wong-Staal F, Dalla ... Tennant RW, Stasiewicz S, Eastin WC, Mennear JH, Spalding JW (2002). "The Tg.AC (v-Ha-ras) transgenic mouse: nature of the ...

Mouse strains generated by the IMPC partners are deposited at the KOMP repository and the European Mutant Mouse Archive. In ... "Knockout Mouse Project (KOMP) Repository". KOMP. 2010-08-01. Retrieved 2013-08-01. "EMMA - the European Mouse Mutant Archive". ... standardized protocols that are used by mouse research clinics to assess biological characteristics of mutant mouse strains. ... developed more than a 150 standardized protocols for the characterization of mutant mouse strains across European research ...

... mice, gerbils, and hamsters, as well as hybrid, mutant, and transgenic animals. Its brochure says it supplies more stocks and ... and stock and strain elimination. It also provided contract research services, which comprised toxicology, environmental ... strains of lab animals than any other commercial supplier in the world. BUAV writes that the company breeds around 450 baby ...

... mutant mice. Brain Res Bull 87, 383-86, 2012. PMID 22245534 (Laboratory mouse strains, Behavioural genetics). ... Malformation of the radial glial scaffold in the dentate gyrus of reeler mice, scrambler mice, and ApoER2/VLDLR-deficient mice ... Scrambler is a spontaneous mouse mutant lacking a functional DAB1 gene, resulting in a phenotype resembling that seen in the ... Relative to non-ataxic controls of the same background strain, Dab1-scm mutants were impaired in the Rotarod Performance test ...

The lifecycle of N. brasiliensis can be passed through lab mice. The availability of inbred and mutant mouse strains can be ... Characterization of Nippostrongylus brasiliensis infection in different strains of mice. The Journal of Parasitology 76:377-382 ... Lab mice previously infected with N. brasiliensis develop massive emphysema with dilation of distal airspaces due to the loss ... The immune response of mice, however, leads to cessation of egglaying by day 8 and adults are expelled by day 10. N. ...

This demonstrates that Myf6 is not essential for the formation of most myofibers, at least in the strains of mice tested. In ... Myod double-mutant mice". Nature. 431 (7007): 466-71. Bibcode:2004Natur.431..466K. doi:10.1038/nature02876. PMID 15386014. ... In mouse, Myf6/Mrf4 differs somewhat from the other MRF genes due to its two-phase expression. Initially, Myf6 is transiently ... Mutations in the mouse Myf6 gene typically exhibit reduced levels of Myf5. Despite reductions in muscle mass of the back and ...

The albino FVB mouse laboratory strain become blind by weaning age due to a mutant allele of the PDE6b gene. There are ... Chang B, Hawes NL, Hurd RE, Davisson MT, Nusinowitz S, Heckenlively JR (Feb 2002). "Retinal degeneration mutants in the mouse ... pigmented derivative strains of FVB that lack this trait. Similar to rd1 in mice, Rod-cone dysplasia type 1 (rcd1-PRA) is a ... The rd1 mouse is a well-characterized animal model of retinitis pigmentosa caused by the mutation of Pde6b gene. The phenotype ...

Mice with mutant carboxypeptidase E, Cpefat, display endocrine disorders like obesity and infertility. In some strains of mice ... but this is not found in all strains of mice. The obesity and infertility in the Cpefat mice develop with age; young mice (. 50 ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. "Entrez Gene: CPE ... This patient had intellectual disability (inability to read or write) and had abnormal glucose homeostasis, similar to mice ...

All Core F strains are now archived at the Mutant Mouse Regional Resource Center (MMRRC) at the University of California, Davis ... At the discretion of the Mouse Subcommittee, Core G also occasionally evaluates mouse lines provided by investigators. Protein- ... Mouse Transgenics Core (F), formerly located at The Scripps Research Institute, is now closed. From 2001 to 2009, Core F ... Mouse Phenotype Core (G), located at the Sanford-Burnham Medical Research Institute, works with participating investigator " ...

... or double mutant mice deficient in both Ku70 and Ku80 exhibit early aging. The mean lifespans of the three mutant mouse strains ... and the three mutant mice were found to display the same aging signs as the control mice, but at a much earlier age. Cancer ... Both subunits of Ku have been experimentally knocked out in mice. These mice exhibit chromosomal instability, indicating that ... incidence was not increased in the mutant mice. These results suggest that Ku function is important for longevity assurance and ...

... aureus directly correlates with the virulence of the strain. Recent research has shown that immunization with a mutant form of ... alpha-toxin that is no longer able to form pores protects against S. aureus pneumonia in mice. Also, introduction of alpha- ... As many strains of S. aureus are proving to be resistant to most available antibiotics, specific targeting of virulence factors ... Alpha-toxin has been shown to play a role in pathogenesis of disease, as hly knockout strains show reductions in invasiveness ...

The SV40 was known to cause cancer tumors to develop in mice. Additionally, the E. coli bacterium (although not the strain used ... The final step involved placing the mutant genetic material into a laboratory strain of the E. coli bacterium. This last step, ...

... or double mutant mice deficient in both Ku70 and Ku80 exhibit early aging. The mean lifespans of the three mutant mouse strains ... and the three mutant mice were found to display the same aging signs as the control mice, but at a much earlier age. Cancer ... A mouse mutant with a defect in this DNA polymerase is only able to replicate its mitochondrial DNA inaccurately, so that it ... However, in mice there is no increase in mutation in the brain with aging. Mice defective in a gene (Pms2) that ordinarily ...

This mouse strain allows the stable labeling of activated neurons in mice in a defined time window of several hours. Two ... The TetTag mouse is a bi-transgenic mutant used in neuroscience research that expresses a persistent marker (e.g. beta- ... The TetTag mouse allows researchers to label activated neurons during a learning experiment (e.g. fear conditioning, water maze ... Navabpour, Shaghayegh; Kwapis, Janine L.; Jarome, Timothy J. (1 January 2020). "A neuroscientist's guide to transgenic mice and ...

A transgenic mouse has been created carrying a single copy of a mutant fibrillin-1, a mutation similar to that found in the ... This mouse strain recapitulates many of the features of the human disease and promises to provide insights into the ... Reducing the level of normal fibrillin 1 causes a Marfan-related disease in mice. Transforming growth factor beta (TGF-β) plays ... January 2012). "Altered tissue behavior of a non-aneurysmal descending thoracic aorta in the mouse model of Marfan syndrome". ...

Mutant strains of S. aureus modified to lack staphyloxanthin are less likely to survive incubation with an oxidizing chemical, ... Mutant colonies are quickly killed when exposed to human neutrophils, while many of the pigmented colonies survive. In mice, ... Strains that produce EsaD also co-produce EsaG, a cytoplasmic anti-toxin that protects the producer strain from EsaD's toxicity ... Tsai is a transmembrane protein that confers immunity to the producer strain of TspA, as well as the attacked strains. There is ...

... can increase the survival of mice susceptible to the Ames strain. The Sterne strain, like all Bacillus anthracis strains, has ... Studies have shown that pXO2 contributes significantly to the observed variation in virulence, as mutants producing greater ... The Ames Strain One Anthrax Answer: Ames Strain Not From Iowa The Ames strain: What's in a name? Anthrax Sterne strain (34F2) ... To create attenuated strains, the virulence plasmid pXO1 is usually removed, but the Ames strain can still be virulent in mouse ...

In experiments with mutant strains of the C. diphtheriae, adhesion and epithelial infiltration decreased significantly. The ... many of which are yet to be fully understood as diphtheria does not affect many model hosts such as mice. One common virulence ... Strain subtyping involves comparing species of bacteria and categorizing them into subspecies. Strain subtyping also helps with ... Bacteriophages introduce a gene into the bacterial cells that makes a strain toxigenic. The strains that are not infected with ...

... performed in mice emphasizes the use of lineage-specific lentiviral vectors to express a normal version of one of the mutant ... Scientists developed this strain of lentivirus by transinfecting 293T cells with pseudotyped virus with the vesicular ... Studies have also found that injection of a lentiviral vector with IL-10 expressing genes in utero in mice can suppress, and ... Haemophilia A has also been studied in gene therapy with a lentiviral vector in mice. The vector targets the haematopoietic ...

She has investigated how the RNA-binding protein mutant FUS behaves in mouse models. Fisher serves as a Council Member at the ... The sex-determining region of the human Y chromosome encodes a finger protein Genealogies of mouse inbred strains Mutations in ... In a paper published in Science, Fisher found that two spontaneous mouse mutants generated from an ENU (N-ethyl-N-nitrosourea) ... Fisher, Elizabeth M. C. (2000). "Genealogies of mouse inbred strains". Nature. 24 (1): 23-25. doi:10.1038/71641. PMID 10615122 ...

The low levels of PER and TIM could be explained by lower protein stability or reduced protein synthesis due to mutant strains ... To compare its function to mouse CLOCK gene, in situ cloning and DNA sequencing was performed. A point mutation that changes a ... Mutants of na lack a significant increase in locomotor activity in response to light and show reduced free-running rhythms and ... This served as an indication that NA likely functions on the clock output and "the mutant is a result of disruption in the ...

... the Rockefeller team sought to obtain an attenuated strain of the virus that would not kill mice when injected into their ... Animal tests showed the attenuated 17D mutant was safe and immunizing. Theiler's team rapidly completed the development of a ... In his test, sera from vaccinated human subjects were injected into mice to see if they protected the mice against yellow fever ... This "mouse protection test" was used with variations as a measure of immunity until after World War II. Subculturing the ...

Its main activity is the reproduction and maintenance of mice stocks either of inbred strains or genetically engineered mice, ... such as transgenic and knockout mouse lines, as well as chemically induced mutants developed by Fleming researchers. The Animal ... Fleming operates its own Animal House, which can house more than 20,000 mice. Fleming's Animal house (certified with ISO 9001) ... Facilities-Units of SPF status and is currently the largest Mouse Unit in Greece in terms of number and variety of mice.[ ...

Earmarking a mutant strain of mice called MRL/MpJ led to the accidental discovery that they had the ability to regenerate ... It was later found that this strain of mice also heals damage to other body parts such as knee cartilage and heart muscle ... Laboratory mice are often kept with several animals in one cage since mice are social animals, therefore it is necessary to ... Microchips are less commonly used in mice because of their expense compared to the short life span of a mouse. ...

... where she characterised a mutant mice strain with a 'pallid' mutation and published the research. During the course of her PhD ... She also scrutinised a 'mottled' mutant, which had a different effect on male and female mice: male embryos sometimes died, and ... where there was room for more mouse facilities. There she continued to investigate the mouse mutations. ... She also did extensive work on the mouse t-complex. She was head of the Genetics Section of the MRC Radiology Unit at Harwell ...

The process, called automated meiotic mapping (AMM), eliminates the need to breed mutant mice to a mapping strain as required ... Sequencing most of the interval, they identified a gene within which each of two LPS-refractory strains of mice (C3H/HeJ and ... This required expansion of a mutant stock, outcrossing to a mapping strain, backcrossing, and genotypic and phenotypic analysis ... This he accomplished by raising an antibody against mouse TNF, which he used to neutralize TNF in living mice challenged with ...