Short QT syndromeAnkyrin-G binding motif of KCNQ2-3: In molecular biology, the ankyrin-G binding motif of KCNQ2-3 is a protein motif found in the potassium channels KCNQ2 and KCNQ3.E-4031: E-4031 is an experimental class III antiarrhythmic drug that blocks potassium channels of the hERG-type.Kim I, Boyle KM, Carrol JL (2005) Postnatal development of E-4031-sensitive potassium current in rat carotid chemoreceptor cells.Voltage-gated potassium channel database: VKCDB (Voltage-gated potassium Channel DataBase) is a database of functional data about the voltage-gated potassium channels.Malformative syndrome: A malformative syndrome (or malformation syndrome) is a recognizable pattern of congenital anomalies that are known or thought to be causally related (VIIth International Congress on Human Genetics).Automated ECG interpretation: Automated ECG interpretation is the use of artificial intelligence and pattern recognition software and knowledge bases to carry out automatically the interpretation, test reporting, and computer-aided diagnosis of electrocardiogram tracings obtained usually from a patient.Sodium channel blocker: Sodium channel blockers are drugs which impair conduction of sodium ions (Na+) through sodium channels.Hair-grooming syncope: Hair-grooming syncope (also known as hair-combing syncope) is a form of syncope (a fainting disorder) associated with combing and brushing one's hair. It is most typically seen in children aged five to sixteen.Proarrhythmia: Proarrhythmia is a new or more frequent occurrence of pre-existing arrhythmias, paradoxically precipitated by antiarrhythmic therapy, which means it is a side effect associated with the administration of some existing antiarrhythmic drugs, as well as drugs for other indications. In other words, it is a tendency of antiarrhythmic drugs to facilitate emergence of new arrhythmias.Sodium channel: Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.Silent mutation: Silent mutations are mutations in DNA that do not significantly alter the phenotype of the organism in which they occur. Silent mutations can occur in non-coding regions (outside of genes or within introns), or they may occur within exons.Jervell and Lange-Nielsen syndromePotassium channel opener: A potassium channel opener is a type of drug which facilitates ion transmission through potassium channels.DMT1: The divalent metal transporter 1 (DMT1), also known as natural resistance-associated macrophage protein 2 (NRAMP 2), and divalent cation transporter 1 (DCT1), is a protein that in humans is encoded by the SLC11A2 (solute carrier family 11, member 2) gene. DMT1 represents a large family of orthologous metal ion transporter proteins that are highly conserved from bacteria to humans.Calciumopathy: A calciumopathy is a disease caused byMissense mutation: In genetics, a missense mutation (a type of nonsynonymous substitution) is a point mutation in which a single nucleotide change results in a codon that codes for a different amino acid. Another type of nonsynonymous substitution is a nonsense mutation in which a codon is changed to a premature stop codon that results in truncation of the resulting protein.CisaprideSinus bradycardiaSympathectomyAsystoleAstemizoleVentricular action potentialPedigree chart: A pedigree chart is a diagram that shows the occurrence and appearance or phenotypes of a particular gene or organism and its ancestors from one generation to the next,pedigree chart Genealogy Glossary - About.com, a part of The New York Times Company.FlecainideSyndactylyNadololPatch clamp: The patch clamp technique is a laboratory technique in electrophysiology that allows the study of single or multiple ion channels in cells. The technique can be applied to a wide variety of cells, but is especially useful in the study of excitable cells such as neurons, cardiomyocytes, muscle fibers, and pancreatic beta cells.Phenotype microarray: The phenotype microarray approach is a technology for high-throughput phenotyping of cells.Achy Breaky HeartDavid Lester (biochemist)First-degree atrioventricular blockJohn HolterInterbeat interval: Interbeat interval is a scientific term used in the study of the mammalian heart.QuinidinePeriodic current reversalMulticenter Automatic Defibrillator Implantation Trial: Multicenter Automatic Defibrillator Implantation Trial and MADIT II are implantable cardioverter defibrillator (or ICD) trials which investigate whether prophylactic ICD therapy in moderately high-risk coronary patients (in addition to conventional therapy) would significantly reduce death compared with patients treated with conventional therapy alone.Potassium channel blocker: Potassium channel blockers are agents which interfere with conduction through potassium channels.National Down Syndrome SocietyNational Cholesterol Education Program: The National Cholesterol Education Program is a program managed by the National Heart, Lung and Blood Institute, a division of the National Institutes of Health. Its goal is to reduce increased cardiovascular disease rates due to hypercholesterolemia (elevated cholesterol levels) in the United States of America.BepridilSudden Unexplained Death in Childhood: Sudden Unexplained Death In Childhood (SUDC) is the death of a child over the age of 12 months which remains unexplained after a thorough investigation and autopsy. There has not been enough research to identify risk factors, common characteristics, or prevention strategies for SUDC.XEN-D0101: XEN-D0101 is a drug that was developed to treat atrial fibrillation. Xention, a biopharmaceutical company based in Cambridge, United Kingdom, created XEN-D0101 along with other ion channel-modulating drugs.SotalolPropranololSingle-strand conformation polymorphism: Single-strand conformation polymorphism (SSCP), or single-strand chain polymorphism, is defined as conformational difference of single-stranded nucleotide sequences of identical length as induced by differences in the sequences under certain experimental conditions. This property allows sequences to be distinguished by means of gel electrophoresis, which separates fragments according to their different conformations.Primary ventricular fibrillation: Primary ventricular fibrillation (PVF) is an unpredictable and potentially fatal arrhythmia occurring during the acute phase of a myocardial infarction leading to immediate [and, if left untreated, leads to sudden cardiac death] within minutes. In developed countries, PVF is a leading cause of death.Ventricular dyssynchrony: In cardiology, Ventricular dyssynchrony is a difference in the timing, or lack of synchrony, of contractions in different ventricles in the heart. Large differences in timing of contractions can reduce cardiac efficiency and is correlated with heart failure.Sudden unexpected death syndromeProtein turnover: Protein turnover is the balance between protein synthesis and protein degradation. More synthesis than breakdown indicates an anabolic state that builds lean tissues, more breakdown than synthesis indicates a catabolic state that burns lean tissues.QRISK: QRISK2 (the most recent version of QRISK) is a prediction algorithm for cardiovascular disease (CVD) that uses traditional risk factors (age, systolic blood pressure, smoking status and ratio of total serum cholesterol to high-density lipoprotein cholesterol) together with body mass index, ethnicity, measures of deprivation, family history, chronic kidney disease, rheumatoid arthritis, atrial fibrillation, diabetes mellitus, and antihypertensive treatment.Global Risks Report: The Global Risks Report is an annual study published by the World Economic Forum ahead of the Forum’s Annual Meeting in Davos, Switzerland. Based on the work of the Global Risk Network, the report describes changes occurring in the global risks landscape from year to year and identifies the global risks that could play a critical role in the upcoming year.Toe walking: Toe walking refers to a condition where a person walks on his or her toes without putting much weight on the heel or any other part of the foot. Toe walking in toddlers is common.Clara W. BeebeMyocytolysis: Myocytolysis refers to a degenerative change (often reversible) that occurs to myocytes upon myocardial strain. This phenomenon tends to occur when neighboring cardiac muscle loses its ability to contract (i.Phenylpiperidine: Phenylpiperidine is a chemical compound with a phenyl moiety directly attached to piperidine. There are a variety of pharmacological effects associated some phenylpiperidines including morphine-like activity or other central nervous system effects.Adrenalin O.D.Congenital nephrotic syndromeReversal potential: In a biological membrane, the reversal potential (also known as the Nernst potential) of an ion is the membrane potential at which there is no net (overall) flow of that particular ion from one side of the membrane to the other. In the case of post-synaptic neurons, the reversal potential is the membrane potential at which a given neurotransmitter causes no net current flow of ions through that neurotransmitter receptor's ion channel.HypokalemiaTrans-tubular potassium gradient: The trans-tubular potassium gradient (TTKG) is an index reflecting the conservation of potassium in the cortical collecting ducts (CCD) of the kidneys. It is useful in diagnosing the causes of hyperkalemia or hypokalemia.
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