Keratinocyte: A keratinocyte is the predominant cell type in the epidermis, the outermost layer of the skin, constituting 90% of the cells found there.Dermal equivalent: The dermal equivalent is an in vitro model of the dermal layer of skin. It is constructed by seeding dermal fibroblasts into a collagen gel.Keratin 6A: Keratin 6A is one of the 27 different type II keratins expressed in humans. Keratin 6A was the first type II keratin sequence determined.Psoriasis: (psora + -iasis)UVB-induced apoptosis: UVB-induced apoptosis is the programmed cell death of cells that become damaged by ultraviolet rays. This is notable in skin cells, to prevent melanoma.Wound healing: Wound healing is an intricate process where the skin or other body tissue repairs itself after injury. In normal skin, the epidermis (surface layer) and dermis (deeper layer) form a protective barrier against the external environment.Interstitial granulomatous dermatitis: Interstitial granulomatous dermatitis with arthritis is a condition that most commonly presents with symmetrical round-to-oval erythematous or violaceous plaques on the flanks, axillae, inner thighs, and lower abdomen.James, William; Berger, Timothy; Elston, Dirk (2005).Biotextile: Biotextiles are structures composed of textile fibers designed for use in specific biological environments where their performance depends on biocompatibility and biostability with cells and biological fluids. Biotextiles include implantible devices such as surgical sutures, hernia repair fabrics, arterial grafts, artificial skin and parts of artificial hearts.Hair follicle nevus: Hair follicle nevus (also known as a "Vellus hamartoma") is a cutaneous condition that presents as a small papule from which fine hairs protrude evenly from the surface.MelanocyteMature messenger RNA: Mature messenger RNA, often abbreviated as mature mRNA is a eukaryotic RNA transcript that has been spliced and processed and is ready for translation in the course of protein synthesis. Unlike the eukaryotic RNA immediately after transcription known as precursor messenger RNA, it consists exclusively of exons, with all introns removed.MinC: The MinC protein is one of three proteins encoded by the minB operon and which is required to generate pole to pole oscillations prior to bacterial cell division as a means of specifying the midzone of the cell. This function is achieved by preventing the formation of the divisome Z-ring around the poles.Dermal fibroblast: Dermal fibroblasts are cells within the dermis layer of skin which are responsible for generating connective tissue and allowing the skin to recover from injury. Using organelles (particularly the rough endoplasmic reticulum), dermal fibroblasts generate and maintain the connective tissue which unites separate cell layers.Papillary dermis: The papillary dermis is the uppermost layer of the dermis. It intertwines with the rete ridges of the epidermis and is composed of fine and loosely arranged collagen fibers.Tonofibril: Tonofibrils, discovered by Rudolf Heidenhain, and first described in detail by Louis-Antoine Ranvier, are cytoplasmic protein structures in epithelial tissues that converge at desmosomes and hemidesmosomes. Characterized by the fine fibrils in the epithelial cells.Transglutaminase: A transglutaminase is an enzyme that catalyzes the formation of an isopeptide bond between a free amine group (e.g.Laryngeal papillomatosisMelanosome: A melanosome is an organelle found in animal cells, and is the cellular site of synthesis, storage and transport of melanin, the most common light-absorbing pigment found in the animal kingdom. These melanosomes are responsible for color and photoprotection in animal tissues.PemphigusHaptotaxis: Haptotaxis (from Greek ἅπτω (hapto, "touch, fasten") and τάξις (taxis, "arrangement, order")) is the directional motility or outgrowth of cells, e.g.Cell adhesionHemidesmosomeSuction blister: Suction blistering is a technique used in dermatology to treat chronic wounds, such as non-healing leg ulcers. When a wound is not healing properly, an autologous skin graft is the best option, to prevent rejection of the tissue.Hair analysisAtopic dermatitisKeratolytic: Keratolytic therapy is treatment to remove warts and other lesions in which the epidermis produces excess skin. In this therapy, acid medicine, such as salicylic acid is put on the lesion.List of Bratz charactersSkin graftingSquamous-cell carcinomaRelapsing linear acantholytic dermatosis: Relapsing linear acantholytic dermatosis is a cutaneous condition characterized by relapsing linear erosions and crusting, histologically identical to Hailey–Hailey disease. It is not to be confused with transient acantholytic dermatosis.Phorbol 12,13-dibutyrateGC box: In molecular biology, a GC box is a distinct pattern of nucleotides found in the promoter region of some eukaryotic genes upstream of the TATA box and approximately 110 bases upstream from the transcription initiation site. It has a consensus sequence GGGCGG which is position dependent and orientation independent.RNA transfection: RNA transfection is the process of deliberately introducing RNA into a living cell. RNA can be purified from cells after lysis or synthesized from free nucleotides either chemically, or enzymatically using an RNA polymerase to transcribe a DNA template.Calcium signaling: Calcium ions are important for cellular signalling, as once they enter the cytosol of the cytoplasm they exert allosteric regulatory effects on many enzymes and proteins. Calcium can act in signal transduction resulting from activation of ion channels or as a second messenger caused by indirect signal transduction pathways such as G protein-coupled receptors.Langerin: CD207, langerin (Cluster of Differentiation 207) is a protein which in humans is encoded by the CD207 gene. Langerin is a type II transmembrane, C-type lectin receptor on Langerhans cells.Keratin 5: Keratin 5, also known as KRT5, K5, or CK5, is a protein that is encoded in humans by the KRT5 gene. It dimerizes with keratin 14 and forms the intermediate filaments (IF) that make up the cytoskeleton of basal epithelial cells.Stratified squamous epithelium: A stratified squamous epithelium consists of squamous (flattened) epithelial cells arranged in layers upon a basal membrane. Only one layer is in contact with the basement membrane; the other layers adhere to one another to maintain structural integrity.Central centrifugal cicatricial alopecia: Central centrifugal cicatricial alopecia (CCCA), also referred to as hot comb alopecia and follicular degeneration syndrome, is a type of alopecia first noticed in African Americans in the 1950s and reported by LoPresti et al. in 1968 as a result of application of petrolatum followed by a stove-heated iron comb.Midkine: Midkine (MK or MDK) also known as neurite growth-promoting factor 2 (NEGF2) is a protein that in humans is encoded by the MDK gene.Secretory Pathway Ca²⁺ ATPase: SPCA, or Secretory Pathway Ca2+-ATPase, is a calcium ATPase-type P-ATPase encoded for by the genes ATP2C1 and ATP2C2.DNA-binding proteinPituitary-specific positive transcription factor 1: POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1), also known as POU1F1, is a transcription factor for growth hormone.Junctional epidermolysis bullosa (medicine): Junctional epidermolysis bullosa}}AcroplaxomeSymmetry element: A symmetry element is a point of reference about which symmetry operations can take place. In particular, symmetry elements can be centers of inversion, axes of rotation and mirror planes.Eukaryotic transcription: Eukaryotic transcription is the elaborate process that eukaryotic cells use to copy genetic information stored in DNA into units of RNA replica. Gene transcription occurs in both eukaryotic and prokaryotic cells.Coles PhillipsHyperphosphorylation: Hyperphosphorylation occurs when a biochemical with multiple phosphorylation sites is fully saturated. Hyperphosphorylation is one of the signalling mechanisms used by the cell to regulate mitosis.Harlequin-type ichthyosisRepressor: In molecular genetics, a repressor is a DNA- or RNA-binding protein that inhibits the expression of one or more genes by binding to the operator or associated silencers. A DNA-binding repressor blocks the attachment of RNA polymerase to the promoter, thus preventing transcription of the genes into messenger RNA.Actinic elastosis: Actinic elastosis, also known as solar elastosis is an accumulation of abnormal elastin (elastic tissue) in the dermis of the skin, or in the conjunctiva of the eye, which occurs as a result of the cumulative effects of prolonged and excessive sun exposure, a process known as photoaging.Squamous epithelial cell: In anatomy, squamous epithelium (squama- + -ous) is that whose outermost (apical) layer consists of thin, flat cells called squamous epithelial cells. The epithelium may be composed of one layer of these cells, in which case it is referred to as simple squamous epithelium, or it may possess multiple layers, referred to then as stratified squamous epithelium.
Download our free solidary book to support research on VHL disease