... (IL-3) is a protein that in humans is encoded by the IL3 gene localized on chromosome 5q31.1. Sometimes also ... Interleukin 3 is an interleukin, a type of biological signal (cytokine) that can improve the body's natural response to disease ... Interleukin 3 was originally discovered in mice and later isolated from humans. The cytokine was originally discovered via the ... "Entrez Gene: IL3 interleukin 3 (colony-stimulating factor, multiple)". Yang YC, Ciarletta AB, Temple PA, Chung MP, Kovacic S, ...
The interleukin-3 receptor (CD123) is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble ... Tagraxofusp, human IL-3 fused to diphtheria toxin, is an approved treatment for BPDCN. An experimental antibody-drug conjugate ... Initiates Phase 1 Trial of SGN-CD123A for Patients with Relapsed or Refractory Acute Myeloid Leukemia Sept 2016 Interleukin-3+ ...
... is a pro-inflammatory pleiotropic cytokine. It's precursor, pro-interleukin-16 is a protein that in humans is ... Interleukin 16 (IL-16) is released by a variety of cells (including lymphocytes and some epithelial cells) that has been ... Interleukin 16 has been shown to interact with: GRIN2A, GRIN2D, KCNJ10, KCNJ15, Kir2.1, PPP1R12A, and PPP1R12B. GRCh38: Ensembl ... "Entrez Gene: IL16 interleukin 16 (lymphocyte chemoattractant factor)". Cruikshank W, Center DM (June 1982). "Modulation of ...
... 1 alpha and interleukin 1 beta (IL1 alpha and IL1 beta) are cytokines that participate in the regulation of immune ... Gately MK, Renzetti LM, Magram J, Stern AS, Adorini L, Gubler U, Presky DH (1998). "The interleukin-12/interleukin-12-receptor ... Recombinant expression enables cells to process precursor Interleukin 1 Beta to the mature form of the enzyme. Interleukin 1 ... di Giovine FS, Duff GW (Jan 1990). "Interleukin 1: the first interleukin". Immunology Today. 11 (1): 13-20. doi:10.1016/0167- ...
"Entrez Gene: IL9R interleukin 9 receptor". Sliva, D; Gu M; Zhu Y X; Chen J; Tsai S; Du X; Yang Y C (February 2000). "14-3-3zeta ... Interleukin 9 receptor (IL9R) also known as CD129 (Cluster of Differentiation 129) is a type I cytokine receptor. IL9R also ... Interleukin-9 receptor has been shown to interact with YWHAZ. Cluster of differentiation GRCh38: Ensembl release 89: ... 1992). "Expression cloning of the murine and human interleukin 9 receptor cDNAs". Proc. Natl. Acad. Sci. U.S.A. 89 (12): 5690-4 ...
... (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In ... Interleukin-6 has been shown to interact with interleukin-6 receptor, glycoprotein 130, and Galectin-3. There is considerable ... Other cytokines that signal through receptors containing gp130 are Interleukin 11 (IL-11), Interleukin 27 (IL-27), ciliary ... "Direct determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopy". The Journal of ...
... (IL-5) is an interleukin produced by type-2 T helper cells and mast cells. Through binding to the interleukin-5 ... The α subunit is specific for the IL-5 molecule, whereas the βc subunit also recognised by interleukin 3 (IL-3) and granulocyte ... Unlike other members of this cytokine family (namely interleukin 3 and GM-CSF), this glycoprotein in its active form is a ... Overview of all the structural information available in the PDB for UniProt: P05113 (Interleukin-5) at the PDBe-KB. (CS1: long ...
... interleukin-28 A (Interferon lambda 1), Interleukin-28B (Interferon lambda 2), interleukin 29 (Interferon lambda 3) and ... The interleukin 28 receptor consists of an interleukin-28R alpha chain (IL-28RA) and another receptor, the beta subunit of the ... Wolk K, Witte K, Sabat R (August 2010). "Interleukin-28 and interleukin-29: novel regulators of skin biology". Journal of ... The interleukin-28 receptor, once a ligand is bound will activate a signaling pathway that causes an increase in MHC class 1 ...
October 2000). "The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells". ... Testa U, Riccioni R, Diverio D, Rossini A, Lo Coco F, Peschle C (February 2004). "Interleukin-3 receptor in acute leukemia". ... 95 (3): 952-8. doi:10.1182/blood.V95.3.952.003k27_952_958. PMID 10648408. Archived from the original on 1 August 2012. Zhou L, ... 9 (3): 196-201. doi:10.1111/j.1087-0024.2004.09313.x. PMID 15369213. Rubin DC, Swietlicki E, Roth KA, Gordon JI (25 July 1992 ...
Its induction in hematopoietic cells was used as an assay for the identification of T cell derived factor interleukin-3. In ... "Biologic properties of homogeneous interleukin 3. I. Demonstration of WEHI-3 growth factor activity, mast cell growth factor ... 148 (3): 976-88. doi:10.1210/en.2006-1100. PMID 17122075. Portal: Biology v t e (Articles with short description, Short ... 266 (5603): 632-3. Bibcode:1977Natur.266..632W. doi:10.1038/266632a0. PMID 300849. S2CID 4146146. Ihle JN, Keller J, Oroszlan S ...
"Entrez Gene: IL3RA interleukin 3 receptor, alpha (low affinity)". Stomski FC, Sun Q, Bagley CJ, Woodcock J, Goodall G, Andrews ... Interleukin 3 receptor, alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123), is a human gene. ... Klein BK, Feng Y, McWherter CA, Hood WF, Paik K, McKearn JP (1997). "The receptor binding site of human interleukin-3 defined ... Stomski FC, Sun Q, Bagley CJ, Woodcock J, Goodall G, Andrews RK, Berndt MC, Lopez AF (1996). "Human interleukin-3 (IL-3) ...
This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist ( ... This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 ... Interleukin 1 receptor, type I has been shown to interact with PIK3R1, Myd88 and IL1RAP. Cluster of differentiation Interleukin ... Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. ...
One is Interleukin enhancer-binding factor 3. ILF3 is a factor that complexes with other proteins and regulates gene expression ... "Proteomic analysis of interleukin enhancer binding factor 3 (Ilf3) and nuclear factor 90 (NF90) interactome". Biochimie. 95 (6 ... The 3-D structure shown shows a prediction made by I-TASSER. This is a possible strture with a C-score of -1.06 on a scale from ...
Nuclear factor, interleukin 3 regulated, also known as NFIL3 or E4BP4 is a protein which in humans is encoded by the NFIL3 gene ... Expression of interleukin-3 (IL-3) is restricted to activated T cells, natural killer (NK) cells, and mast cell lines. ... "Entrez Gene: NFIL3 nuclear factor, interleukin 3 regulated". Zhang W, Zhang J, Kornuc M, Kwan K, Frank R, Nimer SD (November ... "Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes". Proceedings of ...
"Involvement of interleukin-3 in delayed-type hypersensitivity". Blood 92:778-783. "Richard C. Mulligan, Ph.D. , HMS Department ... Writer, GEN Staff (3 March 2017). "Icahn Names Gene Transfer Pioneer as Portfolio Manager". GEN - Genetic Engineering and ... 7 (10): R601-2. doi:10.1016/s0960-9822(06)00308-3. PMID 9382777. S2CID 9998648. "Denner said to start activist health-care ... Molecular Medicine 3:466-476. Goodell, M.A., Rosenzweig, H-.K., Marks, D.G., DeMaria, M., Paradis, G., Grupp, S.A., Sieff, C.A ...
Interleukin-3 receptor Interleukin-9 receptor Mangs, Helena; Morris BJ (2007). "The Human Pseudoautosomal Region (PAR): Origin ... 16 (3): 233-9. doi:10.1016/j.gde.2006.04.004. PMID 16650979. Benito-Sanz S, Thomas NS, Huber C, et al. (October 2005). "A novel ... 9 (3): 395-401. doi:10.1093/hmg/9.3.395. PMID 10655549. Weng S, Stoner SA, Zhang DE (2016). "Sex chromosome loss and the ... 16 (3): 233-9. doi:10.1016/j.gde.2006.04.004. PMID 16650979. Helena Mangs A, Morris BJ (April 2007). "The Human Pseudoautosomal ...
Prakash Babu S, Chen YK, Bonne-Annee S, Yang J, Maric I, Myers TG, Nutman TB, Klion AD (2017). "Dysregulation of interleukin 5 ... interleukin 5) that: a) cause bone marrow precursor cells, i.e. CFU-Eos, to proliferate and mature into eosinophils; b) promote ... interleukin 3, or interleukin 13. The disorder is usually indolent but infrequently progresses to T-cell lymphoma or Sezary ... interleukin 5, and histamine (though this has a narrow range of concentration). Harm resulting from untreated eosinophilia ...
Interleukin-1 receptor-associated kinase 3 is an enzyme that in humans is encoded by the IRAK3 gene. Using in vivo liposome- ... "Entrez Gene: IRAK3 interleukin-1 receptor-associated kinase 3". Soni D, Wang DM, Regmi SC, Mittal M, Vogel SM, Schlüter D, ... Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (July 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 ... Su J, Xie Q, Wilson I, Li L (July 2007). "Differential regulation and role of interleukin-1 receptor associated kinase-M in ...
Interleukin enhancer-binding factor 3 is a protein that in humans is encoded by the ILF3 gene. Nuclear factor of activated T- ... "Entrez Gene: ILF3 interleukin enhancer binding factor 3, 90kDa". Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP (January ... Duchange N, Pidoux J, Camus E, Sauvaget D (December 2000). "Alternative splicing in the human interleukin enhancer binding ... Marcoulatos P, Avgerinos E, Tsantzalos DV, Vamvakopoulos NC (May 1998). "Mapping interleukin enhancer binding factor 3 gene ( ...
... interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion". Eur. Cytokine Netw ... Its receptors were similarly renamed: Interleukin 8 receptor, alpha - CXCR1 Interleukin 8 receptor, beta - CXCR2 GRCh38: ... Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types ... In humans, the interleukin-8 protein is encoded by the CXCL8 gene. IL-8 is initially produced as a precursor peptide of 99 ...
Le Gros, Graham (1987). Role of interleukin 2 and interleukin 3 in haemopoiesis (Doctoral thesis). ResearchSpace@Auckland, ...
del Peso L, González-García M, Page C, Herrera R, Nuñez G (Oct 1997). "Interleukin-3-induced phosphorylation of BAD through the ... 12 (3): 915-27. doi:10.1128/mcb.12.3.915. PMC 369523. PMID 1545823. Tratner I, Ofir R, Verma IM (Mar 1992). "Alteration of a ... 273 (3): 1496-505. doi:10.1074/jbc.273.3.1496. PMID 9430688. Joel PB, Smith J, Sturgill TW, Fisher TL, Blenis J, Lannigan DA ( ... 388 (Pt 3): 973-84. doi:10.1042/BJ20041888. PMC 1183479. PMID 15757502. Cavet ME, Lehoux S, Berk BC (May 2003). "14-3-3beta is ...
After completing a PhD in 1987 under Jim Watson at the University of Auckland, titled Role of interleukin 2 and interleukin 3 ... Le Gros, Graham (1987). Role of interleukin 2 and interleukin 3 in haemopoiesis (Doctoral thesis). ResearchSpace@Auckland, ... Retrieved 3 September 2021. Media related to Graham Le Gros at Wikimedia Commons (CS1 maint: multiple names: authors list, ...
It functions by stimulating ligands for interleukin 3 and c-Mpl. Kratz-Albers K, Scheding S, Möhle R, Bühring H, Baum C, Mc ... 28 (3): 335-46. doi:10.1016/S0301-472X(99)00152-6. PMID 10720698. Definition of promegapoietin - NCI Dictionary of Cancer Terms ... supports megakaryocyte development through activation of IL-3 and c-Mpl ligand signaling pathways". Exp Hematol. 29 (10): 1177- ...
del Peso L, González-García M, Page C, Herrera R, Nuñez G (1997). "Interleukin-3-induced phosphorylation of BAD through the ... 59 (3): 533-7. PMID 9973195. Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, ... 17 (3): 393-403. doi:10.1016/j.molcel.2004.12.030. PMID 15694340. Jin Z, Xin M, Deng X (April 2005). "Survival function of ... Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins". J. Biol. Chem. 272 (49): ...
It transcriptionally activates interleukin-3, and is implicated in apoptotic pathways. No other mammalian homologs have been ... doi:10.1016/S0896-6273(03)00002-3. PMID 12546820. Cyran SA, Buchsbaum AM, Reddy KL, Lin MC, Glossop NR, Hardin PE, et al. ( ... 112 (3): 329-41. doi:10.1016/S0092-8674(03)00074-6. PMID 12581523. Skripka FA (August 1975). "[Orthopedic and sanatorium-health ... Lastly, PDP1 protein, a bZIP transcription factor, serves as an activator of clk transcription and peaks 3-6 hours after the ...
... , also known as IL-9, is a pleiotropic cytokine (cell signalling molecule) belonging to the group of interleukins ... Renauld J (1995). "Interleukin-9: Structural characteristics and biologic properties". Cytokines: Interleukins and Their ... Interleukin 33 (IL-33) induces IL-9 expression and secretion in T cells, which was confirmed by the results obtained in mice by ... Interleukin-9 has also shown to inhibit melanoma growth in mice. Additionally, it gives rise to the multiplication of ...
Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 ... Interleukin 5 receptor alpha subunit has been shown to interact with: Interleukin 5, Janus kinase 2, Protein unc-119 homolog, ... "Entrez Gene: IL5RA interleukin 5 receptor, alpha". Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, ... Scibek JJ, Evergren E, Zahn S, Canziani GA, Van Ryk D, Chaiken IM (2003). "Biosensor analysis of dynamics of interleukin 5 ...
Interleukin-18 (IL-18), also known as interferon-gamma inducing factor is a protein which in humans is encoded by the IL18 gene ... Liu Z, Wang H, Xiao W, Wang C, Liu G, Hong T (October 2010). "Thyrocyte interleukin-18 expression is up-regulated by interferon ... This interleukin was also significantly elevated in patients with microalbuminuria and macroalbuminuria when it was compared ... Nolan KF, Greaves DR, Waldmann H (July 1998). "The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the ...
"IL36B interleukin 36 beta [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-09-09. "IL36G interleukin ... Interleukin 36, or IL-36, is a group of cytokines in the IL-1 family with pro-inflammatory effects. The role of IL-36 in ... "IL36A interleukin 36 alpha [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-09-09. " ... Towne, Jennifer E.; Garka, Kirsten E.; Renshaw, Blair R.; Virca, G. Duke; Sims, John E. (2004-04-02). "Interleukin (IL)-1F6, IL ...