Interleukin 1-alpha
Interleukin-1 alpha (IL-1 alpha) also known as hematopoietin 1 is a cytokine of the interleukin 1 family that in humans is ... In general, Interleukin 1 is responsible for the production of inflammation, as well as the promotion of fever and sepsis. IL-1 ... Interleukin 1 was discovered by Gery in 1972. He named it lymphocyte-activating factor (LAF) because it was a lymphocyte ... Hu B, Wang S, Zhang Y, Feghali CA, Dingman JR, Wright TM (Aug 2003). "A nuclear target for interleukin-1alpha: interaction with ...
Interleukin-1 receptor
... (IL-1R) is a cytokine receptor which binds interleukin 1. Two forms of the receptor exist. The type I ... Receptors,+Interleukin-1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short ... Arend WP (1991). "Interleukin 1 receptor antagonist. A new member of the interleukin 1 family". J. Clin. Invest. 88 (5): 1445- ... Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (March 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP ...
Interleukin-1 family
"IL37 interleukin 37 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2019-08-31. "IL1F10 interleukin 1 ... Liu N, Li X, Liu C, Zhao Y, Cui B, Ning G (April 2010). "The association of interleukin-1alpha and interleukin-1beta ... "Interleukins and interleukin receptors - HUGO Gene Nomenclature Committee". www.genenames.org. Archived from the original on 15 ... Yoshimoto T, Okamura H, Tagawa YI, Iwakura Y, Nakanishi K (April 1997). "Interleukin 18 together with interleukin 12 inhibits ...
Interleukin 1 beta
... interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion". European Cytokine Network. 13 (2): 161- ... "Entrez Gene: IL1B interleukin 1, beta". Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC, Mills KH (August 2009). " ... There are two genes for interleukin-1 (IL-1): IL-1 alpha and IL-1 beta (this gene). IL-1β precursor is cleaved by cytosolic ... This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. IL-1β, in combination with ...
Interleukin-1 receptor family
The term interleukin-1 includes IL-1α, IL-1β and Interleukin 1 receptor antagonist (IL-1Ra). IL-1Rs are involved in immune host ... There are four main groups of TIR domain-containing proteins in animals; Toll-like receptors, Interleukin-1 receptor (IL-1R), ... Martin MU, Wesche H (November 2002). "Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor ... Members of the very wide interleukin-1 receptor (IL-1R) family are characterized by extracellular immunoglobulin-like domains ...
Interleukin-1 receptor antagonist protein
... preventing IL-1's from sending a signal to that cell. IL-1RA is a member of the interleukin 1 cytokine family. IL1Ra is ... The interleukin-1 receptor antagonist protein (IL-1RN) is a protein that in humans is encoded by the IL1RN gene. IL-1RN was ... "Entrez Gene: IL1RN interleukin 1 receptor antagonist". Langdahl BL, Løkke E, Carstens M, Stenkjaer LL, Eriksen EF (March 2000 ... Interleukin+1+Receptor+Antagonist+Protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Articles ...
Interleukin 1 receptor, type I
"Entrez Gene: IL1R1 interleukin 1 receptor, type I". Reddy, S A; Huang J H; Liao W S (November 1997). "Phosphatidylinositol 3- ... 1989). "Cloning the interleukin 1 receptor from human T cells". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8946-50. Bibcode: ... Interleukin 1 receptor, type I has been shown to interact with PIK3R1, Myd88 and IL1RAP. Cluster of differentiation Interleukin ... Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. ...
Interleukin 1 receptor, type II
"Interleukin-13 and interleukin-4 act as interleukin-6 inducers in human microglial cells". Cytokine. 8 (8): 636-41. doi:10.1006 ... Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this ... "Entrez Gene: IL1R2 interleukin 1 receptor, type II". McMahan CJ, Slack JL, Mosley B, Cosman D, Lupton SD, Brunton LL, Grubin CE ... Interleukin 1 receptor, type II (IL-1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. ...
Interleukin 13 receptor, alpha 1
2005). "Characterization of the interaction between interleukin-13 and interleukin-13 receptors". J. Biol. Chem. 280 (26): ... Interleukin 13 receptor, alpha 1, also known as IL13RA1 and CD213A1 (cluster of differentiation 213A1), is a human gene. The ... "Entrez Gene: IL13RA1 interleukin 13 receptor, alpha 1". Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995). "Domain ... Interleukin-13 receptor GRCh38: Ensembl release 89: ENSG00000131724 - Ensembl, May 2017 GRCm38: Ensembl release 89: ...
Interleukin-1 receptor associated kinase
Interleukin 1 is a cytokine that acts locally and systemically in the innate immune system. IL-1a and IL-1ß are known for ... The interleukin-1 receptor (IL-1R) associated kinase (IRAK) family plays a crucial role in the protective response to pathogens ... Interleukin-1 Receptor-Associated Kinases at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Suzuki, N., ... TLRs and IL-1R members have a highly conserved amino acid sequence in their cytoplasmic domain called the Toll/Interleukin-1 ( ...
Interleukin 12 receptor, beta 1 subunit
1998). "Interleukin-12 induces tyrosine phosphorylation of an 85-kDa protein associated with the interleukin-12 receptor beta 1 ... is a subunit of the interleukin 12 receptor and the interleukin 23 receptor. IL12RB1, is the name of its human gene. IL-12Rβ1 ... "Genetic variations in the interleukin-12/interleukin-23 receptor (beta1) chain, and implications for IL-12 and IL-23 receptor ... 1995). "Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist". Eur. J. Immunol. 25 (1): 200-6. doi:10.1002/eji ...
Deficiency of the interleukin-1-receptor antagonist
Interleukin 1 receptor antagonist (IL1RN) has a total of five alleles, of those the (IL1RN*1) and (IL1RN*2) are the most common ... Deficiency of the interleukin-1-receptor antagonist (DIRA) is an autosomal recessive, genetic autoinflammatory syndrome ... The mutations result in an abnormal protein that is not secreted, exposing the cells to unopposed interleukin 1 activity. This ... The mechanism of deficiency of the interleukin-1-receptor antagonist affects the normal function of IL1RN gene. The protein ...
Toll-interleukin receptor
The toll-interleukin-1 receptor (TIR) homology domain is an intracellular signaling domain found in MyD88, SARM1, interleukin-1 ... Essuman K, Summers DW, Sasaki Y, Mao X, DiAntonio A, Milbrandt J (March 2017). "The SARM1 Toll/Interleukin-1 Receptor Domain ... Interleukin-1 receptor InterPro: IPR004075 IL18R1; IL18RAP; IL1R1; IL1RAP; IL1RAPL1; IL1RAPL2; IL1RL1; IL1RL2; MYD88; SIGIRR; ... March 1996). "T1/ST2 signaling establishes it as a member of an expanding interleukin-1 receptor family". The Journal of ...
Interleukin-38
... (IL-38) is a member of the interleukin-1 (IL-1) family and the interleukin-36 (IL-36) subfamily. It is important ... Jung, MY; Kang, SW; Kim, SK; Kim, H-J; Yun, DH; Yim, S-V; Hong, SJ; Chung, J-H (2010-02-09). "The interleukin-1 family gene ... Yuan, X. L.; Li, Y.; Pan, X. H.; Zhou, M.; Gao, Q. Y.; Li, M. C. (May 2016). "Production of recombinant human interleukin-38 ... Also serum levels of IL-17 and interleukin-22 were lower in these mice what approves in vitro observation that IL-38 could ...
Interleukin 36 receptor antagonist
... (IL-36RA) is a member of the interleukin-36 family of cytokines. It was previously named ... "Entrez Gene: IL36RN interleukin 36 receptor antagonist". Towne, JE; Garka, KE; Renshaw, BR; Virca, GD; Sims, JE (2 April 2004 ... Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R, Ford JE (Nov 1999). "IL1HY1: A novel interleukin-1 receptor ... Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE (Feb 2000). "Four new members expand the interleukin-1 superfamily ...
Interleukin 36
"IL36B interleukin 36 beta [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-09-09. "IL36G interleukin ... Interleukin 36, or IL-36, is a group of cytokines in the IL-1 family with pro-inflammatory effects. The role of IL-36 in ... "IL36A interleukin 36 alpha [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-09-09. " ... Towne, Jennifer E.; Garka, Kirsten E.; Renshaw, Blair R.; Virca, G. Duke; Sims, John E. (2004-04-02). "Interleukin (IL)-1F6, IL ...
Interleukin receptor
They include: Interleukin-10 receptor Interleukin-20 receptor Interleukin-22 receptor Interleukin-28 receptor Interleukin-8 ... Interleukin-2 receptor Interleukin-3 receptor Interleukin-4 receptor Interleukin-5 receptor Interleukin-6 receptor Interleukin- ... 7 receptor Interleukin-9 receptor Interleukin-11 receptor Interleukin-12 receptor Interleukin-13 receptor Interleukin-15 ... receptor Interleukin-18 receptor Interleukin-21 receptor Interleukin-23 receptor Interleukin-27 receptor Type 2 interleukin ...
Interleukin 37
... (IL-37), also known as Interleukin-1 family member 7 (IL-1F7), is an anti-inflammatory cytokine important for ... April 2018). "The Role, Involvement and Function(s) of Interleukin-35 and Interleukin-37 in Disease Pathogenesis". ... April 2002). "Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but ... Wang L, Quan Y, Yue Y, Heng X, Che F (April 2018). "Interleukin-37: A crucial cytokine with multiple roles in disease and ...
Interleukin 17
Mudigonda P, Mudigonda T, Feneran AN, Alamdari HS, Sandoval L, Feldman SR (October 2012). "Interleukin-23 and interleukin-17: ... "Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17". The Journal ... Interleukin 17 family (IL17 family) is a family of pro-inflammatory cystine knot cytokines. They are produced by a group of T ... IL-17 is unique in that it bears no resemblance to other known interleukins. Furthermore, IL-17 bears no resemblance to any ...
Interleukin 10 receptor, alpha subunit
... is a subunit for the interleukin-10 receptor. IL10RA, is its human gene. IL10RA has also ... Interleukin 10 receptor, alpha subunit has been shown to interact with: Interleukin 10 and Janus kinase 1. GRCh38: Ensembl ... "Entrez Gene: IL10RA interleukin 10 receptor, alpha". Ho AS, Liu Y, Khan TA, Hsu DH, Bazan JF, Moore KW (December 1993). "A ... Ho AS, Liu Y, Khan TA, Hsu DH, Bazan JF, Moore KW (1994). "A receptor for interleukin 10 is related to interferon receptors". ...
Interleukin 10
Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A (2001). "Interleukin-10 and the interleukin-10 receptor". Annual Review of ... Media related to Interferons or interleukin-10 (IL-10) at Wikimedia Commons Interleukin-10 at the U.S. National Library of ... Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A (2001-01-01). "Interleukin-10 and the interleukin-10 receptor". Annual ... "Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The Interleukin ...
Interleukin-21 receptor
... a receptor subunit also shared by the receptors for interleukin 2 (IL2), interleukin 7 (IL7) and interleukin 15 (IL15). This ... 2004). "Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of ... Interleukin 21 receptor is a type I cytokine receptor. IL21R is its human gene. The protein encoded by this gene is a cytokine ... 2005). "Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity". Mol. Cell ...
Interleukin-12 subunit beta
IL-12B is a common subunit of interleukin 12 and interleukin 23. This gene encodes a subunit of interleukin 12, a cytokine that ... Interleukin-12 p40 also serves as a subunit of interleukin 23. GRCh38: Ensembl release 89: ENSG00000113302 - Ensembl, May 2017 ... "The interleukin-12 and interleukin-12 receptor system in normal and transformed human B lymphocytes". Haematologica. 87 (4): ... "Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated ...
Interleukin 26
August 2004). "The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and ... Interleukin-26 (IL-26) is a protein that in humans is encoded by the IL26 gene. IL-26 is the most recently identified member of ... Interleukin 26 (IL-26) is an inflammatory mediator and a driver of chronic inflammation due to its ability to act as a carrier ... "Entrez Gene: interleukin 26". Knappe A, Hör S, Wittmann S, Fickenscher H (April 2000). "Induction of a novel cellular homolog ...
Interleukin 23 subunit alpha
Interleukin-23 (IL-23) is a heterodimeric cytokine composed of an Interleukin 23 alpha subunit and an IL-12p40 subunit. The IL- ... "Genetic variations in the interleukin-12/interleukin-23 receptor (beta1) chain, and implications for IL-12 and IL-23 receptor ... Interleukin-23 subunit alpha is a protein that in humans is encoded by the IL23A gene. The protein is also known as IL-23p19. ... "Entrez Gene: IL23A interleukin 23, alpha subunit p19". Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, et al. ( ...
Interleukin 9
... , also known as IL-9, is a pleiotropic cytokine (cell signalling molecule) belonging to the group of interleukins ... Renauld J (1995). "Interleukin-9: Structural characteristics and biologic properties". Cytokines: Interleukins and Their ... Interleukin 33 (IL-33) induces IL-9 expression and secretion in T cells, which was confirmed by the results obtained in mice by ... Interleukin-9 has also shown to inhibit melanoma growth in mice. Additionally, it gives rise to the multiplication of ...
Interleukin 35
... (IL-35) is a recently discovered anti-inflammatory cytokine from the IL-12 family. Member of IL-12 family - IL- ... June 2014). "Interleukin-35 induces regulatory B cells that suppress autoimmune disease". Nature Medicine. 20 (6): 633-41. doi: ... Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M (February 1996). "A novel interleukin-12 p40- ... Compared to these two related interleukins, IL-35 is also able to signal through only one of the aforementioned chains. This ...
Interleukin 20 receptor, alpha subunit
... is a subunit of the interleukin-20 receptor, the interleukin-26 receptor, and the interleukin-24 receptor. The interleukin 20 ... 2004). "The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 ... the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin ... 2002). "Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2". J. Biol ...
Interleukin 10 receptor, beta subunit
... is a subunit for the interleukin-10 receptor. IL10RB is its human gene. IL10RB has also ... 2004). "The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 ... "Entrez Gene: IL10RB interleukin 10 receptor, beta". Lutfalla G, McInnis MG, Antonarakis SE, Uzé G (1995). "Structure of the ... 2000). "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL ...
Interleukin 8 receptor, alpha
Interleukin Interleukin 8 Interleukin 8 receptor, beta Interleukin receptor Interleukin-8 receptor GRCh38: Ensembl release 89: ... Interleukin 8 receptor, alpha is a chemokine receptor. This name and the corresponding gene symbol IL8RA have been replaced by ... "Entrez Gene: IL8RA interleukin 8 receptor, alpha". Bergin DA, Reeves EP, Meleady P, Henry M, McElvaney OJ, Carroll TP, Condron ... This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G- ...