... in that the antibodies to DQ1 react to the alpha chain of HLA DQ, these DQA1 allele gene products. The other DQA1 alleles have ... Gyllensten UB, Erlich HA (1990). "Ancient roots for polymorphism at the HLA-DQ alpha locus in primates". Proc. Natl. Acad. Sci ... HLA-DQA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha ( ... Major histocompatibility complex, class II, DQ alpha 1, also known as HLA-DQA1, is a human gene present on short arm of ...
Within the DQ molecule, both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding ... Several alleles of HLA-DQB1 are associated with an increased risk of developing type 1 diabetes. The locus also has the genetic ... HLA class II histocompatibility antigen, DQ beta 1 chain) at the PDBe-KB. v t e (Articles with short description, Short ... HLA-DQB1 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DQA ...
The first identified DQ were DQw1 to DQw3. DQw1 (DQ1) recognized the alpha chain of DQA1*01 alleles. This group was later split ... The DQ loci are in close genetic linkage to HLA-DR, and less closely linked to HLA-DP, HLA-A, HLA-B and HLA-C. Different ... HLA-DQ#Effects of heterogeneity of isoform pairing-Expanded HLA D (-P,-Q,-R) genes are members of the Major histocompatibility ... Both α-chain and β-chain vary greatly. A person often produces two α-chain and two β-chain variants and thus 4 isoforms of DQ. ...
It is distal from HLA-DR and HLA-DQ encoding loci and therefore is much more equilibrated with respect to other HLA loci. In ... HLA-DPA1 Alleles HLA-DPB1 Alleles Before the April 2010 HLA nomenclature update, new HLA-DPB1 allele names were assigned within ... The α-chain and β- of DP is encoded by the HLA-DPA1 locus and HLA-DPB1 loci, respectively. This cluster is located at the ... The name 'HLA-DP' originally describes a transplantation antigen of MHC class II category of the major histocompatibility ...
HLA class II histocompatibility antigen, DQ(6) alpha chain is a protein that in humans is encoded by the HLA-DQA2 gene. Also ... Gyllensten UB, Erlich HA (1990). "Ancient roots for polymorphism at the HLA-DQ alpha locus in primates". Proc. Natl. Acad. Sci ... 1992). "Evolutionary relationships among the primate Mhc-DQA1 and DQA2 alleles". Immunogenetics. 36 (2): 71-8. doi:10.1007/ ... 1987). "Structure and expression of HLA-DQ alpha and -DX alpha genes: interallelic alternate splicing of the HLA-DQ alpha gene ...
DQ alpha chain) genes, producing in cis-haplotype form, a large number of DQ αβ isoforms. These DQ alpha chains are also known ... DQB1*0304 is the minor DQ7 allele DQ haplotypes of this serotype are formed between the cis-chromosomal genes of the DQA1 locus ... derived from IMGT/HLA Arnett FC, Olsen ML, Anderson KL, Reveille JD (1991). "Molecular analysis of major histocompatibility ... HLA-DQ7 (DQ7) is an HLA-DQ serotype that recognizes the common HLA DQB1*0301 and the less common HLA DQB1*0304 gene products. ...
HLA class II histocompatibility antigen, DP(W2) beta chain is a protein that in humans is encoded by the HLA-DPB1 gene. HLA-DPB ... 1992). "Family study on HLA-DPB1 polymorphism: linkage analysis with HLA-DR/DQ and two "new" alleles". Hum. Immunol. 34 (3): ... "Analysis of HLA-DP allelic sequence polymorphism using the in vitro enzymatic DNA amplification of DP-alpha and DP-beta loci". ... 1988). "A newly characterized HLA-DP beta-chain allele. Evidence for DP beta heterogeneity within the DPw4 specificity". J. ...
The β-chain of DQ is encoded by HLA-DQB1 locus and DQ5 are encoded by the HLA-DQB1*05 allele group. This group currently ... Since DQ1 recognizes alpha, the DQ5 and DQ6 recognition are to beta chain. Meaning that DQ1 is corecognized with DQ5 and DQ6. ... 1996). "Investigation of the association of major histocompatibility complex genes, including HLA class I, class II and TAP ... HLA-DQ5 and HLA-DQB1*05 are almost synonymous in meaning. DQ5 β-chains combine with α-chains, encoded by genetically linked HLA ...
1987). "Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes". J. ... HLA class II histocompatibility antigen, DX beta chain is a protein that in humans is encoded by the HLA-DQB2 gene. ... "Remarkable sequence conservation of the HLA-DQB2 locus (DX beta) within the highly polymorphic DQ subregion of the human MHC". ... 1998). "Identification of a new DQB1*0613 allele in a family". Tissue Antigens. 50 (6): 685-7. doi:10.1111/j.1399-0039.1997. ...
The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It ... Major histocompatibility complex, class II, DR beta 4, also known as HLA-DRB4, is a human gene. The protein encoded by this ... 1986). "Analysis of DR beta and DQ beta chain cDNA clones from a DR7 haplotype". J. Immunol. 137 (9): 2886-90. PMID 3020127. ... Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney ...
... not all new alleles are functional variants of the mature subunits]). The DR β-chain is encoded by 4 loci, however no more than ... "Organization of the transcriptional unit of a human class II histocompatibility antigen: HLA-DR heavy chain". Nucleic Acids Res ... "Rapid nonlysosomal degradation of assembled HLA class II glycoproteins incorporating a mutant DR alpha-chain". J. Immunol. 145 ... It is also closely linked to HLA-DQ and this linkage often makes it difficult to resolve the more causative factor in disease. ...
... insulin-dependent diabetes mellitus is associated with C4 allotypes independently of the association with HLA-DQ alleles in HLA ... The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is ... This gene localizes to the RCCX locus within the major histocompatibility complex (MHC) class III region on chromosome 6. ... The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma ...
The haplotype can be written in an extended form covering the major histocompatibility loci as follows: HLA Cw*0702 : B*0702 : ... The other B7-DR2-DQ1 stems from the fact that DQ1 is an alpha chain serotype that is now covered by the beta chain type DQ5 and ... HLA A*0201Cw*0702 : B*0702 : DRB1*1501 : DQA1*0102 : DQB1*0602 The gene-allele representation of the haplotype is: HLA A*0301Cw ... August 2002). "Risk of invasive cervical cancer associated with polymorphic HLA DR/DQ haplotypes". Int. J. Cancer. 100 (6): 698 ...
... at least 350 alleles for HLA-A genes, 620 alleles for HLA-B, 400 alleles for DR, and 90 alleles for DQ. Any two individuals who ... In the class-II locus, each person inherits a pair of HLA-DP genes (DPA1 and DPB1, which encode α and β chains), a couple of ... June 1997). "Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2". Nature. 387 (6633): 630-4. Bibcode: ... The most studied HLA genes are the nine classical MHC genes: HLA-A, HLA-B, HLA-C, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA- ...
The β-chain of DQ is encoded by HLA-DQB1 locus and DQ2 are encoded by the HLA-DQB1*02 allele group. This group currently ... alpha chains. DQA1*03, *05 chains process to near identical alpha chains. The *04 chain can potentially complex with DQ2 ... "Major histocompatibility complex class II alleles and the course and outcome of MS: a population-based study". Neurology. 51 (3 ... HLA-DQ2 and HLA-DQB1*02 are almost synonymous in meaning. DQ2 β-chains combine with α-chains, encoded by genetically linked HLA ...
"An isotype-specific trans-acting factor is defective in a mutant B cell line that expresses HLA-DQ, but not -DR or -DP". The ... At Emory, he also served as the faculty advisor for Emory Christian Fellowship and the Alpha Theta chapter of Alpha Tau Omega ... Enhanced MHC class I heavy-chain gene expression in pancreatic islets". Diabetes. 37 (10): 1411-8. doi:10.2337/diabetes.37.10. ... November 2003). "A natural allele of Nxf1/TAP suppresses retrovirus insertional mutations". Nature Genetics. 35 (3): 221-8. doi ...
DQ8 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. There ... "Frequencies of HLA-A, HLA-B, HLA-DR, and HLA-DQ phenotypes in the United Arab Emirates population". Tissue Antigens. 66 (2): ... "Allele frequencies and haplotypic associations defined by allelic DNA typing at HLA class I and class II loci in the Japanese ... Infrequently, DQA1*0302:DQB1*0302, but this substitution of the alpha chain, DQA1**0301 versus *0302, is outside the binding ...