A hepatocyte is a cell of the main parenchymal tissue of the liver. Hepatocytes make up 80% of the liver's mass. These cells ... In vitro model systems based on hepatocytes have been of great help to better understand the role of hepatocytes in (patho) ... The average life span of the hepatocyte is 5 months; they are able to regenerate. Hepatocyte nuclei are round with dispersed ... Smooth endoplasmic reticulum is abundant in hepatocytes, in contrast to most other cell types. Hepatocytes display an ...
Hepatocyte+growth+factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Hepatocyte growth factor on ... "Heparin-hepatocyte growth factor complex with low plasma clearance and retained hepatocyte proliferating activity". Hepatology ... Hepatocyte growth factor has been shown to interact with the protein product of the c-Met oncogene, identified as the HGF ... "Entrez Gene: HGF hepatocyte growth factor (hepapoietin A; scatter factor)". Yang ZJ, Zhang YR, Chen B, Zhang SL, Jia EZ, Wang ...
Micrograph showing ground glass hepatocytes. H&E stain. Micrograph showing ground glass hepatocytes. H&E stain. Cohen, C (Aug ... Wang, HC; Wu, HC; Chen, CF; Fausto, N; Lei, HY; Su, IJ (Dec 2003). "Different Types of Ground Glass Hepatocytes in Chronic ... In liver pathology, a ground glass hepatocyte, abbreviated GGH, is a liver parenchymal cell with a flat hazy and uniformly dull ... Su, IJ; Wang, HC; Wu, HC; Huang, WY (Aug 2008). "Ground glass hepatocytes contain pre-S mutants and represent preneoplastic ...
Hepatocyte nuclear factor 1A bound to DNA [1] Different rendering of HNF1a bound to DNA Hepatocyte+Nuclear+Factors at the U.S. ... Hence hepatocyte nuclear factors function to ensure liver specific expression of certain genes. As is the case with many ... However HNFs are also expressed and play important roles in a number of other tissues so that the name hepatocyte nuclear ... The following is a list of human hepatocyte nuclear factors (see also boxes to the right for additional information about these ...
Hepatocyte nuclear factors Hepatocyte nuclear factor 4A Chartier FL, Bossu JP, Laudet V, Fruchart JC, Laine B (1994). "Cloning ... Hepatocyte+Nuclear+Factor+4 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short ... HNF4 (Hepatocyte Nuclear Factor 4) is a nuclear receptor protein mostly expressed in the liver, gut, kidney, and pancreatic ... "Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids". Structure. 10 (9): 1225-34. doi: ...
"Fully human monoclonal antibodies to hepatocyte growth factor with therapeutic potential against hepatocyte growth factor/c-Met ... Hepatocyte growth factor receptor (HGF receptor) is a protein that in humans is encoded by the MET gene. The protein possesses ... Hepatocyte growth factor/Scatter Factor (HGF/SF) and its splicing isoform (NK1, NK2) are the only known ligands of the HGF ... Maulik G, Shrikhande A, Kijima T, Ma PC, Morrison PT, Salgia R (2002). "Role of the hepatocyte growth factor receptor, c-Met, ...
Hepatocyte nuclear factor 4 Hepatocyte nuclear factors GRCh38: Ensembl release 89: ENSG00000101076 - Ensembl, May 2017 GRCm38: ... "Entrez Gene: HNF4A hepatocyte nuclear factor 4, alpha". Tirona RG, Lee W, Leake BF, Lan LB, Cline CB, Lamba V, Parviz F, Duncan ... Hepatocyte nuclear factor 4 alpha (HNF4A) also known as NR2A1 (nuclear receptor subfamily 2, group A, member 1) is a nuclear ... Hepatocyte nuclear factor 4 alpha has been shown to interact with: Beta-catenin, CREB binding protein, MED1, MED14, Small ...
"Entrez Gene: HNF4G hepatocyte nuclear factor 4, gamma". Drewes T, Senkel S, Holewa B, Ryffel GU (March 1996). "Human hepatocyte ... Hepatocyte nuclear factor 4 Hepatocyte nuclear factors GRCh38: Ensembl release 89: ENSG00000164749 - Ensembl, May 2017 GRCm38: ... "Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference ... Hepatocyte nuclear factor 4 gamma (HNF4G) also known as NR2A2 (nuclear receptor subfamily 2, group A, member 2) is a nuclear ...
... hepatocytes; 7) multinucleated osteoclasts in bone tissues; 8) kidney podocytes; and 9) cells in the nervous system, e.g., ...
... liver hepatocytes; various types of epithelial cells; and various types of multicellular tissues. FPR2 is also known as the ...
... plateable cryopreserved human hepatocytes). Li and his researchers have developed numerous hepatocyte-based assays, including ... 199, (1-8). Li, A.P., Yang Q., Vermet H., Raoust N., Klieber S., and Fabre G. (2014) Evaluation of Human Hepatocytes Under ... "Hepatocytes, Media, Contract Research , In Vitro ADMET Laboratories". invitroadmet.com. Retrieved 2015-10-08. Li, Albert P. ( ... Li, A. P. and Doshi U. (2011) Higher Throughput Screening Assays for Time-Dependent Inhibition of CYP3A4 in Human Hepatocytes. ...
Lu Y, Zheng MH, Wang H (March 2023). "Are hepatocytes endocrine cells?". Metabolism and Target Organ Damage. 3 (1): 3. doi: ... It has been stated that, "hepatocytes secrete more than 560 types of hepatokines, many of which regulate metabolic and ... Hepatokines, sometimes referred to as hepatocytes-derived cytokines have been shown to relate to non-alcoholic fatty liver ... Hepatokines (Greek heapto-, liver; and -kinos, movement) are proteins produced by liver cells (hepatocytes) that are secreted ...
Hepatocytes are the main cells of the liver. They are large polyhedral cells, with six surfaces, three of which have a relevant ... Hepatocytes measure between 20 and 30 µm in each dimension. They are in charge of developing all the functions of the liver ... The hepatocytes are the parenchymal cells of the liver, which form the lobules. They are intimately associated with the ... Hepatocytes constitute about 80% of the cell population of the liver, with the other 20% being occupied by Kupffer cells, ...
Hepatocytes express blood coagulation factor XII. Currently produced QuikClot products, produced and marketed primarily for use ... Gordon EM, Gallagher CA, Johnson TR, Blossey BK, Ilan J (April 1990). "Hepatocytes express blood coagulation factor XII ( ...
... hepatocytes) have glucagon receptors. When glucagon binds to the glucagon receptors, the liver cells convert the glycogen into ... in hepatocytes. Glucagon also inactivates acetyl-CoA carboxylase, which creates malonyl-CoA from acetyl-CoA, through cAMP- ... "Hormonal control of pyruvate kinase activity and of gluconeogenesis in isolated hepatocytes". Proceedings of the National ...
This route commonly occurs in hepatocytes. The reactions related to the urea cycle produce NADH, and NADH can be produced in ...
cocultures primary rat hepatocytes and endothelial cells. A single-channel is made first. Hepatocytes and endothelial cells are ... cocultures primary rat hepatocytes and 3T3-J2 fibroblasts in an 8*8 element array of microfluidic wells. Each well is separated ... The primary chamber contains rat hepatocytes and 3T3-J2 fibroblasts and is made of glass for cells adhesion. Each of primary ... Later, a dual-channel is made, and endothelial cells and hepatocytes cells have their own channels to supply the substrate or ...
They invade spaces between hepatocytes, causing apoptosis. The damaged hepatocytes and hepatocyte intercellular junctions cause ...
Renner, E. L.; Lake, J. R.; Scharschmidt, B. F.; Zimmerli, B.; Meier, P. J. (1 April 1989). "Rat hepatocytes exhibit ... cotransport and intracellular pH in hepatocytes". Proc. Natl. Acad. Sci. U.S.A. 89 (9): 4197-4201. Bibcode:1992PNAS...89.4197F ... identified of the presence on the basolateral hepatocyte membrane of a sodium-coupled bicarbonate transporter critical to ...
The HepaRG model is considered a surrogate for Primary Human Hepatocytes, which are the most pertinent model to reproduce the ... They are polarized cells that breathe aerobically, consume lactate, and contain as many mitochondria as the human hepatocytes. ... Philippe Gripon later developed these cells, finding that they had the ability to undergo complete hepatocyte differentiation ... HepaRG cells are bipotent progenitors, capable of differentiating into both biliary and hepatocyte lineages. In culture, they ...
Another research in rats showed that the plasma membrane of hepatocytes begun to form blebs after administration of ... Knights KM, Cassidy MR, Drew R (September 1986). "Benoxaprofen induced toxicity in isolated rat hepatocytes". Toxicology. 40 (3 ...
"Metabolism of phenazopyridine by isolated rat hepatocytes". Biopharmaceutics & Drug Disposition. 14 (2): 171-179. doi:10.1002/ ...
Stubberfield, Colin R.; Cohen, Gerald M. (October 1988). "Nad+ depletion and cytotoxicity in isolated hepatocytes". Biochemical ...
B subunits are secreted into blood by hepatocytes. A and B units combine within blood to form heterotetramers of two A units ...
Hepatocytes further contribute to this hyperglycemia through gluconeogenesis. Glycolysis in hepatocytes controls hepatic ...
Some components are synthesized by hepatocytes (liver cells); the rest are extracted from the blood by the liver. Bile is ... Wolkoff, Allan W.; Cohen, David E. (February 2003). "Bile acid regulation of hepatic physiology: I. Hepatocyte transport of ...
"Experimental and Clinical Transplantation of Hepatocytes in MMRC". Imdik.pan.pl. Retrieved 2013-10-13. "Członkowie honorowi PTT ...
Estrogen has also been shown to be a positive regulator of hepatocyte PEMT transcription. Ablation of the estrogen binding site ... Furthermore, PC made via PEMT plays a wide range of physiological roles, utilized in choline synthesis, hepatocyte membrane ... Sundler R, Akesson B (May 1975). "Regulation of phospholipid biosynthesis in isolated rat hepatocytes. Effect of different ... gene expression is induced by estrogen in human and mouse primary hepatocytes". FASEB Journal. 21 (10): 2622-32. doi:10.1096/fj ...
... is More Toxic Than Arsenite in Chang Human Hepatocytes". Toxicology and Applied Pharmacology. 163 (2): 203-7. doi:10.1006/taap. ... "Arsenicals inhibit thioredoxin reductase in cultured rat hepatocytes". Chem. Res. Toxicol. 14 (3): 305-11. doi:10.1021/ ... monomethylated compound was shown to be more reactive and more toxic than the inorganic arsenic compounds to human hepatocytes ...
And its antioxidant effect in isolated rat hepatocytes". Archives of Toxicology. 81 (3): 211-218. doi:10.1007/s00204-006-0139-4 ...