Influenza Research Database: The Influenza Research Database (IRD)IRD Influenza Research Database BRCSquires, R.B.Neuraminidase inhibitor: Neuraminidase inhibitors are a class of drugs which block the neuraminidase enzyme. They are commonly used as antiviral drugs because they block the function of viral neuraminidases of the influenza virus, by preventing its reproduction by budding from the host cell.Global spread of H5N1 in 2006: The global spread of (highly pathogenic) H5N1 in birds is considered a significant pandemic threat.Flu season: Flu season is an annually recurring time period characterized by the prevalence of outbreaks of influenza (flu). The season occurs during the cold half of the year in each hemisphere.Haemagglutination activity domain: In molecular biology, the haemagglutination activity domain is a conserved protein domain found near the N terminus of a number of large, repetitive bacterial proteins, including many proteins of over 2500 amino acids. A number of the members of this family have been designated adhesins, filamentous haemagglutinins, haem/haemopexin-binding protein, etc.Influenza A virus subtype H1N1: Influenza A (H1N1) virus is the subtype of influenza A virus that was the most common cause of human influenza (flu) in 2009, and is associated with the 1918 outbreak known as the Spanish Flu.Influenza A virus subtype H5N1: Influenza A virus subtype H5N1, also known as A(H5N1) or simply H5N1, is a subtype of the influenza A virus which can cause illness in humans and many other animal species. A bird-adapted strain of H5N1, called HPAI A(H5N1) for highly pathogenic avian influenza virus of type A of subtype H5N1, is the highly pathogenic causative agent of H5N1 flu, commonly known as avian influenza ("bird flu").Hemagglutination assay: The hemagglutination assay (or haemagglutination assay; HA) and the hemagglutination inhibition assay (HI) were developed in 1941–42 by American virologist George Hirst as methods for quantitating the relative concentration of viruses, bacteria, or antibodies.CD46: CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) and Membrane Cofactor Protein is a protein which in humans is encoded by the CD46 gene. CD46 is an inhibitory complement receptor.Stem bromelain: Stem bromelain (SBM) (EC 3.4.Coles PhillipsFerret: The ferret (Mustela putorius furo) is the domesticated form of the European polecat, a mammal belonging to the same genus as the weasel, Mustela of the family Mustelidae.Harris & Yalden 2008, pp.Lipid bilayer fusion: In membrane biology, fusion is the process by which two initially distinct lipid bilayers merge their hydrophobic cores, resulting in one interconnected structure. If this fusion proceeds completely through both leaflets of both bilayers, an aqueous bridge is formed and the internal contents of the two structures can mix.Influvac: Influvac is a sub-unit vaccine produced and marketed by Abbott Laboratories. It contains inactivated purified surface fragments (sub-units) from the three different strains of the influenza virus (A/H1N1, A/H3N2, and Influenza B Virus) that are selected and distributed by the World Health Organization, on the basis of their latest recommendations.Protein primary structure: The primary structure of a peptide or protein is the linear sequence of its amino acid structural units, and partly comprises its overall biomolecular structure. By convention, the primary structure of a protein is reported starting from the amino-terminal (N) end to the carboxyl-terminal (C) end.Bird trapping: Bird trapping techniques to capture wild birds include a wide range of techniques that have their origins in the hunting of birds for food. While hunting for food does not require birds to be caught alive, some trapping techniques capture birds without harming them and are of use in ornithology research.Kennel clubCryptic self epitopes: In immunology, cryptic self epitopes are a source of autoimmunity.Chicken as biological research model: Chickens (Gallus gallus domesticus) and their eggs have been used extensively as research models throughout the history of biology. Today they continue to serve as an important model for normal human biology as well as pathological disease processes.CD33: CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells.Antigenic shiftTadorninae: The Tadorninae is the shelduck-sheldgoose subfamily of the Anatidae, the biological family that includes the ducks and most duck-like waterfowl such as the geese and swans.Newmarket, Suffolk: Newmarket is a market town in the English county of Suffolk, approximately 65 miles (105 kilometres) north of London. It is generally considered the birthplace and global centre of thoroughbred horse racing and a potential World Heritage Site.Plaque reduction neutralization test: The Plaque reduction neutralization test is used to quantify the titre of neutralising antibody for a virus.Sialic acid: Sialic acid is a generic term for the N- or O-substituted derivatives of neuraminic acid, a monosaccharide with a nine-carbon backbone.Canine distemperVirulence: Virulence is, by MeSH definition, the degree of pathogenicity within a group or species of parasites as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenicity of an organism - its ability to cause disease - is determined by its virulence factors.Goose egg addling: Goose egg “addling” is a wildlife management method of population control for Canada geese and other bird species. The process of addling involves temporarily removing fertilized eggs from the nest, testing for embryo development, terminating embryo development, and placing the egg back in the nest.Erythrocrine: Erythrocrine describes red blood cell or erythrocyte for production and release of signaling molecules. The term “erythrocrine“ was coined by Song et al.Glycosylation: Glycosylation (see also chemical glycosylation) is the reaction in which a carbohydrate, i.e.El Tor: El Tor is the name given to a particular strain of the bacterium Vibrio cholerae, the causative agent of cholera. Also known as V.Silent mutation: Silent mutations are mutations in DNA that do not significantly alter the phenotype of the organism in which they occur. Silent mutations can occur in non-coding regions (outside of genes or within introns), or they may occur within exons.Measles hemagglutinin: Measles hemagglutinin is a hemagglutinin produced by measles virus.Branching order of bacterial phyla (Gupta, 2001): There are several models of the Branching order of bacterial phyla, one of these was proposed in 2001 by Gupta based on conserved indels or protein, termed "protein signatures", an alternative approach to molecular phylogeny. Some problematic exceptions and conflicts are present to these conserved indels, however, they are in agreement with several groupings of classes and phyla.Symmetry element: A symmetry element is a point of reference about which symmetry operations can take place. In particular, symmetry elements can be centers of inversion, axes of rotation and mirror planes.Database of protein conformational diversity: The Database of protein conformational diversity (PCDB) is a database of diversity of protein tertiary structures within protein domains as determined by X-ray crystallography. Proteins are inherently flexible and this database collects information on this subject for use in molecular research.Reaction coordinateLeguminous lectin family: In molecular biology, the leguminous lectin family is a family of lectin proteins.Cell–cell fusogens: Cell–cell fusogens are glycoproteins that facilitate the fusion of cell to cell membranes. Cell-cell fusion is critical for the merging of gamete genomes and development of organs in multicelluar organisms.Alkaliphile: Alkaliphiles are a class of extremophilic microbes capable of survival in alkaline (pH roughly 8.5-11) environments, growing optimally around a pH of 10.Pandemic: A pandemic (from Greek πᾶν pan "all" and δῆμος demos "people") is an epidemic of infectious disease that has spread through human populations across a large region; for instance multiple continents, or even worldwide. A widespread endemic disease that is stable in terms of how many people are getting sick from it is not a pandemic.Pseudotyping: Pseudotyping is the process of producing viruses or viral vectors in combination with foreign viral envelope proteins. The result is a pseudotyped virus particle.Influenza virus matrix protein 2: Matrix protein 2 of Influenza virus is a single-spanning transmembrane protein. It is expressed on the infected cell surface and incorporated into virions where it is a minor component.British Poultry Standard: [Poultry Standard.png|thumb|right|The front cover of the 6th Edition of the British Poultry Standards.Monoclonal antibody therapyPilin: Pilin refers to a class of fibrous proteins that are found in pilus structures in bacteria. Bacterial pili are used in the exchange of genetic material during bacterial conjugation, while a shorter type of appendages also made up of pilin, called fimbriae, are used as a cell adhesion mechanism.VaccinationGeneralized vaccinia: Generalized vaccinia is a cutaneous condition that occurs 6-9 days after vaccination, characterized by a generalized eruption of skin lesions, and caused by the vaccinia virus.Porphyromonas gingivalis: Porphyromonas gingivalis belongs to the phylum Bacteroidetes and is a nonmotile, Gram-negative, rod-shaped, anaerobic, pathogenic bacterium. It forms black colonies on blood agar.Hemolysis (microbiology): Hemolysis (or haemolysis in British English) is the breakdown of red blood cells. The ability of bacterial colonies to induce hemolysis when grown on blood agar is used to classify certain microorganisms.Tumor-associated glycoprotein: Tumor-associated glycoproteins (TAGs) are glycoproteins found on the surface of many cancer cells. They are mucin-like molecules with a molar mass of over 1000 kDa.Reverse genetics: thumbnail|300px|[[Avian Flu vaccine development by Reverse Genetics techniques. Courtesy: National Institute of Allergy and Infectious Diseases]]Rinderpest: Rinderpest (also cattle plague or steppe murrain) was an infectious viral disease of cattle, domestic buffalo, and some other species of even-toed ungulates, including buffaloes, large antelope and deer, giraffes, wildebeests, and warthogs. The disease was characterized by fever, oral erosions, diarrhea, tenesmus, lymphoid necrosis, and high mortality.ImmunizationDistemper (paint): Distemper is a term with a variety of meanings for paints used in decorating and as a historical medium for painting pictures, and contrasted with tempera. The binding element may be some form of glue or oil; these are known in decorating respectively as soft distemper and oil bound distemper.
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