As a consequence, HEK 293 cells should not be used as an in vitro model of typical kidney cells. HEK 293 cells have a complex ... HEK 293 Transfection and Selection Data @ Cell-culture Database A HEK293 Cell Database 293 Cells (CRL-1573) Archived 2012-06-22 ... Human embryonic kidney 293 cells, also often referred to as HEK 293, HEK-293, 293 cells, or less precisely as HEK cells, are a ... They are quite similar to each other but show detectable divergence from the parental HEK 293 cell line. HEK 293 cells are ...

With Graham's contributions in transfection of the cells with the adenovirus 5 this led to the cell line of HEK 293 cells. HEK ... "HEK293 Cell Line". hek293.com. Archived from the original on 16 October 2014. "In memoriam professor Mathieu Noteborn" (in ... he created the PER.C6 cell line with enhanced traceability compared to the HEK 293 line, this time coming from retinal cells. ... In contrast to HEK 293 the PER.C6 cell line was patented by Leiden University and IntroGene (later Crucell) and used ...

This was verified using GPR18 transfected HEK-293 cells. The same migration wasn't witnessed using non-transfected and GPR55 ... NAGly has been hypothesized to induce cell migration in BV-2 microglia cells. The same research suggests that this migration ... NAGly powerfully stimulates oxygen consumption in multiple cell lines, including murine C2C12 myoblasts and human HEK293T cells ... Cell. 166 (2): 424-435. doi:10.1016/j.cell.2016.05.071. PMC 4947008. PMID 27374330. Lin H, Long JZ, Roche AM, Svensson KJ, Dou ...

2007). "Upregulation of PHLDA2 in Dicer knockdown HEK293 cells". Biochim. Biophys. Acta. 1770 (5): 820-5. doi:10.1016/j.bbagen. ...

"Subcellular localization of human neutral ceramidase expressed in HEK293 cells". Biochemical and Biophysical Research ...

2005). "Subcellular localization of human neutral ceramidase expressed in HEK293 cells". Biochem. Biophys. Res. Commun. 331 (1 ... 2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". ...

"The CAG promoter maintains high-level transgene expression in HEK293 cells". FEBS Open Bio. 11 (1): 95-104. doi:10.1002/2211- ... Okabe M, Ikawa M, Kominami K, Nakanishi T, Nishimune Y (May 1997). "'Green mice' as a source of ubiquitous green cells". FEBS ... BMC Cell Biology. 9: 2. doi:10.1186/1471-2121-9-2. PMC 2254385. PMID 18190688. Miyazaki J, Takaki S, Araki K, Tashiro F, ... promoter can be used to drive transgene expression during the differentiation of murine embryonic stem cells into vascular ...

"Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells". Pflügers Archiv. 444 (5): 597-601. doi: ...

The virus is grown in HEK 293 cells and purified for administration. It was developed by Spark Therapeutics and Children's ... due to inherited retinal dystrophy caused by confirmed biallelic RPE65 mutations and who have sufficient viable retinal cells. ...

Knock down of SIRT7 in HEK293 cells resulted in decreased rRNA levels. This same study found that this SIRT3 knockdown ... In humans cells, SIRT7 has only been shown to interact with two other molecules: RNA polymerase I (RNA Pol I) and upstream ... Mohrin M, Shin J, Liu Y, Brown K, Luo H, Xi Y, Haynes CM, Chen D (Mar 2015). "Stem cell aging. A mitochondrial UPR-mediated ... Sun L, Dang W (July 2020). "SIRT7 slows down stem cell aging by preserving heterochromatin: a perspective on the new discovery ...

"Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical ... Cell. 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923. Guo D ... "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". ... 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell ...

"Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical ...

2006). "Acute hypoxic regulation of recombinant THIK-1 stably expressed in HEK293 cells". Adv. Exp. Med. Biol. ADVANCES IN ... 2008). "Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney". Cell. Physiol. ...

December 2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and ...

December 2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and ... in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells". Molecular and Cellular Biology ... "Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines". Oncogene. 17 (10): ... Cell. 96 (5): 645-53. doi:10.1016/S0092-8674(00)80575-9. PMID 10089880. S2CID 17117789. Deng L, Wang C, Spencer E, Yang L, ...

"Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical ... Cell. 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923. Rual ...

"Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. ... Cell. Biol. 20 (9): 3157-67. doi:10.1128/MCB.20.9.3157-3167.2000. PMC 85610. PMID 10757800. Zhang QH, Ye M, Wu XY, Ren SX, Zhao ... Cell. Biol. 20 (9): 3157-67. doi:10.1128/mcb.20.9.3157-3167.2000. PMC 85610. PMID 10757800. Datta PK, Chytil A, Gorska AE, ... "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621-5. doi:10.1126/science. ...

"Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical ... Molecular Cell. 5 (5): 779-87. doi:10.1016/S1097-2765(00)80318-4. PMID 10882114. Will CL, Schneider C, MacMillan AM, Katopodis ... "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94-101. doi:10.1038/ ...

"Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. ... "Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2". Proc. Natl. Acad ... "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94-101. doi:10.1038/nbt1046. ...

"Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. ... "Identification of candidate radioresistant genes in human squamous cell carcinoma cells through gene expression analysis using ... Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986. Higo M, Uzawa K, Kouzu Y, Bukawa H, Nimura Y, ... Cell. Proteomics. 4 (11): 1725-40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932. Human CCT6A genome location and CCT6A gene ...

"Synthetic ciguatoxins selectively activate Nav1.8-derived chimeric sodium channels expressed in HEK293 cells". The Journal of ... Voltage clamp has been used to show how action potentials in DRG cells are shaped by TTX-resistant sodium channels. Nav1.8 ... Lipid rafts organise the cell membrane, which includes trafficking and localising ion channels. Removal of lipid rafts in the ... Although NaV1.8 is not normally expressed within the cerebellum, its expression is up-regulated in cerebellar Purkinje cells in ...

December 2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and ... Within cells, IDH1 has been observed to localize to the cytoplasm, peroxisome, and endoplasmic reticulum. Under hypoxic ... In addition, IDH1 is key to β-oxidation of unsaturated fatty acids in the peroxisomes of liver cells. IDH1 also participates in ... Vaccination of MHC-humanized transgenic mice with mutant IDH1 peptide induced an IFN-γ CD4+ T-helper 1 cell response, ...

"Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical ... "The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells". Molecular Biology of the Cell. 9 ... "Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells". The Journal of Cell Biology. 143 (6): ... Gangwani L (December 2006). "Deficiency of the zinc finger protein ZPR1 causes defects in transcription and cell cycle ...

"Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical ... IDH3 activity is regulated by the energy needs of the cell: when the cell requires energy, IDH3 is activated by ADP; and when ... Within cells, IDH3 and its subunits have been observed to localize to the mitochondria. IDH3α expression has been linked to ... HIF-1 is largely known for shifting glucose metabolism from oxidative phosphorylation to aerobic glycolysis in cancer cells ( ...

"Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical ... "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". ... 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell ...

"Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines". Oncology Letters. 11 (6): 3917-3924. ... This molecule has the ability to disrupt a bacteria's cell wall and cell membrane, as well as preventing bacterial growth, all ... This further contributes to the loss of calcium ion balance within the cell and eventual cell death. In triple-negative breast ... These mechanisms include inducing apoptosis, arrest of the cell cycle, promoting autophagy of cancerous cells, and the ...

2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. ... Cell. 16 (11): 5445-5454. doi:10.1091/mbc.E05-04-0354. PMC 1266439. PMID 16148047. Guo D, Han J, Adam BL, et al. ( ... doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573. Frum R, Busby SA, Ramamoorthy M, et al. (2007). "HDM2-binding ... 2005). "The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis". J. Biol. Chem. 279 (46): 48197- ...

2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. ...

"Transcriptional activation of the human Klotho gene by epidermal growth factor in HEK293 cells; role of Egr-1". Gene. 450 (1-2 ... The presence of senescent cells decreases α-klotho levels. Senolytic drugs reduce the level of these cells, allowing α-klotho ... Obesity is characterized by FGF21 resistance, believed to be caused by the inhibition of β-klotho by the inflammatory cell ... February 2016). "FGF21 Regulates Sweet and Alcohol Preference". Cell Metabolism. 23 (2): 344-349. doi:10.1016/j.cmet.2015.12. ...

2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. ... 2006). "Stomatin-like protein 2 is overexpressed in cancer and involved in regulating cell growth and cell adhesion in human ... Cell Genet. 92 (3-4): 196-203. doi:10.1159/000056902. PMID 11435687. S2CID 19349691. Strausberg RL, Feingold EA, Grouse LH, et ... 2007). "Stomatin-like protein 2 is overexpressed and related to cell growth in human endometrial adenocarcinoma". Oncol. Rep. ...

However, the HEK 293 cells used for vaccine manufacturing, express several adenoviral genes, including the ones required for ... To manufacture the vaccine the virus is propagated on HEK 293 cell lines and then purified multiple times to completely remove ... Thomas P, Smart TG (2005). "HEK293 cell line: a vehicle for the expression of recombinant proteins". J Pharmacol Toxicol ... Cell Research. 18 (2): 290-301. doi:10.1038/cr.2008.15. PMC 7091891. PMID 18227861. "There are no foetal cells in the ...

Both Ad26 and Ad5 were modified to remove the E1 gene to prevent replication outside the HEK 293 cells. For the production of ... Rarely, Ad5 can acquire the E1 gene from the HEK 293 cells, restoring its ability to replicate. Gamaleya has set an acceptable ... Tan E, Chin CS, Lim ZF, Ng SK (2021). "HEK293 Cell Line as a Platform to Produce Recombinant Proteins and Viral Vectors". ... Large quantities of both adenoviruses are produced by HEK 293 cells that have the E1 gene necessary for viral replication. ...

"Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells". Pflügers Archiv. 444 (5): 597-601. doi: ... Calloe K, Elmedyb P, Olesen SP, Jorgensen NK, Grunnet M (Sep 2005). "Hypoosmotic cell swelling as a novel mechanism for ... Cell. 93 (5): 717-29. doi:10.1016/S0092-8674(00)81434-8. PMID 9630217. S2CID 10265917. Hofmann F, Biel M, Kaupp UB (Dec 2005 ... "Identification of the cyclic-nucleotide-binding domain as a conserved determinant of ion-channel cell-surface localization". ...

"Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. ... "Nonredundant antioxidant defense by multiple two-cysteine peroxiredoxins in human prostate cancer cells". Mol. Med. 8 (2): 95- ...

2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. ... 2008). "Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells". Cell Cycle. 7 (15): 2392-400 ... 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ... doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685. He Y, Mou Z, Li W, et al. (2009). "Identification of IMPDH2 as a ...