Xiang S, Fruehauf J, Li CJ (June 2006). "Short hairpin RNA-expressing bacteria elicit RNA interference in mammals". Nature ... A short hairpin RNA or small hairpin RNA (shRNA/Hairpin Vector) is an artificial RNA molecule with a tight hairpin turn that ... Small interfering RNA VIRsiRNAdb Paddison PJ, Caudy AA, Bernstein E, Hannon GJ, Conklin DS (April 2002). "Short hairpin RNAs ( ... Articles with short description, Short description matches Wikidata, RNA, RNA interference). ...

DNA constructs are designed to express self-complementary double-stranded RNAs, typically short-hairpin RNAs, that bring about ... Any RNA, including endogenous messenger RNA (mRNAs) or viral RNAs, can be silenced by designing constructs to express double- ... RNA, DNA, RNA interference, Gene expression, Molecular genetics, Medical genetics, Genetic engineering, Stem cells, ... DNA detailed study DNA-directed RNA interference (DRNAI) is a gene-silencing technique that utilizes DNA constructs to activate ...

The inhibiting of DNA binding utilizes RNA interference, antisense oligodeoxynucleotide, and short hairpin RNA. The inhibition ... Klosek SK, Nakashiro K, Hara S, Goda H, Hamakawa H (October 2008). "Stat3 as a molecular target in RNA interference-based ...

"Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs". RNA. 11 (2): 220-6. doi: ... Wilson RC, Doudna JA (2013). "Molecular mechanisms of RNA interference". Annual Review of Biophysics. 42: 217-39. doi:10.1146/ ... Wang, Xia (2011). "Dynamic mechanisms for pre-miRNA binding and export by Exportin-5". RNA. 17 (8): 1516-1517. doi:10.1261/rna. ... "Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs". Genes & Development. 17 (24): 3011-6. doi: ...

... developing the small hairpin RNA concept employed in ddRNAi. Benitec Biopharma has an exclusive license to this ddRNAi ... of gene-silencing therapies for the treatment of chronic and life-threatening diseases using DNA-directed RNA interference ( ...

These suppressors encode hairpin RNAs which match the sequence of driver genes (such as Dox), leading host RNA interference ...

... is an artificial RNA molecule with a tight hairpin turn that can be used to silence target gene expression via RNA interference ... As indicated above in learning and memory, a short hairpin RNA (shRNA) is an artificial RNA molecule with a tight hairpin turn ... that can be used to silence target gene expression via RNA interference. Feng et al. injected shRNA targeted to TET1 in the NAc ... When a new event such as fear conditioning causes a memory to be formed, EGR1 messenger RNA is rapidly and selectively up- ...

After processing by the RNA interference (RNAi) molecules Drosha and Dicer, a single, guide-strand is loaded into the RNA ... Gene expression can also be inhibited post-transcriptionally by miRNA, double-stranded RNA, typically formed from hairpin ... Chronic ethanol causes heterologous desensitization of receptors by reducing as messenger RNA. Nature, 333, 848-850 Tabakoff, B ...

... for Burkholderia double-hairpin sRNA regulator. Escherichia coli sRNA Extracellular RNA List of RNAs Rfam RNA interference ... Based on their structure, certain tsRNAs have been proposed to be called 'double hairpin RNAs'. A tsRNA originally identified ... In molecular biology, Toxic Small RNA (tsRNA, not to be confused with tRNA-derived small RNA) is a family of trans-encoded ... Sometimes, this structure only results after the RNA is processed (as in ncS27). Typically, there is a CU-rich (Cytosine and ...

... phenotype has been produced by overexpressing a short hairpin RNA with homology to the myostatin mRNA using RNA interference. ... This non-native segment of DNA may either retain the ability to produce RNA or protein in the transgenic organism or alter the ...

... researchers used short hairpin RNA (shRNA) to induce RNA interference to degrade ZIP12 mRNA and reduce ZIP12 protein. In Neuro- ...

These findings suggested several critical points to be considered for designing more efficient short hairpin RNA (shRNA) ... vectors and also contributed to the improvement of RNA interference technologies. The research team led by Narry Kim and Chang ... "RNA Biology: Narry Kim Lab". www.narrykim.org. UNIVERSITY, SEOUL NATIONAL. "Professor V. Narry KIM Develops Selective RNA ... Hyeshik confirmed the predicted subgenomic RNAs of SARS-CoV-2 along with new RNA and dozens of unknown subgenomic RNAs. The ...

In RNA interference (RNAi), messenger RNA for a particular gene is inactivated using small interfering RNA (siRNA) or short ... hairpin RNA (shRNA). This effectively stops the gene from being expressed. Oncogenes like Bcl-2 and p53, as well as genes ... For gene knockout investigations, RNA interference (RNAi), a more recent method, also known as gene silencing, has gained ... have all been targeted for gene silencing utilizing RNA interference (RNAi). Homologous recombination is the exchange of genes ...

... build small hairpin RNA and panhandle constructs. The hairpin or panhandle constructs exist so that the RNA can remain ... RNA silencing or RNA interference refers to a family of gene silencing effects by which gene expression is negatively regulated ... Svoboda P (2008). "RNA Silencing in Mammalian Oocytes and Early Embryos". RNA Interference. Current Topics in Microbiology and ... Despite early focus in the literature on RNA interference (RNAi) as a core mechanism which occurs at the level of messenger RNA ...

An RNA interference-based mechanism used a lentiviral vector to express short-hairpin RNAi targeting β2-microglobulin ... August 2013). "Efficient generation of human iPSCs by a synthetic self-replicative RNA". Cell Stem Cell. 13 (2): 246-54. doi: ... self-replicating polycistronic RNA and low-molecular weight biologically active substances. In 1895 Thomas Morgan removed one ... as indicated by increased basal glucose secretion and lack of glucose stimulation and confirmed by RNA-seq of whose transcripts ...

... which can come from hairpin, complementary RNAs, and RNA-dependent RNA polymerases) is cleaved by an endo-ribonuclease called ... RNA, RNA interference, Molecular biology, Non-coding RNA). ... "RNA interference is mediated by 21- and 22-nucleotide RNAs". ... Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA at ... Target messenger RNA (mRNA) is cleaved as a result by tiny interfering RNAs coupled to the RNA-induced silencing complex. ...

PMID 16574858 Schaniel C, Li F, Schafer X, Moore T, Lemischka I, Paddison P. Delivery of short hairpin RNAs-triggers of gene ... Dissecting self-renewal in stem cells with RNA interference. Nature 2006; 442: 533-538. PMID 16767105 Moore KA, Lemischka IR. ...

subscription required) Gregory Hannon publications from Europe PubMed Central Hannon, Gregory J. (2002). "RNA interference". ... strategies for manipulation of gene expression in mammalian cells and animals and has generated genome-wide short hairpin RNA ( ... which led to an understanding of the biochemical mechanisms and biological functions of RNA interference (RNAi). He has ... "Role for a bidentate ribonuclease in the initiation step of RNA interference". Nature. 409 (6818): 363-366. Bibcode:2001Natur. ...

RNA-induced transcriptional silencing (RITS) RNA interference Pratt AJ, MacRae IJ (2009). "The RNA-induced silencing complex: A ... Dicer also processes pre-miRNA, which forms a hairpin loop structure to mimic dsRNA, in a similar fashion. dsRNA fragments are ... RNA. 11 (5): 674-682. doi:10.1261/rna.7272305. PMC 1370754. PMID 15811921. Hutvagner, Gyorgy (2005). "Small RNA asymmetry in ... This was only a couple of years after the discovery of RNA interference in 1998 by Andrew Fire and Craig Mello, who shared the ...

... or short hairpin RNAs (shRNAs) in humans, to produce double-stranded fragments of 20-25 base pairs with a 2-nucleotide overhang ... Biology portal Viruses portal DNA-directed RNA interference Saurabh S, Vidyarthi AS, Prasad D (March 2014). "RNA interference: ... Wikimedia Commons has media related to RNA interference. Wikiversity has learning resources about RNA interference Overview of ... RNA interference (RNAi) is a biological process in which RNA molecules are involved in sequence-specific suppression of gene ...

This sequence then associates with RISC which effects RNA interference. miR-338 is located in an intronic region within the ... The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. ...

This sequence then associates with RISC which effects RNA interference. miR-214 is a vertebrate-specific miR family that ... The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. ... RNA Biology. 11 (4): 281-94. doi:10.4161/rna.28141. PMC 4075512. PMID 24643020. Bar-Eli M (May 2011). "Searching for the ' ...

This sequence then associates with RISC which effects RNA interference. In humans, the gene for miR-208 is located in an intron ... The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. ...

This sequence then associates with RISC which effects RNA interference. miR-296 has been named an "angiomiR" due to being ... The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. ...

This sequence then associates with RISC which effects RNA interference. miR-146 is primarily involved in the regulation of ... The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. ... Bellingham SA, Coleman BM, Hill AF (Nov 2012). "Small RNA deep sequencing reveals a distinct miRNA signature released in ...

This sequence then associates with RISC which effects RNA interference. miR-191 has been found to be dysregulated in many types ... The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. ...

This sequence then associates with RISC which effects RNA interference. miR-150 functions in hematopoiesis; it regulates genes ... The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. ...

miRNAs resemble the small interfering RNAs (siRNAs) of the RNA interference (RNAi) pathway, except miRNAs derive from regions ... precursors and their relevance to miRNA biogenesis and small interfering RNA/short hairpin RNA design". The Journal of ... of miRNA target prediction tools MicroDNA MiRNEST MIR222 miR-324-5p RNA interference Small interfering RNA Small nucleolar RNA- ... The double-stranded RNA (dsRNA) structure of the hairpins in a pri-miRNA is recognized by a nuclear protein known as DiGeorge ...

The involvement of Dicer in miRNA processing suggests a relationship with the phenomenon of RNA interference. Mature miRNA-7 is ... The extents of the hairpin precursors are not generally known and are estimated based on hairpin prediction. ... miRNAs are numbered based on the sequence of the mature RNA. miR-7 is directly regulated by the transcription factor HoxD10. ... "Identification of novel genes coding for small expressed RNAs". Science. 294 (5543): 853-8. Bibcode:2001Sci...294..853L. doi: ...

who also coined the term "RNAa" as a contrast to RNA interference (RNAi) to describe such gene activation phenomenon. dsRNAs ... terminus of a gene and these saRNAs can be chemically synthesized or expressed as short hairpin RNA (shRNA). Whereas for ... In C. elegans, Argonaute CSR-1 interacts with 22G small RNAs derived from RNA-dependent RNA polymerase and antisense to ... The RNA-loaded Ago then recruits other proteins such as RHA, also known as nuclear DNA helicase II, and CTR9 to form an RNA- ...