GTP-Binding+Protein+Regulators at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (GTP-binding protein ... GTP-binding protein regulators regulate G proteins in several different ways. Small GTPases act as molecular switches in ... between the GTP-bound and GDP-bound form, regulated by other regulatory proteins. The inactive form of GTPases (GDP-form) are ... They are active or 'ON' when it is bound to GTP and inactive or 'OFF' when bound to GDP. Activation and deactivation of small ...
... also known as Ras-related proteins or simply RAP is a type of small GTPase, similar in structure to Ras ... rap+GTP-Binding+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates ... These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural ... The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is ...
... is a protein that in humans is encoded by the GTPBP2 gene. GTP-binding proteins, or G proteins, ... constitute a superfamily capable of binding GTP or GDP. G proteins are activated by binding GTP and are inactivated by ... "Entrez Gene: GTP binding protein 2". Retrieved 2017-01-18. This article incorporates text from the United States National ... hydrolyzing GTP to GDP. This general mechanism enables G proteins to perform a wide range of biologic activities. GRCh38: ...
ATP/GTP binding protein 1 is gene that encodes the protein known as cytosolic carboxypeptidase 1 (CCP1), originally named NNA1 ... "Entrez Gene: ATP/GTP binding protein 1". Retrieved 2018-06-13. Fernandez-Gonzalez A, La Spada AR, Treadaway J, Higdon JC, ... a novel ATP/GTP-binding protein related to zinc carboxypeptidases". Mol Cell Neurosci. 16 (5): 578-96. doi:10.1006/mcne. ... with alleles containing a zinc carboxypeptidase domain and an ATP/GTP binding motif, a protein first identified in alpha- ...
Nucleolar GTP-binding protein 1 is a protein that in humans is encoded by the GTPBP4 gene. GTPases function as molecular ... a GTP-binding protein that interacts with the neurofibromatosis 2 protein". Mol. Cell. Biol. 27 (6): 2103-19. doi:10.1128/MCB. ... "Entrez Gene: GTPBP4 GTP binding protein 4". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap ... The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, ...
The GPCR can then activate an associated G protein by exchanging the GDP bound to the G protein for a GTP. The G protein's α ... binding of G proteins to receptors affects the receptor's affinity for ligands. Activated G proteins are bound to GTP. Further ... Once bound to GTP, Rho can then go on to activate various proteins responsible for cytoskeleton regulation such as Rho-kinase ( ... It is known that in the inactive state, the GPCR is bound to a heterotrimeric G protein complex. Binding of an agonist to the ...
... the protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is ... allowing RHEB to activate the protein. RHEB acts as an activator for mTORC1 in its GTP-bound form, therefore GTP-bound RHEB ... is a GTP-binding protein that is ubiquitously expressed in humans and other mammals. The protein is largely involved in the ... The protein is a lipid-anchored, cell-membrane protein with five repeats of the RAS-related GTP-binding region. Also present ...
GTP-binding protein 1 is a protein that in humans is encoded by the GTPBP1 gene. This gene is upregulated by interferon-gamma ... "Entrez Gene: GTPBP1 GTP binding protein 1". Goretzki L, Mueller BM (1999). "Low-density-lipoprotein-receptor-related protein ( ... and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has ... interacts with a GTP-binding protein". Biochem. J. 336 (2): 381-6. doi:10.1042/bj3360381. PMC 1219882. PMID 9820815. Dunham I, ...
G proteins can bind either GDP or GTP. When bound to GDP, G proteins are inactive. When a ligand binds a GPCR, an allosteric ... GTP is essential for signal transduction, especially with G proteins. G proteins are coupled with a cell membrane bound ... GTP activates the alpha subunit of the G protein, causing it to dissociate from the G protein and act as a downstream effector ... The activity site can bind either ATP or dATP. When bound to ATP, RNR is active. When ATP or dATP is bound to the S site, RNR ...
"Entrez Gene: GTPBP9 GTP-binding protein 9 (putative)". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace ... "Human OLA1 defines an ATPase subfamily in the Obg family of GTP-binding proteins". J Biol Chem. 282 (27): 19928-37. doi:10.1074 ... Ola1 belongs to the protein family of Obg-like GTPases but defines an exceptional example of a protein that has evolved altered ... 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi: ...
"Small GTP-binding proteins in human endothelial cells". Br J Haematol. 103 (1): 15-9. doi:10.1046/j.1365-2141.1998.00965.x. ... Ras-related protein Rab-14 is a protein that in humans is encoded by the RAB14 gene. GRCh38: Ensembl release 89: ... 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ...
Zahraoui A, Touchot N, Chardin P, Tavitian A (1989). "The human Rab genes encode a family of GTP-binding proteins related to ... Goud B, Zahraoui A, Tavitian A, Saraste J (1990). "Small GTP-binding protein associated with Golgi cisternae". Nature. 345 ( ... Karniguian A, Zahraoui A, Tavitian A (1993). "Identification of small GTP-binding rab proteins in human platelets: thrombin- ... Ras-related protein Rab-6A is a protein that in humans is encoded by the RAB6A gene located in the eleventh chromosome. Its ...
The mammalian RAB proteins show striking similarities to the S. cerevisiae YPT1 and SEC4 proteins, Ras-related GTP-binding ... Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 ... Zahraoui A, Touchot N, Chardin P, Tavitian A (Jul 1989). "The human Rab genes encode a family of GTP-binding proteins related ... highly conserved regions involved in GTP binding and hydrolysis. Rabs are prenylated, membrane-bound proteins involved in ...
"GTP-binding proteins in human platelet membranes serving as the specific substrate of islet-activating protein, pertussis toxin ... Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene. Click on ... "Entrez Gene: GNAI1 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1". Schiaffino MV, ... "Identification of GTP-binding proteins in human glomeruli". Nihon Jinzo Gakkai Shi. 36 (1): 9-12. PMID 8107314. Law SF, Zaina S ...
Developmentally-regulated GTP-binding protein 1 is a protein that in humans is encoded by the DRG1 gene. GRCh38: Ensembl ... Mahajan MA, Park ST, Sun XH (1996). "Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins". Oncogene. ... Schenker T, Lach C, Kessler B, Calderara S, Trueb B (Nov 1994). "A novel GTP-binding protein which is selectively repressed in ... Sazuka T, Tomooka Y, Ikawa Y, Noda M, Kumar S (Dec 1992). "DRG: a novel developmentally regulated GTP-binding protein". Biochem ...
Shin OH, Ross AH, Mihai I, Exton JH (1999). "Identification of arfophilin, a target protein for GTP-bound class II ADP- ... A functionally conserved family of GTP-binding proteins". J. Biol. Chem. 266 (4): 2606-14. doi:10.1016/S0021-9258(18)52288-2. ... These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera ... "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". J. Biol. Chem. 276 (42): 38966-70. doi: ...
A functionally conserved family of GTP-binding proteins". J. Biol. Chem. 266 (4): 2606-14. doi:10.1016/S0021-9258(18)52288-2. ... a novel role for a GTP-binding protein". Cell. 67 (2): 239-53. doi:10.1016/0092-8674(91)90176-Y. PMID 1680566. S2CID 9766090. ... including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized ... The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of ...
ATP/GTP binding protein like 4 is a protein that in humans is encoded by the AGBL4 gene. GRCh38: Ensembl release 89: ... "Entrez Gene: ATP/GTP binding protein like 4". Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, ...
de Leeuw HP, Koster PM, Calafat J, Janssen H, van Zonneveld AJ, van Mourik JA, Voorberg J (1998). "Small GTP-binding proteins ... Ras-related protein Rab-9A is a protein that in humans is encoded by the RAB9A gene. RAB9A has been shown to interact with ... Orzaez D, de Jong AJ, Woltering EJ (2001). "A tomato homologue of the human protein PIRIN is induced during programmed cell ... Soldati T, Riederer MA, Pfeffer SR (1993). "Rab GDI: a solubilizing and recycling factor for rab9 protein". Mol. Biol. Cell. 4 ...
"Entrez Gene: GTPBP3 GTP binding protein 3 (mitochondrial)". Li X, Guan MX (2002). "A human mitochondrial GTP binding protein ... The GTPBP3 gene encodes a GTP-binding protein that is evolutionarily conserved from bacteria to mammals and which is localized ... The GTPBP3 gene contains 10 exons, and encodes a ~44 kDa GTP-binding protein that is evolutionarily conserved from bacteria to ... Li X, Guan MX (Nov 2002). "A human mitochondrial GTP binding protein related to tRNA modification may modulate phenotypic ...
"Regulator of G protein signalling"). Receptors stimulate GTP binding (turning the G protein on). RGS proteins stimulate GTP ... GTP-Binding Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology G protein at ... 5 Gβ proteins, and 12 Gγ proteins. G protein can refer to two distinct families of proteins. Heterotrimeric G proteins, ... They are small (20-kDa to 25-kDa) proteins that bind to guanosine triphosphate (GTP). This family of proteins is homologous to ...
... (IQGAP) is a carrier protein. It is associated with the Rho GTP-binding protein. ... IQGAP1, IQGAP2, IQGAP3 IQ calmodulin-binding motif v t e (All stub articles, Protein stubs, GTP-binding protein regulators). ...
Developmentally-regulated GTP-binding protein 2 is a protein that in humans is encoded by the DRG2 gene. The DRG2 gene encodes ... "Entrez Gene: DRG2 developmentally regulated GTP binding protein 2". Sprang SR (1998). "G proteins, effectors and GAPs: ... Schenker T, Lach C, Kessler B, Calderara S, Trueb B (Nov 1994). "A novel GTP-binding protein which is selectively repressed in ... Schenker T, Trueb B (Jun 1998). "Assignment of the gene for a developmentally regulated GTP-binding protein (DRG2) to human ...
1994). "Identification of GTP-binding proteins in human glomeruli". Nippon Jinzo Gakkai Shi. 36 (1): 9-12. PMID 8107314. ... 1991). "Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two ... Guanine nucleotide-binding protein G(o) subunit alpha is a protein that in humans is encoded by the GNAO1 gene. Mutations in ... Wu HC, Lin CT (1994). "Association of heterotrimeric GTP binding regulatory protein (Go) with mitosis". Lab. Invest. 71 (2): ...
Kaziro focused on GTP binding proteins, the role of GTPases in signal transduction, and the role of GTP in mRNA gene expression ... Kaziro focused on GTP mechanisms and proposed signaling pathways involved with GTP-binding proteins. He researched the role of ... the characterization of G nucleotide binding protein complexes, and the role the GTP hydrolysis in protein mechanisms. His ... In 1971, Kaziro led research on identifying the properties of the two H-GTP binding proteins in E. coli. Factor T is one of two ...
"Entrez Gene: RALB v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)". Simicek M, Lievens S, ... "Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of ... Hsieh CL, Swaroop A, Francke U (1990). "Chromosomal localization and cDNA sequence of human ralB, a GTP binding protein". Somat ... Jilkina O, Bhullar RP (1997). "Generation of antibodies specific for the RalA and RalB GTP-binding proteins and determination ...
Whereas receptors stimulate GTP binding, RGS proteins stimulate GTP hydrolysis. RGS proteins have been conserved in evolution. ... RGS proteins markedly reduce the lifespan of GTP-bound α-subunits by stabilising the G protein transition state. ... G proteins exchange GDP for GTP, are released from the receptor, and dissociate into a free, active GTP-bound α-subunit and βγ- ... G protein gamma subunit-like) for binding G protein beta subunits (InterPro: IPR001770 Those RGS proteins that contain GGL ...
Pereira-Leal JB, Seabra MC (Nov 2001). "Evolution of the Rab family of small GTP-binding proteins". J Mol Biol. 313 (4): 889- ... Ras-related protein Rab-15 is a protein that in humans is encoded by the RAB15 gene. GRCh38: Ensembl release 89: ... Strick DJ, Elferink LA (2006). "Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling ... Fukuda M (2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant ...
Pereira-Leal JB, Seabra MC (Nov 2001). "Evolution of the Rab family of small GTP-binding proteins". J Mol Biol. 313 (4): 889- ... Ras-related protein Rab-40A is a protein that in humans is encoded by the RAB40A gene. GRCh38: Ensembl release 89: ... "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". J. Biol. Chem ... domain-containing proteins based on their Rab-binding activity". Genes Cells. 11 (9): 1023-37. doi:10.1111/j.1365-2443.2006. ...
GTP-binding protein GEM is a protein that in humans is encoded by the GEM gene. The protein encoded by this gene belongs to the ... Ward Y, Yap SF, Ravichandran V, Matsumura F, Ito M, Spinelli B, Kelly K (Apr 2002). "The GTP binding proteins Gem and Rad are ... "Entrez Gene: GEM GTP binding protein overexpressed in skeletal muscle". Cohen L, Mohr R, Chen YY, et al. (1995). " ... Kelly K (2006). "The RGK family: a regulatory tail of small GTP-binding proteins". Trends Cell Biol. 15 (12): 640-3. doi: ...