Complement C4-A is a kind of the Complement component 4 protein that in humans is encoded by the C4A gene. This gene encodes ... C4) into intron 9. Complement component 4 Complement component 4B HLA A1-B8-DR3-DQ2 haplotype Complement system Complement ... "Heterogeneity of human C4 gene size. A large intron (6.5 kb) is present in all C4A genes and some C4B genes". Immunogenetics. ... "Entrez Gene: C4A complement component 4A (Rodgers blood group)". Dawkins RL, Uko G, Christiansen FT, Kay PH (Sep 1983). "Low C4 ...
"Polymorphism of the human complement C4 and steroid 21-hydroxylase genes. Restriction fragment length polymorphisms revealing ... Complement Genetics Homepage Peter M. Schneider publications indexed by Google Scholar Peter M. Schneider on Twitter Homepage ... Parallel to his work on the complement system and immunogenetics, Peter Schneider focussed his early scientific interest on the ... Schneider, Peter M; Würzner, Reinhard (1999). "Complement genetics: biological implications of polymorphisms and deficiencies ...
1996). "Complete sequence of the complement C4 gene from the HLA-A1, B8, C4AQ0, C4B1, DR3 haplotype". Immunogenetics. 43 (4): ... are present between complement component genes factor B and C4 in the class III region of the HLA". Genomics. 53 (3): 338-47. ... "Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes ... "Characterisation of the novel gene G11 lying adjacent to the complement C4A gene in the human major histocompatibility complex ...
Complement C2 is a protein that in humans is encoded by the C2 gene. The protein encoded by this gene is part of the classical ... Patients with LE associated with complement C4 or C2 deficiencies have a better prognosis than those without inherited ... There are numerous forms of naming this gene. For example: ARMD14 C3/C5 convertase CO2 complement component 2 complement ... "Entrez Gene: C2 complement component 2". Krishnan V, Xu Y, Macon K, Volanakis JE, Narayana SV (2009). "The structure of C2b, a ...
The gene cluster was discovered when genes (specifically those of complement components C2, C4, and factor B) were found in ... However, birds (chicken and quail) have only a single gene, which codes for a complement component gene (C4). In fishes, the ... The region containing genes STK19(G11)/C4/Z/CYP21/X/Y, varying in size from 142 to 214 kb, is known as the most complex gene ... MHC class III genes are located on chromosome 6 (6p21.3) in humans. It covers 700 kb and contains 61 genes. The gene cluster is ...
"Human major histocompatibility complex contains a new cluster of genes between the HLA-D and complement C4 loci". Nucleic Acids ... E3 ubiquitin-protein ligase RNF5 is an enzyme that in humans is encoded by the RNF5 gene. The protein encoded by this gene ... Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, Campbell RD, Hood L (December 2003). "Analysis of the gene-dense major ... Kyushiki H, Kuga Y, Suzuki M, Takahashi E, Horie M (Apr 1998). "Cloning, expression and mapping of a novel RING-finger gene ( ...
When a single gene deficiency does cause lupus, it is usually attributed to the complement protein genes C1, C2, or C4. The ... Other genes that are commonly thought to be associated with lupus are those in the human leukocyte antigen (HLA) family. There ... Several studies also indicate a potential association of lupus with mutations in DNA repair genes. Lupus can develop in people ... Lupus is usually influenced by gene polymorphisms, 30 of which have now been linked with the disorder. Some of these ...
... complement component C4, steroid 21-hydroxylase CYP21, and tenascin TNX (the RCCX module). A mechanism for gene deletions and ... C4) into intron 9. Complement component 4 Complement component 4A HLA A1-B8-DR3-DQ2 haplotype Complement system Complement ... is a kind of the Complement component 4 protein that in humans is encoded by the C4B gene. This gene encodes the basic form of ... "Genetic polymorphism of C4 in man and localisation of a structural C4 locus to the HLA gene complex of chromosome 6". Nature. ...
September 2008). "Autoimmune-associated HLA-B8-DR3 haplotypes in Asian Indians are unique in C4 complement gene copy numbers ... A multigene haplotype is a set of inherited alleles covering several genes, or gene-alleles. Long haplotypes, like A30::DQ2, ... Müller CR, Ehninger G, Goldmann SF (January 2003). "Gene and haplotype frequencies for the loci hLA-A, hLA-B, and hLA-DR based ... Ayed K, Ayed-Jendoubi S, Sfar I, Labonne MP, Gebuhrer L (October 2004). "HLA class-I and HLA class-II phenotypic, gene and ...
The C4 gene, as already stated, codes for a component of the complement system; the CYP21gene codes for a key enzyme in the ... The first of these class III loci was the Ss locus, which was later identified as coding for complement component 4. The C4 ... And on the example of two "class III" genes, C4 and CYP21, they illustrated a mechanism by which the accordion might be ... The two genes are thus unrelated to each other and to the class I and class II genes, but they are accidentally hooked together ...
"Features of the two gene pairs RD-SKI2W and DOM3Z-RP1 located between complement component genes factor B and C4 at the MHC ... are present between complement component genes factor B and C4 in the class III region of the HLA". Genomics. 53 (3): 338-47. ... "Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes ... A novel human cDNA, homologous to the yeast gene SKI2, was identified in 1995. Researchers localised the corresponding gene to ...
Also, C4 and C2 cleavage goes unchecked, resulting in auto-activation of the complement system. In its most common form, it ... Lappin DF, Guc D, Hill A, McShane T, Whaley K (January 1992). "Effect of interferon-gamma on complement gene expression in ... This way, C1-inhibitor prevents the proteolytic cleavage of later complement components C4 and C2 by C1 and MBL. Although named ... The activation of the complement cascade can cause damage to cells, therefore the inhibition of the complement cascade can work ...
Genes in the Complement Component 4 (C4) locus of the major histocompatibility complex (MHC), which encode for complement ... Carriers of C4 risk variants have also been found to be tied to this kind of synapse overpruning in microglia. The proposed ... Specifically, complement factors C1q and C3 have been found to have a role in microglia-mediated synaptic pruning. ... factors, have also been tied to schizophrenia risk through gene linkage studies. The fact that some of these complement factors ...
... are present between complement component genes factor B and C4 in the class III region of the HLA". Genomics. 53 (3): 338-47. ... Yu CY (1999). "Molecular genetics of the human MHC complement gene cluster". Experimental and Clinical Immunogenetics. 15 (4): ... Negative elongation factor E is a protein that in humans is encoded by the RDBP gene. The protein encoded by this gene is part ... Speiser PW, White PC (Dec 1989). "Structure of the human RD gene: a highly conserved gene in the class III region of the major ...
... are present between complement component genes factor B and C4 in the class III region of the HLA". Genomics. 53 (3): 338-47. ... "Entrez Gene: DOM3Z dom-3 homolog Z (C. elegans)". Yu CY (1999). "Molecular genetics of the human MHC complement gene cluster". ... Yang Z, Yu CY (2000). "Organizations and gene duplications of the human and mouse MHC complement gene clusters". Exp. Clin. ... Protein Dom3Z is a protein that in humans is encoded by the DOM3Z gene. This gene localizes to the major histocompatibility ...
This study found that the association is caused partly by the complement component 4 (C4) genes and therefore implying that ... A study on the influence of the CCL3L1 gene on HIV-1/AIDS susceptibility tested if the copy number of the CCL3L1 gene had any ... they found that mCNVs create most genetic variation in gene dosage compared to other structural variants and that the gene ... have on gene dosage which leads to variable gene expressions and human phenotypic diversity in the population. There are ...
... which locus is located between complement component C4 and TNX gene, along with CENPA. The CYP21A2 gene travels in tandem with ... Both genes are located on chromosome 6, in the major histocompatibility complex III close to the Complement component 4 genes ... Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion ... "Two genes encoding steroid 21-hydroxylase are located near the genes encoding the fourth component of complement in man". ...
The C4 gene encodes the complement component 4, which is involved in the complement system and is an important part of the ... "Dancing with complement C4 and the RP-C4-CYP21-TNX (RCCX) modules of the major histocompatibility complex". Prog Nucleic Acid ... there is only one copy of each functional gene rest being non-coding pseudogenes with the exception of the C4 gene which always ... The gene has two forms: C4A and C4B, encoding form A and B of the complement component 4 protein, respectively. The CYP21A2 ...
Ogata RT, Rosa PA, Zepf NE (October 1989). "Sequence of the gene for murine complement component C4". The Journal of Biological ... that are produced as part of the activation of the complement system. Complement components C3, C4 and C5 are large ... coded for by a single exon within the complement protein gene. The C3a, C4a and C5a components are referred to as ... This term is reserved only for fragments of the complement system. C3, C4A, C4B, C4B-1, C5, FBLN1, FBLN2 Allergy Anaphylatoxin ...
... in their study of cloning the human C4 gene showed that all six of their clones contained the same C4 gene. The C4 protein ... for all C4 genes and in the second locus (coding for C4B) only in a few C4 genes. The α-chain consists of residues 661-1428, ... C4) in its intron 9 that imposes transcription of an extra 6.36 kb, hence the "longer" string of gene. Thus, C4 genes have a ... "Diversity in intrinsic strengths of the human complement system: serum C4 protein concentrations correlate with C4 gene size ...
In humans, it is encoded by the C1S gene. C1s cleaves C4 and C2, which eventually leads to the production of the classical ... Complement component 1s (EC 3.4.21.42, C1 esterase, activated complement C1s, complement C overbar 1r, C1s) is a protein ... "Entrez Gene: C1S Complement component 1, s subcomponent". Luo C, Thielens NM, Gagnon J, Gal P, Sarvari M, Tseng Y, Tosi M, ... Complement+C1s at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human C1S genome location and C1S gene ...
Based on crystal structure of TPST-2 with C4 complement and PAP, an SN2-like in-line displacement mechanism has been proposed. ... Genes on human chromosome 7, Genes on human chromosome 22, EC 2.8.2). ... Human genes that encode protein-tyrosine sulfotransferase enzymes include: Sulfotransferase Lee RW, Huttner WB (September 1983 ... Complement component 4, follicle-stimulating hormone receptor (FSHR), and other chemokine and G-protein coupled receptors. A ...
"Entrez Gene: C3 complement component 3". Sahu A, Lambris JD (Apr 2001). "Structure and biology of complement protein C3, a ... One form of C3-convertase, also known as C4b2a, is formed by a heterodimer of activated forms of C4 and C2. It catalyzes the ... In humans it is encoded on chromosome 19 by a gene called C3. C3 plays a central role in the activation of the complement ... Complement component 3, often simply called C3, is a protein of the immune system that is found primarily in the blood. It ...
In mice, CR1 is an alternatively spliced variant of the complement receptor 2 (CR2) gene. Certain alleles of this gene have ... Hing S, Day AJ, Linton SJ, Ripoche J, Sim RB, Reid KB, Solomon E (May 1988). "Assignment of complement components C4 binding ... is a protein that in humans is encoded by the CR1 gene. This gene is a member of the regulators of complement activation (RCA) ... "Entrez Gene: CR1 complement component (3b/4b) receptor 1 (Knops blood group)". Moulds JM, Nickells MW, Moulds JJ, Brown MC, ...
"Lectin complement pathway gene profile of donor and recipient determine the risk of bacterial infections after orthotopic liver ... MASP-2 is activated to cleave complement components C4 and C2 into C4a, C4b, C2a, and C2b. MASP1 (protein) Mannan-binding ... MASP-2 is involved in the complement system. MASP-2 is very similar to the C1s molecule, of the classical complement pathway, ... is an enzyme that in humans is encoded by the MASP2 gene. The Ra-reactive factor (RARF) is a complement-dependent bactericidal ...
... is a protein that in humans is encoded by the IFNGR1 gene. The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain ( ... Gerritsma JS, Gerritsen AF, De Ley M, van Es LA, Daha MR (Apr 1997). "Interferon-gamma induces biosynthesis of complement ... components C2, C4 and factor H by human proximal tubular epithelial cells". Cytokine. 9 (4): 276-83. doi:10.1006/cyto.1996.0164 ... "Entrez Gene: IFNGR1 interferon gamma receptor 1". Novick D, Orchansky P, Revel M, Rubinstein M (Jun 1987). "The human ...
... a protein involved in the intricate complement system, encoded by C4A or C4B gene in humans C4 fragments, one of the types of ... Look up C4 or c4 in Wiktionary, the free dictionary. C4, C04, C.IV, C-4, or C-04 may refer to: Caldwell 4 or NGC 7023 or Iris ... c4, also called the English Opening, a chess opening Channel 4, a UK television channel broadcasting since 1982 C4: an EEG ... C4 Records, a record label Tha Carter IV, album by American rapper Lil Wayne C4 (New Zealand TV channel), a former New Zealand ...
It is caused by a deficit of the complement protein, C5; however, case reports have described it in relation to deficits in ... either C3 or C4. The exact cause of Leiner disease remains unknown but biotin deficiency linked to Complement component 5 (a ... protein ) coded by the C5 gene plays a role. This disease is often found during the first two months of an infant's life, ... Complement Deficiencies at eMedicine (Wikipedia articles needing page number citations from July 2015, Articles with short ...
Complement decay-accelerating factor, also known as CD55 or DAF, is a protein that, in humans, is encoded by the CD55 gene. DAF ... It recognizes C4b and C3b fragments that are created during activation of C4 (classical or lectin pathway) or C3 (alternative ... DAF contains four complement control protein (CCP) repeats with a single N-linked glycan positioned between CCP1 and CCP2. CCP2 ... Binding of DAF to human HIV-1 when the virons are budding from the surface of infected cells protects HIV-1 from complement ...
The genes coding for C4BP α-chain (C4BPA) and β-chain (C4BPB) are located in the regulators of complement activation (RCA) gene ... It inhibits the action the classical and the lectin pathways, more specifically C4. It also has ability to bind C3b. C4BP ... Genes on human chromosome 1, All stub articles, Human chromosome 1 gene stubs). ... Complement+C4b-Binding+Protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with ...