Regulation and Genetics Viral Gene Expression and Integration. Plenum Press. p. 73. ISBN 978-1-4684-0832-4. Manzoni, Tomaz B; ... were produced and that these interfered with viral replication. This resulted in a reduction in the infectivity of influenza. ... López, Carolina B (July 2018). "Defective (interfering) viral genomes re-explored: impact on antiviral immunity and virus ...

Thus USP7 may also be important for regulation of viral gene expression. The fact that viral proteins have evolved so as to ... "Entrez Gene: USP7 ubiquitin specific peptidase 7 (herpes virus-associated)". Everett RD, Meredith M, Orr A, Cross A, Kathoria M ... Hong S, Kim SJ, Ka S, Choi I, Kang S (Jun 2002). "USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene ... Hong S, Kim SJ, Ka S, Choi I, Kang S (Jun 2002). "USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene ...

"Importance of codon usage for the temporal regulation of viral gene expression". Proceedings of the National Academy of ... Thus, codon usage can introduce an additional level of transcriptional regulation for appropriate gene expression under ... gene expression level and species-specific diversity of codon usage based on multivariate analysis". Gene. 238 (1): 143-155. ... Fox JM, Erill I (June 2010). "Relative codon adaptation: a generic codon bias index for prediction of gene expression". DNA Res ...

Modifications in tRNA have the well-known ability to control and modulate gene expression. The regulation of gene expression ... Even if m6A-marked viral transcripts are involved in regulating gene expression of a number of different viruses, the ... Yue Y, Liu J, He C (July 2015). "RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation". Genes ... "Epitranscriptomic regulation of viral replication". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1860 (4 ...

McClung CA, Nestler EJ (2003). "Regulation of gene expression and cocaine reward by CREB and ∆FosB". Nature Neuroscience. 6 (11 ... Carlezon WA, Boundy VA, Haile CN, Kalb RG, Neve R, Nestler EJ (1997). "Sensitization to morphine induced by viral-mediated gene ... The Nestler laboratory has driven innovative use of viral-mediated gene transfer, inducible, cell-type specific mutations in ... "Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area". Nat Neurosci. 18 (3): 415-422. ...

Evidence for immediate early/Early/Late regulation of viral gene expression". Virology. 145 (1): 49-61. doi:10.1016/0042-6822( ... the interactions of viral and cellular proteins, and how these interactions either up-regulate or retard viral gene expression ... "Regulation of equine herpesvirus type 1 gene expression: Characterization of immediate early, early, and late transcription". ... research on the biochemistry of herpesviruses reveals how viral regulator proteins govern the viral genome's expression. He and ...

Analysis of Mouse Polyomavirus Infection Reveals Dynamic Regulation of Viral and Host Gene Expression and Promiscuous Viral RNA ... MTag plays a role in viral DNA replication and in the transition from early to late gene expression, and its absence can cause ... The LTag gene is usually encoded in two exons, of which the first overlaps with the genes for STag and MTag. The result of this ... The "late region" contains genes encoding the viral capsid proteins.) In MTag-containing polyomaviruses, the early region ...

They play a role in gene expression regulation, transposon silencing, and viral infection inhibition. Once considered as "dark ... Li L (2008). "Small RNA-Mediated Gene Activation". In Morris KV (ed.). RNA and the Regulation of Gene Expression: A Hidden ... The upregulation of gene expression can partially be explained by the predicted gene targets of endogenous miRNAs. ... It has been found that dsRNA can also activate gene expression, a mechanism that has been termed "small RNA-induced gene ...

... on the sequences of expression regulation of viral and cellular genes. He identified cellular transcription factors responsible ... His work on gene expression regulation has led him to focus on the role of transcription factors and chromatin remodeling ... for the expression of viral genes and their functions in regulating cell growth and oncogenic transformation. His team ... Factors involved in control of tissue-specific expression of albumin gene », Cell, 1987, p. 50:627 Klochendler-Yeivin A, et al ...

In addition, the expression of IRF genes is under epigenetic regulation by promoter DNA methylation. IRFs primarily regulate ... Following a viral infection, pathogens are detected by Pattern Recognition Receptors (PRRs), including various types of Toll- ... Interferon regulatory factors (IRF) are proteins which regulate transcription of interferons (see regulation of gene expression ... IRF4 and IRF8 specify and direct the differentiation of different subsets of DCs by stimulating subset-specific gene expression ...

Concurrently, the down-regulation of anti-viral gene expression leaves the individual more vulnerable to viral infection such ... This process of translation, or "turning on" of a gene to its final gene products is termed gene expression. Genetic expression ... characterized by increased pro-inflammatory gene expression and a suppression of anti-viral gene expression, has been proposed ... on the expression of individual genes, or more commonly, clusters of many genes (i.e. gene profiles, or gene programs). In the ...

... her research focused upon gene regulation in cancer, regulation of viral gene expression, expression of viral genome fragments ... Later she made discoveries about the molecular biology of cancer and of viral gene regulation. Ru-Chih Chow was born April 2, ... was done when little was known about the molecular approach to gene expression. The term chromatin as an interphase state of ... 1980) "Sequence organization of clones intracisternal a particle genes." Cell 21 (2):465-473. L Hoopes, A Brown, and Ru Chih C ...

... which is notably involved in the epigenetic regulation of retroelements and which regulates critical gene expression programs ... Despite a longstanding interests in the biology of viruses and viral infections, research in Trono's lab at EPFL has shifted ... towards the study of mobile genetic elements called transposons and their role in the regulation of mammalian gene expression. ... awarded with two Advanced Grants from the European Research Council in 2010 and 2015 for projects on mammalian gene regulation ...

"MiR-155-5p modulates HSV-1 replication via the epigenetic regulation of SRSF2 gene expression". Epigenetics. 14 (5): 494-503. ... Hence, based on location Paraspeckles are thought to play a role in cancer regulation, reproduction and viral management. One ... an immune-responsive gene, or can activate the ADARB2 gene. Thus, gene regulation can be manipulated not just through ... "NEAT1 regulates neuroglial cell mediating Aβ clearance via the epigenetic regulation of endocytosis-related genes expression". ...

... working on transcriptional regulation of cell and viral gene expressions, as well as viral vectors in gene therapy. He was the ... At the University of Michigan, Nabel's basic research investigated gene transfer, basic mechanisms of HIV gene regulation and ... studying regulation of HIV gene expression by the recently discovered NF-κB, a host transcription factor. He completed his ... "Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans". ...

As miRNAs generally function to repress gene expression by binding to 3'UTR sites, this positive regulation of viral ... June 2009). "Integration of microRNA miR-122 in hepatic circadian gene expression". Genes & Development. 23 (11): 1313-1326. ... September 2011). "Positive regulation of hepatic miR-122 expression by HNF4α". Journal of Hepatology. 55 (3): 602-611. doi: ... August 2010). "MicroRNA expression in ACTH-producing pituitary tumors: up-regulation of microRNA-122 and -493 in pituitary ...

Because of its central role in controlling eukaryotic gene expression, P-TEFb is subject to stringent regulation at the level ... The structure of HIV Tat bound to P-TEFb demonstrated that the viral protein forms extensive contacts with the cyclin T1 ... Genes Dev 2011; 25:661-72. He N, Liu M, Hsu J, Xue Y, Chou S, Burlingame A, et al. HIV-1 Tat and host AFF4 recruit two ... Genes Dev 1998; 12:755-62. Yang Z, Yik JH, Chen R, He N, Jang MK, Ozato K, et al. Recruitment of P-TEFb for stimulation of ...

... and mRNA translation and regulation of gene expression. VP1 is located in the core of the virus particle and is an RNA- ... Viral particles are up to 76.5 nm in diameter and are not enveloped. There are six viral proteins (VPs) that form the virus ... Each helix, or segment, is a gene, numbered 1 to 11 by decreasing size. Each gene codes for one protein, except genes 9, which ... NSP4 is a viral enterotoxin that induces diarrhoea and was the first viral enterotoxin discovered. It is a viroporin that ...

"Epigenetic regulation of latent HSV-1 gene expression". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1799 ... In the lytic phase, the viral genes are being actively transcribed and many times ultimately lead to cell death. In the lytic ... Instead, it appears that the main way that expression of viral transcripts is maintained at a lower level during latency is ... The mechanism that controls this is very complex because expression of viral proteins during latency is decreased a great deal ...

Env is a viral gene that encodes the protein forming the viral envelope. The expression of the env gene enables retroviruses to ... "Regulation of human immunodeficiency virus env expression by the rev gene product". J. Virol. 63 (5): 1959-66. doi:10.1128/JVI. ... The env mRNA must be spliced for expression. The mature product of the env gene is the viral spike protein, which has two main ... Env expression is regulated by the gene product of rev. Experimental deletion of rev resulted in the inability to detect the ...

... gene expression regulation, plant MeSH G05.315.385 - gene expression regulation, viral MeSH G05.315.410 - gene silencing MeSH ... gene expression regulation, fungal MeSH G05.315.370 - gene expression regulation, neoplastic MeSH G05.315.370.500 - gene ... gene amplification MeSH G05.315.290 - gene expression regulation, archaeal MeSH G05.315.300 - gene expression regulation, ... gene expression regulation, developmental MeSH G05.315.320 - gene expression regulation, enzymologic MeSH G05.315.320.200 - ...

Regulation: Regulation of gene expression and protein activity; information processing in response to environmental input; ... Other/Unknown: an unknown function, viral proteins, or toxins. Each domain superfamily in SCOP classes a to g were manually ... Gene Ontology Domain-centric Gene Ontology (GO) automatically annotated. Due to the growing gap between sequenced proteins and ... "Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium". Nature Genetics. 25 (1): 25-29. doi:10.1038/ ...

Singer's research interests are in the areas of regulation of transcription in cancer, gene expression and molecular immunology ... to expand serological testing capacity and research to characterize the immune responses elicited by the SARS-CoV-2 viral ... Dinah Schiffer Singer (born 1948) is an American immunologist specialized in the regulation of transcription in cancer, gene ... of the interplay between promoter elements and transcription complexes that establish appropriate regulation of gene expression ...

In the context of gene regulation: transactivation is the increased rate of gene expression triggered either by biological ... HIV and HTLV are just two of the many viruses that encode transactivators to enhance viral gene expression. These ... Because the expression of the transactivator gene can be controlled, transactivation can be used to turn genes on and off. If ... The expression of one transactivator gene can activate multiple genes, as long as they have the same, specific promoter region ...

The viral promoter or other transcription regulation elements, in turn, cause over-expression of that proto-oncogene, which, in ... In either case, expression of these genes promotes the malignant phenotype of cancer cells. Tumor suppressor genes are genes ... reduced or absent expression of DNA repair genes is due to epigenetic alterations that reduce or silence gene expression. This ... One key factor in healing is the regulation of cytokine gene expression, which enables complementary groups of cells to respond ...

"Role of Polycomb Repressive Complex 2 in Regulation of Human Transcription Factor Gene Expression" (PDF). Brown, Jay C. ( ... Copeland, A. M., Newcomb, W. W., & Brown, J. C. (2009). Herpes simplex virus replication: roles of viral proteins and ... Whilst working on gene expression, he proposed that for the protection of promoter's ability to regulate gene expression from ... Brown, J. C. (2022). Control of Expression Level in Human Genes: Observations with Apoptosis Genes and Genes Involved in B cell ...

Her work focused on regulation of the expression of major histocompatibility complex type 1 genes, producing cell surface ... She and her team have built a global HIV database of more than 840,000 sequences from publications of the viral genome. In ... Korber, B.; Hood, L.; Stroynowski, I. (1987). "Regulation of murine Class I genes by interferons is controlled by regions ... Williams, B. R. G. (1991). Christen, P.; Hofmann, E. (eds.). "Transcriptional regulation of interferon-stimulated genes". ...

Rothman-Denes combines biophysical, biochemical and structural characterisation techniques to understand gene expression at the ... She studies the target of these viral-encoded products in an effort to design new antibiotics. She served on the board of ... She is known for studying the regulation of transcription and host interactions that occur during bacterial virus infection. ... She is also working on the characterisation of viral-encoded products that inhibit the essential function of the host. ...

"Reduced Expression of Brain-Enriched microRNAs in Glioblastomas Permits Targeted Regulation of a Cell Death Gene". PLOS ONE. 6 ... Tax mediated downregulation of miRNAs associated with chromatin remodeling factors in T cells with stably integrated viral ... The common target gene for miR-873, β-glycan, has increased expression. It is thought that miR-873, along with other miRNAs, ... MicroRNAs function to regulate the expression levels of other genes by several mechanisms. Significant miR-873 reductions have ...

... can control the physiology of infected hosts through the regulation of Juvenile hormone levels and the level of gene expression ... This gene more closely resembles host genes than viral genes. In fact, an MFS gene has never before been found in a viral ... In addition, this gene more closely resembles a host gene than a viral gene. Hz2V012 and Hz2V015 encode inhibitor of apoptosis ... This gene most more closely resembles host genes than viral genes. It likely synthesizes zinc and calcium dependent enzymes to ...