... is a transcription factor that in humans is encoded by the GATA3 gene. Studies in animal models and humans indicate that ... GATA3 belongs to the GATA family of transcription factors. Gene-deletion studies in mice indicate that Gata3 (mouse gene ... "Entrez Gene: GATA3 GATA binding protein 3". Zheng, Wei-ping; Flavell, Richard A (May 1997). "The Transcription Factor GATA-3 Is ... that modulate GATA3's gene-stimulating actions. The GATA3 transcription factor regulates the expression of genes involved in ...

The key Th2 transcription factors are STAT6 and GATA3. IL-4 is the positive feedback cytokine for Th2 cells differentiation. ... The key Th1 transcription factors are STAT4 and T-bet. IFN-γ secreted by CD4 T cells can activate macrophages to phagocytose ... The key THαβ transcription factors are STAT1 and STAT3 as well as IRFs. IL-10 from CD4 T cells activate NK cells' ADCC to ... These are defined by the presence of a lineage-determining (or lineage-specifying) transcription factor (also called master ...

The transcription factor gene GATA3 is altered in mammary tumors. Down-regulation of GATA3 expression and activity by the Zinc- ... Ikeda R, Yoshida K, Inoue I (May 2007). "Identification of FAZF as a novel BMP2-induced transcription factor during ... "Regulation of the Development and Function of B Cells by ZBTB Transcription Factors". Frontiers in Immunology. 9: 580. doi: ... "Identification and gene structure of a novel human PLZF-related transcription factor gene, TZFP". Biochemical and Biophysical ...

This up-regulation is directly controlled by GATA3 transcription factor. IL-33 combined with IL-2, IL-7 or TSLP also stimulates ... These signaling pathways lead to activation of many transcription factors, such as NF-κB, AP-1, c-Jun N-terminal kinase (JNK) ... Its expression is induced by transcription factor NF-κB after exposure of innate immune cells to alarmins. This occurs, for ... functioning as a transcription factor. The precursor form of IL-1α, which has both the N-terminal and C-terminal receptor ...

IL-5 expression is regulated by several transcription factors including GATA3. IL-5 has long been associated with the cause of ... "Role of GATA-3 in IL-5 gene transcription by CD4+ T cells of asthmatic patients". Int. Arch. Allergy Immunol. 137 Suppl 1: 55- ... Lopez AF, Begley CG, Williamson DJ, Warren DJ, Vadas MA, Sanderson CJ (May 1986). "Murine eosinophil differentiation factor. An ... 6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these ...

ROG then downregulates GATA-3, a characteristic transcription factor for Th2 cells. Tr1 cells express high levels of regulatory ... IL-6 and IL-21 also plays a role in differentiation as they regulate expression of transcription factors necessary for IL-10 ... factors, such as glucocorticoid-induced tumor necrosis factor receptor (GITR), OX40 (CD134), and tumor-necrosis factor receptor ... the repressor of GATA-3 (ROG) early growth response protein 2 (Egr-2) Expression of these transcriptional factors are driven by ...

"Regulation of the human interleukin-5 promoter by Ets transcription factors. Ets1 and Ets2, but not Elf-1, cooperate with GATA3 ... Pastorcic M, Das HK (Nov 2000). "Regulation of transcription of the human presenilin-1 gene by ets transcription factors and ... The protein encoded by this gene belongs to the ETS family of transcription factors. ETS2 has been shown to interact with: C- ... Basuyaux JP, Ferreira E, Stéhelin D, Butticè G (Oct 1997). "The Ets transcription factors interact with each other and with the ...

Gaynor, Katherine Ursula (2011). The role of the transcription factor GATA3 in calcium homeostasis and tumourigenesis (DPhil ...

POU3F1, a factor required for the activation of the transcription factor PU.1. PU.1 negatively regulates GATA3 expression, ... mir-126 is regulated by the binding of two transcription factors: ETS1 and ETS2. Binding of these factors induce the ... Transcription of both occur, however mature mir-126 binds to a complementary sequence within EGFL7 preventing translation of ... Sun YQ, Zhang F, Bai YF, Guo LL (2010). "[miR-126 modulates the expression of epidermal growth factor-like domain 7 in human ...

... protein also regulates other transcription factor as Gata3, which is important regulator of Th2 differentiation. STAT6 is ... Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that belongs to the Signal Transducer and ... STAT6+Transcription+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Articles with short ... Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, McKnight SL (September 1994). "An interleukin-4-induced transcription factor ...

GATA3 transcription factor has been shown to promote ST2 gene expression by binding to an enhancer element of foxp3 gene. Foxp3 ... There is clear correlation between T regulatory cell ST2 and Th2 specific transcription factor GATA3 expressions. Both ... transcription factor is necessary for T regulatory cell phenotype stability and suppression function mainly based on gene ... It looks, that GATA3 with presence of STAT3 has different preferences in gene expression regulation. This observation suggest ...

ILC2s require IL-7 for their development, activating the fundamental transcription factors RORα and GATA3. GATA3 is also ... their transcription factors, and access of defined chromatin regions to the transcription factors, however, it still remains ... October 2012). "The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells". Immunity. ... Both cell types produce IFN-γ as their principle cytokine and require the transcription factor T-bet to do so. Both cells can ...

... transcription factor for its role in the development of breast cancer suggest that a specific GATA transcription factor GATA3 ... GATA transcription factors are a family of transcription factors characterized by their ability to bind to the DNA sequence " ... GATA+transcription+factors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short ... that there is a specific gene called the TRP1 that is expressed in breast cancer cells and the GATA3 transcription factor plays ...

Th2 cells, which express IL-4, are inhibited by IL-27 through the transcription factor GATA-3. Th17 cells, which express IL-17 ... Tr1 cells, which express IL-10, are induced by IL-27 through the transcription factor c-Maf. Treg cells are inhibited by IL-27 ... Also involved are the STAT1 and STAT3 transcription factors that bind specifically to the receptor subunits, IL-27ɑ and ... are inhibited by IL-27 through STAT1 and expression of transcription factor RORγt. ...

"Expression of the T-cell transcription factors, GATA-3 and T-bet, in the neoplastic cells of Hodgkin lymphomas". The American ... T-bet also recruits other transcription factors like HLX, RUNX1, RUNX3 which aid it in setting Th1 transcription profile. Apart ... "T-bet transcription factor in cardiovascular disease: Attenuation or inflammation factor?". Journal of Cellular Physiology. 234 ... T-box transcription factor TBX21, also called T-bet (T-box expressed in T cells) is a protein that in humans is encoded by the ...

The transcription factor GATA-3 is also an interesting target, of the DNAzyme topical formulation SB012, for a novel ... By targeting the transcription factor, GATA3, of the Th2 pathway, with DNAzyme it may be possible to negate the inflammation. ... The hemin/G-Quadruplex DNAzyme consists of G-Quadruplex forming DNA that can bind the co-factor hemin (a.k.a. Fe(III) ... The development of a 10-23 DNAzyme that can block the expression of IGF-I (Insulin-like growth factor I, a contributor to ...

STAT6 repress the expression of transcription factors T-bet and Foxp3 in TH9 cells, that normally block IL-9 production. GATA-3 ... There are numbers of cytokines, transcription factors and other molecules, that have a role in TH9 differentiation. Cytokines ... Once activated, phosphorylated STAT6 mediate the transcription of Gata3 and Irf4, which are both necessary for polarization of ... All mentioned cytokines then signal through specific transcription factors, which are later on required for a TH9 polarization ...

"Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 ...

... which activates two transcription factors (both required by these cells)-RORα and GATA3. After stimulation with Th2 polarising ... IL-5 secreted by ILC2s is essential growth factor for B1 B cells and therefore important in the IgA antibody production. ... Research identified dysregulated responses of ILC2s in adipose tissue as a factor in the development of obesity in mice since ... acts as a growth factor for plasmablasts and contributes in regulation of T follicular helper cells. ILC2s are also known to be ...

TH2 and ILC2 cells both express the transcription factor GATA-3, which promotes the production of TH2 cytokines, including the ... Their lineage fate is determined by transcription factors, including GATA and C/EBP. Eosinophils produce and store many ... Horiuchi T, Weller PF (July 1997). "Expression of vascular endothelial growth factor by human eosinophils: upregulation by ... such as elastase Growth factors such as TGF beta, VEGF, and PDGF Cytokines such as IL-1, IL-2, IL-4, IL-5, IL-6, IL-8, IL-9, IL ...

... of zinc-finger transcription factor GATA3 or mutations in the GATA3 gene appear to be the underlying cause of this syndrome. It ... Transcription factor deficiencies, Congenital disorders, Rare syndromes, Syndromes affecting the kidneys, Syndromes affecting ... October 2009). "A missense GATA3 mutation, Thr272Ile, causes the hypoparathyroidism, deafness, and renal dysplasia syndrome". J ... July 2009). "HDR (Hypoparathyroidism, Deafness, Renal dysplasia) syndrome associated to GATA3 gene duplication". Clin. Genet. ...

... and conserved regions Fam158a chromosomal location and neighboring genes transcription factor binding sites in the promoter of ... "Mutation of GATA3 in human breast tumors". Oncogene. 23 (46): 7669-78. doi:10.1038/sj.onc.1207966. PMID 15361840. Dutta-Simmons ... Genomatix ElDorado predicts several transcription factor binding sites in the promoter region.[citation needed] found that ... Several micro-arrays demonstrate the variable expression of Fam158a in response to other factors and in various cancer types. ...

"Entrez Gene: POU4F3 POU domain, class 4, transcription factor 3". In Vivo Interplay between p27Kip1, GATA3, ATOH1, and POU4F3 ... POU domain, class 4, transcription factor 3 is a protein that in humans is encoded by the POU4F3 gene. It's a member of BRN-3 ... 1996). "Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development". Nature. 381 (6583): 603-6 ... 2002). "Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel ...

... has been found to bind to transcription factor binding sites AREB6, GATA-1, GATA-2, GATA-3, ATF6, c-Myc, Max, CHOP-10 ...

... encoding the GATA3 transcription factor. GATA3 is critical for the embryonic development of the parathyroid gland, neural ... undifferentiated embryonic cell transcription factor 1 VIM-AS1: VIM antisense RNA 1 WASHC2C: WASH complex subunit 2C WBP1L: WW ... fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1 ... nuclear receptor-binding factor 2 NSMCE4A: non-SMC element 4 homolog A OTUD1: encoding protein OTU deubiquitinase 1 PAPSS2: ...

"Sequence and expression analysis of two T helper master transcription factors, T-bet and GATA3, in rainbow trout Oncorhynchus ...

Activating transcription factor), NF-κβ, NF-κβ1, GATA-3, C/EBPα (CCAAT/enhancer-binding protein alpha), glucocorticoid ... a guanine nucleotide exchange factor (GEF) for RAP1. PTP-PEST, a soluble protein tyrosine phosphatase that is ubiquitously ... is crucial for their functional maturation and growth factor-mediated expansion. mTECs are important for proper T-cell ...

... as decreased expression of the T helper type 2 cell transcription factor GATA3 is also important for ST2 production. Activated ... All Treg cells express the Foxp3 transcription factor, establishing their suppressive phenotype. Foxp3 expression is not ... In humans, a promoter 261 bp upstream consists of five NF-κB and three interferon regulatory factor binding sites, reflecting ... April 2013). "Multiple interferon regulatory factor and NF-κB sites cooperate in mediating cell-type- and maturation-specific ...

... virus latent membrane protein 1 targeting DNAzyme and the latter a DNAzyme targeting the transcription factor GATA3 which ... Dz13 is a 10-23 DNAzyme that targets c-Jun, a transcription factor found in diseased blood vessels, eyes, lungs and joints. The ... Fahmy, R. et al (2006) Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun. ... Krug, N. et al (2015) Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme. N Engl J Med. 372(21):1987-95 ...

... targeting EBV-LMP1 in patients with nasopharyngeal cancer and DNAzymes targeting another nuclear transcription factor GATA3 in ... Khachigian invented Dz13, a molecule that targets the transcription factor c-Jun, implicated in a range of common proliferative ... with first-class honours in biochemistry in 1986 and Ph.D. in growth factor biochemistry and cell biology in 1993 from the ... On returning to Australia in 1996 he established the Transcription Laboratory within the Centre for Vascular Research, Faculty ...