Dopamine receptorTalipexoleNafadotrideDopamine reuptake inhibitor: A dopamine reuptake inhibitor (DRI) is a type of drug which acts as a reuptake inhibitor of the monoamine neurotransmitter dopamine by blocking the action of the dopamine transporter (DAT). Reuptake inhibition is achieved when extracellular dopamine not absorbed by the postsynaptic neuron is blocked from re-entering the presynaptic neuron.Dopamine beta hydroxylase deficiency: Dopamine beta hydroxylase deficiency is a condition involving inadequate Dopamine beta hydroxylase. It is characterized by increased amounts of serum dopamine and the absence of nor-epinephrine and epinephrine.Frontostriatal circuit: Frontostriatal circuits are neural pathways that connect frontal lobe regions with the basal ganglia (striatum) that mediate motor, cognitive, and behavioural functions within the brain. They receive inputs from dopaminergic, serotonergic, noradrenergic, and cholinergic cell groups that modulate information processing.BenazeprilSynaptic gating: Synaptic gating is the ability of neural circuits to gate inputs by either suppressing or facilitating specific synaptic activity. Selective inhibition of certain synapses has been studied thoroughly (see Gate theory of pain), and recent studies have supported the existence of permissively gated synaptic transmission.AmisulprideHaloperidolApomorphineSalicylamideCocaine intoxicationDopamine dysregulation syndrome: Dopamine dysregulation syndrome (DDS) is a dysfunction of the reward system observed in some individuals taking dopaminergic medications for an extended length of time. It can occur in subjects with Parkinson's disease (PD) due to a long exposure to dopamine replacement therapy (DRT).Substituted amphetamine: Substituted amphetamines are a class of compounds based upon the amphetamine structure; it includes all derivative compounds which are formed by replacing, or substituting, one or more hydrogen atoms in the amphetamine core structure with substituents. The compounds in this class span a variety of pharmacological subclasses, including stimulants, entactogens, hallucinogens, among others.Rolf Hassler: Rolf Hassler (1914-1984) was a German pathologist who made important discoveries on the pathophisiology and treatment of Parkinson's disease (PD).Ventral tegmental area: The ventral tegmental area (VTA), (tegmentum is Latin for covering), also known as the ventral tegmental area of Tsai, or simply ventral tegmentum, is a group of neurons located close to the midline on the floor of the midbrain (mesencephalon). The VTA is the origin of the dopaminergic cell bodies of the mesocorticolimbic dopamine system and is widely implicated in the drug and natural reward circuitry of the brain.CabergolineLipoatrophia semicircularis: Lipoatrophia semicircularis (also known as semicircular lipoatrophy) is a medical condition in humans, commonly known as ribbed thighs.AMPTDomperidoneHSD2 neurons: HSD2 neurons are a small group of neurons in the brainstem which are uniquely sensitive to the mineralocorticosteroid hormone aldosterone, through expression of HSD11B2. They are located within the caudal medulla oblongata, in the nucleus of the solitary tract (NTS).FluorodopaDiclofensineAnatoxin-aBromocriptineReserpineReward system: The reward system is a group of neural structures that are critically involved in mediating the effects of reinforcement. A reward is an appetitive stimulus given to a human or some other animal to alter its behavior.Prenatal methamphetamine exposure: Prenatal methamphetamine exposure (PME) is the exposure of a prenatal fetus to methamphetamine when a woman uses the drug during her pregnancy. Methamphetamine (MA) has shown increasing popularity in the past two decades among women of childbearing age.ButaclamolSerotonergic: Serotonergic (, ) or serotoninergic (, ) means "pertaining to or affecting serotonin". Serotonin is a neurotransmitter.Concentration effect: In the study of inhaled anesthetics, the concentration effect is the increase in the rate that the Fa(alveolar concentration)/Fi(inspired concentration) ratio rises as the alveolar concentration of that gas is increased. In simple terms, the higher the concentration of gas administered, the faster the alveolar concentration of that gas approaches the inspired concentration.Beta-Phenylmethamphetamine: β-Phenylmethamphetamine (N,α-dimethyl-β-phenyl-phenethylamine) is a potent and long lasting stimulant drug.Pharmazie 1973;28(10):677.Lentiform nucleus: The lentiform nucleus or lenticular nucleus comprises the putamen and the globus pallidus within the basal ganglia. It is a large, cone-shaped mass of gray matter just lateral to the internal capsule.Catecholaminergic cell groups: Catecholaminergic cell groups refers to collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain one of the neurotransmitters dopamine or norepinephrine. Thus, it represents the combination of dopaminergic cell groups and noradrenergic cell groups.Atypical antipsychotic: The atypical antipsychotics (AAP; also known as second generation antipsychotics (SGAs)) are a group of antipsychotic drugs (antipsychotic drugs in general are also known as major tranquilisers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) used to treat psychiatric conditions. Some atypical antipsychotics have received regulatory approval (e.Pleasure center: Pleasure center is the general term used for the brain regions involved in pleasure. Discoveries made in the 1950s initially suggested that rodents could not stop electrically stimulating parts of their brain, mainly the nucleus accumbens, which was theorized to produce great pleasure.PergolideDextroamphetamineCarbidopaSelf-administration: Self-administration is, in its medical sense, the process of a subject administering a pharmacological substance to him-, her-, or itself. A clinical example of this is the subcutaneous "self-injection" of insulin by a diabetic patient.Desmethylclozapine: N-Desmethylclozapine (NDMC), or norclozapine, is a major active metabolite of the atypical antipsychotic drug clozapine. Unlike clozapine, it possesses intrinsic activity at the D2/D3 receptors, and acts as a weak partial agonist at these sites similarly to aripiprazole and bifeprunox.Jaehoon Ahn: Jaehoon Ahn (May 13, 1941 – June 1, 2011) was a North Korean-born American journalist and researcher. Ahn worked as a researcher for the Washington Post for more than twenty-five years, until 1996.Levodopa-induced dyskinesia: Levodopa-induced dyskinesia is a form of dyskinesia associated with levodopa used to treat Parkinson's disease. It often involves hyperkinetic movements, including chorea, dystonia, and athetosis.CatalepsyAromatic L-amino acid decarboxylase inhibitor: An aromatic L-amino acid decarboxylase inhibitor (synonyms: DOPA decarboxylase inhibitor, DDCI and AAADI) is a drug which inhibits the synthesis of dopamine by the enzyme aromatic L-amino acid decarboxylase (AAAD, or DOPA decarboxylase, DDC).OctopaminePyrrolidineMeta-TyramineMethylphenidateChronoamperometry: Chronoamperometry is an electrochemical technique in which the potential of the working electrode is stepped and the resulting current from faradaic processes occurring at the electrode (caused by the potential step) is monitored as a function of time. Limited information about the identity of the electrolyzed species can be obtained from the ratio of the peak oxidation current versus the peak reduction current.TamibaroteneBiogenic amine: A biogenic amine is a biogenic substance with one or more amine groups. They are basic nitrogenous compounds formed mainly by decarboxylation of amino acids or by amination and transamination of aldehydes and ketones.
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