... some cases of cryptorchidism or Sertoli cell-only syndrome as well as acquired conditions by infection (orchitis), surgery ( ... Mast cells releasing inflammatory mediators appear to directly suppress sperm motility in a potentially reversible manner, and ... Menzies, F. M.; Shepherd, M. C.; Nibbs, R. J.; Nelson, S. M. (2010). "The role of mast cells and their mediators in ... Serum inhibin-B weakly indicates presence of sperm cells in the testes, raising chances for successfully achieving pregnancy ...

It has been shown that individuals with Cryptorchidism and Sertoli-cell-only syndrome, which are both associated with sterility ... Yu Z, Wu B, Tang A, Chen J, Guo X, Qin J, Gui Y, Cai Z (October 2009). "Expression profile of a novel germ cell-specific gene, ... Uroplakin 1B is known to regulate cell development, activation, growth, and motility. This could indicate why abnormalities in ... cellular localization probability of Tex55 and its orthologs indicate that it is most likely located in the nucleus of the cell ...

... meigs syndrome MeSH C19.344.410.648 - sertoli-leydig cell tumor MeSH C19.344.410.765 - thecoma MeSH C19.344.421.249 - adenoma, ... kallmann syndrome MeSH C19.391.775.454 - klinefelter syndrome MeSH C19.391.829.258 - cryptorchidism MeSH C19.391.829.493 - ... meigs syndrome MeSH C19.391.630.705.648 - sertoli-leydig cell tumor MeSH C19.391.630.705.765 - thecoma MeSH C19.391.775.129 - ... sertoli-leydig cell tumor MeSH C19.344.894.800 - thyroid nodule MeSH C19.391.482.293 - eunuchism MeSH C19.391.482.600 - ...

... can lead to abnormalities in Sertoli and/or Leydig cell function. This leads to both impaired germ cell development and ... In cryptorchidism a diagnosis is made from a physical examination which is performed when the baby is lacking one or both ... If a substance affects Sertoli and Leydig cell differentiation (a common feature of TDS disorders) at an early developmental ... Testicular germ cell cancer (TGCC) shows a strong genetic disposition, with the most significant gene variants being those ...

LH acts on Leydig cells in the male testes and theca cells in the female. FSH acts on Sertoli cells in the male and follicular ... Kallmann syndrome results in a loss of smell (anosmia) and is associated with KAL1 mutations. The KAL1 gene encodes anosmin-1, ... CHH can be diagnosed in the male neonate with cryptorchidism (maldescended testes) and a micropenis as signs of GnRH deficiency ... In men with CHH, serum levels of inhibin B are typically very low as inhibin B is a marker of Sertoli cell number. For females ...

... renal cell MeSH C12.740.800.820.750.585 - wilms tumor MeSH C12.740.800.820.750.585.220 - denys-drash syndrome MeSH C12.740. ... sertoli-leydig cell tumor MeSH C12.294.365.700 - infertility, male MeSH C12.294.365.700.508 - oligospermia MeSH C12.294.494.136 ... cryptorchidism MeSH C12.740.700.374 - epispadias MeSH C12.740.700.445 - frasier syndrome MeSH C12.740.700.516 - hypospadias ... denys-drash syndrome MeSH C12.740.700.842.425 - kallmann syndrome MeSH C12.740.700.842.454 - klinefelter syndrome MeSH C12.740. ...

High circulating AMH continues on after testis development and is secreted from the Sertoli Cells. It has been reported that ... A syndrome called "Persistent Mullerian Duct Syndrome" (PMDS) can occur in human males and results in the uterus, vagina, and ... and these males often have undescended testes or cryptorchidism, where one testis fails to descend outside of the body cavity. ... November 1999). "Human ovarian cancer, cell lines, and primary ascites cells express the human Mullerian inhibiting substance ( ...

The Sertoli cells in males secrete AMH, through the presence of a Y chromosome. The role of the AMH gene in reproductive ... Along with cryptorchidism, is also inguinal hernias which may be presented unilaterally (affects one testicle) or bilaterally ( ... At approximately the end of the 7th and the beginning of the 8th week of gestation, the Sertoli cell's secretion of AMH occurs ... AMH, or sometimes referred to as Müllerian inhibiting substance (MIS), is secreted by Sertoli cells during an individual's ...

"Incidental detection of Sertoli-Leydig cell tumor by FDG PET/CT imaging in a patient with androgen insensitivity syndrome". Ann ... Kallmann syndrome (often associated with anosmia) Hypospadias not otherwise specified Cryptorchidism not otherwise specified ... and Goldberg-Maxwell syndrome; PAIS includes Reifenstein syndrome, Gilbert-Dreyfus syndrome, Lub's syndrome, "incomplete ... such as Reifenstein syndrome (1947), Goldberg-Maxwell syndrome (1948), Morris' syndrome (1953), Gilbert-Dreyfus syndrome (1957 ...

AMH is activated by SOX9 in the Sertoli cells of the male fetus. Its expression inhibits the development of the female ... AMH levels can also be used to diagnose cases of ovarian remnant syndrome. Polycystic ovary syndrome (PCOS) is an endocrine ... and cryptorchidism. A study published in Nature Medicine found a link between hormonal imbalance in the womb and polycystic ... AMH production by the Sertoli cells of the testes remains high throughout childhood in males but declines to low levels during ...

... the cells in the testes differentiate into testosterone-producing Leydig cells, and anti-Müllerian hormone-producing Sertoli ... Among the more common are Down syndrome, Prader-Willi syndrome, and Noonan syndrome. In vitro fertilization, use of cosmetics ... Cryptorchidism, hypospadias, testicular cancer, and poor semen quality make up the syndrome known as testicular dysgenesis ... Androgen Insensitivity Syndrome generally manifests itself in Cryptorchidism. In CAIS the testis are generally located ...

Since the Sertoli cells are not affected by Leydig cell hypoplasia, anti-Müllerian hormone is secreted normally and so there ... also known as Leydig cell agenesis, is a rare autosomal recessive genetic and endocrine syndrome affecting an estimated 1 in ... and/or cryptorchidism [undescended testes]) external genitalia, a female gender identity or gender variance, hypergonadotropic ... The inside of the testis will be grayish and mucous, displaying arrested spermatogenesis and the presence of Sertoli cells. The ...

The anti-Müllerian hormone is used for evaluating the function of Sertoli cells. A urinary steroid profile shows the ratio of ... hypogonadism and cryptorchidism. In females, this includes Malformation syndromes, Müllerian agenesis/hypoplasia, uterine ... This includes sex chromosome DSDs such as Klinefelter syndrome, Turner syndrome and 45,X or 46,XY gonadal dysgenesis. Males ... Klinefelter syndrome and Turner syndrome). Thirdly, the term 'DSD' lacks specificity and clarity; and therefore unhelpful in ...

AMH is a glycoprotein hormone that is secreted by sustentacular cells (Sertoli cells) in males as they begin their morphologic ... Cryptorchidism (undescended testis) or ectopic testis with inguinal hernias have been identified in human males due to AMH and ... A male that has persistent müllerian duct syndrome may have an upper vagina, uterus, and uterine tubes as well as ductus ... During this time primordial germ cells migrate from the yolk sac to the genital ridge; a region of mesenchyme arising from, and ...

Mutations in this gene have been associated with Sertoli cell-only syndrome (SCO) and male infertility. The USP9Y gene is found ... Dada R, Gupta NP, Kucheria K (2003). "Cryptorchidism and AZF microdeletion". Asian J. Androl. 4 (2): 148. PMID 12085107. Dada R ... Mesco ER, Timiras PS (1992). "Tau-ubiquitin protein conjugates in a human cell line". Mech. Ageing Dev. 61 (1): 1-9. doi: ... 2003). "Screening for microdeletions in human Y chromosome--AZF candidate genes and male infertility". J. Cell. Mol. Med. 7 (1 ...

"Incidental detection of Sertoli-Leydig cell tumor by FDG PET/CT imaging in a patient with androgen insensitivity syndrome". Ann ... Cryptorchidism is common, and carries with it a 50% risk of germ cell malignancy. If the testes are located intrascrotally, ... Partial androgen insensitivity syndrome (PAIS) is a condition that results in the partial inability of the cell to respond to ... Partial androgen insensitivity syndrome is diagnosed when the degree of androgen insensitivity in an individual with a 46,XY ...

... cell tumor Leydig cell tumor Sertoli cell tumor Sertoli cell tumor Large cell calcifying Sertoli cell tumor Granulosa cell ... cryptorchidism, hypospadias, and poor semen quality make up the syndrome known as testicular dysgenesis syndrome. A major risk ... Germ cells derived from germ cell neoplasia in situ Noninvasive germ cell neoplasia Germ cell neoplasia in situ' Specific forms ... Diffuse embryoma Germ cell tumors of unknown type Regressed germ cell tumors Germ cell tumors unrelated to germ cell neoplasia ...

"Incidental detection of Sertoli-Leydig cell tumor by FDG PET/CT imaging in a patient with androgen insensitivity syndrome". Ann ... "Linkage between cryptorchidism, hypospadias, and GGN repeat length in the androgen receptor gene". J. Clin. Endocrinol. Metab. ... Mild androgen insensitivity syndrome (MAIS) is a condition that results in a mild impairment of the cell's ability to respond ... Androgen insensitivity syndrome is the largest single entity that leads to 46,XY undermasculinization. Individuals with mild ( ...

Testicular cancer, Leydig cell tumours and Sertoli cell tumours are also associated with reduced sperm count and quality. A ... Cryptorchidism, hypospadias, testicular cancer and poor semen quality make up the syndrome known as testicular dysgenesis ... Other environmental agents associated with decreased semen quality include: Cadmium, causing damage to Sertoli cells, thereby ... If the grade of mobility is poor, 10 million motile cells per ml is required. Home insemination of previously frozen sperm can ...

With both the electron and confocal laser microscopy, it was prevalent that the Sertoli cells, which are somatic cells where ... Lisser H, Curtis LE (October 1947). "The syndrome of congenitally aplastic ovaries with sexual infantilism, high urinary ... teratogenicity penile and testicular hypoplasia cryptorchidism (in rats and rhesus monkeys), liver and renal cancer (in ... it was understood that rats of older age who were injected with DES experienced delay in sertoli cell maturation, ...

HESX1 SERKAL syndrome; 611812; WNT4 Sertoli cell-only syndrome; 400042; ZNF148 SESAME syndrome; 612780; KCNJ10 Severe combined ... CRLF1 Crouzon syndrome with acanthosis nigricans; 612247; FGFR3 Crouzon syndrome; 123500; FGFR2 Cryptorchidism, bilateral; ... T cell-negative, B-cell/natural killer-cell positive; 608971; CD3D Severe combined immunodeficiency, T cell-negative, B-cell/ ... T cell-negative, B-cell/natural killer-cell positive; 608971; PTPRC Severe combined immunodeficiency, T-cell negative, B-cell/ ...