COS cells
Three COS lines were created (COS-1, COS-3 and COS-7), of which two are commonly used (COS-1 and COS-7). The COS cell lines are ... COS are fibroblast-like cell lines derived from monkey kidney tissue. COS cells are obtained by immortalizing CV-1 cells with a ... The CV-1 cell line in turn was derived from the kidney of the African green monkey. The acronym "COS" is derived from the cells ... Cellosaurus entry for COS-1 Cellosaurus entry for COS-3 Cellosaurus entry for COS-7 (CS1: long volume value, Commons category ...
Cobalt sulfide
"Honeycomb-like CoS Counter Electrodes for Transparent Dye-Sensitized Solar Cells". Electrochemical and Solid-State Letters. 14 ... Well-characterized species include minerals with the formulas CoS, CoS2, Co3S4, and Co9S8. In general, the sulfides of cobalt ... Khaja (2014). "Dye-sensitized solar cells with 13% efficiency achieved through the molecular engineering of porphyrin ... CoS is known as jaipurite. However, this species is questionable. Cobalt sulfide minerals are converted to cobalt via roasting ...
MAN1A1
cDNA cloning and expression of the enzyme in COS 1 cells". Eur. J. Biochem. 246 (3): 681-9. doi:10.1111/j.1432-1033.1997.t01-1- ... Bieberich E, Bause E (1995). "Man9-mannosidase from human kidney is expressed in COS cells as a Golgi-resident type II ... expressed in Chinese hamster ovary cells". J. Biol. Chem. 265 (18): 10373-82. doi:10.1016/S0021-9258(18)86956-3. PMID 2355006. ...
Fibrinogen beta chain
Danishefsky K, Hartwig R, Banerjee D, Redman C (1990). "Intracellular fate of fibrinogen B beta chain expressed in COS cells". ... Cell Biol. 31 (7): 741-6. doi:10.1016/S1357-2725(99)00032-1. PMID 10467729. Redman CM, Xia H (2001). "Fibrinogen biosynthesis. ... In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor ... and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, ...
Glycylpeptide N-tetradecanoyltransferase 1
... and membrane association in COS cells". Proc. Natl. Acad. Sci. U.S.A. 87 (2): 728-32. Bibcode:1990PNAS...87..728M. doi:10.1073/ ... Cell. Biochem. 204 (1-2): 135-55. doi:10.1023/A:1007012622030. PMID 10718634. Geyer M, Fackler OT, Peterlin BM (2001). " ... Wice BM, Gordon JI (1992). "A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell ... "Antimyristoylation of the gag proteins in the human immunodeficiency virus-infected cells with N-myristoyl glycinal ...
UGT2B7
Ritter JK, Sheen YY, Owens IS (May 1990). "Cloning and expression of human liver UDP-glucuronosyltransferase in COS-1 cells. 3, ... A study of erlotinib clearance in non-small cell lung cancer patients showed no statistical significance for SNPs of UGT2B7, ... This enzyme is located on the endoplasmic reticulum and nuclear membranes of cells. Its function is to catalyse the conjugation ... epithelial cells of the lower gastrointestinal tract and also has been reported in the brain. In humans, UDP- ...
GNAZ
... and membrane association in COS cells". Proc. Natl. Acad. Sci. U.S.A. 87 (2): 728-32. Bibcode:1990PNAS...87..728M. doi:10.1073/ ... Cell Sci. 115 (Pt 23): 4483-93. doi:10.1242/jcs.00093. PMID 12414994. Glick JL, Meigs TE, Miron A, Casey PJ (October 1998). " ... Cell Biol. 141 (7): 1515-27. doi:10.1083/jcb.141.7.1515. PMC 2132997. PMID 9647645. Glick JL, Meigs TE, Miron A, Casey PJ (1998 ... "Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells". Proc. Natl. Acad. Sci. U.S.A. 88 (9): 3907 ...
P53
... cDNA sequence and expression in COS cells". The EMBO Journal. 4 (5): 1251-5. doi:10.1002/j.1460-2075.1985.tb03768.x. PMC 554332 ... Suppression of p53 plays important roles in cancer stem cell phenotype, induced pluripotent stem cells and other stem cell ... Tsai RY, McKay RD (December 2002). "A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells". Genes ... "Critical role for P53 in regulating the cell cycle of ground state embryonic stem cells". Stem Cell Reports. 14 (2): 175-183. ...
CD79B
1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells". J. Biol. Chem. 270 (45): 27072-8. doi ... is identical in B cell and plasma cell lines producing all the human Ig isotypes". J. Immunol. 150 (2): 491-8. doi:10.4049/ ... PDBe-KB provides an overview of all the structure information available in the PDB for Human B-cell antigen receptor complex- ... Müller B, Cooper L, Terhorst C (1995). "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated ...
Tyrosine-protein kinase BLK
1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells". J. Biol. Chem. 270 (45): 27072-8. doi ... Cell. Biol. 13 (9): 5877-87. doi:10.1128/MCB.13.9.5877. PMC 360336. PMID 8395016. Malek SN, Yang CH, Earnshaw WC, et al. (1996 ... Cell. Biol. 16 (9): 4735-43. doi:10.1128/MCB.16.9.4735. PMC 231474. PMID 8756631. Saouaf SJ, Wolven A, Resh MD, Bolen JB (1997 ... Dymecki SM, Niederhuber JE, Desiderio SV (1990). "Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells". ...
Sandra Saouaf
1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells". The Journal of Biological Chemistry. ... After completion of her degree, Saouaf went to work in the cell signaling laboratory of Bristol-Myers Squibb where she ... December 1990). "Mechanisms of Autoimmunity in the Context of T-Cell Tolerance: Insights from Natural and Transgenic Animal ... January 1989). "Molecular characterization of suppressor T cells". Transplantation Proceedings. 20 (6): 1151-1153. PMID 2974197 ...
EPHX1
Complementary DNA sequence, complementary DNA-directed expression in COS-1 cells, and chromosomal localization". J. Biol. Chem ... Cell Genet. 83 (1-2): 44-5. doi:10.1159/000015164. PMID 9925921. S2CID 42482323. Lu AY, Thomas PE, Ryan D, Jerina DM, Levin W ( ... Cell Genet. 83 (1-2): 44-5. doi:10.1159/000015164. PMID 9925921. S2CID 42482323. "Entrez Gene: EPHX1 epoxide hydrolase 1, ... EPHX1 protein can be found predominantly in the membrane fraction of the endoplasmic reticulum of eucaryotic cells. Its ...
Carbonic anhydrase 4
... and expression in COS cell membranes". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1315-9. Bibcode:1992PNAS...89.1315O. doi:10.1073/ ... from the interior of the Red Blood Cell to the plasma. HCO− 3 does not diffuse across cell membranes and, in the absence of CA ... CO2 in the plasma diffuses into the Red Blood Cell. CA is present within the Red Blood Cell, facilitating the conversion of CO2 ... It is traditionally thought that HCO− 3 is returned to the interior of the Red Blood Cell by a reversal of the HCO− 3/Cl- ...
Sialidase-2
Expression studies in COS-7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was ... Cell Res. 17 (4): 357-362. doi:10.1038/cr.2007.27. PMID 17426694. Chavas LM, Tringali C, Fusi P, et al. (2005). "Crystal ... demonstrated by cell fractionation experiments. GRCh38: Ensembl release 89: ENSG00000115488 - Ensembl, May 2017 GRCm38: Ensembl ...
Forkhead box d1
FOXD1 is expressed by two kidney derived cell line COS 7 and 293 cells. It also has high degree of sequence similarity with ... Delayed expression of FOX D1 causes decreased glioma cell growth and reduce cell migration. There is a high probability that ... FOXD1 and stromal cell have essential function during kidney Morphogenesis. Placental growth factor (PIGF) is a direct and ... During visual system development, retinal ganglion cell (RGC) axons leave the retina via optic disc until they reach the optic ...
SCP2
Yamamoto R (1993). "[Localization of human sterol carrier protein 2 gene and cDNA expression in COS-7 cell]". Hokkaido Igaku ... Cell. 24 (5): 653-63. doi:10.1016/j.molcel.2006.10.024. PMC 5030714. PMID 17157249. Seedorf U, Ellinghaus P, Roch Nofer J (2000 ... in which cells are deficient in peroxisomes and have impaired bile acid synthesis. SCP2 has been shown to interact with ... DNA Cell Biol. 10 (9): 695-8. doi:10.1089/dna.1991.10.695. PMID 1755959. Schroeder F, Butko P, Nemecz G, Scallen TJ (1990). " ...
UGT1A6
"Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells". The Journal of ... "Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells". Proceedings of the ...
Testosterone
COS 1) cells". Science. 234 (4781): 1258-61. Bibcode:1986Sci...234.1258Z. doi:10.1126/science.3535074. PMID 3535074. Zouboulis ... In the testes, testosterone is produced by the Leydig cells. The male generative glands also contain Sertoli cells, which ... testosterone is synthesized primarily in Leydig cells. The number of Leydig cells in turn is regulated by luteinizing hormone ( ... Cell Biol. 42 (6): 813-27. doi:10.1016/j.biocel.2009.11.013. PMID 19931639. Wang C, Liu Y, Cao JM (2014). "G protein-coupled ...
STAT5A
Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells". J. Biol. Chem. 271 (18): 10738- ... Cell. Endocrinol. 166 (2): 89-99. doi:10.1016/S0303-7207(00)00277-X. PMID 10996427. S2CID 45725648. Zhu M, John S, Berg M, ... Cell Biol. 42 (2): 186-92. doi:10.1016/j.biocel.2009.11.001. PMC 2818495. PMID 19914392. Pestell, Richard G.; Nevalainen, Marja ... This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, ...
STAT5B
Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells". J. Biol. Chem. 271 (18): 10738- ... This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth ... or heterodimers that translocate to the cell nucleus where they act as transcription activators. ...
UGT1A4
"Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells". J. Biol. Chem. 266 (2 ... Cell Genet. 63 (2): 114-6. doi:10.1159/000133513. PMID 8467709. Strassburg CP, Oldhafer K, Manns MP, Tukey RH (1997). " ...
CUGBP1
2002). "Coexpression of the CUG-binding protein reduces DM protein kinase expression in COS cells". J. Biochem. 130 (5): 581-7 ... In mammalian cell extract as well as in xenopus egg extracts, depletion and rescue experiments showed that specific binding of ... In human cells, tethering of hCUGBP1 to a mRNA decreases its steadystate suggesting the destabilization of the mRNA. The first ... Cell. Biol. 16 (4): 1490-9. doi:10.1128/MCB.16.4.1490. PMC 231133. PMID 8657122. Vlasova IA, Tahoe NM, Fan D, Larsson O, ...
Steroid 11β-hydroxylase
... in COS-1 cells". Eur. J. Biochem. 262 (3): 720-6. doi:10.1046/j.1432-1327.1999.00414.x. PMID 10411633. Loidi L, Quinteiro C, ... The expression of the enzyme in adrenocortical cells is regulated by the trophic hormone corticotropin (ACTH). A mutation in ... "Mechanism of corticotropin and cAMP induction of mitochondrial cytochrome P450 system enzymes in adrenal cortex cells" (PDF). J ...
GABAA-rho receptor
"Pharmacology of GABA ρ1 and GABA α/β receptors expressed in Xenopus oocytes and COS cells". Br. J. Pharmacol. 109 (1): 200-206 ... Native responses of the GABAC receptor type occur in retinal bipolar or horizontal cells across vertebrate species. GABAС ... Feigenspan A, Wässle H, Bormann J (January 1993). "Pharmacology of GABA receptor Cl− channels in rat retinal bipolar cells". ... Qian H, Dowling JE (January 1993). "Novel GABA responses from rod-driven retinal horizontal cells". Nature. 361 (6408): 162-164 ...
Insulin-like growth factor 2 receptor
Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells". J. Biol. Chem. 263 (5): 2553- ... Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells". J. Biol. Chem. 263 (5): 2553- ... Cell Genet. 66 (4): 272-3. doi:10.1159/000133710. PMID 8162705. Ishiwata T, Bergmann U, Kornmann M, Lopez M, Beger HG, Korc M ( ... Cell Biol. 30 (7): 767-71. doi:10.1016/S1357-2725(98)00048-X. PMID 9722981. Hawkes C, Kar S (2004). "The insulin-like growth ...
CD7
Aruffo A, Seed B (November 1987). "Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system ... This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B- ... Baker E, Sandrin MS, Garson OM, Sutherland GR, McKenzie IF, Webber LM (1990). "Localization of the cell surface antigen CD7 by ... Subrahmanyam G, Rudd CE, Schneider H (January 2003). "Association of T cell antigen CD7 with type II phosphatidylinositol-4 ...
ITIH3
"Intracellular coupling of bikunin and the heavy chain of rat pre-alpha-inhibitor in COS-1 cells". Biochem. J. 328 (1): 185-91. ...
KCTD7
Overexpression of KCTD7 in HeLa and COS-1 cells, which do not express endogenous KCTD7, shows diffuse cytosolic localization, ... in granular and pyramidal cell layers of the hippocampus, and in cerebellar Purkinje cells. However, not all neuronal cells are ... Immunofluorescence microscopy shows a cytosolic expression of the recombinant GFP-KCTD7 protein in transfected COS-7 cells. One ... In cultured mouse hippocampal cells, expression is found in the cell soma, in neuritic varicosities along the developing ...
GABA receptor
"Pharmacology of GABA rho 1 and GABA alpha/beta receptors expressed in Xenopus oocytes and COS cells". Br. J. Pharmacol. 109 (1 ... After this period of development, a chloride pump is upregulated and inserted into the cell membrane, pumping Cl− ions into the ... Native responses of the GABAC receptor type occur in retinal bipolar or horizontal cells across vertebrate species. GABAС ... Tomiko SA, Taraskevich PS, Douglas WW (February 1983). "GABA acts directly on cells of pituitary pars intermedia to alter ...
SPINT2
"Intracellular coupling of bikunin and the heavy chain of rat pre-alpha-inhibitor in COS-1 cells". The Biochemical Journal. 328 ... "Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor ... "Quantitative analysis of bikunin-laden mast cells in follicular eruptions and chronic skin lesions of atopic dermatitis". ... "Bikunin target genes in ovarian cancer cells identified by microarray analysis". The Journal of Biological Chemistry. 278 (17 ...