The chromosomal region (locus) contained 70 genes. The locus was given the official name "SPCH1" (for speech-and-language- ... Mapping and sequencing of the chromosomal region was performed with the aid of bacterial artificial chromosome clones. Around ... The zebrafish FOXP2 gene has an 85% similarity to the human FOX2P ortholog. FOXP2 and its gene were discovered as a result of ... Mutations in FOXP2 are among several (26 genes plus 2 intergenic) loci which correlate to ADHD diagnosis in adults - clinical ...

"Analysis of the 1.1-Mb human alpha/delta T-cell receptor locus with bacterial artificial chromosome clones". Genome Res. 7 (4 ... The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and ... "Entrez Gene: OR10G3 olfactory receptor, family 10, subfamily G, member 3". Boysen C, Simon MI, Hood L (1997). " ... Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584-9 ...

"Analysis of the 1.1-Mb human alpha/delta T-cell receptor locus with bacterial artificial chromosome clones". Genome Res. 7 (4 ... The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and ... "Entrez Gene: OR10G2 olfactory receptor, family 10, subfamily G, member 2". Boysen C, Simon MI, Hood L (1997). " ... Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584-9 ...

"Analysis of the 1.1-Mb human alpha/delta T-cell receptor locus with bacterial artificial chromosome clones". Genome Res. 7 (4 ... The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and ... "Entrez Gene: OR4E2 olfactory receptor, family 4, subfamily E, member 2". Koop BF, Rowen L, Wang K, et al. (1994). "The human T- ... Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584-9 ...

... first discovered by the observation of mosaic genes at loci encoding antibiotic resistance. The discovery of homologous ... Bacteria reproduces asexually, where daughter cells are clones of the parent. This clonal nature leads to random mutations that ... Bacterial transformation is carried out by numerous interacting bacterial gene products. Evolution in bacteria was previously ... Bacterial DNA is placed into the bacteriophage genome via bacterial transduction. In bacterial conjugation, DNA is transferred ...

... appear in almost any gene or locus of interest on any chromosome. Furthermore, almost all artificial plasmids include a (often ... such as a cloning vector or an expression vector). The vector typically contains a multiple cloning site where many restriction ... by insertion into replicating bacterial cells. After restriction digest, DNA can then be analysed using agarose gel ... Restriction digest is most commonly used as part of the process of the molecular cloning of DNA fragment into a vector ( ...

The P1 gene product was named Cre (causes recombination) and the recombination site was named loxP (locus of crossing (x) over ... The mechanism of these recombination events was known to be unique as they occurred in the absence of bacterial RecA and RecBCD ... EcoRI fragments of the P1 bacteriophage genome were generated and cloned into lambda vectors. A 6.5kb EcoRI fragment (Fragment ... doi:10.1002/gene.10023. PMID 11835670. S2CID 46000513. Eroshenko N, Church GM (Sep 2013). "Mutants of Cre recombinase with ...

... particularly from bacterial or viral specimens. Additionally, genes encoding proteins with related functions can be identified ... Because of this, this method focuses on all the genetic material at a chromosomal locus and makes no assumptions about function ... As with other cloning techniques, vector and host choice affect the success of gene identification via functional cloning due ... Positional cloning is another molecular cloning technique for identification of a gene of interest. This method uses exact ...

The gene of interest is then targeted to recombine into the ccdB locus, inactivating the transcription of the toxic protein. ... The toxic effects of the protein are neutralised by the RNA gene. One example is the ToxIN system from the bacterial plant ... Ensuring a plasmid accepts an insert is a common problem of DNA cloning. Toxin-antitoxin systems can be used to positively ... Toxin-antitoxin genes are often inherited through horizontal gene transfer and are associated with pathogenic bacteria, having ...

Cloning of an A. thaliana gene, an alcohol dehydrogenase-encoding locus, was described in 1986, by which time mutations at over ... Later work showed that transgenic seed can be obtained by simply dipping flowers into a suitable bacterial suspension. The ... Arondel, V.; Lemieux, B.; Hwang, I.; Gibson, S.; Goodman, H. M.; Somerville, C. R. (1992-11-20). "Map-based cloning of a gene ... KNOTTED-like homeobox genes, homologs of the maize KNOTTED1 gene that control shoot apical meristem identity, were described in ...

... and clone a specific sequence existing near the gene to be mapped. Libraries of large fragments, mainly bacterial artificial ... This method necessitates the discovery of a marker that is firmly related to the mutant locus. The fragment is first sequenced ... Primer walking is a technique used to clone a gene (e.g., disease gene) from its known closest markers (e.g., known gene). As a ... Chromosome walking is a technique used to clone a gene (e.g., disease gene) from its known closest markers (e.g., known gene) ...

Stacking R genes that each recognize a different core effector could delay or prevent adaptation. More than 50 loci in wheat ... The avrBs2 effector gene from Xanthomona perforans is the causal agent of bacterial spot disease of pepper and tomato. The ... The Stem rust 35 (Sr35) NLR gene, cloned from a diploid relative of cultivated wheat, Triticum monococcum, provides resistance ... a plant R gene has specificity for a pathogen avirulence gene (Avr gene). Avirulence genes are now known to encode effectors. ...

The YAC vector cloning site for foreign DNA is located within the SUP4 gene. This gene compensates for a mutation in the yeast ... "Isolation and characterization of yeast artificial chromosome clones linking the HLA-B and HLA-C loci". Proceedings of the ... Due to these issues, the Human Genome Project ultimately abandoned the use of YACs and switched to bacterial artificial ... Cloning of a foreign DNA fragment into the YAC causes insertional inactivation of the gene, restoring the red color. Therefore ...

It is a 94 kDa outer membrane protein encoded by eaeA gene in the locus of enterocyte effacement (LEE), a 35-Kb pathogenicity ... Intimin is expressed on the bacterial cell surface where it can bind to its receptor Tir (Translocated intimin receptor). Tir, ... McDaniel TK, Kaper JB (January 1997). "A cloned pathogenicity island from enteropathogenic Escherichia coli confers the ... Mutations in the eaeA gene result in loss of ability to cause A/E lesions, and is required for full virulence in infected ...

... and rely on libraries made from large-insert clones. The most common type of large-insert clone is the bacterial artificial ... 2017). It mainly provides genome sequences, gene models, functional annotations and polymorphic loci. For some of the plant ... The pieces of DNA are then inserted into BAC clones that are further multiplied by inserting them into bacterial cells that ... Clone-by-clone sequencing strategies are based on the construction of a map for each chromosome before the sequencing, ...

Humans possess two genes encoding pyrophosphatase, PPA1 and PPA2. PPA1 has been assigned to a gene locus on human chromosome 10 ... Sarafian V, Kim Y, Poole RJ, Rea PA (March 1992). "Molecular cloning and sequence of cDNA encoding the pyrophosphate-energized ... "Functional complementation of yeast cytosolic pyrophosphatase by bacterial and plant H+-translocating pyrophosphatases". Proc. ... McAlpine PJ, Mohandas T, Ray M, Wang H, Hamerton JL (1976). "Assignment of the inorganic pyrophosphatase gene locus (PP) to ...

Lee JK, Buckhaults P, Wilkes C, Teilhet M, King ML, Moremen KW, Pierce M (Apr 1997). "Cloning and expression of a Xenopus ... Genes on human chromosome 1, Pages using gallery with unknown parameters, Lectins, Glycobiology, Immune system, Protein ... Nagata S, Nishiyama S, Ikazaki Y (Jun 2013). "Bacterial lipopolysaccharides stimulate production of XCL1, a calcium-dependent ... "Strain-specific copy number variation in the intelectin locus on the 129 mouse chromosome 1". BMC Genomics. 12 (1): 110. doi: ...

As a general rule, rejection is mediated by the gene products of highly variable loci, which must match (or nearly match) ... Allorecognition phenomena have been recognized in bacterial self-identity and social recognition systems, kin discrimination in ... a unicellular bottleneck assures that each representative of the next generation of organisms represents a distinct clone. Some ... Lymphocyte-like cells in these fish express highly variable lymphocyte receptor genes, which undergo somatic rearrangements ...

Differential gene expression can be achieved by modifying the efficiency of sgRNA base-pairing to the target loci. In theory, ... For hypermorphs, this is in contrast to the conventional method of cloning the gene of interest under promoters with variable ... December 2014). "Specific gene repression by CRISPRi system transferred through bacterial conjugation". ACS Synthetic Biology. ... CRISPRi can influence genes that are in close proximity to the target gene. This is especially important when targeting genes ...

The AMY1 locus, as well as the amylase enzyme, is one of the most extensively studied and sequenced gene in the human genome. ... Reference sequences have been compared to other sequences of interest using fosmids by strictly controlling the fosmid clones ... Initially these advances involved using bacterial artificial chromosome (BAC) array with around 1 megabase of intervals ... The globin gene family is an elaborate network of genes consisting of alpha and beta globin genes including genes that are ...

"Cloning and expression of a gene encoding an integrin-like protein in Candida albicans". Proc. Natl. Acad. Sci. U.S.A. 93 (1): ... a locus of Arabidopsis thaliana that is required for disease resistance to both a bacterial and a fungal pathogen". Proceedings ...

... this locus encodes strain-dependent gene regulatory RNAs known as psm-mecRNA. SCCmec also contains ccrA and ccrB; both genes ... Owing to the size of the SCCmec element and the constraints of horizontal gene transfer, a minimum of five clones are thought ... which normally prevent bacterial growth by inhibiting synthesis of cell wall material. This is due to a resistance gene, mecA, ... SCCmec contains additional genes beyond mecA, including the cytolysin gene psm-mec, which may suppress virulence in HA-acquired ...

A second widely used locus (e.g. Amend et al. 2010, Weber et al. 2013), the D1-D3 region of 28S ribosomal RNA genes, may not ... Molecular ecological techniques are used to study in situ questions of bacterial diversity. Many microorganisms are not easily ... The classic technique to achieve this is through cloning, which involves incorporating the amplified DNA fragments into ... Individuals that are heterozygous at a particular locus have a higher fitness than homozygotes at that locus. Inbreeding leads ...

A new resistance gene to bacterial blight derived from O. longistaminata. Jap. J. Breed, 280-281 Khush G.S. et al. 1990. A new ... the USDA awarded Ronald and Mackill a grant to isolate the Sub1 locus. Ronald's laboratory led the positional cloning of the ... Ronald's group subsequently mapped, sequenced, and cloned the Xa21 gene from this rice strain. When US patent 5859339 was ... 1992). "Genetic and physical analysis of the rice bacterial blight disease resistance locus, Xa21". Mol Gen Genet. 236 (1): 113 ...

Hühne K, Axelsson L, Holck A, Kröckel L (1996). "Analysis of the sakacin P gene cluster from Lactobacillus sake Lb674 and its ... They are also used to repress unwanted bacterial growth that might cause ropiness, sliminess, malodor and other product defects ... Tichaczek PS, Vogel RF, Hammes WP (1994). "Cloning and sequencing of sakP encoding sakacin P, the bacteriocin produced by ... Vaughan A, Eijsink VG, Van Sinderen D (2003). "Functional characterization of a composite bacteriocin locus from malt isolate ...

For example, when DNA was amplified in PCR or bacterial cloning techniques, the methylation pattern was not copied and thus the ... This technique was used to compare the DNA methylation modification patterns in the human adult and hemoglobin gene loci. ... without the need for PCR amplicon sub-cloning. First mathematical models for different nucleosome states affecting gene ... was historically limited to methylation patterns of specific gene loci, until whole genome sequencing technologies became ...

"Entrez Gene: non-SMC condensin II complex". Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other ... 2004). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10- ... 2003). "Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners". Mol. Cell. 11 (3): 571-5. doi:10.1016/S1097- ... 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction ...

... karyotype knockout leukemia List of human genetic disorders locus LOD score lymphocyte malformation Gene mapping marker ... cancer candidate gene carcinoma carrier cDNA library cell centimorgan centromere chromosome chromosomal translocation cloning ... Messenger RNA mRNA Enzyme Exon Intron nucleotide allele animal model antisense apoptosis autosomal dominant autosome bacterial ... gene gene amplification gene expression gene library gene mapping gene pool gene therapy gene transfer genetic code ATGC ...

... sub-cloning - substitution - succinate-citramalate CoA-transferase - suicide gene - sulfate-transporting ATPase - supercoil - ... YecM bacterial protein domain - YjeF N terminal protein domain - YopH, N-terminal - YopR bacterial protein domain - Y Y Y - ... locus - LOD score - lymphocyte - lysine-tRNA(Pyl) ligase - M13 phage - m7G(5')pppN diphosphatase - malformation - maltose- ... gene - gene amplification - gene conversion - gene expression - gene mapping - gene pool - gene therapy - gene transfer - ...

1984). "Cloning of eukaryotic genes in single-strand phage vectors: the human interferon genes". Gene. 27 (1): 87-99. doi: ... 2005). "Characterization of the type I interferon locus and identification of novel genes". Genomics. 84 (2): 331-45. doi: ... 1981). "Bacterial synthesis of a novel human leukocyte interferon". Nucleic Acids Res. 9 (3): 731-41. doi:10.1093/nar/9.3.731. ... "Entrez Gene: IFNA8 interferon, alpha 8". Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human ...