Clavulanic acid
... was patented in 1974. Amoxicillin-clavulanic acid is a first-line treatment for many types of infections, ... which produces clavulanic acid. The β-lactam like structure of clavulanic acid looks structurally similar to penicillin, but ... which is the first step of the clavulanic acid biosynthesis. Clavulanic acid was discovered around 1974-75 by British ... This restructures the clavulanic acid molecule, creating a much more reactive species that attacks another amino acid in the ...
Amoxicillin
It may also increase the risk of yeast infections and, when used in combination with clavulanic acid, diarrhea. It should not ... For this reason, it may be combined with clavulanic acid, a β-lactamase inhibitor. This drug combination is commonly called co- ... 2015). "Amoxicillin/Clavulanic Acid for the Treatment of Odontogenic Infections: A Randomised Study Comparing Efficacy and ... Use of the amoxicillin/clavulanic acid combination for more than one week has caused a drug-induced immunoallergic-type ...
Proclavaminate amidinohydrolase
This enzyme participates in clavulanic acid biosynthesis. Salowe SP, Krol WJ, Iwata-Reuyl D, Townsend CA (1991). "Elucidation ... Townsend CA (2002). "New reactions in clavulanic acid biosynthesis". Curr. Opin. Chem. Biol. 6 (5): 583-9. doi:10.1016/S1367- ... of the gene encoding proclavaminate amidino hydrolase and characterization of protein function in clavulanic acid biosynthesis ...
Clavaminate synthase
Townsend CA (October 2002). "New reactions in clavulanic acid biosynthesis". Current Opinion in Chemical Biology. 6 (5): 583-9 ... Clavaminate synthase (EC 1.14.11.21, clavaminate synthase 2, clavaminic acid synthase) is an enzyme with systematic name ... "Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase". Nature Structural Biology. 7 (2 ...
carboxyethyl)arginine beta-lactam-synthase
Townsend CA (2002). "New reactions in clavulanic acid biosynthesis". Curr. Opin. Chem. Biol. 6 (5): 583-9. doi:10.1016/S1367- ... This enzyme participates in clavulanic acid biosynthesis. Miller, M. T.; Bachmann, B. O.; Townsend, C. A.; Rosenzweig, A. C. ( ...
N2-(2-carboxyethyl)arginine synthase
Khaleeli N; Li R; Townsend CA (1999). "Origin of the beta-lactam carbons in clavulanic acid from an unusual thiamine ... This enzyme participates in clavulanic acid biosynthesis. As of late 2007, two structures have been solved for this class of ... the first enzyme in the clavulanic acid biosynthesis pathway". J. Biol. Chem. 279 (7): 5685-92. doi:10.1074/jbc.M310803200. ...
Ureohydrolase
Proclavaminate amidinohydrolase is involved in clavulanic acid biosynthesis. Clavulanic acid acts as an inhibitor of a wide ... evolution of a hydrolytic enzyme in clavulanic acid biosynthesis". Biochem. J. 366 (Pt 2): 423-434. doi:10.1042/BJ20020125. PMC ... Clifton IJ, Elkins JM, Hernandez H (2002). "Oligomeric structure of proclavaminic acid amidino hydrolase: ...
Clavam
An example is clavulanic acid, from which this compound class receives its name. Clavulanic acid, a type of Clavam, has ... This class is divided into the clavulanic acid class and the 5S clavams class. Clavulanic acid is a broad-spectrum antibiotic ... Clavulanic acid strongly inhibits b-lactamase in bacteria, which is associated with its antibiotic properties. B - lactam ... This is essential for the cephamycin C and clavulanic acid but not the 5S claims. CcaR is important for the expression of ...
Streptomyces clavuligerus
Baggaley K, Brown A, Schofield C (1997). "Chemistry and biosynthesis of clavulanic acid and other clavams". Nat Prod Rep. 14 (4 ... Tahlan K, Anders C, Jensen S (2004). "The Paralogous Pairs of Genes Involved in Clavulanic Acid and Clavam Metabolite ... Streptomyces clavuligerus is a species of Gram-positive bacterium notable for producing clavulanic acid. S. clavuligerus ATCC ... Kirk S (2000). "The physiology of clavulanic acid production by Streptomyces clavuligerus (PhD thesis)". University of Surrey, ...
List of antibiotics
"APO-Amoxycillin and Clavulanic Acid 500mg/125 mg Tablets" (PDF). Retrieved November 27, 2014. Mechanism of Action of Bacitracin ... "Amoxicillin-sulbactam versus amoxicillin-clavulanic acid for the treatment of non-recurrent-acute otitis media in Argentinean ... Piperacillin and Piperacillin/tazobactam Ticarcillin/clavulanic acid Certain carbapenems and carbapenem-beta-lactamase- ... Clindamycin Dalbavancin Delafloxacin Fusidic acid Mupirocin (topical) Omadacycline Oritavancin Tedizolid Telavancin Tigecycline ...
Antibiotic
Amoxicillin and amoxicillin/clavulanic acid were the most frequently consumed. Antibiotics are screened for any negative ... For example, β-lactam antibiotics may be used in combination with β-lactamase inhibitors, such as clavulanic acid or sulbactam ... Methicillin-resistant Staphylococcus aureus infections may be treated with a combination therapy of fusidic acid and rifampicin ... and Amino Acids)". Applied Microbiology. Springer India. pp. 83-120. doi:10.1007/978-81-322-2259-0. ISBN 978-81-322-2258-3. ...
Urinary tract infection
Cephalosporins, amoxicillin/clavulanic acid, or a fluoroquinolone may also be used. However, antibiotic resistance to ...
Beta-glucan
Mennink-Kersten MA, Warris A, Verweij PE (2006). "1,3-β-D-Glucan in patients receiving intravenous amoxicillin-clavulanic acid ... increasing fecal bulk and producing short-chain fatty acids as byproducts with wide-ranging physiological activities. This ...
Cilastatin
Thus imipenem/cilastatin, like amoxicillin/clavulanic acid, is a commonly used combination product. Keynan S, Hooper NM, Felici ... Alpha-Amino acids, Amino acid derivatives, Thioethers, Dicarboxylic acids). ...
Mycobacteroides saopaulense
A strain isolated from mangroves has been demonstrated to produce clavulanic acid and streptomycin. The genome of M. ... v t e (Articles with short description, Short description matches Wikidata, Articles with 'species' microformats, Acid-fast ...
ArgJ protein family
"X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster". Biochem. J. 385 (Pt ...
Ticarcillin
It can be sold and used in combination with clavulanate as ticarcillin/clavulanic acid. Because it is a penicillin, it also ... Ticarcillin is also often paired with a β-lactamase inhibitor such as clavulanic acid (co-ticarclav).[citation needed] In ... One synthesis began by making the monobenzyl ester of 3-Thienylmalonic acid, converting this to the acid chloride with SOCl2, ... and condensing it with 6-Aminopenicillanic acid (6-APA). Hydrogenolysis (Pd/C) completed the synthesis of ticarcillin. Fischer ...
Proteus penneri
However, HugA does not affect cephamycins or carbapenems and is inhibited by clavulanic acid. Similar to other Proteus species ... penneri LPS are the amide of D-galacturonic acid with L-lysine α-D-GalA-(L-Lys) (and the amide of D-galacturonic acid with L- ... penneri from the experiment were found to be multiple drug-resistant including resistance to amoxy-clavulanic acid combination ...
Haemophilus influenzae biogroup aegyptius
These include ampicillin, chloramphenicol, amoxicillin-clavulanic acid, cefamandole, cefuroxime, cefotaxime, tetracycline, ... "Deoxyribonucleic acid relatedness between Haemophilus aegyptius and Haemophilus influenzae," Elsevier, 137B (1986): 155-163. ...
Noma (disease)
The first therapy includes the concurrent use of amoxicillin, clavulanic acid, gentamicin, and metronidazole. The second option ...
Adenoiditis
Bacterial adenoiditis may be treated with antibiotics, such as amoxicillin - clavulanic acid or a cephalosporin. In case of ...
British Approved Name
For example, the BAN Co-amoxiclav is assigned to preparations containing amoxicillin and clavulanic acid. Most other ... "amoxicillin with clavulanic acid". The prefix of "co-" is used for many combination drugs, including opioid with paracetamol or ...
GSK plc
Brown AG (August 1986). "Clavulanic acid, a novel beta-lactamase inhibitor--a case study in drug discovery and development". ...
Park Jong-sei
"Simultaneous determination of amoxicillin and clavulanic acid in human plasma by HPLC-ESI mass spectrometry". Journal of ...
Disk diffusion test
Each disk is labelled with the antibiotic it contains (e.g. AMC30, 30µg amoxicillin/clavulanic acid) Antibiotic sensitivity ...
Thienamycin
Spratt BG, Jobanputra V, Zimmermann W (1977). "Binding of Thienamycin and Clavulanic Acid to the Penicillin-Binding Proteins of ... and l-α-aminoadipic acid by ACV synthetase (ACVS, a nonribosomal peptide synthetase) and then cyclization of this formed ...
Cholestasis
Due to its clavulanic acid component, penicillin amoxicillin-clavulanate is the most common culprit of cholestatic liver injury ... The primary bile acids cholic acid (CA) and chenodeoxycholic acid (CDCA) are synthesized in the liver and undergo conjugation ... a bile acid analogue), simtuzumab (a monoclonal antibody), and 24-norursodeoxycholic acid (a synthetic bile acid). Although the ... In the treatment of ICP, current evidence suggests ursodeoxycholic acid (UDCA), a minor secondary bile acid in humans, is the ...
Campylobacter
In case of systemic infection, other bactericidal antibiotics are used, such as ampicillin, amoxicillin/clavulanic acid, or ... Campylobacter is sensitive to the stomach's normal production of hydrochloric acid: as a result, the infectious dose is ... since this type of medication neutralizes normal gastric acid. In humans, the sites of tissue injury include the jejunum, the ...
Animal bite
The first choice is amoxicillin with clavulanic acid, and if the person is penicillin-allergic, doxycycline and metronidazole. ...
Multidrug-resistant tuberculosis
"Early Bactericidal Activity of Amoxicillin in Combination with Clavulanic Acid in Patients with Sputum Smear-positive Pulmonary ... Amino acid replacements in the NADH binding site of InhA apparently result in INH resistance by preventing the inhibition of ... Mutation in the rpoB gene changes the sequence of amino acids and eventual conformation, or arrangement, of the beta subunit. ... p-aminosalicylic acid) For patients with RR-TB or MDR-TB, "not previously treated with second-line drugs and in whom resistance ...