Nasal chondrocytes
... (NC) are present in the hyaline cartilage of the nasal septum and in fact are the only cell type within the ... Similar to other chondrocytes from hyaline cartilage tissues in other locations in the human body, NC undergo a process of cell ... Although articular chondrocytes derived from older individuals have been shown to have a lower proliferation capacity than from ... Articular chondrocytes have typically been the cell type used for cartilage tissue engineering strategies for articular ...
Chondrocyte
Chondrocytes in hyaline cartilage Transmission electron micrograph of a chondrocyte, stained for calcium, showing its nucleus ( ... While the pug mutation deals with the pre-maturation of chondrocytes, multiple other mutations alter chondrocyte proliferation ... marrow stromal cell Chondrocyte Hypertrophic chondrocyte Mesenchymal (mesoderm origin) stem cells are undifferentiated, meaning ... which are present at high levels in the chondrocyte extracellular matrix and are crucial in regulating chondrocyte maturation. ...
Autologous chondrocyte implantation
During the implantation, chondrocytes are applied on the damaged area in combination with a membrane (tibial periosteum or ... Autologous chondrocyte implantation (ACI, ATC code M09AX02 (WHO)) is a biomedical treatment that repairs damages in articular ... The patient then undergoes a second treatment, in which the chondrocytes are applied on the damaged area during an open-knee ... The matrix is removed enzymatically and the chondrocytes isolated. These cells are grown in vitro in a specialised laboratory ...
Spheroids of human autologous matrix-associated chondrocytes
This allows the chondrocyte spheroids to fill in the cartilage defect. Spherox has been shown to improve symptoms and knee ... The chondrocyte spheroids attach to the cartilage within 20 minutes. People treated with Spherox should follow a specific ... The cartilage cells are then grown in the laboratory to prepare a suspension of chondrocyte spheroids. During arthroscopy, the ... Spheroids of human autologous matrix-associated chondrocytes, sold under the brand name Spherox, is a medication used to repair ...
Autologous cultured chondrocytes on porcine collagen membrane
Autologous cultured chondrocytes on porcine collagen membrane (Maci) is a treatment to correct cartilage defects in the knee. ... Autologous cultured chondrocytes on porcine collagen membrane was approved for use in the United States in May 2019. ... "Maci (Autologous Cultured Chondrocytes on a Porcine Collagen Membrane)". U.S. Food and Drug Administration (FDA). Retrieved 13 ... Autologous cultured chondrocytes on porcine collagen membrane is an autologous cellularized scaffold product. This treatment is ...
Osteochondroprogenitor cell
citation needed] Chondrocytes are only present in cartilage where they will produce cartilaginous matrix to maintain the ... These factors also have a role in hypertrophic chondrocyte maturation. β-catenin of the canonical Wnt signalling pathway plays ... Lefebvre, V; Behringer RR; de Crombrugghe B (2001). "L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte ... They have the ability to differentiate into osteoblasts or chondrocytes depending on the signalling molecules they are exposed ...
Ossification
The primary center In long bones, bone tissue first appears in the diaphysis (middle of shaft). Chondrocytes multiply and form ...
MMP8
1996). "Chondrocyte matrix metalloproteinase-8. Human articular chondrocytes express neutrophil collagenase". J. Biol. Chem. ...
PTK2B
Loeser RF (2002). "Integrins and cell signaling in chondrocytes". Biorheology. 39 (1-2): 119-24. PMID 12082274. Overview of all ...
Sodium-hydrogen antiporter 3
Expression of ENaC, Na+/K+/2Cl- cotransporter and Na+/H+ exchangers in healthy and arthritic chondrocytes". Histol. Histopathol ... "Sodium transport systems in human chondrocytes. II. ...
Osteochondritis dissecans
The chondrocytes are grown and injected into the defect under a periosteal patch. ACI surgery has reported good to excellent ... In this surgery, chondrocytes are arthroscopically extracted from the intercondylar notch of the articular surface. ... One such technique is autologous chondrocyte implantation (ACI), which is useful for large, isolated femoral defects in younger ... Open growth plates are characterized by increased numbers of undifferentiated chondrocytes (stem cells) which are precursors to ...
Cartilage
The chondrocytes present different morphologies related to their position in the tissue. The embryos of Sepia officinalis ... It is a vesicular cell-rich cartilage due to the large, spherical and vacuolated chondrocytes with no homologies in other ... Nutrition is supplied to the chondrocytes by diffusion. The compression of the articular cartilage or flexion of the elastic ... The odontophore contains muscle cells along with the chondrocytes in the case of Lymnaea and other mollusks that graze ...
Cell potency
MSCs can differentiate into osteoblasts, chondrocytes, and adipocytes. In biology, oligopotency is the ability of progenitor ...
Chondrocalcin
Some examples of chondrocytes include collagen and proteoglycans. The chondrocytes that produce chondrocalcin are typically ... This calcium-binding protein comes from chondrocytes, which are cells that produce and maintain cartilage. ... "Chondrocalcin is internalized by chondrocytes and triggers cartilage destruction via an interleukin-1β-dependent pathway, ...
Collagen receptor
Functions include: Chondrocyte proliferation and bone growth; regulation of cell proliferation, cell adhesion and induction of ... It is expressed on chondrocytes and cardiac muscle. Involved in growth plate morphogenesis and function. Integrin α11β1 is ...
Complement component 1r
"Synthesis of classical pathway complement components by chondrocytes". Immunology. 88 (4): 648-56. PMC 1456645. PMID 8881771. ...
Life Length
"Study of Telomere Length in Preimplanted Cultured Chondrocytes". Cartilage. 10 (1): 36-42. doi:10.1177/1947603517749918. PMC ... Stem Cell Exhibiting Pattern Ability and Epigenetic Rejuvenation Study of Telomere Length in Preimplanted Cultured Chondrocytes ...
Epiphyseal plate
Depletion of chondrocytes due to apoptosis leads to less ossification and growth slows down and later stops when the entire ... As the older chondrocytes degenerate, osteoblasts ossify the remains to form new bone. In puberty increasing levels of estrogen ... The plate's chondrocytes are under constant division by mitosis. These daughter cells stack facing the epiphysis while the ... Zhong, M; Carney, DH; Boyan, BD; Schwartz, Z (January 2011). "17β-Estradiol regulates rat growth plate chondrocyte apoptosis ...
ALX1
... a homeoprotein selectively expressed in chondrocytes". Proceedings of the National Academy of Sciences of the United States of ...
Pseudoachondroplasia
It is also found near chondrocytes (cartilage-forming cells). Chondrocytes play a vital role in osteogenesis (the formation of ... Though some chondrocytes do manage to survive, growth is significantly reduced, resulting in the characteristically short limbs ... It is observed at a high frequency in chondrocytes in developing bone and tendon. In pseudochondroplasia, COMP is not secreted ... The researchers found that IX collagen was amassed within the pseudoachondroplasia chondrocytes. This discovery suggests that ...
Chondroblast
Remaining chondrocytes divide in order to form more chondroblasts. HMGB-1, a growth factor which promotes chondrocyte division ... Chondroblasts are called chondrocytes when they embed themselves in the cartilage matrix, consisting of proteoglycan and ... These cells are extremely important in chondrogenesis due to their role in forming both the chondrocytes and cartilage matrix ... Higher levels of Wnt14 prevented chondrocyte differentiation whereas lower levels appeared to allow it. If the Wnt/ β-Catenin ...
Rho kinase inhibitor
"ROCK inhibitor prevents the dedifferentiation of human articular chondrocytes". Biochemical and Biophysical Research ... inhibition enhances aggrecan deposition and suppresses matrix metalloproteinase-3 production in human articular chondrocytes". ...
ADAM15
... also has an antiapoptotic effect in osteoarthritic chondrocytes. The precise role of ADAM15 in cancer is still unclear ... 1997). "Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes". ... "ADAM15 exerts an antiapoptotic effect on osteoarthritic chondrocytes via up-regulation of the X-linked inhibitor of apoptosis ...
ZBTB7B
2000). "Regulation of human COL2A1 gene expression in chondrocytes. Identification of C-Krox-responsive elements and modulation ...
Mechanotransduction
... where they are subsequently dissipated and transmitted to chondrocytes (cartilage cells). Chondrocytes sense and convert the ... there need to be mechanoreceptors on the surface of chondrocytes. Candidates for chondrocyte mechanoreceptors include stretch- ... Each chondrocyte has one cilium and it is hypothesized to transmit mechanical signals by way of bending in response to ECM ... Chondrocytes have been shown to secrete TGF-b, and upregulate TGF-b receptors in response to mechanical stimulation; this ...
HAPLN1
... structure and transcription pattern in chondrocytes". The Biochemical Journal. 303. 303 ( Pt 1) (Pt 1): 329-33. doi:10.1042/ ...
Cartilage-derived angiogenesis inhibitor
They are usually highly expressed in cartilage and within chondrocytes. Their genetic transcription increases upon the ...
Gordon M. Keller
Craft AM, Ahmed N, Rockel JS, Baht GS, Alman BA, Kandel RA, Grigoriadis AE, Keller GM (2013). "Specification of chondrocytes ... chondrocytes, T lymphocytes and myeloid precursors. Keller holds a Tier I Canada Research Chair in Embryonic Stem Cell Biology ...
SLC2A9
2002). "Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9". Cell ... The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript ... "Cytokine regulation of facilitated glucose transport in human articular chondrocytes". J. Immunol. 167 (12): 7001-8. doi: ... characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; ...
Chondrogenesis
Ihh stimulates chondrocyte proliferation and regulates chondrocyte maturation by maintaining the expression of PTHrP. PTHrP ... Because chondrocytes are bound in lacunae, they cannot migrate to damaged areas. Also, because hyaline cartilage does not have ... The expression of Sox9 induces the expression of BMP, which causes chondrocytes to proliferate and differentiate. L-Sox5 and ... The molecule Indian hedgehog (Ihh) is expressed by prehypertrophic chondrocytes. ...