... inbreeding and maintenance of inbred strains of laboratory mice and rats is of great importance for biomedical research. The ... The use of inbred strains is also important for genetic studies in animal models, for example to distinguish genetic from ... 2006). "Selection and Inbreeding Depression: Effects of Inbreeding Rate and Inbreeding Environment". Evolution. 60 (5): 1014- ... 6 Although there are several examples of inbred populations of wild animals, the negative consequences of this inbreeding are ...
... including International Index of Laboratory Animals and Inbred Strains in Biomedical Research. He was the winner in 1996 of the ... Michael Festing is a British research scientist best known for his interest in animal testing. He is one of 19 members of the ... He is also a council member of the Institute of Laboratory Animals Research USA. [2] Most of Michael Festing's career has been ... Nonetheless, Festing has been criticized by the animal rights movement for his investment in companies that engage in animal ...
Its main activity is the reproduction and maintenance of mice stocks either of inbred strains or genetically engineered mice, ... Fleming's Animal house (certified with ISO 9001) provides husbandry of animals and services to the biomedical research ... The Biomedical Sciences Research Center "Alexander Fleming" is a non-profit research organisation based in Vari, Athens, Greece ... Main areas of research: Functional genomics and proteomics; Molecular and cellular immunology; Animal models of human disease; ...
... to be integrated into the National Animal Resource Facility for Biomedical Research), the Food and Drug Toxicology Research ... NCLAS also came into the limelight due to the WNIN/Ob obese rat strain which is the heaviest inbred rat model available. It has ... Management and Experimentation using laboratory animals in biomedical research. It started as a unit called Laboratory Animal ... Genome Valley National Animal Resource Facility for Biomedical Research Central Drugs Standard Control Organization Bhargava, ...
National Research Council and Institute of Medicine (1988). Use of Laboratory Animals in Biomedical and Behavioral Research. ... inbred mouse strain and the systematic generation of other inbred strains. The mouse has since been used extensively as a model ... Animals in space Animal testing Animal testing on invertebrates Animal testing on rodents Cellular model (numerical), e.g., ... National Research Council and Institute of Medicine (1988). Use of Laboratory Animals in Biomedical and Behavioral Research. ...
There are many strains of mice used in research, however, inbred strains are usually the animals of choice for most fields. ... While mice are by far the most widely used animals in biomedical research, recent studies have highlighted their limitations. ... "Inbred Strain - an overview , ScienceDirect Topics". Silver, L. (2001). "Inbred Strain". Brenner's Encyclopedia of Genetics. p ... Laboratory rat Animal testing Animal testing on rodents Animal model Animal Identification Fe, Fi, Fo, Fum, and Phooey, five ...
While mice, rats and other rodents are by far the most widely used animals in biomedical research, recent studies have ... In addition, inbred mouse strains are used in the overwhelming majority of studies, while the human population is heterogeneous ... Another study in 2016 suggested that gut microbiomes in mice may have an impact upon scientific research. Animal testing Animal ... Speaking of Research Carbone, L (2004). What Animals Want: Expertise and Advocacy in Laboratory Animal Welfare Policy. Oxford ...
... combine strains that are wild-derived (with high genetic diversity) and historically significant biomedical research bred ... The CC population consists of 83 inbred mouse strains that over many generations in labs came from the 8 founder strains. These ... They are of potential health concern because they are known to disrupt the endocrine system of animals, and some research has ... Patisaul HB, Fenton SE, Aylor D (June 2018). "Animal models of endocrine disruption". Best Practice & Research. Clinical ...
"A Fix For Gender-Bias In Animal Research Could Help Humans". NPR. Feb 10, 2016. Retrieved July 4, 2020. "Les découvertes de ... In 1999, they showed that different inbred strains of mice displayed very different pain sensitivity. Chief among these ... For the past century, the measurement of pain in rodent biomedical research was considered complicated and imprecise, and many ... "Does sex make a difference in preclinical research". Canadian Institutes of Health Research. Clayton, Janine Austin (2015-10-29 ...
It is also used in stem cell research using it cell line called ES. This is another inbred strain that is popularly used as a ... "Unique inbred strain MSM/Ms established from the Japanese wild mouse". Experimental Animals. 58 (2): 123-134. doi:10.1538/ ... Marshall, J. T. (1981). "Taxonomy". In Foster, H. L.; Small, J. D.; Fox, J. G. (eds.). The Mouse in Biomedical Research: ... "The ancestor of extant Japanese fancy mice contributed to the mosaic genomes of classical inbred strains". Genome Research. 23 ...
Therefore, the strains that were isolated from animals a few decades ago and went through multiple passages in eggs are less ... The Mouse in Biomedical Research (2nd ed.). Amsterdam: Academic Press. pp. 281-309. doi:10.1016/B978-012369454-6/50039-X. Eaton ... Inbred and outbred mouse and rat strains have very different susceptibility to Sendai virus infection. Visualization of SeV ... All Sendai virus strains belong to the same serotype. The origin of many strains of SeV was described in 1978. Some strains ...
Animal breeding). In biomedical research, this work can assist in finding candidates gene alleles that can cause or influence ... like an F2 or Recombinant inbred strains/lines (RILs). To scan for QTLs regions in a genome, a gene map based on linkage have ... The research question will define the objective of a study. The research will be headed by the question, so it needs to be ... As an example, consider groups of similar animals (mice, for example) under two different diet systems. The research question ...
... was a rodent fancier who bred fancy mice and inbred strains for animal models, particularly for research on development and ... ISBN 978-1-84520-153-1. Rader, Karen A. (2004). Making Mice: Standardizing Animals for American Biomedical Research, 1900-1955 ... Lathrop began developing inbred strains around 1910. Loeb and Lathrop performed experiments at her farm and the pair authored ... Eisen, Eugene J. (2005). The Mouse in Animal Genetics and Breeding Research. London: Imperial College Press. p. 3. ISBN 1-86094 ...
... student apprenticeships in biomedical research technician work; high school fellowships in biomedical research; and the ... King researched the genetics of inbreeding and sex determination. She was instrumental in creating and breeding the Wistar rat ... Hayflick, L. (1965-03-01). "The limited in vitro lifetime of human diploid cell strains". Experimental Cell Research. 37 (3): ... Joseph Leidy, who added animal specimens, fossils and anthropological samples. By the late 1880s, the collection was beginning ...
At the turn of the century much biomedical research was being done using animals and especially mammalian bodies to further ... The idea of inbreeding to achieve this goal of a 'pure strain' in mice was one that may have created a negative response to the ... Making Mice: Standardizing Animals for American Biomedical Research. Princeton, NJ: Princeton University Press, 2004. "Science ... History of animal testing History of research on Arabidopsis thaliana History of research on Caenorhabditis elegans Rader, ...
Animal models, Stem cell research, Regenerative biomedicine, Animal models in neuroscience, Taxa named by Francis Buchanan- ... Inbred strains and traditional outbred stocks have not been developed for laboratory zebrafish, and the genetic variability of ... Japanese rice fish or medaka, another fish used for genetic, developmental, and biomedical research List of freshwater aquarium ... Embryo viability was significantly reduced in inbred exposed fish and there was a tendency for inbred males to sire fewer ...
... is the tendency of outbred strains to exceed both inbred parents in fitness. Selective breeding of plants and animals, ... Risch N, Burchard E, Ziv E, Tang H (July 2002). "Categorization of humans in biomedical research: genes, race and disease". ... But overdominance implies that yields on an inbred strain should decrease as inbred strains are selected for the performance of ... Inbreeding depression is the loss of fitness due to loss of genetic diversity. Inbred strains tend to be homozygous for ...
Intentionally bred albinistic strains of some animal species are commonly used as model organisms in biomedical research and ... Familiar albino animals include in-bred strains of laboratory animals (rats, mice and rabbits), but populations of naturally ... In Japan, research has identified a dominant albinism in the rainbow trout. Albinism occurs throughout the animal kingdom. The ... ISBN 978-1-58196-019-8. Creel, D. (June 1980). "Inappropriate use of albino animals as models in research". Pharmacology ...
... rats have served as an important animal model for research in psychology and biomedical science. In 18th-century Europe, wild ... Inbred strains are also available, but are not as commonly used as inbred mice. Much of the genome of Rattus norvegicus has ... The strain re-capitulates many of the features of human type 1 diabetes and has contributed greatly to the research of T1DM ... Institute for Laboratory Animal Research (ILAR). 32 (3): 4-8. doi:10.1093/ilar.32.3.4. Suckow, Mark A.; Weisbroth, Steven H.; ...
... required the departments of the Interior and Agriculture to protect the animals, required studies of the animals' habits and ... The Pryor Mountain mustang is a substrain of mustang considered to be genetically unique and one of the few strains of horses ... Research by biologists and veterinarians at Colorado State University, the University of Kentucky, and other colleges found ... Genetic studies have revealed that the herd exhibits a high degree of genetic diversity and a low degree of inbreeding, and BLM ...
"Enteric Coronavirus". Diseases of Research Animals. Archived from the original on 1 July 2019. Retrieved 24 January 2020. ... "Acute and chronic changes in the microcirculation of the liver in inbred strains of mice following infection with mouse ... Biomedical Perspectives. Methods in Microbiology. Vol. 50. pp. 27-81. doi:10.1016/bs.mim.2021.10.002. ISBN 9780323850612. S2CID ... Enterotropic strains include mouse hepatitis virus (MHV) strains D, Y, RI, and DVIM, whereas polytropic strains, such as JHM ...
The first inbred strain, DBA (dilute brown agouti), was developed in 1909. Among the earliest references to the use of inbred ... Shultz, L.D. (Feb 2007). "Humanized mice in translational biomedical research". Nat. Rev. Immunol. 7 (2): 118-30. doi:10.1038/ ... and genome editing technologies transformed the use of mice in cancer research by allowing researchers to develop animal models ... Inbred mouse strains are the result of at least 20 generations of successive brother/sister matings which lead to a population ...
"Use of Laboratory Animals in Biomedical and Behavioral Research", Institute for Laboratory Animal Research, The National ... and worms are inbred through many generations to create strains with defined characteristics. These provide animals of a known ... "Animal research numbers in 2017". Understanding Animal Research. 2017. "Home Office Statistics for Animals Used in Research in ... Animal testing, also known as animal experimentation, animal research, and in vivo testing, is the use of non-human animals in ...
... and has aided in biomedical research. A 2017 molecular study of the tammar and the mink found the potential involvement of EGF ... As it lands, the energy of the jump is converted into strain energy made when its leg tendons are stretched. As it leaps back ... The amount of energy stored in the tendons increases with the animal's speed and the weight of the load it is carrying. This is ... However, the fragmentation of its range has led to high amounts of inbreeding and physical deformities in some populations. ...
Cryopreservation is also commonly employed in biomedical research to archive and distribute genetically engineered mice (Mus ... strains and any conserved genetic material; all of which are currently categorized as Breeds." Genetic materials that are ... inbreeding, crossbreeding, climate change, natural disasters, disease, cultural changes, and urbanization. Indigenous livestock ... During this process it may be beneficial to have a teaser animal-an animal used to sexually tease but not impregnate the animal ...
All articles that may contain original research, Articles that may contain original research from July 2023, Wikipedia articles ... He believes that it is not physically different from breeding domestic animals for traits such as speed or herding skill. ... Another criticism is that eugenics policies eventually lead to a loss of genetic diversity, thereby resulting in inbreeding ... ISBN 978-1-56858-258-0. Buchanan, Allen (2017). Better than Human: The Promise and Perils of Deliberate Biomedical Enhancement ...
Joe Holson's research career has spanned a diverse range of test agents using a variety of experimental animal models and human ... Multireplicated Dose-Response Studies in Four Inbred Strains and One Outbred Stock of Mice". Toxicological Sciences. 19 (2): ... From 1980-1986, he also served as a member of the Board of Directors and Secretary for the San Diego Biomedical Research ... From 1985 through 1986, he served as President of Biomedical Research Institute of America in La Jolla, California and as an ...
"Nonhuman Primates: Research Animals". Animal Welfare Information Center. United States Department of Agriculture. Archived from ... ISBN 978-1-4422-1957-1. "The supply and use of primates in the EU". European Biomedical Research Association. 1996. Archived ... This effect of inbreeding on infant mortality is probably largely a result of increased expression of deleterious recessive ... A bony ridge above the eye sockets reinforces weaker bones in the face, which are put under strain during chewing. ...
Genetically modified mice have been the most common mammals used in biomedical research, as they are cheap and easy to ... Naturally occurring mutant axolotls like the white strain that are often used in research have a transcriptional mutation at ... Inbred and Mutant Animals, Training Opportunities, and Web-Based Support". Frontiers in Physiology. 10: 387. doi:10.3389/fphys. ... The vast majority of genetically modified animals are at the research stage while the number close to entering the market ...
Chromosome-From the Whitehead Institute for Biomedical Research Nature-focus on the Y chromosome National Human Genome Research ... Genealogical DNA test Genetic genealogy Haplodiploid sex-determination system Human Y chromosome DNA haplogroups List of Y-STR ... A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology". Science. 156 (3774): ... when an ancestral animal developed an allelic variation, a so-called "sex locus" - simply possessing this allele caused the ...