... of all IGF binding. IGF-1 binds to IGFBP-3 in a 1:1 molar ratio. IGF-BP also binds to IGF-1 inside the liver, allowing growth ... The insulin-like growth factor-binding protein (IGFBP) serves as a transport protein for insulin-like growth factor 1 (IGF-1). ... "Role of insulin-like growth factor binding proteins in the control of IGF actions". Prog. Growth Factor Res. 6 (2-4): 357-66. ... November 1998). "Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): ...
Firth SM, Baxter RC (December 2002). "Cellular actions of the insulin-like growth factor binding proteins". Endocrine Reviews. ... It combines peptide-coated iron oxide attached to "reporter chemicals". When a peptide binds to a thrombin molecule, the report ... Activated protein C inactivates factors Va and VIIIa. Binding of activated protein C to protein S leads to a modest increase in ... Thrombin bound to thrombomodulin activates protein C, an inhibitor of the coagulation cascade. The activation of protein C is ...
Jones JI, Clemmons DR (February 1995). "Insulin-like growth factors and their binding proteins: biological actions". Endocrine ... the reason for the confusion is that binding studies show that IGF-1 binds the insulin receptor 100-fold less well than insulin ... "Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor". Growth ... "Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase ...
"Plasminogen binds the heparin-binding domain of insulin-like growth factor-binding protein-3". The American Journal of ... The exposure of this receptor binding domain allows the α2-macroglobulin protease complex to bind to clearance receptors and be ... These movements expose the KR5 lysine-binding site to potential binding partners, and suggest a requirement for spatially ... and factor XII (Hageman factor). Fibrin is a cofactor for plasminogen activation by tissue plasminogen activator. Urokinase ...
Nam TJ, Busby W, Clemmons DR (1997). "Insulin-like growth factor binding protein-5 binds to plasminogen activator inhibitor-I ... Insulin-like growth factor-binding protein 5 (IBF-5) is a protein that in humans is encoded by the IGFBP5 gene. An IGFBP5 gene ... 1999). "Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF ... Kiefer MC, Ioh RS, Bauer DM, Zapf J (1991). "Molecular cloning of a new human insulin-like growth factor binding protein". ...
2000). "H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein". J. Biol. Chem. 275 (38): 29562-9. ... 2005). "Targeted knockdown of the RNA-binding protein CRD-BP promotes cell proliferation via an insulin-like growth factor II- ... 2004). "Dwarfism and Impaired Gut Development in Insulin-Like Growth Factor II mRNA-Binding Protein 1-Deficient Mice". Mol. ... "A Family of Insulin-Like Growth Factor II mRNA-Binding Proteins Represses Translation in Late Development". Mol Cell Biol. 19 ( ...
IGF2R is a multifunctional protein receptor that binds insulin-like growth factor 2 (IGF2) at the cell surface and mannose-6- ... Ilvesmäki V, Blum WF, Voutilainen R (1994). "Insulin-like growth factor binding proteins in the human adrenal gland". Mol. Cell ... Zhou J, Bondy C (1992). "Insulin-like growth factor-II and its binding proteins in placental development". Endocrinology. 131 ( ... growth factor II binding site to amino acids 1508-1566 in repeat 11 of the mannose 6-phosphate/insulin-like growth factor II ...
"Total and free insulin-like growth factor I, insulin-like growth factor binding protein 3 and acid-labile subunit reflect ... The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and ... IGFALS insulin-like growth factor binding protein, acid labile subunit". Twigg SM, Baxter RC (March 1998). "Insulin-like growth ... Insulin-like growth factor binding protein, acid labile subunit, also known as IGFALS, is a protein which in humans is encoded ...
The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein ... IGFBP1 insulin-like growth factor binding protein 1". Rajaram S, Baylink DJ, Mohan S (1998). "Insulin-like growth factor- ... Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is ... 1993). "Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by ...
"Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6". J. Biol. Chem. ... The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non- ... Insulin-like growth factor-binding protein 4 is a protein that in humans is encoded by the IGFBP4 gene. This gene is a member ... "Purification of a colon cancer cell growth inhibitor and its identification as an insulin-like growth factor binding protein". ...
Lin-28 homolog A is a protein that in humans is encoded by the LIN28 gene. LIN28 encodes an RNA-binding protein that binds to ... insulin-like growth factor 2) mRNA. Lin28 binds to the let-7 pre-microRNA and blocks production of the mature let-7 microRNA in ... LIN28 can regulate glucose homeostasis in mammals by increasing insulin-PI3K-mTOR signaling and insulin sensitivity, thereby ... Moss EG, Lee RC, Ambros V (Mar 1997). "The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is ...
... have been characterized as direct m6A readers and have a conserved m6A-binding pocket. Insulin-like growth factor-2 mRNA- ... These binding proteins are named m6A readers. The YT521-B homology (YTH) domain family of proteins (YTHDF1, YTHDF2, YTHDF3 and ... which is the subunit that binds S-adenosyl-L-methionine (SAM). In vitro, this methyltransferase complex preferentially ... The biological functions of m6A are mediated through a group of RNA binding proteins that specifically recognize the methylated ...
"Transferrin binds insulin-like growth factors and affects binding properties of insulin-like growth factor binding protein-3". ... It is believed to be a major fetal growth factor in contrast to insulin-like growth factor 1 (IGF-1), which is a major growth ... "Structural determinants of ligand and cell surface binding of insulin-like growth factor-binding protein-3". The Journal of ... Twigg SM, Baxter RC (Mar 1998). "Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with ...
In the extracellular space, tTG binds to proteins of the extracellular matrix (ECM), binding particularly tightly to ... Heat Shock Factor 1) and thus the body's response to heat shock. In the absence of tTG, the response to heat shock is impaired ... Multiple Ca2+ can bind to a single tTG molecule. Specifically, tTG binds up to 6 calcium ions at 5 different binding sites. ... Endoplasmic reticulum (ER)-resident protein 57 (ERp57), a protein in the ER that promotes folding of nascent proteins and is ...
"Insulin-like growth factor-binding protein 5 (IGFBP-5) interacts with a four and a half LIM protein 2 (FHL2)". J. Biol. Chem. ... "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to ... "Insulin-like growth factor-binding protein 5 (IGFBP-5) interacts with a four and a half LIM protein 2 (FHL2)". J. Biol. Chem. ... The Four-and-a-half LIM (FHL)-only protein subfamily is one of the members of the LIM-only protein family. Protein members ...
"Expression of growth hormone-releasing factor, growth hormone, insulin-like growth factor-1 and its binding proteins in human ... "IGFBP7 Binds to the IGF-1 Receptor and Blocks Its Activation by Insulin-Like Growth Factors". Science Signaling. 5 (255): ra92 ... Insulin-like growth factor-binding protein 7 is a protein that in humans is encoded by the IGFBP7 gene. The major function of ... Wilson HM, Birnbaum RS, Poot M, Quinn LS, Swisshelm K (2002). "Insulin-like growth factor binding protein-related protein 1 ...
"Transferrin binds insulin-like growth factors and affects binding properties of insulin-like growth factor binding protein-3". ... "Transferrin is an insulin-like growth factor-binding protein-3 binding protein". The Journal of Clinical Endocrinology and ... Transferrin has been shown to interact with insulin-like growth factor 2 and IGFBP3. Transcriptional regulation of transferrin ... Some invertebrates have proteins that act like transferrin found in the hemolymph. When not bound to iron, transferrin is known ...
The RNA-binding protein IMP-3 is a translational activator of insulin-growth factor II leader-3 mRNA during proliferation of ... Purification and properties of a protein that binds to the C-terminal coding region of human c-myc mRNA. Journal of Biological ... CRD-BP belongs to a family of RNA binding proteins that show close a relation to the chicken β-actin zipcode-binding protein ... The c-myc¬ coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins. Nuc. Acid. Res. ...
3 protein interacts with the insulin-like growth factor-I receptor". Biochem. Biophys. Res. Commun. 278 (1): 38-43. doi:10.1006 ... "The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to ... 3 protein interacts with the insulin-like growth factor-I receptor". Biochem. Biophys. Res. Commun. 278 (1): 38-43. doi:10.1006 ... SOCS3 has been shown to interact with: Erythropoietin receptor, Glycoprotein 130, Insulin-like growth factor 1 receptor, Janus ...
"Transferrin binds insulin-like growth factors and affects binding properties of insulin-like growth factor binding protein-3". ... "Factors regulating insulin-like growth factor-binding protein-3 binding, processing, and potentiation of insulin-like growth ... "Interaction of insulin-like growth factor binding protein-3 with latent transforming growth factor-beta binding protein-1". ... of insulin-like growth factor binding proteins and of the acid-labile subunit of the insulin-like growth factor ternary binding ...
"Association of insulin-like growth factor I and insulin-like growth factor-binding protein-3 with intelligence quotient among 8 ... IGF-1 binds to it at significantly higher affinity than it binds the insulin receptor. Like the insulin receptor, the IGF-1 ... "Effect of insulin on the hepatic production of insulin-like growth factor-binding protein-1 (IGFBP-1), IGFBP-3, and IGF-I in ... The insulin-like growth factors (IGFs) are proteins with high sequence similarity to insulin. IGFs are part of a complex system ...
... the most abundant protein, accounts for 80% of all IGF binding. IGF-1 binds to IGFBP-3 in a 1:1 molar ratio. IGFBP-1 is ... Insulin-like growth factor 1 has been shown to bind and interact with all seven IGF-1 binding proteins (IGFBPs): IGFBP1, IGFBP2 ... "insulin-like growth factor 1" implies, IGF-1 is structurally related to insulin, and is even capable of binding the insulin ... Insulin-like growth factor receptor agonists, Insulin receptor agonists, Aging-related proteins, Neurotrophic factors, ...
... p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins". Molecular ... Tyrosine phosphorylation of IRS-1 by insulin receptor (IR) introduces multiple binding sites for proteins bearing SH2 homology ... IRS-1 integrates signalling from insulin receptor (InsR), insulin-like growth factor-1 receptor (IGF1R) and many other cytokine ... Insulin receptor substrate 1 plays a key role in transmitting signals from the insulin receptor (IR) and insulin-like growth ...
Sui D, Wilson JE (October 2000). "Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type ... Within cells, HK3 localizes to the cytoplasm and putatively binds the perinuclear envelope. HK3 is the predominant hexokinase ... This protein has a molecular weight of 100 kDa and is composed of two highly similar 50-kDa domains at its N- and C-terminals. ... The transcription factor PU.1 is known to directly activate transcription of the antiapoptotic BCL2A1 gene or inhibit ...
Sui D, Wilson JE (Oct 2000). "Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type ... Sakurai T, Itoh K, Higashitsuji H, Nagao T, Nonoguchi K, Chiba T, Fujita J (Apr 2004). "A cleaved form of MAGE-A4 binds to Miz- ... Zinc finger and BTB domain-containing protein 17 is a protein that in humans is encoded by the ZBTB17 gene. ZBTB17 has been ... "Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1". The Journal of ...
"Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase ... Cacalano NA, Sanden D, Johnston JA (May 2001). "Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 ... the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, ... tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding protein". J. Biol. Chem. 276 (16): 13087-95. doi: ...
ADAM 12, a metalloprotease that binds insulin growth factor binding protein-3 (IGFBP-3), appears to be an effective early Down ... binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor ... interacts with insulin-like growth factor-binding protein-3". J. Biol. Chem. 275 (24): 18574-80. doi:10.1074/jbc.M002172200. ... interacts with insulin-like growth factor-binding protein-3". J. Biol. Chem. 275 (24): 18574-80. doi:10.1074/jbc.M002172200. ...
Albumin Vitamin D-binding protein Hemoglobin Myoglobin Angiotensin II Insulin Leptin Prolactin Epidermal Growth Factor ... 460-kDa protein that facilitates endocytosis of intrinsic factor-vitamin B12 and binds receptor-associated protein". The ... The fraction of LRP2 at the apical surface is important for the continued ability of the protein to reabsorb filtered proteins ... "The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes". Journal of the ...
... is also an abbreviation for chicken or rat β-actin zipcode-binding protein 1, a homolog of the human insulin-like growth ... Z-DNA-binding protein 1, also known as DNA-dependent activator of IFN-regulatory factors (DAI) and DLM-1, is a protein that in ... DLM1 then binds to cytosolic Viral DNA using two Z-DNA-binding domains (Zα and Zβ) at its N-terminus along with a DNA binding ... the proteins involved in mRNA transport (RNA-binding proteins, RBPs). DLM1 encodes a Z-DNA binding protein. Z-DNA formation is ...
"The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to ... The suppressor of cytokine signaling 1 has been shown to interact with: Tax, CD117, Colony stimulating factor 1 receptor Growth ... inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation". The ... "Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation". The EMBO Journal. 18 (4): 904 ...